Sash3 (SAM and SH3 domain containing 3)

Advanced Search (OLGA)

Gene: Sash3 (SAM and SH3 domain containing 3) Chinchilla lanigera

Analyze

Symbol:

Sash3

Name:

SAM and SH3 domain containing 3

RGD ID:

8910507

Description:

INVOLVED IN B cell homeostasis (ortholog); B cell proliferation (ortholog); CD4-positive, alpha-beta T cell differentiation (ortholog); ASSOCIATED WITH autistic disorder (ortholog); autosomal hemophilia A (ortholog); Charcot-Marie-Tooth disease type X (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

SAM and SH3 domain-containing protein 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955473	5,222,408 - 5,237,260 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955473	5,224,635 - 5,237,066 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

autosomal hemophilia A (ISO)

Charcot-Marie-Tooth disease type X (ISO)

Experimental Liver Cirrhosis (ISO)

factor VIII deficiency (ISO)

Immunodeficiency 102 (ISO)

oculocerebrorenal syndrome (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

syndromic X-linked intellectual disability Raymond type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell homeostasis (ISO)

B cell proliferation (ISO)

CD4-positive, alpha-beta T cell differentiation (ISO)

homeostasis of number of cells within a tissue (ISO)

positive regulation of adaptive immune response (ISO)

positive regulation of B cell proliferation (ISO)

positive regulation of CD4-positive, alpha-beta T cell differentiation (ISO)

positive regulation of immunoglobulin production (ISO)

positive regulation of interleukin-10 production (ISO)

positive regulation of interleukin-2 production (ISO)

positive regulation of interleukin-4 production (ISO)

positive regulation of lymphocyte activation (ISO)

positive regulation of organ growth (ISO)

positive regulation of T cell cytokine production (ISO)

positive regulation of T cell proliferation (ISO)

positive regulation of tumor necrosis factor production (ISO)

positive regulation of type II interferon production (ISO)

T cell proliferation (ISO)

Cellular Component

cytoplasm (ISO)

nucleus (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Sash3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955473	5,222,408 - 5,237,260 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955473	5,224,635 - 5,237,066 (-)	NCBI	ChiLan1.0	ChiLan1.0

SASH3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	129,779,949 - 129,795,201 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	129,779,949 - 129,795,201 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	128,913,925 - 128,929,177 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	128,741,641 - 128,756,858 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	128,639,494 - 128,654,709	NCBI
Celera	X	129,300,396 - 129,315,681 (+)	NCBI		Celera
Cytogenetic Map	X	q26.1	NCBI
HuRef	X	118,315,088 - 118,330,679 (+)	NCBI		HuRef
CHM1_1	X	128,825,238 - 128,840,527 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	128,098,744 - 128,113,978 (+)	NCBI		T2T-CHM13v2.0

Sash3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	47,235,313 - 47,250,442 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	47,235,313 - 47,250,442 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	48,146,436 - 48,161,565 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	48,146,436 - 48,161,565 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	45,499,704 - 45,514,740 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	44,391,154 - 44,406,190 (+)	NCBI		MGSCv36	mm8
Celera	X	35,648,999 - 35,664,024 (+)	NCBI		Celera
Cytogenetic Map	X	A4	NCBI
cM Map	X	25.54	NCBI

Sash3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	132,204,717 - 132,219,421 (+)	NCBI		GRCr8
mRatBN7.2	X	127,326,815 - 127,341,521 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	127,326,859 - 127,341,519 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	129,452,837 - 129,467,495 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	133,023,434 - 133,038,098 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	130,549,991 - 130,564,647 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	134,979,637 - 134,994,351 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	134,979,646 - 134,994,349 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	135,052,951 - 135,067,689 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	134,511,776 - 134,526,489 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	126,277,336 - 126,292,010 (+)	NCBI		Celera
Cytogenetic Map	X	q36	NCBI

SASH3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	129,203,040 - 129,218,311 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	129,206,616 - 129,221,925 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	118,909,980 - 118,924,779 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	129,207,049 - 129,222,342 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	129,207,049 - 129,222,342 (+)	Ensembl	panpan1.1		panPan2

SASH3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	100,989,605 - 101,003,162 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	100,989,685 - 101,001,885 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	87,163,546 - 87,177,092 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	102,841,088 - 102,854,632 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	102,841,145 - 102,854,642 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	100,259,370 - 100,272,917 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	102,105,560 - 102,119,104 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	101,883,353 - 101,896,898 (+)	NCBI		UU_Cfam_GSD_1.0

Sash3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	99,222,104 - 99,235,375 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	1,750,746 - 1,765,361 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	1,752,180 - 1,765,330 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SASH3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	106,373,954 - 106,389,444 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	106,373,871 - 106,389,454 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	122,142,841 - 122,158,398 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SASH3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	105,057,782 - 105,072,994 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	105,057,570 - 105,073,354 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	42,472,786 - 42,488,013 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sash3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624797	9,001,795 - 9,018,027 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624797	9,001,846 - 9,017,441 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005401258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01053973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01090094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000001970 ⟹ ENSCLAP00000001926

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955473	5,222,408 - 5,237,260 (-)	Ensembl

RefSeq Acc Id:

XM_005401258 ⟹ XP_005401315

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955473	5,224,635 - 5,237,066 (-)	NCBI

Sequence:

show sequence

TTCCTGTATGCTGTTGCTGCCGGGTGTCCATGGCCCGCACCCCCAAGCTGCCACTGCAGCAGTC
AGAGTGGCAGCCGGAGGCTTGGTCCATGCTGTGCCCTCCGCACGGTGCTGGTGAGGCTAAGCAA
GAGGCCTCCACATCTCAATACCTAGGAGAGCAGGGAAGGAGTCTCACCAGGGTAAAGGACCATG
TTACGCCGCAAGCCCTCCAATGCCAGTGAGAAGGAGCCCACTCAGAAGAAAAAGCTCTCCCTTC
AGCGCTCCAGCAGCTTCAAGGATTTTGCCAAATCCAAACCCAGCTCCCCCGTGGTGAGCGAGAA
GGAATTTAATCTGGATGATAATATTCCAGAAGATGACTCAGGTGTTCCCACCCCAGAGGATGCT
GGGAAAAGTGGCAAAAAGCTGGGGAAGAAATGGAGAGCAGTGATTTCCCGAACCATGAACAGGA
AGATGGGCAAAATGATGGTGAAGGCCCTGTCAGAGGAGATGGCAGACACGCTGGAGGAGGGCTC
AGCCTCCCCAACGTCTCCAGATTGCAGCCTTGACAGCCCTGGCCCTGAGAAAATGGCCCTGGCC
TTTGCTGAGCAGGAGGAGCATGCACTCCCAGTGCTCAGCCGCCAGGCATCAACGGGCAGTGAGC
TCTACAGCCCCAGCACAGGCTCCGGCAGCTTTGGGGAGGAATCACCTGCTCCGCTGCACATAGG
ACCCTTCTGTGGCCGAGCTCGAGTTCACACCGACTTCACTCCCAGCCCCTATGATCACGACTCG
CTGAAACTGCAGAAAGGAGACGTGATCCAGATCATTGAAAAGCCACCTGTGGGCACATGGCTGG
GCCTGCTCAATGGAAAGCTGGGCTCTTTCAAATTCATCTACGTGGATGTGCTGCCTGAGGAGGC
TGTGGGGCCTGCCCGCCCCAGCCGCCGACAGAGCAAGGGCAAAAGGCCCAAGCCCAAGACTCTG
CATGAGCTGCTGGAGCGCATTGGCCTGGAGGAGCACACATCCACCCTGCTTCTCAATGGCTACC
AGACACTGGAAGACTTCAAAGAGCTACGGGAAACACACCTCAATGAGCTGAACATCATGGACCC
ACAACACCGGGCCAAGCTGCTCACGGCTGCCGAGTTGCTGCTGGACTATGACACTGGCAGTGAG
GAGGCCGAAGAGGGTGCTGAGAGTGGTCATGAGCCAGTGCTGCACACAGTGTCAGAACCCAAGG
TGGACATCCCACGGGACTCCGGATGCTTCGAGGGCTCCGAGAGCGGGCGTGATGAAGTGGAGCT
GGCAGGCGCTGAGGAGCAGCTGCAAGGCCTCTCCCTAGCTGGGGCACCTTGAGGTAGAGGTGGC
GCAGGCCAAGGTTGGGCCTGAGCTGCAGAGGTCGCAGGGATGAAACGCCTGGGCCCAGAGGACA
GTGCCAAGCCTGGTCCTGCTTTCCCAGGGTCACTTACAGCCACAGGCATGGCCAGAGCCCTATA
AGCTCCACCTGAAGTGGACAAAGGGACACCCAAAGGCACATCCCACCTGCCAGACCCCTCCCTC
TTCCAACGACTGACAGTACAGCCCTCCTGGCACCACCCACTCCCCTAGGCCACAGCCTTAGCAG
GTGGGATATCAAGGGAAGAAAGCCCAGTGTACCACACTTTCCTTCTCCCTAACTGTCTCAGAGG
TCTGGCTGCCCAGTCACGATGAGATTTGAACCAAGCGCTTTCCCCCTCTGGGCTTTGTACTTGC
CGAATAGAACGGGTAGTCACTGAGGACCTTCCTGGCCAGCTGACACTCTAGGATTTTAAATGCC
TGCTCTCCTGCTACCTGTGGCCTGGGGCACCAGTGGAGTTTATTGAAGAGGCTGGAGGAGCCTC
CGGCTTTCAAGTGAATCGGTTCGTCCTGCCTATTTCACACCTTCAATGTGCCAGCCTAAGCTGC
AACTTCCTCCGGTTTAAAACAATGCCTATACCTTATATAATGTGTGCCCCCTTCTGTCCCTGGC
CCTCTCAAATTAGACTTCCCACCAGACTAATAGCAGGTGGTCATACGCGGCTTCCAAGGACACA
GATGCCCCTCAGATGCCAGTTGCAGGTCTAGGTCCAGACTTGGCCATGTGTGTGGGTCCTTACA
AGCGAAGAAAGCACCAAGCTTGACACTGAGAAGGCCACTGGCTGACACTGCTTTGCTGATGTTG
TGGTGTGCCTTGAGCTGCAGAGAGTGCGGAGTGCATCTGGTGATAAAGGCCTCCCTTGACCCCA
GTAGCCAATCTTTGCCACATGAATCACCCAGAAGAGCCCTTCCCTGGTACAGGACAAACAGTGC
CCACTACCTCTAGGACTGCCTGCTTTGTAGTCACACTTCTTGACCTGCTATCAGGAACTTTGGG
ACAAGCTAGCTTTGGGGAAGGGGCTAGGTATAAATATGAAGGGGTGGAGGGAGACAAATAAAGA
AGAAATAAAATATAGGTAGAATTAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005401315	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000001926
	ENSCLAP00000001926.1

RefSeq Acc Id:

XP_005401315 ⟸ XM_005401258

- UniProtKB:

A0A8C2UJQ1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLRRKPSNASEKEPTQKKKLSLQRSSSFKDFAKSKPSSPVVSEKEFNLDDNIPEDDSGVPTPED
AGKSGKKLGKKWRAVISRTMNRKMGKMMVKALSEEMADTLEEGSASPTSPDCSLDSPGPEKMAL
AFAEQEEHALPVLSRQASTGSELYSPSTGSGSFGEESPAPLHIGPFCGRARVHTDFTPSPYDHD
SLKLQKGDVIQIIEKPPVGTWLGLLNGKLGSFKFIYVDVLPEEAVGPARPSRRQSKGKRPKPKT
LHELLERIGLEEHTSTLLLNGYQTLEDFKELRETHLNELNIMDPQHRAKLLTAAELLLDYDTGS
EEAEEGAESGHEPVLHTVSEPKVDIPRDSGCFEGSESGRDEVELAGAEEQLQGLSLAGAP

hide sequence

Ensembl Acc Id:

ENSCLAP00000001926 ⟸ ENSCLAT00000001970

Protein Domains

SAM SH3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000001420	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000001970	ENTREZGENE
	ENSCLAT00000001970.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.150.50	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
InterPro	rSAM/SH3_domain-containing	UniProtKB/TrEMBL
	SAM	UniProtKB/TrEMBL
	SAM-SH3_domain_protein	UniProtKB/TrEMBL
	SAM/pointed_sf	UniProtKB/TrEMBL
	SASH3_SH3	UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
NCBI Gene	Sash3	ENTREZGENE
PANTHER	PTHR12301:SF5	UniProtKB/TrEMBL
	SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED	UniProtKB/TrEMBL
Pfam	SAM_1	UniProtKB/TrEMBL
	SH3_2	UniProtKB/TrEMBL
	SLY	UniProtKB/TrEMBL
PROSITE	SAM_DOMAIN	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
SMART	SAM	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47769	UniProtKB/TrEMBL
	SSF50044	UniProtKB/TrEMBL
UniProt	A0A8C2UJQ1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM