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Gene: Pelo (pelota mRNA surveillance and ribosome rescue factor) Chinchilla lanigera

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Symbol:

Pelo

Name:

pelota mRNA surveillance and ribosome rescue factor

RGD ID:

8949102

Description:

ENCODES a protein that exhibits nucleoside-triphosphatase regulator activity (ortholog); ribosome binding (ortholog); stalled ribosome sensor activity (ortholog); INVOLVED IN chromosome organization (ortholog); endoderm development (ortholog); inner cell mass cell proliferation (ortholog); PARTICIPATES IN translation termination pathway; ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN cytosolic ribosome (ortholog); Dom34-Hbs1 complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

pelota homolog; pelota homolog (Drosophila)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955446	14,564,366 - 14,566,178 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955446	14,564,366 - 14,566,178 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromosome organization (ISO)

endoderm development (ISO)

inner cell mass cell proliferation (ISO)

mesenchymal to epithelial transition (ISO)

nuclear-transcribed mRNA catabolic process, no-go decay (ISO)

positive regulation of BMP signaling pathway (ISO)

rescue of stalled ribosome (ISO)

ribosome disassembly (ISO)

stem cell population maintenance (ISO)

Cellular Component

cytosolic ribosome (ISO)

Dom34-Hbs1 complex (ISO)

Molecular Function

nucleoside-triphosphatase regulator activity (ISO)

protein binding (ISO)

ribosome binding (ISO)

stalled ribosome sensor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

translation termination pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Pelo
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955446	14,564,366 - 14,566,178 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955446	14,564,366 - 14,566,178 (-)	NCBI	ChiLan1.0	ChiLan1.0

PELO
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	52,787,916 - 52,804,044 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	52,787,916 - 52,804,044 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	52,083,750 - 52,099,878 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	52,119,531 - 52,134,208 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	52,119,530 - 52,134,206	NCBI
Celera	5	49,037,324 - 49,052,004 (+)	NCBI		Celera
Cytogenetic Map	5	q11.2	NCBI
HuRef	5	49,055,620 - 49,070,302 (+)	NCBI		HuRef
CHM1_1	5	52,086,424 - 52,101,104 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	53,615,621 - 53,631,750 (+)	NCBI		T2T-CHM13v2.0

Pelo
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	115,224,891 - 115,226,694 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	115,224,891 - 115,226,722 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	115,088,355 - 115,090,158 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	115,088,355 - 115,090,186 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	115,878,563 - 115,880,366 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	116,209,242 - 116,211,703 (-)	NCBI		MGSCv36	mm8
Celera	13	119,447,710 - 119,449,318 (-)	NCBI		Celera
Cytogenetic Map	13	D2.2	NCBI
cM Map	13	64.61	NCBI

Pelo
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	48,530,902 - 48,532,670 (-)	NCBI		GRCr8
mRatBN7.2	2	46,797,853 - 46,799,621 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	46,797,853 - 46,799,746 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	53,898,237 - 53,900,005 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	51,957,441 - 51,959,209 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	46,827,651 - 46,829,417 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	47,266,758 - 47,268,526 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	47,266,738 - 47,268,625 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	71,808,491 - 71,810,259 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	45,900,723 - 45,902,491 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	45,828,956 - 45,830,724 (-)	NCBI
Celera	2	42,545,596 - 42,547,364 (-)	NCBI		Celera
Cytogenetic Map	2	q14	NCBI

PELO
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	61,140,900 - 61,158,121 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	59,297,530 - 59,307,873 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	61,229,841 - 61,247,565 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	62,851,499 - 62,865,786 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	62,851,099 - 62,865,786 (-)	Ensembl	panpan1.1		panPan2

PELO
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	62,440,923 - 62,443,598 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	62,216,402 - 62,218,376 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	62,939,633 - 62,941,473 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	62,791,553 - 62,953,332 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	62,714,001 - 62,716,979 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	62,831,158 - 62,834,996 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	63,366,543 - 63,368,230 (-)	NCBI		UU_Cfam_GSD_1.0

Pelo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	205,642,223 - 205,644,180 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936480	14,577,381 - 14,582,144 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936480	14,578,718 - 14,580,690 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PELO
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	32,142,034 - 32,148,287 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	32,130,254 - 32,146,114 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	33,953,117 - 33,955,102 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PELO
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	49,094,330 - 49,097,545 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	49,094,528 - 49,100,838 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666082	2,036,319 - 2,040,892 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pelo
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	6,525,418 - 6,527,322 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624759	6,525,529 - 6,527,320 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005392726	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01040279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01001142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000007278 ⟹ ENSCLAP00000007165

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955446	14,564,366 - 14,566,178 (-)	Ensembl

RefSeq Acc Id:

XM_005392726 ⟹ XP_005392783

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955446	14,564,366 - 14,566,178 (-)	NCBI

Sequence:

show sequence

GGCAAGAGTAAGTGCTCCCCTCGATTGTGTGAGTCAGTTCTAGAATATTTCCTTCCCCCCAGGC
ACGCGTCCATACTTCCCGGGCCCGCCCCCTTCCAGGCCGAGATTGCCTTTCCCCTGCCCTGCAC
CTTTCCGGTCGGGAACCATCTCCGTACCTTTTGCTCGCCAGTGGAGCCCCTGGTAAGGCCATGA
GGCTTGTGAGGAAGGACATTGAGAAGGACAACGCGGGCCAGGTGACTCTGGTCCCCGAGGAGCC
TGAGGACATGTGGCACACCTACAATCTAGTGCAGGTGGGCGACAGCCTGCGCGCCTCCACCATC
CGCAAGGTGCAGACCGAGTCCTCCACGGGCAGCGTGGGAAGCAACCGGGTCCGCACCACCCTCA
CCCTCTGCGTGGAGGCCATCGACTTTGACTCGCAAGCCTGCCAGCTGAGGGTGAAGGGGACTAA
CATCCAGGAGAACGAGTATGTCAAGATGGGGGCGTACCACACCATAGAGCTGGAGCCCAACCGC
CAGTTCACCCTGGCAAAGAAGCAGTGGGACAGTGTGGTTCTGGAGCGCATCGAGCAAGCCTGCG
ACCCAGCCTGGAGTGCTGATGTGGCGGCCGTGGTCATGCAGGAAGGCCTCGCCCATATCTGCTT
AGTCACTCCCAGCATGACCCTCACCCGGGCCAAGGTGGAGGTGAACATCCCGAGGAAGCGGAAA
GGCAACTGCTCCCAGCATGACCGAGCCTTAGAGCGGTTCTACGAGCAGGTGGTCCAAGCCATCC
AACGCCACATCAACTTCGATGTTGTAAAGTGCGTGCTGGTGGCCAGCCCAGGGTTTGTGCGGGA
GCAGTTCTGCGACTACATGTTTCAGCAAGCGGTGAAGACGGACAACAAAGTTCTCCTGGAAAAT
CGGTCCAAGTTCCTTCAGGTCCATGCCTCCTCTGGACACAAGTACTCCCTGAAAGAGGCCCTTT
GTGACCCTTCTGTAGCTAGCCGTCTTTCAGACACTAAAGCTGCTGGGGAAGTAAAAGCCTTAGA
TGACTTCTATAAAATGTTACAACATGAACCCGACCGGGCTTTCTATGGACTCAAGCAGGTGGAG
AAGGCCAATGAAGCCATGGCAGTTGACACATTGCTCATCAGTGATGAGCTCTTCAGGCACCAGG
ATGTAGCCACGCGCAGTCGGTATGTGAGGCTGGTGGACAGTGTGAAAGAGAACGCAGGCACAGT
TAGGATATTCTCTAGTCTTCATGTGTCTGGGGAACAGCTCAGCCAATTGACTGGAGTAGCTGCC
ATTCTCCGCTTCCCTGTCCCTGAACTTTCTGACCAAGAGGATGATTCTAGCTCTGAAGAGGATT
AGTAATTGAAACTTGAGACAACTCGTGCCTGACTTCCTCACTGTGACATTTTCTTGGCATACTG
TGACAAGCTCCAAGAGTGGCATTTTTTGATCATGCTGGGATTTTTCATGTGTTGGGTAACACTT
GGTGTTTCATGGTTTGCAGAACATGTATTCAATCTAAACAATAAACTAAAAGGAAATAAT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005392783	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000007165
	ENSCLAP00000007165.1

RefSeq Acc Id:

XP_005392783 ⟸ XM_005392726

- UniProtKB:

A0A8C2UYB4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRLVRKDIEKDNAGQVTLVPEEPEDMWHTYNLVQVGDSLRASTIRKVQTESSTGSVGSNRVRTT
LTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQA
CDPAWSADVAAVVMQEGLAHICLVTPSMTLTRAKVEVNIPRKRKGNCSQHDRALERFYEQVVQA
IQRHINFDVVKCVLVASPGFVREQFCDYMFQQAVKTDNKVLLENRSKFLQVHASSGHKYSLKEA
LCDPSVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVEKANEAMAVDTLLISDELFRH
QDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLSQLTGVAAILRFPVPELSDQEDDSSSEE
D

hide sequence

Ensembl Acc Id:

ENSCLAP00000007165 ⟸ ENSCLAT00000007278

Protein Domains

eRF1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000005043	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000007278	ENTREZGENE
	ENSCLAT00000007278.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.30.870	UniProtKB/TrEMBL
	3.30.1330.30	UniProtKB/TrEMBL
	3.30.420.60	UniProtKB/TrEMBL
InterPro	eFR1_2_sf	UniProtKB/TrEMBL
	eRF1_1_Pelota	UniProtKB/TrEMBL
	eRF1_2	UniProtKB/TrEMBL
	eRF1_3	UniProtKB/TrEMBL
	L30e-like	UniProtKB/TrEMBL
	Pelota/DOM34_N	UniProtKB/TrEMBL
	Transl-rel_pelota	UniProtKB/TrEMBL
NCBI Gene	Pelo	ENTREZGENE
PANTHER	PROTEIN PELOTA HOMOLOG	UniProtKB/TrEMBL
	PTHR10853	UniProtKB/TrEMBL
Pfam	eRF1_1	UniProtKB/TrEMBL
	eRF1_2	UniProtKB/TrEMBL
	eRF1_3	UniProtKB/TrEMBL
SMART	eRF1_1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF159065	UniProtKB/TrEMBL
	SSF55315	UniProtKB/TrEMBL
	Translational machinery components	UniProtKB/TrEMBL
UniProt	A0A8C2UYB4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-06-13	Pelo	pelota mRNA surveillance and ribosome rescue factor		pelota homolog (Drosophila)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations