Metap2 (methionyl aminopeptidase 2)

Gene: Metap2 (methionyl aminopeptidase 2) Chinchilla lanigera

Analyze

Symbol:

Metap2

Name:

methionyl aminopeptidase 2

RGD ID:

8904476

Description:

ENCODES a protein that exhibits aminopeptidase activity (ortholog); metalloexopeptidase activity (ortholog); INVOLVED IN protein processing (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

methionine aminopeptidase 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	31,942,427 - 31,976,678 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	31,942,427 - 31,976,678 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein processing (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

plasma membrane (ISO)

Molecular Function

aminopeptidase activity (ISO)

metalloexopeptidase activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Metap2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	31,942,427 - 31,976,678 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	31,942,427 - 31,976,678 (+)	NCBI	ChiLan1.0	ChiLan1.0

METAP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	95,474,152 - 95,515,839 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	95,473,520 - 95,515,839 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	95,867,928 - 95,909,615 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	94,391,953 - 94,433,746 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	94,370,389 - 94,410,587	NCBI
Celera	12	95,538,718 - 95,580,736 (+)	NCBI		Celera
Cytogenetic Map	12	q22	NCBI
HuRef	12	92,936,350 - 92,977,989 (+)	NCBI		HuRef
CHM1_1	12	95,833,252 - 95,875,049 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	95,455,178 - 95,496,879 (+)	NCBI		T2T-CHM13v2.0

Metap2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	93,694,351 - 93,732,952 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	93,694,351 - 93,732,955 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	93,858,489 - 93,897,090 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	93,858,489 - 93,897,093 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	93,321,234 - 93,353,947 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	93,288,288 - 93,321,001 (-)	NCBI		MGSCv36	mm8
Celera	10	95,828,659 - 95,861,285 (-)	NCBI		Celera
Cytogenetic Map	10	C2	NCBI
cM Map	10	48.69	NCBI

Metap2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	30,299,433 - 30,327,477 (-)	NCBI		GRCr8
mRatBN7.2	7	28,412,429 - 28,440,458 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	28,411,608 - 28,440,434 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	30,402,812 - 30,430,792 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	32,565,048 - 32,593,032 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	32,342,482 - 32,370,504 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	34,762,241 - 34,789,456 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	34,762,231 - 34,789,479 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	34,821,214 - 34,848,430 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	30,974,071 - 31,001,641 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	30,994,341 - 31,021,912 (-)	NCBI
Celera	7	25,509,781 - 25,535,670 (-)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

METAP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	103,548,786 - 103,590,522 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	103,545,904 - 103,586,912 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	93,068,921 - 93,109,098 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	96,461,418 - 96,503,087 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	96,461,549 - 96,503,508 (+)	Ensembl	panpan1.1		panPan2

METAP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	35,363,494 - 35,398,926 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	35,363,528 - 35,398,168 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	35,750,123 - 35,785,289 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	36,028,074 - 36,063,311 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	36,028,136 - 36,064,772 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	35,301,082 - 35,336,182 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	35,395,570 - 35,430,722 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	35,658,719 - 35,693,877 (+)	NCBI		UU_Cfam_GSD_1.0

Metap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	24,573,140 - 24,610,683 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936507	11,624,060 - 11,660,875 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936507	11,624,696 - 11,661,632 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

METAP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	87,888,674 - 87,926,148 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	87,890,821 - 87,926,155 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	92,091,623 - 92,127,676 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

METAP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	90,872,672 - 90,914,257 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	90,872,699 - 90,912,499 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	154,255,439 - 154,297,723 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Metap2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624750	11,726,303 - 11,756,671 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005374484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01005318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01005319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01005320	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01005321	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01005322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01003406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000013344 ⟹ ENSCLAP00000013193

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955405	31,942,427 - 31,976,678 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000013345 ⟹ ENSCLAP00000013194

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955405	31,942,499 - 31,976,659 (+)	Ensembl

RefSeq Acc Id:

XM_005374484 ⟹ XP_005374541

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955405	31,942,427 - 31,976,678 (+)	NCBI

Sequence:

show sequence

CGTGGGGGAGGGAGTGAAGGAGGAGCGCGCCCTCGCCGCGCCGTCTCGCGCCCTCGCGCTCTCT
CCGGCATCATGGCGGGCGTGGAGGAGGCAGAGGCCTCCGGGAGCCACTTGAATGGCGACCTGGA
CCCGGACGACCGGGAAGAGGGAGCTGCCTCTACGGCCGAGGAAGCAGCCAAGAAGAAGAAGCGG
AAGAAGAAGAAGAGTAAAGGGGCTGGTGCAGGGCAGCAAGAACTTGATAAGGAATCAGGAGCCT
CTGTGGACGAGGTTGCAAAACAGTTGGAAAGACAGGCACTGGAGGAGAAAGAAAGAGATGACGA
CGATGAAGATGGAGATGGTGATGCAGATGGAGCAACTGGAAAGAAGAAAAAGAAGAAGAAGAAG
AAGAGAGGACCAAAAGTCCAGACGGACCCGCCCTCGGTGCCGATCTGTGACTTGTACCCTAGTG
GCGTGTTCCCGAAGGGGCAGGAGTGCGAGTACCCACCCACGCAAGACGGGCGAACAGCTGCTTG
GAGAACTACAAGTGAAGAAAAGAAAGCATTAGATCAGGCTAGCGAAGAGATTTGGAATGATTTT
CGAGAAGCTGCGGAAGCACATCGGCAAGTTAGAAAATACGTTATGAGTTGGATCAAGCCTGGGA
TGACAATGATAGAAATCTGTGAGAAGCTGGAGGACTGTTCTCGCAAGCTTATAAAAGAGAACGG
CTTGAACGCGGGACTGGCGTTTCCGACTGGGTGTTCTCTCAATAACTGTGCCGCTCACTACACG
CCCAACGCAGGGGACACCACGGTGTTACAGTACGATGACATCTGTAAGATCGACTTCGGAACGC
ATATAAGCGGTAGGATAATTGACTGTGCTTTTACTGTCACTTTTAATCCCAAATATGATATATT
ATTAAAAGCTGTAAAAGATGCCACTAATACTGGAATAAAGTGTGCTGGCATCGACGTCCGTCTG
TGTGATGTGGGTGAGGCCATCCAGGAAGTTATGGAGTCCTATGAAGTGGAAATAGACGGGAAGA
CATACCAAGTGAAGCCCATCCGCAATCTGAACGGACACTCAATTGGGCCGTACAGAATACACGC
GGGGAAGACCGTGCCCATCGTGAAGGGCGGCGAGGCCACGAGGATGGAGGAAGGAGAAGTGTAT
GCCATTGAGACCTTCGGGAGCACAGGAAAGGGTGTTGTTCACGACGACATGGAGTGTTCGCATT
ACATGAAAAATTTTGATGTTGGGCACGTGCCAATAAGGCTCCCAAGAACAAAACACTTGTTAAA
CGTCATCAATGAGAACTTCGGCACCCTTGCCTTCTGCCGCCGATGGCTGGATCGCCTGGGAGAA
AGTAAATACTTGATGGCGCTGAAGAACCTGTGTGACTTGGGCATCGTAGACCCGTACCCACCAC
TGTGTGACATTAAAGGGTCATACACAGCGCAGTTCGAACACACTATCCTGCTGCGTCCGACTTG
TAAAGAAGTTGTCAGCAGAGGAGATGACTATTAAACTTAGTCCAAAGCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005374541	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000011628.1
	ENSCLAP00000011629.1
	ENSCLAP00000013193
	ENSCLAP00000013193.1
	ENSCLAP00000013194.1

RefSeq Acc Id:

XP_005374541 ⟸ XM_005374484

- UniProtKB:

A0A8C2VDA6 (UniProtKB/TrEMBL), A0A8C2VFD1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGVEEAEASGSHLNGDLDPDDREEGAASTAEEAAKKKKRKKKKSKGAGAGQQELDKESGASVD
EVAKQLERQALEEKERDDDDEDGDGDADGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPSGVF
PKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTM
IEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHIS
GRIIDCAFTVTFNPKYDILLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQ
VKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMK
NFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCD
IKGSYTAQFEHTILLRPTCKEVVSRGDDY

hide sequence

RefSeq Acc Id:

ENSCLAP00000013193 ⟸ ENSCLAT00000013344

RefSeq Acc Id:

ENSCLAP00000013194 ⟸ ENSCLAT00000013345

Protein Domains

Peptidase M24

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000008018	UniProtKB/TrEMBL
	ENSCLAG00000009110	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000011765.1	UniProtKB/TrEMBL
	ENSCLAT00000011766.1	UniProtKB/TrEMBL
	ENSCLAT00000013344	ENTREZGENE
	ENSCLAT00000013344.1	UniProtKB/TrEMBL
	ENSCLAT00000013345.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	3.90.230.10	UniProtKB/TrEMBL
InterPro	Creatinase/aminopeptidase-like	UniProtKB/TrEMBL
	Pept_M24	UniProtKB/TrEMBL
	Pept_M24_MAP	UniProtKB/TrEMBL
	Pept_M24A_MAP2	UniProtKB/TrEMBL
	Pept_M24A_MAP2_BS	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	Metap2	ENTREZGENE
PANTHER	METHIONINE AMINOPEPTIDASE 2	UniProtKB/TrEMBL
	METHIONINE AMINOPEPTIDASE 2	UniProtKB/TrEMBL
Pfam	Peptidase_M24	UniProtKB/TrEMBL
PRINTS	MAPEPTIDASE	UniProtKB/TrEMBL
PROSITE	MAP_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
	SSF55920	UniProtKB/TrEMBL
UniProt	A0A8C2VDA6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2VFD1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2YNH4_CHILA	UniProtKB/TrEMBL
	A0A8C2YNH5_CHILA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar