Gabarap (GABA type A receptor-associated protein)

Gene: Gabarap (GABA type A receptor-associated protein) Chinchilla lanigera

Analyze

Symbol:

Gabarap

Name:

GABA type A receptor-associated protein

RGD ID:

8912353

Description:

ENCODES a protein that exhibits beta-tubulin binding (ortholog); GABA receptor binding (ortholog); microtubule binding (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway via death domain receptors (ortholog); microtubule cytoskeleton organization (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); PARTICIPATES IN autophagy pathway; ASSOCIATED WITH common variable immunodeficiency (ortholog); congenital myasthenic syndrome 2A (ortholog); dyskeratosis congenita (ortholog); FOUND IN actin cytoskeleton (ortholog); autophagosome (ortholog); autophagosome membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	9,667,941 - 9,670,067 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	9,667,938 - 9,670,067 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

common variable immunodeficiency (ISO)

congenital myasthenic syndrome 2A (ISO)

dyskeratosis congenita (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Li-Fraumeni syndrome (ISO)

very long chain acyl-CoA dehydrogenase deficiency (ISO)

Weissenbacher-Zweymuller syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

extrinsic apoptotic signaling pathway via death domain receptors (ISO)

microtubule cytoskeleton organization (ISO)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ISO)

positive regulation of protein K48-linked ubiquitination (ISO)

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (ISO)

regulation of Rac protein signal transduction (ISO)

Cellular Component

actin cytoskeleton (ISO)

autophagosome (ISO)

autophagosome membrane (ISO)

axoneme (ISO)

cell body (ISO)

GABA-ergic synapse (ISO)

Golgi apparatus (ISO)

lysosome (ISO)

microtubule associated complex (ISO)

perinuclear region of cytoplasm (ISO)

plasma membrane (ISO)

smooth endoplasmic reticulum (ISO)

sperm midpiece (ISO)

Molecular Function

beta-tubulin binding (ISO)

GABA receptor binding (ISO)

microtubule binding (ISO)

phosphatidylethanolamine binding (ISO)

protein binding (ISO)

ubiquitin protein ligase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

autophagy pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Gabarap
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	9,667,941 - 9,670,067 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	9,667,938 - 9,670,067 (+)	NCBI	ChiLan1.0	ChiLan1.0

GABARAP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	7,240,008 - 7,242,449 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	7,240,008 - 7,242,449 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	7,143,327 - 7,145,768 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	7,084,462 - 7,086,477 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	7,084,462 - 7,086,477	NCBI
Celera	17	7,168,385 - 7,170,397 (-)	NCBI		Celera
Cytogenetic Map	17	p13.1	NCBI
HuRef	17	7,035,144 - 7,037,156 (-)	NCBI		HuRef
CHM1_1	17	7,152,530 - 7,154,546 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	7,140,933 - 7,143,371 (-)	NCBI		T2T-CHM13v2.0

Gabarap
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	69,882,196 - 69,885,775 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	69,881,969 - 69,885,777 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	69,991,370 - 69,994,949 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	69,991,143 - 69,994,951 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	69,804,872 - 69,808,451 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	69,807,565 - 69,811,141 (+)	NCBI		MGSCv36	mm8
Celera	11	77,539,180 - 77,542,759 (+)	NCBI		Celera
Cytogenetic Map	11	B3	NCBI
cM Map	11	42.95	NCBI

Gabarap
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	55,213,465 - 55,216,787 (+)	NCBI		GRCr8
mRatBN7.2	10	54,714,777 - 54,718,099 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	54,714,198 - 54,717,765 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	59,376,972 - 59,380,294 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	58,865,552 - 58,868,874 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	54,372,830 - 54,376,146 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	56,601,288 - 56,604,223 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	56,601,288 - 56,604,221 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	56,346,407 - 56,349,342 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	56,837,772 - 56,840,707 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	56,851,394 - 56,854,330 (+)	NCBI
Celera	10	53,868,419 - 53,871,353 (+)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

GABARAP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	14,833,095 - 14,836,107 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	16,799,099 - 16,801,668 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	7,270,316 - 7,272,365 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	7,257,659 - 7,260,276 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	7,257,659 - 7,260,276 (-)	Ensembl	panpan1.1		panPan2

GABARAP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	32,207,879 - 32,209,976 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	32,207,887 - 32,209,908 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	32,346,200 - 32,348,297 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	32,313,526 - 32,315,623 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	32,313,534 - 32,315,555 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	32,278,810 - 32,280,907 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	32,237,838 - 32,239,935 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	32,414,791 - 32,416,888 (-)	NCBI		UU_Cfam_GSD_1.0

Gabarap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	47,059,854 - 47,061,872 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936595	533,977 - 536,271 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936595	534,042 - 536,289 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GABARAP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	52,596,543 - 52,598,194 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	52,596,130 - 52,598,166 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	54,842,339 - 54,844,400 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GABARAP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	6,614,478 - 6,616,516 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	6,614,688 - 6,616,443 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	14,793,285 - 14,796,280 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gabarap
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624786	9,857,370 - 9,860,063 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624786	9,857,370 - 9,859,675 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005399538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013522089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01051521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01002377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000011568 ⟹ ENSCLAP00000011431

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955467	9,667,941 - 9,670,067 (+)	Ensembl

RefSeq Acc Id:

XM_005399538 ⟹ XP_005399595

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955467	9,667,941 - 9,670,067 (+)	NCBI

Sequence:

show sequence

AATAGGGAAGTGGCGCAAATTCGTGGATCGCTCCGCTGAGTCCGCCCGCGCGTCTCTGCCATCG
CCGCCGCCCCCTGTCCCGGCCCCCCCTCCCCGGGTTCCCTCAGCCTAGCCCGGTCCAGCCCGGT
TCCCGGGAGGATGAAGTTCGTGTACAAAGAGGAGCATCCGTTCGAAAAGCGCCGCTCTGAGGGC
GAGAAGATCCGAAAAAAATACCCGGACCGGGTTCCGGTGATAGTAGAAAAGGCTCCCAAAGCTC
GGATAGGGGACCTGGACAAAAAGAAATACCTGGTGCCTTCTGATCTCACAGTTGGTCAGTTCTA
CTTCTTGATCCGGAAGCGAATTCATCTCCGAGCTGAGGACGCCTTGTTTTTCTTTGTCAACAAT
GTTATTCCACCCACCAGTGCCACAATGGGTCAGCTATACCAGGAACACCATGAAGAAGACTTCT
TTCTATACATTGCCTACAGTGATGAAAGTGTCTACGGTCTGTGAAGCTGCTACCCCTGAGGTGG
GAGGTTCCATTCTACAAAGAGAGAGGTGGCACCCCTTCCCTGATCTCCAGCTCCTTCAGGCTCA
AACACAACTTCCCTTTTTCAGGACCTGCACTTCTTAAAGATTAAGGCTTTCTATCTAGCCCCTC
TTAGCAGGAGGGGTAATGGTGGACATGGCCTTTTGTACCTCTCTTTTCTCCTTTCTTCCCTTTC
TTTACCATCCTTTCCCACTGTGGTTTAGACTTCTTGATTGTCAATCTGTCACACCCAGTGATTG
TTTTGGTTTCTGTTCCCTTTCCAACTGTCCAGGGTGTTCAGAACCCCAACAATCCCTTTCACAA
CCTTCTTTCTTGGGGGGTAATGGAAGAGATTGAAATTGTGGAAGGAAGGTAGGAGTCACATCAA
TAAAGAGGAAACCACCAATTGAACTGAA

hide sequence

RefSeq Acc Id:

XM_013522089 ⟹ XP_013377543

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955467	9,667,938 - 9,670,067 (+)	NCBI

Sequence:

show sequence

GTGAATAGGGAAGTGGCGCAAATTCGTGGATCGCTCCGCTGAGTCCGCCCGCGCGTCTCTGCCA
TCGCCGCCGCCCCCTGTCCCGGCCCCCCCTCCCCGGGTTCCCTCAGCCTAGCCCGGTCCAGCCC
GGTTCCCGGGAGGATGAAGTTCGTGTACAAAGAGGAGCATCCGTTCGAAAAGCGCCGCTCTGAG
GGCGAGAAGATCCGAAAAAAATACCCGGACCGGGTTCCGGGATTGATCCTGGGTATTTAGATGA
GCCAAGTGAGGTCAGGATGTCTGGACTTAGTGCTGCACCGCGTGTACAGAGACAAAGAAGTGAT
AGTAGAAAAGGCTCCCAAAGCTCGGATAGGGGACCTGGACAAAAAGAAATACCTGGTGCCTTCT
GATCTCACAGTTGGTCAGTTCTACTTCTTGATCCGGAAGCGAATTCATCTCCGAGCTGAGGACG
CCTTGTTTTTCTTTGTCAACAATGTTATTCCACCCACCAGTGCCACAATGGGTCAGCTATACCA
GGAACACCATGAAGAAGACTTCTTTCTATACATTGCCTACAGTGATGAAAGTGTCTACGGTCTG
TGAAGCTGCTACCCCTGAGGTGGGAGGTTCCATTCTACAAAGAGAGAGGTGGCACCCCTTCCCT
GATCTCCAGCTCCTTCAGGCTCAAACACAACTTCCCTTTTTCAGGACCTGCACTTCTTAAAGAT
TAAGGCTTTCTATCTAGCCCCTCTTAGCAGGAGGGGTAATGGTGGACATGGCCTTTTGTACCTC
TCTTTTCTCCTTTCTTCCCTTTCTTTACCATCCTTTCCCACTGTGGTTTAGACTTCTTGATTGT
CAATCTGTCACACCCAGTGATTGTTTTGGTTTCTGTTCCCTTTCCAACTGTCCAGGGTGTTCAG
AACCCCAACAATCCCTTTCACAACCTTCTTTCTTGGGGGGTAATGGAAGAGATTGAAATTGTGG
AAGGAAGGTAGGAGTCACATCAATAAAGAGGAAACCACCAATTGAACTGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005399595	(Get FASTA)	NCBI Sequence Viewer
	XP_013377543	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000011431
	ENSCLAP00000011431.1

RefSeq Acc Id:	XP_005399595 ⟸ XM_005399538
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2V9S1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLI RKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL hide sequence

RefSeq Acc Id:	XP_013377543 ⟸ XM_013522089
- Peptide Label:	isoform X2
- Sequence:	show sequence MSQVRSGCLDLVLHRVYRDKEVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAE DALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL hide sequence

RefSeq Acc Id:

ENSCLAP00000011431 ⟸ ENSCLAT00000011568

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000007883	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000011568	ENTREZGENE
	ENSCLAT00000011568.1	UniProtKB/TrEMBL
InterPro	Atg8-like	UniProtKB/TrEMBL
	Ubiquitin-like_domsf	UniProtKB/TrEMBL
NCBI Gene	Gabarap	ENTREZGENE
PANTHER	GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN	UniProtKB/TrEMBL
	PTHR10969	UniProtKB/TrEMBL
Pfam	ATG8	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54236	UniProtKB/TrEMBL
UniProt	A0A8C2V9S1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Gabarap	GABA type A receptor-associated protein		GABA(A) receptor-associated protein	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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