Marchf2 (membrane associated ring-CH-type finger 2) - Rat Genome Database

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Gene: Marchf2 (membrane associated ring-CH-type finger 2) Chinchilla lanigera
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Symbol: Marchf2
Name: membrane associated ring-CH-type finger 2
RGD ID: 8896569
Description: ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN antibacterial innate immune response (ortholog); antiviral innate immune response (ortholog); positive regulation of lysosomal protein catabolic process (ortholog); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); mucolipidosis type IV (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic vesicle (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase MARCH2; March2; membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955563977,030 - 998,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955563977,030 - 998,487 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Marchf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955563977,030 - 998,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955563977,030 - 998,487 (-)NCBIChiLan1.0ChiLan1.0
MARCHF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38198,413,305 - 8,439,017 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl198,413,270 - 8,439,017 (+)EnsemblGRCh38hg38GRCh38
GRCh37198,478,189 - 8,503,901 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36198,384,187 - 8,409,901 (+)NCBINCBI36Build 36hg18NCBI36
Build 34198,384,186 - 8,409,897NCBI
Celera198,334,842 - 8,361,884 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef198,132,371 - 8,159,550 (+)NCBIHuRef
CHM1_1198,477,636 - 8,503,333 (+)NCBICHM1_1
T2T-CHM13v2.0198,399,779 - 8,426,935 (+)NCBIT2T-CHM13v2.0
Marchf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391733,904,666 - 33,937,651 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1733,904,666 - 33,937,644 (-)EnsemblGRCm39 Ensembl
GRCm381733,685,692 - 33,718,677 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,685,692 - 33,718,670 (-)EnsemblGRCm38mm10GRCm38
MGSCv371733,822,657 - 33,855,615 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,292,399 - 33,325,385 (-)NCBIMGSCv36mm8
Celera1736,441,177 - 36,475,971 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Marchf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8715,183,931 - 15,209,988 (-)NCBIGRCr8
mRatBN7.2714,480,605 - 14,507,821 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl714,481,761 - 14,507,794 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx717,490,362 - 17,516,265 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0719,355,483 - 19,381,495 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0717,235,943 - 17,261,859 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0718,559,301 - 18,585,351 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,559,205 - 18,585,313 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0718,736,884 - 18,762,951 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4716,193,114 - 16,219,081 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1716,193,541 - 16,211,213 (-)NCBI
Celera713,380,395 - 13,406,283 (-)NCBICelera
Cytogenetic Map7q13NCBI
MARCHF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22013,080,891 - 13,107,158 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11912,198,448 - 12,224,713 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,699,828 - 7,726,094 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,549,319 - 8,573,678 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,554,242 - 8,573,672 (+)Ensemblpanpan1.1panPan2
MARCHF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,976,503 - 52,990,694 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,980,002 - 52,990,470 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,777,685 - 52,791,769 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02053,504,582 - 53,518,755 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,504,571 - 53,518,533 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,706,554 - 52,720,643 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,152,411 - 53,166,498 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,384,032 - 53,398,140 (+)NCBIUU_Cfam_GSD_1.0
MARCHF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,862,432 - 70,877,402 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1270,862,178 - 70,877,450 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,228,812 - 71,244,144 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MARCHF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,756,600 - 7,790,121 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607412,469,358 - 12,495,908 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Marchf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248281,181,870 - 1,199,307 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248281,182,261 - 1,197,327 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000003956   ⟹   ENSCLAP00000003880
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955563977,030 - 991,891 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000003957   ⟹   ENSCLAP00000003881
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955563977,468 - 998,485 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000003958   ⟹   ENSCLAP00000003882
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955563977,560 - 987,790 (-)Ensembl
RefSeq Acc Id: XM_005413127   ⟹   XP_005413184
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955563977,030 - 998,485 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013509139   ⟹   XP_013364593
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955563977,030 - 998,487 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013509140   ⟹   XP_013364594
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955563977,030 - 991,994 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013509141   ⟹   XP_013364595
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955563977,030 - 991,891 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013509142   ⟹   XP_013364596
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955563977,030 - 998,486 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005413184   ⟸   XM_005413127
- Peptide Label: isoform X2
- UniProtKB: A0A8C2US08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013364593   ⟸   XM_013509139
- Peptide Label: isoform X1
- UniProtKB: A0A8C2US08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013364596   ⟸   XM_013509142
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013364594   ⟸   XM_013509140
- Peptide Label: isoform X1
- UniProtKB: A0A8C2US08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013364595   ⟸   XM_013509141
- Peptide Label: isoform X1
- UniProtKB: A0A8C2US08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000003881   ⟸   ENSCLAT00000003957
RefSeq Acc Id: ENSCLAP00000003882   ⟸   ENSCLAT00000003958
RefSeq Acc Id: ENSCLAP00000003880   ⟸   ENSCLAT00000003956
Protein Domains
RING-CH-type   RING-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002760 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000003956.1 UniProtKB/TrEMBL
  ENSCLAT00000003957 ENTREZGENE
  ENSCLAT00000003957.1 UniProtKB/TrEMBL
  ENSCLAT00000003958.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro Znf_RING UniProtKB/TrEMBL
  Znf_RING-CH UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene March2 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE MARCHF2 UniProtKB/TrEMBL
Pfam RINGv UniProtKB/TrEMBL
PROSITE ZF_RING_2 UniProtKB/TrEMBL
  ZF_RING_CH UniProtKB/TrEMBL
SMART RINGv UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A8C2US08 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UUI5_CHILA UniProtKB/TrEMBL
  A0A8C2UVF8_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-16 Marchf2  membrane associated ring-CH-type finger 2  March2  membrane associated ring-CH-type finger 2  Symbol and/or name change 5135510 APPROVED
2016-08-16 March2  membrane associated ring-CH-type finger 2    membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase  Symbol and/or name change 5135510 APPROVED