Cd8b (CD8 subunit beta) - Rat Genome Database

Name: Cd8b
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Cd8b (CD8 subunit beta) Chinchilla lanigera

Analyze

Symbol:

Cd8b

Name:

CD8 subunit beta

RGD ID:

8909067

Description:

INVOLVED IN T cell activation (ortholog); T cell receptor signaling pathway (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH genetic disease (ortholog); juvenile rheumatoid arthritis (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

CD8b molecule; T-cell surface glycoprotein CD8 beta chain

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CD8B (CD8 subunit beta)	NCBI	Ortholog
Mus musculus (house mouse):	Cd8b1 (CD8 subunit beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cd8b (CD8 subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CD8B (CD8 subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CD8B (CD8 subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cd8b (CD8 subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CD8B (CD8 subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CD8B (CD8 subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cd8b (CD8 subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955424	922,916 - 939,469 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

juvenile rheumatoid arthritis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

T cell activation (ISO)

T cell receptor signaling pathway (ISO)

Cellular Component

cell surface (ISO)

external side of plasma membrane (ISO)

plasma membrane (ISO)

receptor complex (ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-12 signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Cd8b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955424	922,916 - 939,469 (+)	NCBI	ChiLan1.0	ChiLan1.0

CD8B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	86,815,369 - 86,861,886 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	86,815,339 - 86,861,924 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	87,042,492 - 87,089,009 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	86,895,971 - 86,942,549 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	86,989,886 - 87,000,696	NCBI
Celera	2	86,870,194 - 86,880,209 (-)	NCBI		Celera
Cytogenetic Map	2	p11.2	NCBI
HuRef	2	86,928,738 - 86,973,684 (-)	NCBI		HuRef
CHM1_1	2	86,972,492 - 87,019,072 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	86,817,280 - 86,863,804 (-)	NCBI		T2T-CHM13v2.0

Cd8b1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	71,299,772 - 71,314,476 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	71,299,772 - 71,314,478 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	71,322,788 - 71,337,492 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	71,322,788 - 71,337,494 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	71,272,806 - 71,287,445 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	71,252,321 - 71,266,960 (+)	NCBI		MGSCv36	mm8
Celera	6	73,402,170 - 73,416,806 (+)	NCBI		Celera
Cytogenetic Map	6	C1	NCBI
cM Map	6	32.14	NCBI

Cd8b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	104,870,911 - 104,886,838 (+)	NCBI		GRCr8
mRatBN7.2	4	103,312,596 - 103,328,523 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	103,312,578 - 103,328,553 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	108,695,395 - 108,711,355 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	104,470,502 - 104,486,462 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	103,082,525 - 103,098,460 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	99,185,960 - 99,201,887 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	99,185,885 - 99,202,023 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	163,964,393 - 163,980,405 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	104,536,454 - 104,552,683 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	104,780,934 - 104,797,161 (+)	NCBI
Celera	4	92,485,472 - 92,501,403 (+)	NCBI		Celera
Cytogenetic Map	4	q32	NCBI

CD8B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	39,525,605 - 39,576,307 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	39,528,365 - 39,575,084 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	86,863,320 - 86,909,989 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	88,406,690 - 88,453,052 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

CD8B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	38,342,897 - 38,358,127 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	38,027,714 - 38,042,969 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	39,074,878 - 39,090,088 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	17	38,242,011 - 38,257,216 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	38,277,858 - 38,293,076 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	38,626,364 - 38,641,576 (+)	NCBI		UU_Cfam_GSD_1.0

Cd8b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	80,016,544 - 80,030,393 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936712	828,073 - 841,889 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CD8B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	57,968,383 - 57,986,441 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	57,968,358 - 57,986,450 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	60,577,367 - 60,679,569 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CD8B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	18,807,378 - 18,854,323 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666080	927,459 - 974,437 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cd8b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624749	16,513,360 - 16,525,494 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005385386	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01024223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01430415	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005385386 ⟹ XP_005385443

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955424	922,916 - 939,469 (+)	NCBI

Sequence:

show sequence

CCGCCGCAGCCCGCGGGCCGCAGGCGACCGAGCGCCGAGATGCAGCCGCGGCTCTGGCTCCTCG
TGGCCGCGAAGCTCGCAGTTCTCCAGGGCAGCGGTGGCCTCCTGCAGAACCCCGGCTCCCTGGT
GCTCCAGACCAACCAAGTGGCTGCAATGAGCTGCGACTTTAAAACCACCGGCAGCAACAGCCGC
ATCTACTGGCTGAGGCAGCGCCAGGCCCCCAGCGAGGACAGCCACCACGAGTTCCTGGCCTCTC
AGGAGTACTTAGGGAACGTCACCTATGGCGAGGCTGTGACACCAAGAACACTCACTCTAACTCG
GAGTGGCGCCCGCGTCACCCTCAACCTCAAACACACGAAGCCTGAGGACAGCGGCATCTACTTC
TGCATGACCATAGGGTCCCCTGAGCTCATCTTCGGGAGAGGAACCACCCTGAGCGTGGTTGACG
TCCTGCCCACCACCGCCCAGCCCACCCAGAAATTGCCCCCTGGGAAATTGCCCCCCGGGAAGAA
AAAGTGCCAGCCCCCCAGCCCACGGACCCAGAAAGGCCTGCGGTGTGGTCACGTCACCCTCAGC
CTTCTGGTGGCCAGCGTCCTGCTCCTGCTGCTGTCCCTGGCCGTGGCCGTCCACCTGTACTGCC
TGCGGAGGAGAGCGCGGCTTCGCTTCATCAAACAGTTCTACAAATGAGTGGAGATGGCGCTTGT
GGTGGCCTGCTATGCGAAGCCACTGGTCAGGAAGGAGCAACATCTGGACAGAGGAGGAAGAAGG
GGACACACTCAAGGCTGGACATTTCACTGCCATGCGCGAGCTGCCTGCTTTTAACTGCTGCAAC
TTCTGTCTGGGGAGCCTCGCACTGGAGCCCTTCAGGATTCACTGCTGAGCATCAGAGAGAAGGC
TCCAGAGCCCCAGGGCACTTCGCAGAGTGTGCTAGAGGACTGATAATCTGCACCAGAGACACCG
CCTTTGGTTCCTGTGCTCTCCCCAGGCTGGGCTGGGGCCTTGGTGGTAGCTATGCAGCCACCAT
CTTTGCAAGTTGCTTTGCCCTAGTATGGCAGGGACATTGGCTCCCAGGTCTGTTATTGGGTGGA
CTTGTGACTGAGGCTTCCGGAGAGGGAATTCCCAGCAGCCCTGGGAGCCTCCAGCCTTCCTTTG
GGGCTGGGAGGCTGTGGGGTTGGGGAAGGAATTTCACTCCACGGCTTGTATACTTCTCTCACTC
TGTCCTTTTAGGAAAATATCTGAGCTATAAAAATAAAGTCTTGATTTAAAGATA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005385443	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000006916
	ENSCLAP00000006916.1

RefSeq Acc Id:

XP_005385443 ⟸ XM_005385386

- UniProtKB:

A0A8C2V0C4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQPRLWLLVAAKLAVLQGSGGLLQNPGSLVLQTNQVAAMSCDFKTTGSNSRIYWLRQRQAPSED
SHHEFLASQEYLGNVTYGEAVTPRTLTLTRSGARVTLNLKHTKPEDSGIYFCMTIGSPELIFGR
GTTLSVVDVLPTTAQPTQKLPPGKLPPGKKKCQPPSPRTQKGLRCGHVTLSLLVASVLLLLLSL
AVAVHLYCLRRRARLRFIKQFYK

hide sequence

Protein Domains

Ig-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000004867	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000007028	ENTREZGENE
	ENSCLAT00000007028.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	CD8B	UniProtKB/TrEMBL
	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_V-set	UniProtKB/TrEMBL
NCBI Gene	Cd8b	ENTREZGENE
PANTHER	PTHR11292	UniProtKB/TrEMBL
	T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN-RELATED	UniProtKB/TrEMBL
Pfam	V-set	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
SMART	IGv	UniProtKB/TrEMBL
	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A0A8C2V0C4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-01-10	Cd8b	CD8 subunit beta	Cd8b	CD8b molecule	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)