Gdf7 (growth differentiation factor 7)

Gene: Gdf7 (growth differentiation factor 7) Chinchilla lanigera

Analyze

Symbol:

Gdf7

Name:

growth differentiation factor 7

RGD ID:

8930409

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN activin receptor signaling pathway (ortholog); axon guidance (ortholog); BMP signaling pathway (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN extracellular region (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

growth/differentiation factor 7

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955469	3,134,355 - 3,149,177 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activin receptor signaling pathway (ISO)

axon guidance (ISO)

BMP signaling pathway (ISO)

branching morphogenesis of an epithelial tube (ISO)

cell fate commitment (ISO)

epithelial cell differentiation (ISO)

forebrain morphogenesis (ISO)

gland morphogenesis (ISO)

midbrain development (ISO)

morphogenesis of an epithelial fold (ISO)

neural tube development (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of gene expression (ISO)

positive regulation of neuron differentiation (ISO)

positive regulation of SMAD protein signal transduction (ISO)

positive regulation of tendon cell differentiation (ISO)

reproductive structure development (ISO)

roof plate formation (ISO)

spinal cord association neuron differentiation (ISO)

Cellular Component

extracellular region (ISO)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gdf7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955469	3,134,355 - 3,149,177 (+)	NCBI	ChiLan1.0	ChiLan1.0

GDF7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	20,667,144 - 20,679,243 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	20,667,144 - 20,679,243 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	20,866,904 - 20,879,003 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	20,729,905 - 20,734,731 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	20,788,051 - 20,792,878	NCBI
Celera	2	20,728,800 - 20,733,639 (+)	NCBI		Celera
Cytogenetic Map	2	p24.1	NCBI
HuRef	2	20,623,337 - 20,628,206 (+)	NCBI		HuRef
CHM1_1	2	20,795,793 - 20,800,641 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	20,700,448 - 20,712,559 (+)	NCBI		T2T-CHM13v2.0

Gdf7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	8,347,918 - 8,351,954 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	8,347,918 - 8,351,954 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	8,297,918 - 8,301,954 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	8,297,918 - 8,301,954 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	8,304,724 - 8,308,760 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	8,323,926 - 8,327,962 (-)	NCBI		MGSCv36	mm8
Celera	12	8,691,764 - 8,695,838 (-)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	3.85	NCBI

Gdf7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	36,890,799 - 36,901,783 (-)	NCBI		GRCr8
mRatBN7.2	6	31,171,495 - 31,182,484 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	31,178,119 - 31,182,447 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	31,463,589 - 31,474,571 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	31,779,510 - 31,790,492 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	31,254,019 - 31,265,005 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	33,496,596 - 33,507,626 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	33,503,217 - 33,507,542 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	43,281,722 - 43,292,667 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	31,857,104 - 31,861,428 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	31,860,390 - 31,860,592 (-)	NCBI
Celera	6	30,628,297 - 30,632,622 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

GDF7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	105,850,267 - 105,862,341 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	105,859,696 - 105,866,313 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	20,651,617 - 20,664,586 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	20,766,776 - 20,773,082 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

GDF7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	15,627,739 - 15,636,513 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	15,589,160 - 15,593,215 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	15,776,555 - 15,780,607 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	15,776,555 - 15,780,607 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	15,630,398 - 15,634,442 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	15,637,476 - 15,641,523 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	15,669,550 - 15,673,607 (+)	NCBI		UU_Cfam_GSD_1.0

Gdf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	60,026,695 - 60,039,004 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	10,808,714 - 10,812,761 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	10,808,714 - 10,812,761 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GDF7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	117,587,430 - 117,592,466 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	117,586,188 - 117,592,541 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	125,548,358 - 125,553,115 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GDF7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	87,013,821 - 87,027,977 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	87,023,028 - 87,027,194 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	25,180,063 - 25,192,565 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gdf7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624738	3,281,828 - 3,286,627 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013522564	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01052290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01101331	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_013522564 ⟹ XP_013378018

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955469	3,134,355 - 3,149,177 (+)	NCBI

Sequence:

show sequence

ATGGGGACCAGTTTACCTCAGAGAGCAGCTGGGTTGGGGGCCTGGAGAAGGGAACAGACCCGCC
CACACCAGGCCCCAGTCTGCGGGAGGAGAACAGAGCCTCTTGCCCTTACACAGTACTTCCAAAG
GGGGGTCATCAAAGCCCCGAAGAAACAGGCGTGGGAAGAAGAGAGTAGGAGAATCTGCAAAGCC
CTAGCGACAGGAAGAACGTGTTGGGAATCAGCAGAGAGGCAGCAGCTGGGCCGGAGCACCTGGT
GCACCGAGTTTAAGACTCCGCGTGCCCTCTGCCACACCACCTGCCTGGAGCCAGCCGACTACGG
ACTGAACCTCTGCAACTGTGAGCCAGATAAACTTCTCAACCTGTGGTCAGACACTTTGGCCCAG
CAACAAGAATGTAACCAAGACATGTCCTTTTCGGTGACAGAGCACTTGGAGAAGAGCACAGTTC
TGGATCTTCCCTTGCTGTGGGCGGCCCGAGCGCCCCCTCCACCCACCTCTAGCCTGTGCACCTG
GGCTCCACCAGGCACACTGTCACCCTCCTGGCTTCTGGCCGCGGCAGAACACATACCGGGTTGC
AGTAGGACAGGGGATACCCGAAACTGTGACCGAGAACGCGCCTTTGTGGCTGCGCAGCGCGTCC
TGGTGGCCTCCGGTGCGCAGGGACGCCGGGACCGTGGGCGAACTCTCCCTCCTCCCCACATGTG
GCTTCCGCGGCCTTACCGGACCAGAGCGCTGAAGGGGGGCGTTTCTGCGCGGAGGAGTGGGTCG
GAGGCGGGGCCGCTGCGCTGCGGCCTGAGTCTCGAACCCGCAGTGCGCGTCTGGTTGCGCCCGG
GCGGCCGCGGGGATCCGGCGCCTGGGGACCGGAGGCGGGGCACCAGCTGTGATGGGAGCACGGG
CTTTTGGCGGGAGCCTCGGGCCGGCGAGAGTGGGGGCGAGGAGCTGTGGTGTTGGGGGAGGCCC
GGGCCCCCGACTCCGCGAGGCCAGGGAGAGGGGGCGCGGCGCTGCCAGAGCGTTCAGCAGGGGG
CGCTGCTCCGGGCGTCGGGAGGAGGTGGGGGGGCCCGCGCCGCGCGCCGCTCTGCCGGTCCCGG
CTTCAGGAACGGCTCAGTGGTGCCGCACCACTTCATGATGGCTCTGTACCGCAGCCTGTCCGGG
AGGGCGCCGGCCGAGACAGCCGCTGCCTCGGGCCACGGCCGCGCGGACACCATCACCGGCTTCG
CAGACCAGGCAACCCAAGACGAATCGGTGGCCGAGGCTGGCCAGAGCTTCTTGTTTGACGTGTC
CAGTCTTCCCGACGCAGACGAGGTGGTGGGAGCCGAGCTGCGCGTGCTGCGCCGCAAGCCGGCT
CGGCCGGACCCGGAGAGCCCGACTGCCCCGCCGCTGCTACTGCTGTCCACGTGTCCGGGGGCTG
GGCACACGCCGCGTCTGCTGTACTCGCGGGCTGCAGAGGCGCTGGACGGCGCGCGCTGGGAGGT
GTTCGACGTGGCGGACGCCGTGCGGAGCCACCGCCGGGAGCCCCGCCACGGCCGAGGCCACGGG
CGCAGGGGCCGGAGCCGCTGTAGCCGCAAGCCGCTGCACGTGGACTTCAAGGAGCTGGGCTGGG
ACGACTGGATCATCGCGCCGCTGGATTACGAGGCCTACCACTGCGAGGGCGTCTGCGACTTCCC
ATTGCGCTCGCACCTCGAGCCCACCAACCACGCCATCATCCAGACGCTGCTCAATTCCATGGCG
CCCGACGCGGCGCCCGCCTCTTGCTGCGTGCCCGCGCGCCTCAGCCCCATCAGCATCCTCTACA
TCGACTCGGCCAACAACGTGGTCTACAAGCAGTACGAGGACATGGTGGTGGAAGCGTGCGGCTG
CAGGTAGCGCGCCGGAGGCTCAG

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Protein Sequences


Protein RefSeqs	XP_013378018	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_013378018 ⟸ XM_013522564

- Sequence:

show sequence

MGTSLPQRAAGLGAWRREQTRPHQAPVCGRRTEPLALTQYFQRGVIKAPKKQAWEEESRRICKA
LATGRTCWESAERQQLGRSTWCTEFKTPRALCHTTCLEPADYGLNLCNCEPDKLLNLWSDTLAQ
QQECNQDMSFSVTEHLEKSTVLDLPLLWAARAPPPPTSSLCTWAPPGTLSPSWLLAAAEHIPGC
SRTGDTRNCDRERAFVAAQRVLVASGAQGRRDRGRTLPPPHMWLPRPYRTRALKGGVSARRSGS
EAGPLRCGLSLEPAVRVWLRPGGRGDPAPGDRRRGTSCDGSTGFWREPRAGESGGEELWCWGRP
GPPTPRGQGEGARRCQSVQQGALLRASGGGGGARAARRSAGPGFRNGSVVPHHFMMALYRSLSG
RAPAETAAASGHGRADTITGFADQATQDESVAEAGQSFLFDVSSLPDADEVVGAELRVLRRKPA
RPDPESPTAPPLLLLSTCPGAGHTPRLLYSRAAEALDGARWEVFDVADAVRSHRREPRHGRGHG
RRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGVCDFPLRSHLEPTNHAIIQTLLNSMA
PDAAPASCCVPARLSPISILYIDSANNVVYKQYEDMVVEACGCR

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Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Gdf7	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar