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Gene: Pwp1 (PWP1 homolog, endonuclein) Chinchilla lanigera

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Symbol:

Pwp1

Name:

PWP1 homolog, endonuclein

RGD ID:

8930943

Description:

ENCODES a protein that exhibits H4K20me3 modified histone binding (ortholog); histone chaperone activity (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); positive regulation of stem cell differentiation (ortholog); positive regulation of transcription of nucleolar large rRNA by RNA polymerase I (ortholog); FOUND IN Golgi apparatus (ortholog); nucleolus (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

periodic tryptophan protein 1 homolog; PWP1 homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	41,314,978 - 41,329,979 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	41,314,978 - 41,329,988 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of DNA-templated transcription (ISO)

positive regulation of stem cell differentiation (ISO)

positive regulation of transcription of nucleolar large rRNA by RNA polymerase I (ISO)

Cellular Component

Golgi apparatus (ISO)

nucleolus (ISO)

nucleus (ISO)

Molecular Function

H4K20me3 modified histone binding (ISO)

histone chaperone activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Pwp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	41,314,978 - 41,329,979 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	41,314,978 - 41,329,988 (+)	NCBI	ChiLan1.0	ChiLan1.0

PWP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	107,685,799 - 107,713,162 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	107,685,799 - 107,713,162 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	108,079,576 - 108,106,939 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	106,603,720 - 106,630,387 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	107,745,148 - 107,771,815 (+)	NCBI		Celera
Cytogenetic Map	12	q23.3	NCBI
HuRef	12	105,139,992 - 105,166,399 (+)	NCBI		HuRef
CHM1_1	12	108,045,562 - 108,072,208 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	107,649,292 - 107,676,654 (+)	NCBI		T2T-CHM13v2.0

Pwp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	85,707,695 - 85,724,967 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	85,665,358 - 85,724,960 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	85,871,831 - 85,889,103 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	85,829,494 - 85,889,096 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	85,334,576 - 85,351,848 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	85,301,664 - 85,318,895 (+)	NCBI		MGSCv36	mm8
Celera	10	87,846,400 - 87,863,672 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	41.73	NCBI

Pwp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	19,870,465 - 19,886,463 (-)	NCBI		GRCr8
mRatBN7.2	7	17,982,730 - 17,998,728 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	17,982,235 - 17,998,731 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	19,944,886 - 19,960,878 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	22,107,256 - 22,123,255 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	21,884,528 - 21,900,521 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	23,988,776 - 24,004,774 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	23,988,776 - 24,004,774 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	24,138,856 - 24,154,854 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	20,120,919 - 20,136,917 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	20,134,743 - 20,150,979 (-)	NCBI
Celera	7	15,214,789 - 15,230,786 (-)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

PWP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	115,744,264 - 115,771,046 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	115,740,682 - 115,767,443 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	105,255,755 - 105,282,519 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	108,652,024 - 108,679,503 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	108,652,024 - 108,679,503 (+)	Ensembl	panpan1.1		panPan2

PWP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	31,121,411 - 31,146,791 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	31,117,044 - 31,146,726 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	31,106,725 - 31,131,840 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	31,966,427 - 31,991,573 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	31,963,399 - 31,991,569 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	31,705,879 - 31,730,950 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	31,995,000 - 32,020,274 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	32,181,687 - 32,206,812 (-)	NCBI		UU_Cfam_GSD_1.0

Pwp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	14,425,723 - 14,447,295 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	7,431,990 - 7,457,709 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	7,436,137 - 7,457,709 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PWP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	12,701,589 - 12,730,849 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	12,703,067 - 12,730,884 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	12,488,889 - 12,517,518 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PWP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	102,917,553 - 102,943,696 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	102,917,606 - 102,942,481 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	142,129,905 - 142,155,174 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pwp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624750	2,103,469 - 2,119,166 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624750	2,103,530 - 2,119,088 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005374640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01005546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01005547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01048521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000010362 ⟹ ENSCLAP00000010232

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955405	41,314,978 - 41,329,979 (+)	Ensembl

RefSeq Acc Id:

XM_005374640 ⟹ XP_005374697

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955405	41,314,978 - 41,329,988 (+)	NCBI

Sequence:

show sequence

GACGTCAGACGCGCGACTGCACGTCTCCTGCGTCTTCCGCCCGCGAGCCCTTGGAGCCGGGGAC
CATGAACCGCAGCCGCCAGGTGACGTGCGTGGCCTGGGTCCGCTGCGGCGTGGCCAAAGAGACG
CCGGACAAGGTAGAGCTAAGTAAAGATGAAGTAAAACGCCTCATTGCTGAAGCAAAGGAAAAGT
TACAAGAGGAAGGTGGCAGCGATGAGGAGGAGGCAGGCAGTCCTTCAGAAGATGGCATGCAGAG
TGCCCGGACCCAGGCACGACCAAGGGAGCCCCTGGAGGATGGTGACCCTGAGGATGACCGCACA
GTGGATGATGATGAGCTGGCCGAATACGACCTGGACAGGTACGATGAGGATGACGACCCAGATG
CCGAGACTCTTGGAGAATCTCTTTTGGGGCTTACAGTCTATGGGAGCAACGATCAAGATCCCTA
TGTTACTCTGAAAGATACGGAACAATATGAACGAGAAGATTTCCTGATCAAGCCTAGTGACAAT
CTCATAGTCTGTGGCCGAGCTGAGCAGGAGCAGTGCAATTTAGAGGTGCATATTTACAACCAGG
AGGAAGACTCGTTCTACGTGCACCATGACATCCTCTTGTCTGCATATCCTCTGAGTGTGGAGTG
GCTGAACTTTGATCCTAGCCCAGATGATTCCACTGGAAATTACATTGCTGTGGGAACTATGACC
CCTGTCATTGAAGTATGGGACCTTGATATTGTGGACTCTTTGGAGCCAGTTTTCACACTTGGAA
GTAAGCTCTCTAAAAAGAAGAAGAAGAAAGGAAAAAAGAGTCCCCTCATAGAAGGGCACACGGA
TGCCGTCCTTGACCTCTCGTGGAATAAGCTAACCAGGAATGTGCTGGCAAGCGCGTCTGCTGAC
GGCACCGTCATTCTGTGGGACATGTCCCTGGGGAAGCCCGCAGCCAGCCTCGCCGTACACGCAG
ACAAGGTACAGACGCTGCAGTTTCACCCATTCGAAGCCCAGACTCTGATCTCTGGATCCTATGA
TAAGTCCGTGGCGCTGTATGACTGTCGGAGTCCAGATGAGACCCACCGCGTGTGGCGGTTCAGC
GGGCAGATCGAGCGGGTGACGTGGAACCCCTTCTCCCCCTGTCACTTTCTGGTGAGCACTGACG
ACGGCTTCGTGTACGATTTGGACGCACGGTCAGATAAGCCGGTGTTCACACTCAATGCACACAA
CGACGAGATCTCTGGGCTCGAGCTGAGCAGTCAGATCAAGGGCTGCCTGGTGACTGCGTCAGCG
GACAAGTACGTGAAGATCTGGGACATCCTGGGCGACAGGCCGAGTCTCATCCACTCCAGGGACA
TGAAGATGGGTGTTCTCTTCTGTTCCTCGTGTTGCCCTGATTTGCCATTTGTTTATGCCTTCGG
GGGTCAGAAGGAAGGCCTGCGGGTGTGGGACATCAGCACCGTCTCTTCAGTAAATGAAGCATTC
GGAAGACGAGAGCGGCTCGTTCTGAGCAGTTCAAGAAGCTCAGCTGTTGGCGGCCCTTTGAGGG
GCAGGAGCGCAGAGACCCCGATGGAGTCCTAGTGGAGCTCACGCCGCACCAGCTTGTGTCCTTG
ACCAAGGCTGCAGGGCGGGCTGCGGCACCAAGGGCAGGAGGGACAGCGGGTTCACCTCGCTGGC
TGCTGTCCACTCTAGCGGGTATCGACACAGCTGGGCTTTGCGCTTGACTCGCATGGGCACTGTC
TTGGGTCCTTGTGTTTCTTGAAAACGGTCTAATTTTGAAAATGTTTTTAAACTACTTAATTCTT
TGACATGCTGTCACAATAAATCCAGGTTTATAAAGTAGGTAGCAACCTATAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005374697	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000010232
	ENSCLAP00000010232.1

RefSeq Acc Id:

XP_005374697 ⟸ XM_005374640

- UniProtKB:

A0A8C2V9Q1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNRSRQVTCVAWVRCGVAKETPDKVELSKDEVKRLIAEAKEKLQEEGGSDEEEAGSPSEDGMQS
ARTQARPREPLEDGDPEDDRTVDDDELAEYDLDRYDEDDDPDAETLGESLLGLTVYGSNDQDPY
VTLKDTEQYEREDFLIKPSDNLIVCGRAEQEQCNLEVHIYNQEEDSFYVHHDILLSAYPLSVEW
LNFDPSPDDSTGNYIAVGTMTPVIEVWDLDIVDSLEPVFTLGSKLSKKKKKKGKKSPLIEGHTD
AVLDLSWNKLTRNVLASASADGTVILWDMSLGKPAASLAVHADKVQTLQFHPFEAQTLISGSYD
KSVALYDCRSPDETHRVWRFSGQIERVTWNPFSPCHFLVSTDDGFVYDLDARSDKPVFTLNAHN
DEISGLELSSQIKGCLVTASADKYVKIWDILGDRPSLIHSRDMKMGVLFCSSCCPDLPFVYAFG
GQKEGLRVWDISTVSSVNEAFGRRERLVLSSSRSSAVGGPLRGRSAETPMES

hide sequence

Ensembl Acc Id:

ENSCLAP00000010232 ⟸ ENSCLAT00000010362

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000007078	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000010362	ENTREZGENE
	ENSCLAT00000010362.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	G-protein_beta_WD-40_rep	UniProtKB/TrEMBL
	PWP1	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Pwp1	ENTREZGENE
PANTHER	PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG	UniProtKB/TrEMBL
	PTHR14091	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
UniProt	A0A8C2V9Q1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-25	Pwp1	PWP1 homolog, endonuclein		PWP1 homolog (S. cerevisiae)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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