Ndc80 (NDC80 kinetochore complex component)

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Gene: Ndc80 (NDC80 kinetochore complex component) Chinchilla lanigera

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Symbol:

Ndc80

Name:

NDC80 kinetochore complex component

RGD ID:

8910656

Description:

ENCODES a protein that exhibits cyclin binding (ortholog); identical protein binding (ortholog); kinetochore adaptor activity (ortholog); INVOLVED IN attachment of mitotic spindle microtubules to kinetochore (ortholog); attachment of spindle microtubules to kinetochore (ortholog); centrosome duplication (ortholog); ASSOCIATED WITH colorectal cancer (ortholog); hepatocellular carcinoma (ortholog); intellectual disability (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); kinetochore (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

kinetochore protein NDC80 homolog; NDC80, kinetochore complex component

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	7,691,937 - 7,729,690 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	7,692,009 - 7,728,876 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

colorectal cancer (ISO)

hepatocellular carcinoma (ISO)

intellectual disability (ISO)

lung non-small cell carcinoma (ISO)

Neoplasm Metastasis (ISO)

stomach cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

attachment of mitotic spindle microtubules to kinetochore (ISO)

attachment of spindle microtubules to kinetochore (ISO)

centrosome duplication (ISO)

chromosome segregation (ISO)

establishment of mitotic spindle orientation (ISO)

G2/MI transition of meiotic cell cycle (ISO)

kinetochore organization (ISO)

metaphase chromosome alignment (ISO)

mitotic spindle organization (ISO)

positive regulation of mitotic cell cycle spindle assembly checkpoint (ISO)

regulation of protein stability (ISO)

skeletal muscle satellite cell proliferation (ISO)

spindle assembly involved in female meiosis I (ISO)

Cellular Component

centrosome (ISO)

cytoplasm (ISO)

kinetochore (ISO)

Ndc80 complex (ISO)

nucleoplasm (ISO)

outer kinetochore (ISO)

Molecular Function

cyclin binding (ISO)

identical protein binding (ISO)

kinetochore adaptor activity (ISO)

microtubule binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ndc80
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	7,691,937 - 7,729,690 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	7,692,009 - 7,728,876 (-)	NCBI	ChiLan1.0	ChiLan1.0

NDC80
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	2,571,557 - 2,616,635 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	2,571,557 - 2,616,635 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	2,571,556 - 2,616,634 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	2,561,605 - 2,606,629 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	2,561,604 - 2,606,626	NCBI
Celera	18	2,446,814 - 2,491,757 (+)	NCBI		Celera
Cytogenetic Map	18	p11.32	NCBI
HuRef	18	2,532,999 - 2,577,942 (+)	NCBI		HuRef
CHM1_1	18	2,570,883 - 2,615,800 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	2,727,304 - 2,772,223 (+)	NCBI		T2T-CHM13v2.0

Ndc80
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	71,803,095 - 71,833,852 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	71,803,095 - 71,833,852 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	71,496,100 - 71,526,857 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	71,496,100 - 71,526,857 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	71,845,440 - 71,876,197 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	71,400,962 - 71,431,714 (-)	NCBI		MGSCv36	mm8
Celera	17	75,767,449 - 75,800,160 (-)	NCBI		Celera
Cytogenetic Map	17	E1.3	NCBI
cM Map	17	41.87	NCBI

Ndc80
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	118,853,806 - 118,887,582 (-)	NCBI		GRCr8
mRatBN7.2	9	111,407,191 - 111,440,921 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	111,407,191 - 111,440,924 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	119,805,258 - 119,842,593 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	124,934,621 - 124,971,844 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	123,271,148 - 123,308,405 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	119,837,857 - 119,871,435 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	119,839,016 - 119,871,382 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	119,291,271 - 119,324,839 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	110,702,935 - 110,718,894 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	110,912,517 - 110,945,708 (-)	NCBI
Celera	9	108,536,354 - 108,552,152 (-)	NCBI		Celera
Cytogenetic Map	9	q38	NCBI

NDC80
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	35,829,184 - 35,874,768 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	21,521,776 - 21,567,360 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	11,666,099 - 11,711,456 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	13,972,637 - 14,018,261 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	13,972,637 - 14,018,261 (-)	Ensembl	panpan1.1		panPan2

NDC80
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	69,268,218 - 69,317,126 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	69,268,242 - 69,317,072 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	68,723,201 - 68,772,189 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	69,329,940 - 69,378,870 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	69,329,990 - 69,378,835 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	69,012,589 - 69,061,471 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	69,032,710 - 69,081,627 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	69,329,927 - 69,378,829 (+)	NCBI		UU_Cfam_GSD_1.0

Ndc80
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	65,630,900 - 65,669,747 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936672	1,872,193 - 1,909,675 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936672	1,872,205 - 1,910,956 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NDC80
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	103,999,034 - 104,055,760 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	104,000,794 - 104,055,785 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	97,024,076 - 97,061,162 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NDC80
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	61,835,027 - 61,882,660 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	61,835,064 - 61,881,627 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	36,694,925 - 36,740,902 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ndc80
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	12,939,763 - 12,974,162 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624770	12,937,887 - 12,974,352 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005372664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01000181	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01000182	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01305956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000016331 ⟹ ENSCLAP00000016167

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955402	7,691,937 - 7,729,690 (-)	Ensembl

RefSeq Acc Id:

XM_005372664 ⟹ XP_005372721

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955402	7,692,009 - 7,728,876 (-)	NCBI

Sequence:

show sequence

TCCTTGGCGGGCGGAGACAGTGGCTCTTGTTTTGGCGGCTGCTGTTGTCTCTGGAGGTCCGTTT
CCCACCGTATAGAAATTCGGCCTCTGGGTCTCGTCAGGAAACTGGAGGAAGGTCGTAAGCATGA
AGCGCAGCTCAGTGTCCACCGGTGGTGCTGGCCGCCTCTCTATGCAGGAGTTAAGATCCCTGGA
CATGAATAAACCGGGCCTTTATACCCCTCAAATGAAAGAGAAACCAAGTTTCAGCAAGTTGAGT
ATAAGCAAATCTACATCTGAAAGAAAAGTCTCTGTATTCGGTAAAAGAACCAGCGGACATGGAT
CCCGGAATAGTCAACTTGGTATATTTTCCAGTTCTGAAAAAATCAAGGACCCGCGACCACTTAA
TGACAAAGCGTTCATTCAGCAGTGTATTCGACAACTCTGCGAGTTTCTTACAGAAAATGGTTAT
GCATACAGTGTATCCATGAAATCTCTCCAAGCTCCATCTGTGAAAGACTTCCTAAAGATCTTCA
CTTTTCTTTATGGTTTCCTGTGCCCTTCCTATGAGCTTCCCGACACAAAATTTGAAGAAGAGGT
GCCAAGAATTTTTAAAGACCTTGGATACCCTTTTGCTCTGTCCAAAAGCTCCATGTACACGGTG
GGAGCCCCCCACACCTGGCCGCACATCGTGGCAGCCTTGGTTTGGCTAATAGACTGCATCAAGA
TACATAATGCCATGAAAGAAAGCTCACCTTTATTTGATGATGGACAACCTTGGGTAGAAGAAAC
TGAAGATGGAATTATGCATAATAAGCTGTTTTTGGACTATACCATTAAATGCTACGAGAGCTTC
ATGACTGGCGCTGACACCTTTGAAGAGATGAATGCAGAGTTGCAGTCCAAGCTGAAGGATTTAT
ATAATGTCGATGCTGCCAAGCTGGAATCATTAGCCGCAAAAAACAAAGCACTGAATGAGCAGAT
CGCAAGACTGGAGCAGGAAAGAGAAAAAGAACCGAATCGTCTAGAGTCTTTGAGGAAACTGAAA
ACCTCCCTACAAGCAGATGTTCAAAAGTATCAATCATACATGAGCAATTTGGAGTCTCATTCAG
CTATTCTTGACCAGAAACTGAGTGGTCTTGATGAAGAAATTTCTAGAGTAGAAATAGAGTGTGA
AACCGTGAAACAGGAGAATGCCCGGCTGCAGAACATTGTTGATAACCAGAAGTACTCGGTCGCT
GACATTGAGAGAATAAACCATGAAAAAAATGACTTGCAACAAACCATCAATAAATTAACCAAGG
ACCTGGAGACTGAACAGCAGCAGTTGTGGAATGAGGAGCTGAAGTACGCACGCGCCAAAGAGGC
GATTGAAACACAATTAGCAGAATATCACAAAATGGCTAGAAAGTTGAAACTAATCCCAAAAGGT
GCAGAGAATTCCAAAGGTTACGACTTTGAAATTAAGTTTAATCCTGAAGCTGGTGCCAACTGCC
TTGTCAAATACAGGGCACAAGTTTATGTACCTCTCAAGGAACTCCTGAACGAAAATGAAGAAGA
AATTAATAAAGCTCTAAATAAAAAAATGGGTTTGGAGGATACGTTAGAACAATTGAATACAATG
ATAACAGAAAGCAAGAGAAGTGTGAGAACTCTGAAGGAAGAAGTTCAAAAGCTGGATGATCTTT
ACCAACAAAAAGTTAAGGAAGCTGAGGAGGAGGACGAGAAGTGCGCCAGCGAGCTGGAGTCCTT
GGAGAAGCACAAGCACCTGCTGGAGAGCGCCGTGAACGAGGGCCTCAGCGAGGCGATGGCCGCG
CTGGACGCCGTGCAGCGGGAGTACCAGCTAGTTGTGCAGACCACAACTGAAGAAAGAAGGAAAG
TGGGGAGTAACCTGCAGCGTCTGCTAGAGATGGTGGCCATGCACGTGGGGTCCGTGGAGAAACA
TCTTGAGGAGCAGATTCCTAAAGTTGATAGAGAGTACGAAGAATGCATGTCTGAAGATCTCTTG
GAAAATATTAGAGAGATTACAGAAAAATATAAGAAGAACGCTGCTCTCATTAAGCCTTCCGATG
AGTGAAGATAAAATGTTGATTATCTTGTACATTTTATAAATCTAGTTGATATGTATAACTTGAA
ATTATGATGACTTGTGGATTATTTTTAGCTGTGGAAGAGCAGTTTTATATGTACCTGTAGTTAA
TAAAATTGTATCAGTAAAGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005372721	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000016167
	ENSCLAP00000016167.1

RefSeq Acc Id:

XP_005372721 ⟸ XM_005372664

- UniProtKB:

A0A8C2YQN2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKRSSVSTGGAGRLSMQELRSLDMNKPGLYTPQMKEKPSFSKLSISKSTSERKVSVFGKRTSGH
GSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLCEFLTENGYAYSVSMKSLQAPSVKDFLKI
FTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKSSMYTVGAPHTWPHIVAALVWLIDCI
KIHNAMKESSPLFDDGQPWVEETEDGIMHNKLFLDYTIKCYESFMTGADTFEEMNAELQSKLKD
LYNVDAAKLESLAAKNKALNEQIARLEQEREKEPNRLESLRKLKTSLQADVQKYQSYMSNLESH
SAILDQKLSGLDEEISRVEIECETVKQENARLQNIVDNQKYSVADIERINHEKNDLQQTINKLT
KDLETEQQQLWNEELKYARAKEAIETQLAEYHKMARKLKLIPKGAENSKGYDFEIKFNPEAGAN
CLVKYRAQVYVPLKELLNENEEEINKALNKKMGLEDTLEQLNTMITESKRSVRTLKEEVQKLDD
LYQQKVKEAEEEDEKCASELESLEKHKHLLESAVNEGLSEAMAALDAVQREYQLVVQTTTEERR
KVGSNLQRLLEMVAMHVGSVEKHLEEQIPKVDREYEECMSEDLLENIREITEKYKKNAALIKPS
DE

hide sequence

Ensembl Acc Id:

ENSCLAP00000016167 ⟸ ENSCLAT00000016331

Protein Domains

DUF5595

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000011120	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000016331	ENTREZGENE
	ENSCLAT00000016331.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.418.30	UniProtKB/TrEMBL
	6.10.250.1950	UniProtKB/TrEMBL
InterPro	DUF5595	UniProtKB/TrEMBL
	Kinetochore_Ndc80	UniProtKB/TrEMBL
	Ndc80_sf	UniProtKB/TrEMBL
NCBI Gene	Ndc80	ENTREZGENE
PANTHER	KINETOCHORE PROTEIN NDC80 HOMOLOG	UniProtKB/TrEMBL
	PTHR10643	UniProtKB/TrEMBL
Pfam	DUF5595	UniProtKB/TrEMBL
	Ndc80_HEC	UniProtKB/TrEMBL
UniProt	A0A8C2YQN2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-01-29	Ndc80	NDC80 kinetochore complex component		NDC80, kinetochore complex component	Symbol and/or name change	5135510	APPROVED
2016-08-03	Ndc80	NDC80, kinetochore complex component		NDC80 kinetochore complex component	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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