Emc1 (ER membrane protein complex subunit 1)

Gene: Emc1 (ER membrane protein complex subunit 1) Chinchilla lanigera

Analyze

Symbol:

Emc1

Name:

ER membrane protein complex subunit 1

RGD ID:

8940806

Description:

ENCODES a protein that exhibits membrane insertase activity (ortholog); INVOLVED IN protein insertion into ER membrane by stop-transfer membrane-anchor sequence (ortholog); tail-anchored membrane protein insertion into ER membrane (ortholog); ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ortholog); CAKUT (ortholog); cerebellar atrophy, visual impairment, and psychomotor retardation (ortholog); FOUND IN EMC complex (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955527	19,069 - 45,951 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955527	19,069 - 45,951 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ISO)

CAKUT (ISO)

cerebellar atrophy, visual impairment, and psychomotor retardation (ISO)

chromosome 1p36 deletion syndrome (ISO)

congenital disorder of glycosylation Ir (ISO)

Developmental Disabilities (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

hyperprolinemia type 2 (ISO)

microcephaly (ISO)

obesity (ISO)

Parkinson's disease 6 (ISO)

retinitis pigmentosa (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein insertion into ER membrane by stop-transfer membrane-anchor sequence (ISO)

tail-anchored membrane protein insertion into ER membrane (ISO)

Cellular Component

EMC complex (ISO)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (ISO)

membrane (ISO)

protein-containing complex (ISO)

Molecular Function

membrane insertase activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Emc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955527	19,069 - 45,951 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955527	19,069 - 45,951 (+)	NCBI	ChiLan1.0	ChiLan1.0

EMC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	19,215,660 - 19,251,524 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	19,215,660 - 19,251,552 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	19,542,154 - 19,578,018 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	19,417,171 - 19,450,633 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	17,871,571 - 17,905,031 (-)	NCBI		Celera
Cytogenetic Map	1	p36.13	NCBI
HuRef	1	17,788,712 - 17,824,597 (-)	NCBI		HuRef
CHM1_1	1	19,651,459 - 19,687,383 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	19,039,172 - 19,075,048 (-)	NCBI		T2T-CHM13v2.0

Emc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	139,079,898 - 139,106,046 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	139,079,898 - 139,106,041 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	139,352,587 - 139,378,735 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	139,352,587 - 139,378,730 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	138,908,508 - 138,934,645 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	138,624,669 - 138,650,806 (+)	NCBI		MGSCv36	mm8
Celera	4	141,139,814 - 141,166,369 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	70.66	NCBI

Emc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	156,891,773 - 156,917,092 (+)	NCBI		GRCr8
mRatBN7.2	5	151,608,557 - 151,633,888 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	151,608,568 - 151,633,888 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	154,307,221 - 154,332,538 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	156,081,582 - 156,106,902 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	156,062,524 - 156,087,840 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	157,820,908 - 157,846,226 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	157,820,908 - 157,846,226 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	161,560,596 - 161,585,938 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	158,154,690 - 158,180,008 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	158,164,710 - 158,188,722 (+)	NCBI
Celera	5	149,988,173 - 150,013,491 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

EMC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	207,863,577 - 207,896,375 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	206,980,515 - 207,013,143 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	18,176,791 - 18,210,280 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	19,223,355 - 19,257,161 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	19,223,355 - 19,257,835 (-)	Ensembl	panpan1.1		panPan2

EMC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	79,367,154 - 79,393,096 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	79,367,185 - 79,392,314 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	75,882,043 - 75,907,985 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	79,989,857 - 80,015,776 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	79,989,863 - 80,018,920 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	76,750,669 - 76,776,568 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	77,760,595 - 77,786,780 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	78,831,297 - 78,857,218 (+)	NCBI		UU_Cfam_GSD_1.0

Emc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	39,687,322 - 39,714,441 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	5,511,661 - 5,539,237 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	5,512,100 - 5,539,198 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EMC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	77,718,849 - 77,747,771 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	77,723,374 - 77,747,780 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	71,787,200 - 71,809,141 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EMC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	113,306,936 - 113,338,125 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	113,307,026 - 113,337,976 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	2,820,311 - 2,849,784 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Emc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	4,370,591 - 4,400,920 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	4,367,780 - 4,401,000 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005409788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005409789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01069371	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01069372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01001898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000002956 ⟹ ENSCLAP00000002899

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955527	19,069 - 45,951 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000002957 ⟹ ENSCLAP00000002900

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955527	19,164 - 45,633 (+)	Ensembl

RefSeq Acc Id:

XM_005409788 ⟹ XP_005409845

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955527	19,069 - 45,951 (+)	NCBI

Sequence:

show sequence

GCCTCGCGCTCCGTCGCAACTCTATGGTTCCGGGAGGCGGAGCCTACGGCCCGGTGCATGCCGG
GGCGGCAGCAGGGAGTCTCGGGTCTTCTGTCATGGCGGCGGTGCTGGGATCCGGGCTTTGGTTC
TGGGTTGTGTTGCTTGTCCCTGCGGTCGCGGTTTATGAAGACCAAGTAGGGAAGTTTGACTGGA
GACAGCAGTATGTTGGGAAGCTCAAGTTTGCCTCCTTGGAATTTTCTCCTGGATCCAAGAAGTT
GGTTGTGGCCACTGAGAAGAACGTGATTGCAGCATTAAATTCTCGTACTGGGGAGATCTTGTGG
CGCCATGTTGACAAAGGCACGGCAGAAGGGGCCGTGGACGCCATGCTGGTGCACGGACAGGATG
CAATCACTGTGTCCAATGGGGGCCGCATCATGCGCTCCTGGGAGACTAACATCGGGGGCCTGAA
CTGGGAGATAACGTTGGACAGCGGCAGTTTCCAGGCACTGGGGCTGGTAGGCCTGCAGGAGTCA
GTGAGGTACGTTGCGGTCCTGAAGAAGACAACTCTCGCCCTCCATCACCTCTCCAGTGGGCACC
TAAAGTGGATGGAGCGTCTCCCAGAGAGTGACAGCATCCACTACCAGATGGTGTATTCCTACGG
CTCTGGGGTGGTGTGGGCCCTCGGCATCGTTCCCTTCAGTCATGTGAACACTGTGAAGTTTAAC
GTGGAGGACGGAGAGATTGTTCAGCAGGTCAGGGTTTCGACTCCGTGGCTGCAGCGTCTCACCG
GAGCCTGCGGCGTGGTGGAGGAGGCGGTCCTGGTATGCCCTGACCCAAGCTCGCGCTCGCTGCA
CACTTTGGCGCTGGAGACGGAGTGGGAACTGCGGCAGATCCCACTGCAGTCTCTTGACTTAGAA
TTTGAAAGTGGATTCCAGCCCCGCGTGCTGCCCACACAGCCCAACCCAGTGGATCCTTCTCGGC
CCCAGTTCTTCCTGCAGTTGTCCCCAAGCCATTATGCCCTGCTGCACTACCACCAGGGGACTCT
GAGTCTGCTCAAAAACTTCCCCCAGACTGCCCTTGTGAGCTTTGCCACTACCGGGGAGAAGACA
GTGGCCGCAGTCATGACCTGTCGGAACGAAGTGCAGAAACCTAGCAGTTCTGAAGATGGATCAA
TGGGGAGCTTTGCGGAGAAGTCCAGTGCACAGGACCCACTGGCTTGCTTCAACCAGACCTACAC
CATTAACCTCTACTTAGCGGAGACGGGCCGGCGGCTGCTGGACACCATGATTACGTTTAGCCTG
GAGCAGAATGATACTCGGCCTGAGTGGCTGTACATCCAGGTGTTCTTGAAGAAGGATGACTCCG
TGGGCTACCGGGCTTTGGTGCAGATGCAAGACCATTTGCTACTTTTCCTGCAGCAGCTGGCTGG
GAAGGTGGTACTGTGGAGCCGCGAGGAGTCCCTGGCAGAGGTGGTGTGCCTGGAGATGGTGGAC
CTGCCCCTGACTGGGGCACAGGCTGAGCTGGAAGGAGAGTTTGGCAAGAAGGCAGATGGCCTGC
TGGGGATGTTCCTAAAACGCCTCTCATCTCAGCTCATCCTACTGCAAGCGTGGACTTCCCACCT
CTGGAAAATGTTCTATGATGCTCGGAAGCCCCGAAGCCAGATTAAGAATGAGATCAACATCGAC
ACCTTGGCCAGGGATGAATTCAACCTGCAGAAGATGATGGTGATGGTAACAGCCTCAGGGAAGC
TTTTTGGCATTGAGAGCAGCTCTGGCACAATTCTGTGGAAACAGTATCTACCCAGTGTCAAGCC
AGACTCCTCCTTTAAGCTGATGGTCCAAAGAACTACTGCTCACTTCCCCCACCCCCCGCAGTGC
ACGCTCCTGATAAAGGACAAGGAAACAGGAATGAGTTCTCTGTACGTCTTCAATCCCATTTTTG
GGAAGTGGAGTCAGGTGGCTCCCCCAGTGCTCAAACGCCCCATCTTGCAGTCCTTGCTTCTCCC
AGTCATGGACCAAGACTATGCCAAGGTCTTGCTCTTGATAGATGATGAGTACAAGGTCACAGCT
TTCCCAGCCACTCGGAATGTCTTGCGACAGCTACATGAGCTTGCCCCGTCCATCTTCTTCTATT
TGGTGGATGCAGAGCAGGGGCGGCTCAGTGGATATCGGCTTCGGAAGGACCTCACCACTGAACT
GAGCTGGGCGCTGACCATCCCCCCAGAAGTACAGCGGATCGTCAAGGTGAAGGGGAAGCGCAGC
AGCGAGCACGTCCACTCGCAGGGCCGGGTGATGGGGGACCGCAGTGTGCTCTACAAGAGCCTGA
ACCCCAACCTGCTGGCCGTGGTGACAGAGAGCACAGACGTACACCACGAGCGTACCTTCATTGG
CGTCTTCCTCATCGATGGTGTCACAGGACGCATCATCCACTCCTCGGTGCAGAAGAAAGCCAAG
GGCCCTGTCCACATCGTGCACTCGGAGAACTGGGTGGTGTACCAGTACTGGAACACCAAGGCTC
GGCGCAATGAGTTCACGGCCCTGGAGCTCTACGAGGGAACCGAGCAATACAACGCCACCGCCTT
CAGCTCCCTGGACCGTCCACAGCTCCCCCAGGTCCTTCAGCAGTCCTACATCTTCCCCTCCTCC
ATCAGTGCCATGGAGGCCACCATCACGGAGCGGGGCATCACCAGCCGACACCTGCTCATTGGAC
TACCTTCCGGAGCAATTCTTTCTCTCCCTAAGGCCTTGCTGGATCCCCGGCGTCCTGAGATCCC
AACCGAACAAAGCAGAGAGGAGAACCTCATCCCCTATTCTCCAGATGTCCAGATCCACGCAGAG
CGATTCATCAACTATAACCAGACTGTCTCTCGAATGCGAGGTATCTACACAGCTCCCTCGGGCC
TGGAGTCTACATGTTTGGTTGTAGCCTATGGTTTGGACATTTACCAAACTCGAGTCTACCCATC
CAAACAGTTTGATGTCCTGAAGGATGACTATGACTACGTGTTAATCAGCGGTGTTCTCTTTGGC
CTGGTTTTTGCCACCATGATCACTAAGAGGCTGGCACAGGTGAAACTCCTGAATCGAGCCTGGA
GGTAGACTGAAGACTTGGAGCCCCAGTGGAGAGTTGTAGTGGCCTCAGCTAAGGTGCTACAGCT
GCAGCTGTGATTGGGCAGATTCATGGAATGTGTGTGTTGGATTCTGCTCTCAGTTGCATTGGAG
GAAAGGTGGACCTTAATGTATAACTGCTTTTGAGACACATGATCCGCAATCCTGTGGATAAAGG
CTGAACTCACTCAACGCAGTTGAGGATCTGCAAGCATCTGATAGATTTTCCTCCAACATCCAGG
GCCACTGCCATTTCCTTTCTTTGCCCATTCATGAATGTTCTGTTTTAAAATATGAACTTTAACT
GAG

hide sequence

RefSeq Acc Id:

XM_005409789 ⟹ XP_005409846

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955527	19,069 - 45,951 (+)	NCBI

Sequence:

show sequence

GCCTCGCGCTCCGTCGCAACTCTATGGTTCCGGGAGGCGGAGCCTACGGCCCGGTGCATGCCGG
GGCGGCAGCAGGGAGTCTCGGGTCTTCTGTCATGGCGGCGGTGCTGGGATCCGGGCTTTGGTTC
TGGGTTGTGTTGCTTGTCCCTGCGGTCGCGGTTTATGAAGACCAAGTAGGGAAGTTTGACTGGA
GACAGCAGTATGTTGGGAAGCTCAAGTTTGCCTCCTTGGAATTTTCTCCTGGATCCAAGAAGTT
GGTTGTGGCCACTGAGAAGAACGTGATTGCAGCATTAAATTCTCGTACTGGGGAGATCTTGTGG
CGCCATGTTGACAAAGGCACGGCAGAAGGGGCCGTGGACGCCATGCTGGTGCACGGACAGGATG
CAATCACTGTGTCCAATGGGGGCCGCATCATGCGCTCCTGGGAGACTAACATCGGGGGCCTGAA
CTGGGAGATAACGTTGGACAGCGGCAGTTTCCAGGCACTGGGGCTGGTAGGCCTGCAGGAGTCA
GTGAGGTACGTTGCGGTCCTGAAGAAGACAACTCTCGCCCTCCATCACCTCTCCAGTGGGCACC
TAAAGTGGATGGAGCGTCTCCCAGAGAGTGACAGCATCCACTACCAGATGGTGTATTCCTACGG
CTCTGGGGTGGTGTGGGCCCTCGGCATCGTTCCCTTCAGTCATGTGAACACTGTGAAGTTTAAC
GTGGAGGACGGAGAGATTGTTCAGCAGGTCAGGGTTTCGACTCCGTGGCTGCAGCGTCTCACCG
GAGCCTGCGGCGTGGTGGAGGAGGCGGTCCTGGTATGCCCTGACCCAAGCTCGCGCTCGCTGCA
CACTTTGGCGCTGGAGACGGAGTGGGAACTGCGGCAGATCCCACTGCAGTCTCTTGACTTAGAA
TTTGAAAGTGGATTCCAGCCCCGCGTGCTGCCCACACAGCCCAACCCAGTGGATCCTTCTCGGC
CCCAGTTCTTCCTGCAGTTGTCCCCAAGCCATTATGCCCTGCTGCACTACCACCAGGGGACTCT
GAGTCTGCTCAAAAACTTCCCCCAGACTGCCCTTGTGAGCTTTGCCACTACCGGGGAGAAGACA
GTGGCCGCAGTCATGACCTGTCGGAACGAAGTGAAACCTAGCAGTTCTGAAGATGGATCAATGG
GGAGCTTTGCGGAGAAGTCCAGTGCACAGGACCCACTGGCTTGCTTCAACCAGACCTACACCAT
TAACCTCTACTTAGCGGAGACGGGCCGGCGGCTGCTGGACACCATGATTACGTTTAGCCTGGAG
CAGAATGATACTCGGCCTGAGTGGCTGTACATCCAGGTGTTCTTGAAGAAGGATGACTCCGTGG
GCTACCGGGCTTTGGTGCAGATGCAAGACCATTTGCTACTTTTCCTGCAGCAGCTGGCTGGGAA
GGTGGTACTGTGGAGCCGCGAGGAGTCCCTGGCAGAGGTGGTGTGCCTGGAGATGGTGGACCTG
CCCCTGACTGGGGCACAGGCTGAGCTGGAAGGAGAGTTTGGCAAGAAGGCAGATGGCCTGCTGG
GGATGTTCCTAAAACGCCTCTCATCTCAGCTCATCCTACTGCAAGCGTGGACTTCCCACCTCTG
GAAAATGTTCTATGATGCTCGGAAGCCCCGAAGCCAGATTAAGAATGAGATCAACATCGACACC
TTGGCCAGGGATGAATTCAACCTGCAGAAGATGATGGTGATGGTAACAGCCTCAGGGAAGCTTT
TTGGCATTGAGAGCAGCTCTGGCACAATTCTGTGGAAACAGTATCTACCCAGTGTCAAGCCAGA
CTCCTCCTTTAAGCTGATGGTCCAAAGAACTACTGCTCACTTCCCCCACCCCCCGCAGTGCACG
CTCCTGATAAAGGACAAGGAAACAGGAATGAGTTCTCTGTACGTCTTCAATCCCATTTTTGGGA
AGTGGAGTCAGGTGGCTCCCCCAGTGCTCAAACGCCCCATCTTGCAGTCCTTGCTTCTCCCAGT
CATGGACCAAGACTATGCCAAGGTCTTGCTCTTGATAGATGATGAGTACAAGGTCACAGCTTTC
CCAGCCACTCGGAATGTCTTGCGACAGCTACATGAGCTTGCCCCGTCCATCTTCTTCTATTTGG
TGGATGCAGAGCAGGGGCGGCTCAGTGGATATCGGCTTCGGAAGGACCTCACCACTGAACTGAG
CTGGGCGCTGACCATCCCCCCAGAAGTACAGCGGATCGTCAAGGTGAAGGGGAAGCGCAGCAGC
GAGCACGTCCACTCGCAGGGCCGGGTGATGGGGGACCGCAGTGTGCTCTACAAGAGCCTGAACC
CCAACCTGCTGGCCGTGGTGACAGAGAGCACAGACGTACACCACGAGCGTACCTTCATTGGCGT
CTTCCTCATCGATGGTGTCACAGGACGCATCATCCACTCCTCGGTGCAGAAGAAAGCCAAGGGC
CCTGTCCACATCGTGCACTCGGAGAACTGGGTGGTGTACCAGTACTGGAACACCAAGGCTCGGC
GCAATGAGTTCACGGCCCTGGAGCTCTACGAGGGAACCGAGCAATACAACGCCACCGCCTTCAG
CTCCCTGGACCGTCCACAGCTCCCCCAGGTCCTTCAGCAGTCCTACATCTTCCCCTCCTCCATC
AGTGCCATGGAGGCCACCATCACGGAGCGGGGCATCACCAGCCGACACCTGCTCATTGGACTAC
CTTCCGGAGCAATTCTTTCTCTCCCTAAGGCCTTGCTGGATCCCCGGCGTCCTGAGATCCCAAC
CGAACAAAGCAGAGAGGAGAACCTCATCCCCTATTCTCCAGATGTCCAGATCCACGCAGAGCGA
TTCATCAACTATAACCAGACTGTCTCTCGAATGCGAGGTATCTACACAGCTCCCTCGGGCCTGG
AGTCTACATGTTTGGTTGTAGCCTATGGTTTGGACATTTACCAAACTCGAGTCTACCCATCCAA
ACAGTTTGATGTCCTGAAGGATGACTATGACTACGTGTTAATCAGCGGTGTTCTCTTTGGCCTG
GTTTTTGCCACCATGATCACTAAGAGGCTGGCACAGGTGAAACTCCTGAATCGAGCCTGGAGGT
AGACTGAAGACTTGGAGCCCCAGTGGAGAGTTGTAGTGGCCTCAGCTAAGGTGCTACAGCTGCA
GCTGTGATTGGGCAGATTCATGGAATGTGTGTGTTGGATTCTGCTCTCAGTTGCATTGGAGGAA
AGGTGGACCTTAATGTATAACTGCTTTTGAGACACATGATCCGCAATCCTGTGGATAAAGGCTG
AACTCACTCAACGCAGTTGAGGATCTGCAAGCATCTGATAGATTTTCCTCCAACATCCAGGGCC
ACTGCCATTTCCTTTCTTTGCCCATTCATGAATGTTCTGTTTTAAAATATGAACTTTAACTGAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005409845	(Get FASTA)	NCBI Sequence Viewer
	XP_005409846	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000002899
	ENSCLAP00000002899.1
	ENSCLAP00000002900.1

RefSeq Acc Id:	XP_005409845 ⟸ XM_005409788
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2UM16 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVPGGGAYGPVHAGAAAGSLGSSVMAAVLGSGLWFWVVLLVPAVAVYEDQVGKFDWRQQYVGKL KFASLEFSPGSKKLVVATEKNVIAALNSRTGEILWRHVDKGTAEGAVDAMLVHGQDAITVSNGG RIMRSWETNIGGLNWEITLDSGSFQALGLVGLQESVRYVAVLKKTTLALHHLSSGHLKWMERLP ESDSIHYQMVYSYGSGVVWALGIVPFSHVNTVKFNVEDGEIVQQVRVSTPWLQRLTGACGVVEE AVLVCPDPSSRSLHTLALETEWELRQIPLQSLDLEFESGFQPRVLPTQPNPVDPSRPQFFLQLS PSHYALLHYHQGTLSLLKNFPQTALVSFATTGEKTVAAVMTCRNEVQKPSSSEDGSMGSFAEKS SAQDPLACFNQTYTINLYLAETGRRLLDTMITFSLEQNDTRPEWLYIQVFLKKDDSVGYRALVQ MQDHLLLFLQQLAGKVVLWSREESLAEVVCLEMVDLPLTGAQAELEGEFGKKADGLLGMFLKRL SSQLILLQAWTSHLWKMFYDARKPRSQIKNEINIDTLARDEFNLQKMMVMVTASGKLFGIESSS GTILWKQYLPSVKPDSSFKLMVQRTTAHFPHPPQCTLLIKDKETGMSSLYVFNPIFGKWSQVAP PVLKRPILQSLLLPVMDQDYAKVLLLIDDEYKVTAFPATRNVLRQLHELAPSIFFYLVDAEQGR LSGYRLRKDLTTELSWALTIPPEVQRIVKVKGKRSSEHVHSQGRVMGDRSVLYKSLNPNLLAVV TESTDVHHERTFIGVFLIDGVTGRIIHSSVQKKAKGPVHIVHSENWVVYQYWNTKARRNEFTAL ELYEGTEQYNATAFSSLDRPQLPQVLQQSYIFPSSISAMEATITERGITSRHLLIGLPSGAILS LPKALLDPRRPEIPTEQSREENLIPYSPDVQIHAERFINYNQTVSRMRGIYTAPSGLESTCLVV AYGLDIYQTRVYPSKQFDVLKDDYDYVLISGVLFGLVFATMITKRLAQVKLLNRAWR hide sequence

RefSeq Acc Id:	XP_005409846 ⟸ XM_005409789
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C2UM16 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVPGGGAYGPVHAGAAAGSLGSSVMAAVLGSGLWFWVVLLVPAVAVYEDQVGKFDWRQQYVGKL KFASLEFSPGSKKLVVATEKNVIAALNSRTGEILWRHVDKGTAEGAVDAMLVHGQDAITVSNGG RIMRSWETNIGGLNWEITLDSGSFQALGLVGLQESVRYVAVLKKTTLALHHLSSGHLKWMERLP ESDSIHYQMVYSYGSGVVWALGIVPFSHVNTVKFNVEDGEIVQQVRVSTPWLQRLTGACGVVEE AVLVCPDPSSRSLHTLALETEWELRQIPLQSLDLEFESGFQPRVLPTQPNPVDPSRPQFFLQLS PSHYALLHYHQGTLSLLKNFPQTALVSFATTGEKTVAAVMTCRNEVKPSSSEDGSMGSFAEKSS AQDPLACFNQTYTINLYLAETGRRLLDTMITFSLEQNDTRPEWLYIQVFLKKDDSVGYRALVQM QDHLLLFLQQLAGKVVLWSREESLAEVVCLEMVDLPLTGAQAELEGEFGKKADGLLGMFLKRLS SQLILLQAWTSHLWKMFYDARKPRSQIKNEINIDTLARDEFNLQKMMVMVTASGKLFGIESSSG TILWKQYLPSVKPDSSFKLMVQRTTAHFPHPPQCTLLIKDKETGMSSLYVFNPIFGKWSQVAPP VLKRPILQSLLLPVMDQDYAKVLLLIDDEYKVTAFPATRNVLRQLHELAPSIFFYLVDAEQGRL SGYRLRKDLTTELSWALTIPPEVQRIVKVKGKRSSEHVHSQGRVMGDRSVLYKSLNPNLLAVVT ESTDVHHERTFIGVFLIDGVTGRIIHSSVQKKAKGPVHIVHSENWVVYQYWNTKARRNEFTALE LYEGTEQYNATAFSSLDRPQLPQVLQQSYIFPSSISAMEATITERGITSRHLLIGLPSGAILSL PKALLDPRRPEIPTEQSREENLIPYSPDVQIHAERFINYNQTVSRMRGIYTAPSGLESTCLVVA YGLDIYQTRVYPSKQFDVLKDDYDYVLISGVLFGLVFATMITKRLAQVKLLNRAWR hide sequence

RefSeq Acc Id:

ENSCLAP00000002900 ⟸ ENSCLAT00000002957

RefSeq Acc Id:

ENSCLAP00000002899 ⟸ ENSCLAT00000002956

Protein Domains

ER membrane protein complex subunit 1 C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000002085	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000002956	ENTREZGENE
	ENSCLAT00000002956.1	UniProtKB/TrEMBL
	ENSCLAT00000002957.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	EMC1	UniProtKB/TrEMBL
	EMC1_C	UniProtKB/TrEMBL
	PQQ_repeat	UniProtKB/TrEMBL
	Quinoprotein_ADH-like_supfam	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Emc1	ENTREZGENE
PANTHER	ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1	UniProtKB/TrEMBL
	PTHR21573	UniProtKB/TrEMBL
Pfam	EMC1_C	UniProtKB/TrEMBL
	PQQ_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50998	UniProtKB/TrEMBL
UniProt	A0A8C2UM16	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2UM23_CHILA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM