Akr1a1 (aldo-keto reductase family 1 member A1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Akr1a1 (aldo-keto reductase family 1 member A1) Chinchilla lanigera
Analyze
Symbol: Akr1a1
Name: aldo-keto reductase family 1 member A1
RGD ID: 8950512
Description: ENCODES a protein that exhibits aldose reductase (NADPH) activity (ortholog); all-trans-retinol dehydrogenase (NAD+) activity (ortholog); glucuronolactone reductase activity (ortholog); INVOLVED IN aldehyde catabolic process (ortholog); cellular detoxification of aldehyde (ortholog); D-glucuronate catabolic process (ortholog); PARTICIPATES IN doxorubicin pharmacokinetics pathway; prostaglandin biosynthetic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); breast cancer (ortholog); Carcinogenesis (ortholog); FOUND IN apical plasma membrane (ortholog); cytosol (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alcohol dehydrogenase [NADP(+)]; aldo-keto reductase family 1, member A1 (aldehyde reductase)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546412,714,717 - 12,729,662 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546412,715,238 - 12,729,034 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Akr1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546412,714,717 - 12,729,662 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546412,715,238 - 12,729,034 (-)NCBIChiLan1.0ChiLan1.0
AKR1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38145,550,826 - 45,570,049 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl145,550,543 - 45,570,049 (+)EnsemblGRCh38hg38GRCh38
GRCh37146,016,498 - 46,035,721 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,789,085 - 45,808,308 (+)NCBINCBI36Build 36hg18NCBI36
Build 34145,685,590 - 45,704,813NCBI
Celera144,300,464 - 44,319,706 (+)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef144,127,818 - 44,147,063 (+)NCBIHuRef
CHM1_1146,133,579 - 46,152,870 (+)NCBICHM1_1
T2T-CHM13v2.0145,423,192 - 45,442,415 (+)NCBIT2T-CHM13v2.0
Akr1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,493,707 - 116,508,871 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,493,707 - 116,508,877 (-)EnsemblGRCm39 Ensembl
GRCm384116,636,510 - 116,651,674 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,636,510 - 116,651,680 (-)EnsemblGRCm38mm10GRCm38
MGSCv374116,309,115 - 116,324,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364116,134,442 - 116,149,583 (-)NCBIMGSCv36mm8
Celera4115,370,207 - 115,385,626 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.26NCBI
Akr1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,329,605 - 135,367,037 (-)NCBIGRCr8
mRatBN7.25130,092,945 - 130,130,277 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,092,732 - 130,113,674 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,717,057 - 132,734,057 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,471,650 - 134,488,650 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,494,047 - 134,511,049 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,482,068 - 135,498,693 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,482,068 - 135,498,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,278,242 - 139,294,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,920,561 - 136,937,422 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,925,785 - 136,942,923 (-)NCBI
Celera5128,620,481 - 128,637,092 (-)NCBICelera
Cytogenetic Map5q35NCBI
AKR1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21181,239,683 - 181,257,580 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,381,197 - 180,399,087 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,853,867 - 44,871,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1146,211,859 - 46,230,072 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,211,859 - 46,230,072 (+)Ensemblpanpan1.1panPan2
AKR1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,792,398 - 14,808,805 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,742,012 - 14,808,592 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,913,465 - 14,929,729 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,947,192 - 14,963,694 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,896,489 - 14,963,353 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,744,329 - 14,760,787 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,814,053 - 14,828,473 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,884,045 - 14,900,543 (-)NCBIUU_Cfam_GSD_1.0
Akr1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,855,920 - 60,872,212 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647426,680,676 - 26,697,214 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647426,680,736 - 26,696,996 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKR1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,811,247 - 165,824,896 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,811,245 - 165,825,168 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AKR1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,228,348 - 87,245,511 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2087,228,189 - 87,245,466 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603329,719,096 - 29,738,521 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akr1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249061,462,693 - 1,474,214 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249061,463,201 - 1,474,001 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000013879   ⟹   ENSCLAP00000013724
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495546412,714,717 - 12,729,662 (-)Ensembl
RefSeq Acc Id: XM_005398702   ⟹   XP_005398759
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546412,715,238 - 12,729,034 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013521760   ⟹   XP_013377214
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546412,715,238 - 12,729,029 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005398759 (Get FASTA)   NCBI Sequence Viewer  
  XP_013377214 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000013724
  ENSCLAP00000013724.1
RefSeq Acc Id: XP_005398759   ⟸   XM_005398702
- UniProtKB: A0A8C2VF49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013377214   ⟸   XM_013521760
- UniProtKB: A0A8C2VF49 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000013724   ⟸   ENSCLAT00000013879

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009484 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000013879 ENTREZGENE
  ENSCLAT00000013879.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro AKR UniProtKB/TrEMBL
  AKR1A UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
NCBI Gene Akr1a1 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER A1 UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/TrEMBL
UniProt A0A8C2VF49 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Akr1a1  aldo-keto reductase family 1 member A1    aldo-keto reductase family 1, member A1 (aldehyde reductase)  Symbol and/or name change 5135510 APPROVED