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Gene: Lamtor1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1) Chinchilla lanigera

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Symbol:

Lamtor1

Name:

late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

RGD ID:

8919443

Description:

ENCODES a protein that exhibits GTPase binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN autophagosome assembly (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to nutrient levels (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH 3-methylglutaconic aciduria type 7b (ortholog); cerebral folate receptor alpha deficiency (ortholog); intellectual disability (ortholog); FOUND IN FNIP-folliculin RagC/D GAP (ortholog); late endosome membrane (ortholog); lysosomal membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ragulator complex protein LAMTOR1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	19,228,615 - 19,247,765 (+)	Ensembl
ChiLan1.0	NW_004955414	19,228,615 - 19,235,523 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-methylglutaconic aciduria type 7b (ISO)

cerebral folate receptor alpha deficiency (ISO)

intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagosome assembly (ISO)

cellular response to amino acid stimulus (ISO)

cellular response to nutrient levels (ISO)

cholesterol homeostasis (ISO)

cytoplasmic translation (ISO)

endosomal transport (ISO)

endosome organization (ISO)

intracellular protein localization (ISO)

lysosome localization (ISO)

lysosome organization (ISO)

negative regulation of autophagy (ISO)

negative regulation of translational initiation (ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of protein localization to lysosome (ISO)

positive regulation of TOR signaling (ISO)

positive regulation of TORC1 signaling (ISO)

positive regulation of translational initiation (ISO)

protein localization to lysosome (ISO)

protein localization to membrane (ISO)

regulation of cell growth (ISO)

regulation of cholesterol efflux (ISO)

regulation of cholesterol import (ISO)

regulation of receptor recycling (ISO)

TORC1 signaling (ISO)

Cellular Component

FNIP-folliculin RagC/D GAP (ISO)

late endosome membrane (ISO)

lysosomal membrane (ISO)

lysosome (ISO)

membrane raft (ISO)

Ragulator complex (ISO)

Molecular Function

GTPase binding (ISO)

guanyl-nucleotide exchange factor activity (ISO)

molecular adaptor activity (ISO)

protein binding (ISO)

protein-membrane adaptor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Lamtor1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	19,228,615 - 19,247,765 (+)	Ensembl
ChiLan1.0	NW_004955414	19,228,615 - 19,235,523 (+)	NCBI	ChiLan1.0	ChiLan1.0

LAMTOR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	72,097,292 - 72,103,297 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	72,085,895 - 72,103,297 (-)	Ensembl			hg38	GRCh38
GRCh37	11	71,808,338 - 71,814,343 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	71,485,986 - 71,491,970 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	11	69,110,285 - 69,116,380 (-)	NCBI		Celera
Cytogenetic Map	11	q13.4	NCBI
HuRef	11	68,101,932 - 68,108,027 (-)	NCBI		HuRef
CHM1_1	11	71,692,146 - 71,698,241 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	72,024,182 - 72,030,187 (-)	NCBI		T2T-CHM13v2.0

Lamtor1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	101,555,044 - 101,561,110 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	101,555,111 - 101,575,882 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	101,905,837 - 101,911,903 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	101,905,904 - 101,926,675 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	109,054,351 - 109,060,417 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	101,779,750 - 101,785,705 (+)	NCBI		MGSCv36	mm8
Celera	7	102,280,164 - 102,286,229 (+)	NCBI		Celera
Cytogenetic Map	7	E2	NCBI
cM Map	7	54.68	NCBI

Lamtor1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	165,684,001 - 165,689,698 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	165,684,091 - 165,703,178 (+)	Ensembl				GRCr8
mRatBN7.2	1	156,272,116 - 156,277,687 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	156,272,064 - 156,291,179 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	164,256,283 - 164,261,855 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	171,436,377 - 171,441,949 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	164,313,824 - 164,319,389 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	166,991,474 - 166,997,045 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	166,991,474 - 166,997,045 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	173,182,228 - 173,187,799 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	159,367,471 - 159,373,042 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	154,345,774 - 154,351,345 (+)	NCBI		Celera
RGSC_v3.1	1	159,446,487 - 159,452,059 (+)	NCBI
Cytogenetic Map	1	q32	NCBI

LAMTOR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	73,047,036 - 73,053,146 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	74,089,380 - 74,095,462 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	67,177,580 - 67,183,631 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	70,401,167 - 70,407,246 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	70,390,141 - 70,407,246 (-)	Ensembl			panPan2	panpan1.1

LAMTOR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	25,981,170 - 25,986,942 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	25,981,254 - 25,996,432 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	25,750,825 - 25,756,606 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	26,190,008 - 26,195,789 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	26,190,102 - 26,205,280 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	25,981,266 - 25,987,047 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	26,197,390 - 26,203,172 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	26,099,021 - 26,104,803 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lamtor1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	59,847,252 - 59,860,045 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	1,442,754 - 1,459,673 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	1,446,794 - 1,459,590 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LAMTOR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	6,672,475 - 6,680,053 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	6,674,045 - 6,680,067 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	7,435,536 - 7,441,539 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LAMTOR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	63,301,354 - 63,307,716 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	63,301,885 - 63,307,553 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666043	62,591,235 - 62,597,696 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lamtor1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624817	4,872,672 - 4,890,791 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624817	4,872,630 - 4,879,217 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005380006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01015308	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01062278	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000023581 ⟹ ENSCLAP00000023360

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955414	19,228,615 - 19,235,523 (+)	Ensembl

Ensembl Acc Id:

ENSCLAT00000023582 ⟹ ENSCLAP00000023361

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955414	19,228,732 - 19,247,765 (+)	Ensembl

RefSeq Acc Id:

XM_005380006 ⟹ XP_005380063

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955414	19,228,615 - 19,235,523 (+)	NCBI

Sequence:

show sequence

GGGGAGGGGAACGGGTAGTAGCTCGCGGGAGGCAGCCGCGGGTCATGTGACCGGAAGGGCTCCT
GACGGACGCCGTCCCTCCTCGGCGCTGCCTGAGCGCCCGGCCCTACCCCAGCAATGGGGTGCTG
CTACAGCAGCGAAAACGAAGACTCGGACCAGGATCGAGAGGAGCGGAAGCTGCTGCTAGACCCT
AGTAGCCCCCCCACCAAAGCCCTCAATGGAGCTGAGCCCAACTACCACAGCCTGCCTTCTGCTC
GCACAGATGAGCAGGCCCTGCTCTCCTCCATCCTTGCCAAGACAGCCAGCAACATCATTGATGT
GTCCGCTGCAGACTCGCAGGGCATGGAGCAGCATGAGTACATGGACCGGGCAAGGCAGTACAGT
ACCCGCTTGGCTGTGCTAAGCAGTAGCCTGACCCATTGGAAGAAGTTGCCACCGCTACCATCTC
TCACCAGCCAGCCCCACCAAGTGCTGGCCAGCGAGCCCATCCCCTTCTCTGACTTGCAGCAGGT
CTCCAGGATAGCTGCTTACGCCTACAGTGCACTTTCTCAGATCCGTGTGGACGCAAAAGAAGAG
CTGGTTGTACAGTTTGGGATCCCATGAAGAGAGGGTCCTTGGACAGCTCTTCTCCTCTCTTCAG
CCCGTCTCCACCGCGCCTCCCCTGGTCCCCAGCCTCACTGCGGCTTAAACAGTACCCTAACCTG
CTACTAATCACGGAGAAGAATGTGGAGGAGAAGAGCGAGGGTAGAAGCCCGAGCAAGTGAGGAC
GGAACAAGGGGGGGTAGAACCTTTGGGACTGGCCTTCGAAGCCCTGGCCGAGGTCGGGTGGGGG
CCAAGAGGACAGGGCCTGGTAGGTGTCCCAGTCATTGGAAAGGTAGAGATACCACTGTGGGGGT
GAACAACAGGGGACTTAGGCATCCCCTTCCCACCCTTTCTCTTGGCCTCAGATTATTCACTCCG
GTCCCCCTCTCCCTGACTTGGTGCTCACATGCACCTCACTAGGGTTTGTGACCAGGGTCTGGAC
GAGCTTGAATTTGAACGGAGTTTGTACTTCTAGCACCCTGGGTTTTTATATGTTTGGTCTTTTT
TCTTTTTGTTTTTGTTTGTCACCCTTGATAAAGGAAGTGTATTCATTTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005380063	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000023360
	ENSCLAP00000023360.1
	ENSCLAP00000023361.1

RefSeq Acc Id:	XP_005380063 ⟸ XM_005380006
- UniProtKB:	A0A8C2YU25 (UniProtKB/TrEMBL), A0A8C2W0H6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASN IIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSD LQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP hide sequence

Ensembl Acc Id:

ENSCLAP00000023360 ⟸ ENSCLAT00000023581

Ensembl Acc Id:

ENSCLAP00000023361 ⟸ ENSCLAT00000023582

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000016024	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000023581	ENTREZGENE
	ENSCLAT00000023581.1	UniProtKB/TrEMBL
	ENSCLAT00000023582.1	UniProtKB/TrEMBL
InterPro	LAMTOR1/MEH1	UniProtKB/TrEMBL
NCBI Gene	Lamtor1	ENTREZGENE
PANTHER	RAGULATOR COMPLEX PROTEIN LAMTOR1	UniProtKB/TrEMBL
	RAGULATOR COMPLEX PROTEIN LAMTOR1	UniProtKB/TrEMBL
Pfam	LAMTOR	UniProtKB/TrEMBL
SMART	LAMTOR	UniProtKB/TrEMBL
UniProt	A0A8C2W0H6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2YU25	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations