Enpp7 (ectonucleotide pyrophosphatase/phosphodiesterase 7)

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Gene: Enpp7 (ectonucleotide pyrophosphatase/phosphodiesterase 7) Chinchilla lanigera

Analyze

Symbol:

Enpp7

Name:

ectonucleotide pyrophosphatase/phosphodiesterase 7

RGD ID:

8944882

Description:

ENCODES a protein that exhibits phosphoric diester hydrolase activity (ortholog); sphingomyelin phosphodiesterase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN fatty acid homeostasis (ortholog); lipid digestion (ortholog); negative regulation of cell population proliferation (ortholog); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; ASSOCIATED WITH genetic disease (ortholog); pityriasis rubra pilaris (ortholog); prostate cancer (ortholog); FOUND IN Golgi apparatus (ortholog); microvillus (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ectonucleotide pyrophosphatase/phosphodiesterase family member 7

RGD Orthologs

Human

Mouse

Rat

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	3,151,133 - 3,154,613 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955506	3,151,133 - 3,154,613 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

pityriasis rubra pilaris (ISO)

prostate cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid homeostasis (ISO)

lipid digestion (ISO)

negative regulation of cell population proliferation (ISO)

negative regulation of DNA replication (ISO)

positive regulation of ceramide biosynthetic process (ISO)

positive regulation of intestinal cholesterol absorption (ISO)

positive regulation of sphingomyelin catabolic process (ISO)

regulation of intestinal lipid absorption (ISO)

sphingomyelin metabolic process (ISO)

Cellular Component

Golgi apparatus (ISO)

microvillus (ISO)

plasma membrane (ISO)

Molecular Function

phosphoric diester hydrolase activity (ISO)

protein binding (ISO)

sphingomyelin phosphodiesterase activity (ISO)

zinc ion binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Fabry disease pathway (ISO)

Gaucher's disease pathway (ISO)

Krabbe disease pathway (ISO)

metachromatic leukodystrophy pathway (ISO)

sphingolipid metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Genomics

Comparative Map Data

Enpp7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	3,151,133 - 3,154,613 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955506	3,151,133 - 3,154,613 (-)	NCBI	ChiLan1.0	ChiLan1.0

ENPP7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	79,730,943 - 79,742,219 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	17	79,730,943 - 79,742,219 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	77,704,705 - 77,716,018 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	75,319,477 - 75,330,616 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	75,319,476 - 75,330,615	NCBI
Celera	17	74,329,818 - 74,341,104 (+)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	73,145,753 - 73,156,851 (+)	NCBI		HuRef
CHM1_1	17	77,791,152 - 77,802,246 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	80,628,701 - 80,640,020 (+)	NCBI		T2T-CHM13v2.0

Enpp7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	118,879,007 - 118,884,047 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	118,879,014 - 118,884,047 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	118,988,181 - 118,993,221 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	118,988,188 - 118,993,221 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	118,849,502 - 118,854,155 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	118,804,278 - 118,808,931 (+)	NCBI		MGSCv36	mm8
Celera	11	130,732,697 - 130,737,351 (+)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI

Enpp7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	104,242,223 - 104,246,589 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	104,242,223 - 104,246,589 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	109,345,533 - 109,350,503 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	108,808,555 - 108,813,525 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	104,162,858 - 104,167,855 (+)	NCBI	Rnor_WKY
Rnor_6.0	10	108,095,131 - 108,099,483 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	108,095,131 - 108,099,483 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	107,709,166 - 107,713,518 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	10	102,790,410 - 102,794,661 (+)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

ENPP7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	17	100,614,721 - 100,621,831 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	73,811,249 - 73,822,719 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	79,347,505 - 79,359,349 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	79,347,505 - 79,359,349 (+)	Ensembl	panpan1.1		panPan2

ENPP7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	1,887,093 - 1,894,728 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	1,887,201 - 1,897,473 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	2,530,265 - 2,537,749 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	2,522,957 - 2,530,442 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	2,522,959 - 2,532,965 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	2,546,349 - 2,553,429 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	2,671,411 - 2,678,888 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	2,752,722 - 2,760,208 (-)	NCBI		UU_Cfam_GSD_1.0

Enpp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	2,553,048 - 2,557,497 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	3,855,150 - 3,858,317 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936594	3,855,071 - 3,864,034 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ENPP7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	2,612,574 - 2,619,519 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	2,612,543 - 2,619,541 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	2,680,088 - 2,687,063 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ENPP7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	71,693,148 - 71,701,517 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	71,693,851 - 71,699,926 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	42,988,775 - 43,000,398 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Enpp7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	8,895,836 - 8,903,952 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	8,895,138 - 8,901,848 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005407509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01065313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCLAT00000011556 ⟹ ENSCLAP00000011419

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955506	3,151,133 - 3,154,613 (-)	Ensembl

RefSeq Acc Id:

XM_005407509 ⟹ XP_005407566

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955506	3,151,133 - 3,154,613 (-)	NCBI

Sequence:

show sequence

ATGACACACTCAGATGTCCTCCTCGCTGTGACTCTGGCCACCCTTCTGACTGCAGGGGCTGGGG
CTCCTGTCCACACAGAGGGCCCCCCACAGAAGCTGCTCCTTGTGTCATTCGATGGCTTCCGCTG
GAACTATGACCAGGATGTGGACACCCCCAACCTGGATGCCATGGCTCAAGATGGGGTGAAAGCT
CGCTACATGACCCCTGCCTTTGTCACCCTGACCAGCCCCTGCCACTTCACGCTGGTCACTGGCA
AATACGTGGAGAACCATGGGGTCGTCCACAACATGTTCTACAACGTCACCAGCAAGCTAAGGCT
GCCCTACTACACCACGCTTGGCATCCAGAGCTGGTGGGACAACGGCAGTGTGCCCATCTGGATT
ACAGCCCAGAGGCAGGGCTTAAAGACCGGCTCTTTCTTCTACCCTGGTGGAAACGTCACCTACC
AAGGGGAGGCGGTGACGCTGAGCCGGAAGGAAGGCCCTGTACACAACTACAAAGACGAGCAGGA
GTGGAGGGCGAATGTGGACACTGTGATGAGGTGGTTCACTGAGGAGGACCTGGCTCTGGTCACC
CTCTACTTCGGGGAGCCGGACTCAACTGGCCACAGGTATGGCCCCGAGTCCCCGCAGAGGAAGG
AGATGGTGAGGCAAGTGGACCGGACGGTGGGCTACCTTCGTGACAGCATTGAGCGCCACAACCT
CACAGGCAGCCTCAACCTCATCATCACATCTGACCACGGTATGACAACTGTCAACAAGACAGCC
AGTGACTTGGTGGAGTTCCACAAGTTCCCCAACTTCACCTTCCAGGACATTGAGTTCGAGCTCC
TGGACTATGGGCCAAATGGGATGCTAATTCCCAAGGAGGGGCTGCTGGAGAAGGTGTACGAGGT
GCTCAAGGACGCCCACCCCAGGCTGCATGTCTACAAGAAGGAGGAGTTCCCCGAGTCCTTCCAC
TACGCCAACAACGCCAGGATCACTCCCCTGCTCATGTACAGTGACCTGGGCTATGTCATCCATG
GGAGATGGAGTGTCCAATTCAACCAAGGTGAGCATGGCTTTGACCACAGAGCCATGGACATGAA
GACCATCTTCCGGGCCGTGGGCCCCAGCTTCAAGGCTGGCCTGGAGGTAGAGCCCTTCGAGAGC
ATCCATGTATATGAGCTCCTATGCCAGCTGCTGGGTATCACACCTGAGGCCAATGACGGGCATC
CGGATACACTGAGGCCCATGCTCCGATCAGGCTCTGCTCTCCCGCCTCACAGACAGCCCCTCTC
TGCGATGGCACTGCTGGGAGCCCTGATTCTTCTGGTCCACGTTGCATAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005407566	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_005407566 ⟸ XM_005407509

- UniProtKB:

A0A8C2V9R1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTHSDVLLAVTLATLLTAGAGAPVHTEGPPQKLLLVSFDGFRWNYDQDVDTPNLDAMAQDGVKA
RYMTPAFVTLTSPCHFTLVTGKYVENHGVVHNMFYNVTSKLRLPYYTTLGIQSWWDNGSVPIWI
TAQRQGLKTGSFFYPGGNVTYQGEAVTLSRKEGPVHNYKDEQEWRANVDTVMRWFTEEDLALVT
LYFGEPDSTGHRYGPESPQRKEMVRQVDRTVGYLRDSIERHNLTGSLNLIITSDHGMTTVNKTA
SDLVEFHKFPNFTFQDIEFELLDYGPNGMLIPKEGLLEKVYEVLKDAHPRLHVYKKEEFPESFH
YANNARITPLLMYSDLGYVIHGRWSVQFNQGEHGFDHRAMDMKTIFRAVGPSFKAGLEVEPFES
IHVYELLCQLLGITPEANDGHPDTLRPMLRSGSALPPHRQPLSAMALLGALILLVHVA

hide sequence

RefSeq Acc Id:

ENSCLAP00000011419 ⟸ ENSCLAT00000011556

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000007876	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSCLAP00000011419	ENTREZGENE
	ENSCLAP00000011419.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000011556	ENTREZGENE
	ENSCLAT00000011556.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1360.180	UniProtKB/TrEMBL
	3.40.720.10	UniProtKB/TrEMBL
InterPro	Alkaline_phosphatase_core_sf	UniProtKB/TrEMBL
	Phosphodiest/P_Trfase	UniProtKB/TrEMBL
NCBI Gene	Enpp7	ENTREZGENE
PANTHER	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE	UniProtKB/TrEMBL
	PTHR10151:SF63	UniProtKB/TrEMBL
Pfam	Phosphodiest	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53649	UniProtKB/TrEMBL
UniProt	A0A8C2V9R1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB