Tomm20 (translocase of outer mitochondrial membrane 20)

Gene: Tomm20 (translocase of outer mitochondrial membrane 20) Chinchilla lanigera

Analyze

Symbol:

Tomm20

Name:

translocase of outer mitochondrial membrane 20

RGD ID:

8921083

Description:

ENCODES a protein that exhibits mitochondrion targeting sequence binding (ortholog); protein-transporting ATPase activity (ortholog); unfolded protein binding (ortholog); INVOLVED IN protein targeting to mitochondrion (ortholog); response to 3,3',5-triiodo-L-thyronine (ortholog); response to muscle activity (ortholog); PARTICIPATES IN beta-barrel pathway of mitochondrial protein import; carrier pathway of mitochondrial protein import; presequence pathway of mitochondrial protein import; ASSOCIATED WITH common variable immunodeficiency 14 (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN cell periphery (ortholog); migrasome (ortholog); mitochondria-associated endoplasmic reticulum membrane contact site (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

mitochondrial import receptor subunit TOM20 homolog; translocase of outer mitochondrial membrane 20 homolog (yeast)

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955492	4,759,611 - 4,769,847 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955492	4,759,438 - 4,771,060 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

common variable immunodeficiency 14 (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

muscular atrophy (ISO)

parathyroid carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein targeting to mitochondrion (ISO)

response to 3,3',5-triiodo-L-thyronine (ISO)

response to muscle activity (ISO)

Cellular Component

cell periphery (ISO)

migrasome (ISO)

mitochondria-associated endoplasmic reticulum membrane contact site (ISO)

mitochondrial envelope (ISO)

mitochondrial outer membrane (ISO)

mitochondrion (ISO)

sperm midpiece (ISO)

Molecular Function

mitochondrion targeting sequence binding (ISO)

protein binding (ISO)

protein-transporting ATPase activity (ISO)

unfolded protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

beta-barrel pathway of mitochondrial protein import (ISO)

carrier pathway of mitochondrial protein import (ISO)

presequence pathway of mitochondrial protein import (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Tomm20
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955492	4,759,611 - 4,769,847 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955492	4,759,438 - 4,771,060 (+)	NCBI	ChiLan1.0	ChiLan1.0

TOMM20
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	235,109,341 - 235,128,837 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	235,109,341 - 235,128,837 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	235,272,656 - 235,292,152 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	233,339,283 - 233,358,754 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	231,598,700 - 231,618,172	NCBI
Celera	1	208,515,476 - 208,534,891 (-)	NCBI		Celera
Cytogenetic Map	1	q42.3	NCBI
HuRef	1	205,721,246 - 205,740,848 (-)	NCBI		HuRef
CHM1_1	1	236,544,978 - 236,564,578 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	234,501,058 - 234,520,553 (-)	NCBI		T2T-CHM13v2.0

Tomm20
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	127,657,414 - 127,672,671 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	127,657,417 - 127,672,594 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	126,930,664 - 126,945,921 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	126,930,667 - 126,945,844 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	129,458,450 - 129,469,730 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	129,820,640 - 129,831,920 (-)	NCBI		MGSCv36	mm8
Celera	8	131,250,666 - 131,261,945 (-)	NCBI		Celera
Cytogenetic Map	8	E2	NCBI
cM Map	8	74.64	NCBI

Tomm20
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	71,822,429 - 71,832,420 (-)	NCBI		GRCr8
mRatBN7.2	19	54,925,197 - 54,935,188 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	54,923,402 - 54,935,198 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	61,715,264 - 61,725,255 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	62,575,165 - 62,585,156 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	64,657,703 - 64,667,694 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	59,863,421 - 59,873,411 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	59,863,421 - 59,873,411 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	70,530,583 - 70,540,402 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	56,850,851 - 56,863,167 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	56,855,910 - 56,868,227 (-)	NCBI
Celera	19	54,265,379 - 54,274,601 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

TOMM20
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	14,065,296 - 14,085,234 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	14,276,223 - 14,296,142 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	210,654,256 - 210,674,157 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	215,672,538 - 215,692,471 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	215,672,544 - 215,692,471 (-)	Ensembl	panpan1.1		panPan2

TOMM20
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	4,785,589 - 4,802,170 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	4,785,584 - 4,801,006 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	4,768,144 - 4,784,739 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	4,807,784 - 4,824,378 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	4,807,831 - 4,825,529 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	4,818,627 - 4,835,209 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	4,936,217 - 4,952,808 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	5,157,946 - 5,174,766 (+)	NCBI		UU_Cfam_GSD_1.0

Tomm20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	41,117,944 - 41,129,927 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	17,283,548 - 17,295,157 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936484	17,283,527 - 17,295,157 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TOMM20
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	56,113,192 - 56,127,677 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	56,113,087 - 56,127,686 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	60,218,706 - 60,233,246 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TOMM20
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	72,286,666 - 72,304,129 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666055	74,318,901 - 74,336,764 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tomm20
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624775	15,331,047 - 15,355,206 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624775	15,331,214 - 15,355,206 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005404954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01060729	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01010948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000005105 ⟹ ENSCLAP00000005013

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955492	4,759,611 - 4,769,847 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000005106 ⟹ ENSCLAP00000005014

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955492	4,759,611 - 4,769,847 (+)	Ensembl

RefSeq Acc Id:

XM_005404954 ⟹ XP_005405011

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955492	4,759,438 - 4,771,060 (+)	NCBI

Sequence:

show sequence

TGCGCAGGCACAACTGAAGACGCCCTGCGGACCTGTGACCCGGAAGTGCTCCTGCTCGTTCTTT
CCGGTCCTTTTCACCAGGTTTCGGCTGCAGGAGGTACAATTGCCTCTTGTGTGTGGCCAGCCTC
TCCGGTGAATTCCTGCTGCGGCCGGCGCCTTGAAGTCGGGAGGAGATGGTGGGTCGGAACAGCG
CCATCGCCGCTGGCGTGTGCGGGGCCCTCTTCATCGGATACTGCATCTATTTCGACCGCAAGAG
GCGAAGCGATCCCAACTTCAAGAACAGGCTTCGAGAACGAAGAAAGAAACAGAAGCTTGCCAAG
GAGAGAGCTGGGCTTTCCAAGTTACCTGACCTTAAAGATGCCGAAGCTGTTCAGAAATTTTTTC
TTGAAGAAATACAGCTTGGTGAAGAGTTACTGGCTCAAGGTGAATATGAGAAGGGTGTGGACCA
TCTGACAAATGCAATTGCTGTGTGTGGACAGCCACAGCAGTTGCTGCAGGTGCTACAGCAAACT
CTTCCACCACCTGTGTTCCAGATGCTTCTCACTAAGCTCCCAACAATTAGTCAGAGAATTGTAA
GTGCTCAGAGCTTGGCTGAAGATGATGTGGAATGAAAACAAATCTCAACATAATAAAATCTCAA
AAAGATTTTAAAAATTCTAAGCTCAGAAGTTGAACAACTGGGGGAATAAGGGCAAATATGCTTG
TTAACGGACTGTGCTACACTGAAATCTACCAAAGTTAATGTTTACTTTGTGTAGATCCATTTGT
CTATTATTTATTTTTCCCAGTGAAAAGTGTATTTTAATAGAGAGCTTTTCATTTTATAAAAACA
CTATGAGTTACCAAAATATGAATTTTGTTTATTTCTTAGACCTGCAGTTAAAATGTACATATAT
CATTTAAAAACCCAGTGCTTAGTTTCAAAGAACAGGCAAAAGGGCTGGGATTGCAGCTGAGTAT
CGAGTACTTGTCTAGCGTGTGTGAGGCCCTAGTTTTGGCCCCAGCACCACAAAAACAAAGTGAA
AAAGTGTAGGAGAGTGGTGAATGTACATTTGTAAAGCTAGCACATTTTCTTATGAGAGTTGGAT
AGAGACTTGATTGTATTTTTGAAAAGTGTTACAGTGAGAGGTCCTTTCCTTTTACTCTTCAACA
CGCTGCTGTGCTGTACTAATGGCTCCCACCTCTTTCCTTGATACCAGTTTTGAGCAATTTTATT
TAAATCAGTGTACTTAATGTTTGTGGGTATTTATCTTGTGTTTTAAGTATATGTGACTACAAGT
AGTACGGGGAATTAAATCCACGTACCTAATCTCACCTATGAGCTTCACCGGTTGGAGTCTGCTC
ACTCTCATTTATAAAACCAGGGAATCAACTTTGGTGATTTTGAGGTGTCCCTTTCAATTTCTCC
TTCTTTTGTTCTATTCAGCATCTTCAAATTCACCTTCACCTGAGGAGTGTATTTGGCCAACCAG
GACTTGCATTTTTTTAATATTCTGAATCTTGCATGCTTGCCTGACTTAGTATTTCTGAATTAAT
CTTTTGATTTTCACTGGAATTGGTCAGTTCTGTGACTTTGTAAATTTGAAAATTAACCTTTAAG
GTAACTGGGATCATCTGCCTGTAAAAATGTTTATTCCCTTTTGCTTTCATCCTCTGTACGTTTC
AGGTTGATTAATTTATATCATATAATGAGTGGGATGTAATACTGACTAAAGACCGAATACAGTT
TGTGGGACCTCTTACTCTCACAGTGACATATTGTCTGCCATTTCAGATGTGAGTCAGTATCAGA
ATTGAGAATAAAGATCTTTGGTACTTAAAGACA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005405011	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000005013
	ENSCLAP00000005013.1
	ENSCLAP00000005014.1

RefSeq Acc Id:	XP_005405011 ⟸ XM_005404954
- UniProtKB:	A0A8C2UTE5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKKQKLAKERAGLSKLPDLKDAE AVQKFFLEEIQLGEELLAQGEYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLPT ISQRIVSAQSLAEDDVE hide sequence

RefSeq Acc Id:

ENSCLAP00000005014 ⟸ ENSCLAT00000005106

RefSeq Acc Id:

ENSCLAP00000005013 ⟸ ENSCLAT00000005105

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000003558	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000005105	ENTREZGENE
	ENSCLAT00000005105.1	UniProtKB/TrEMBL
	ENSCLAT00000005106.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.960.10	UniProtKB/TrEMBL
InterPro	MAS20	UniProtKB/TrEMBL
	MAS20_rcpt_metazoan	UniProtKB/TrEMBL
	Tom20_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Tomm20	ENTREZGENE
PANTHER	MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 HOMOLOG	UniProtKB/TrEMBL
	MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 HOMOLOG B	UniProtKB/TrEMBL
	PTHR12430	UniProtKB/TrEMBL
Pfam	MAS20	UniProtKB/TrEMBL
PIRSF	MAS20_rcpt	UniProtKB/TrEMBL
PRINTS	EUOM20RECPTR	UniProtKB/TrEMBL
	OM20RECEPTOR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47157	UniProtKB/TrEMBL
UniProt	A0A8C2UTE5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2YKB7_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Tomm20	translocase of outer mitochondrial membrane 20		translocase of outer mitochondrial membrane 20 homolog (yeast)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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