Dr1 (down-regulator of transcription 1) - Rat Genome Database

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Gene: Dr1 (down-regulator of transcription 1) Chinchilla lanigera
Analyze
Symbol: Dr1
Name: down-regulator of transcription 1
RGD ID: 8925658
Description: ENCODES a protein that exhibits RNA polymerase II general transcription initiation factor activity (ortholog); TBP-class protein binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); regulation of cell cycle (ortholog); regulation of cell division (ortholog); PARTICIPATES IN RNA polymerase II transcription initiation pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN ATAC complex (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: down-regulator of transcription 1, TBP-binding (negative cofactor 2)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554231,262,633 - 1,281,870 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554231,262,633 - 1,281,870 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554231,262,633 - 1,281,870 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554231,262,633 - 1,281,870 (-)NCBIChiLan1.0ChiLan1.0
DR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,345,907 - 93,369,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,345,907 - 93,369,493 (+)EnsemblGRCh38hg38GRCh38
GRCh37193,811,464 - 93,835,050 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,584,066 - 93,600,737 (+)NCBINCBI36Build 36hg18NCBI36
Build 34193,523,498 - 93,540,167NCBI
Celera192,065,544 - 92,082,224 (+)NCBICelera
Cytogenetic Map1p22.1NCBI
HuRef191,933,028 - 91,949,702 (+)NCBIHuRef
CHM1_1193,926,443 - 93,943,112 (+)NCBICHM1_1
T2T-CHM13v2.0193,191,628 - 93,215,212 (+)NCBIT2T-CHM13v2.0
Dr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395108,416,763 - 108,428,387 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5108,416,763 - 108,428,392 (+)EnsemblGRCm39 Ensembl
GRCm385108,268,897 - 108,280,521 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5108,268,897 - 108,280,526 (+)EnsemblGRCm38mm10GRCm38
MGSCv375108,697,916 - 108,709,540 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365108,509,199 - 108,520,823 (+)NCBIMGSCv36mm8
Celera5105,388,795 - 105,400,436 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map552.82NCBI
Dr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8141,603,203 - 1,614,556 (-)NCBIGRCr8
mRatBN7.2141,458,223 - 1,469,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,458,223 - 1,469,638 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx141,339,940 - 1,351,298 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0142,641,692 - 2,653,050 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,338,369 - 1,349,747 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0142,463,651 - 2,475,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl142,463,643 - 2,474,780 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,621,026 - 1,632,378 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,462,579 - 2,473,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,005,938 - 2,017,291 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,005,938 - 2,017,291 (-)NCBI
Celera141,480,040 - 1,491,393 (-)NCBICelera
Cytogenetic Map14p22NCBI
DR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21133,654,446 - 133,671,092 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11132,809,630 - 132,826,270 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,014,758 - 96,031,402 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,746,109 - 94,762,736 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,746,109 - 94,762,736 (+)Ensemblpanpan1.1panPan2
DR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1655,687,581 - 55,717,118 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl655,693,752 - 55,716,516 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha658,394,802 - 58,423,443 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0656,062,710 - 56,091,972 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl656,066,414 - 56,091,908 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1655,742,084 - 55,770,728 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0655,726,996 - 55,756,232 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0656,180,439 - 56,209,096 (-)NCBIUU_Cfam_GSD_1.0
Dr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058103,094,464 - 103,112,245 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365375,835,774 - 5,853,515 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365375,835,774 - 5,853,509 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4123,815,461 - 123,835,825 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14123,815,088 - 123,835,875 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24135,471,129 - 135,491,365 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12039,873,024 - 39,890,090 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2039,870,814 - 39,890,106 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603378,142,864 - 78,159,920 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247424,263,288 - 4,282,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247424,263,288 - 4,282,097 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000014544   ⟹   ENSCLAP00000014386
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554231,262,633 - 1,281,870 (-)Ensembl
RefSeq Acc Id: XM_005385020   ⟹   XP_005385077
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554231,262,633 - 1,281,870 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005385077 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000014386
  ENSCLAP00000014386.1
Reference Protein Sequences
RefSeq Acc Id: XP_005385077   ⟸   XM_005385020
- UniProtKB: A0A8C2VEI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000014386   ⟸   ENSCLAT00000014544
Protein Domains
Transcription factor CBF/NF-Y/archaeal histone


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009918 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000014544 ENTREZGENE
  ENSCLAT00000014544.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
InterPro CBFA_NFYB_domain UniProtKB/TrEMBL
  Histone-fold UniProtKB/TrEMBL
  Ncb2 UniProtKB/TrEMBL
NCBI Gene Dr1 ENTREZGENE
PANTHER PROTEIN DR1 UniProtKB/TrEMBL
  PTHR46138 UniProtKB/TrEMBL
Pfam CBFD_NFYB_HMF UniProtKB/TrEMBL
PRINTS CCAATSUBUNTA UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/TrEMBL
UniProt A0A8C2VEI5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Dr1  down-regulator of transcription 1    down-regulator of transcription 1, TBP-binding (negative cofactor 2)  Symbol and/or name change 5135510 APPROVED