Mbip (MAP3K12 binding inhibitory protein 1)

Gene: Mbip (MAP3K12 binding inhibitory protein 1) Chinchilla lanigera

Analyze

Symbol:

Mbip

Name:

MAP3K12 binding inhibitory protein 1

RGD ID:

8896428

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); protein kinase inhibitor activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of gene expression (ortholog); positive regulation of JNK cascade (ortholog); PARTICIPATES IN RNA polymerase II transcription initiation pathway; ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); choreatic disease (ortholog); genetic disease (ortholog); FOUND IN ATAC complex (ortholog); cytosol (ortholog); nucleolus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

MAP3K12-binding inhibitory protein 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	24,821,884 - 24,848,125 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	24,821,884 - 24,848,125 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain-Lung-Thyroid Syndrome (ISO)

choreatic disease (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of transcription by RNA polymerase II (ISO)

positive regulation of gene expression (ISO)

positive regulation of JNK cascade (ISO)

regulation of cell cycle (ISO)

regulation of cell division (ISO)

regulation of DNA-templated transcription (ISO)

regulation of embryonic development (ISO)

regulation of transcription by RNA polymerase II (ISO)

regulation of tubulin deacetylation (ISO)

Cellular Component

ATAC complex (ISO)

cytosol (ISO)

nucleolus (ISO)

nucleoplasm (ISO)

nucleus (ISO)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

protein kinase inhibitor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase II transcription initiation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Mbip
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	24,821,884 - 24,848,125 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	24,821,884 - 24,848,125 (+)	NCBI	ChiLan1.0	ChiLan1.0

MBIP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	36,298,564 - 36,320,637 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	36,298,564 - 36,320,637 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	36,767,770 - 36,789,843 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	35,837,521 - 35,859,596 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	35,837,521 - 35,859,596	NCBI
Celera	14	16,631,420 - 16,653,542 (-)	NCBI		Celera
Cytogenetic Map	14	q13.3	NCBI
HuRef	14	16,882,521 - 16,904,638 (-)	NCBI		HuRef
CHM1_1	14	36,766,890 - 36,789,007 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	30,487,901 - 30,509,973 (-)	NCBI		T2T-CHM13v2.0

Mbip
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	56,375,091 - 56,392,681 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	56,375,088 - 56,392,679 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	56,328,306 - 56,345,933 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	56,328,303 - 56,345,894 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	57,429,293 - 57,446,881 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	57,246,332 - 57,263,880 (-)	NCBI		MGSCv36	mm8
Celera	12	57,476,994 - 57,494,582 (-)	NCBI		Celera
Cytogenetic Map	12	C1	NCBI
cM Map	12	24.3	NCBI

Mbip
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	79,543,223 - 79,560,476 (-)	NCBI		GRCr8
mRatBN7.2	6	73,808,133 - 73,825,394 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	73,808,133 - 73,825,374 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	74,200,556 - 74,217,783 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	74,506,958 - 74,524,185 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	73,934,431 - 73,951,658 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	77,226,439 - 77,243,696 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	77,226,439 - 77,243,677 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	86,758,207 - 86,775,445 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	76,728,025 - 76,745,263 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	76,731,167 - 76,748,391 (-)	NCBI
Celera	6	72,615,080 - 72,632,164 (-)	NCBI		Celera
Cytogenetic Map	6	q23	NCBI

MBIP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	37,613,116 - 37,635,468 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	36,829,619 - 36,851,961 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	17,052,270 - 17,074,609 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	35,231,398 - 35,253,746 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	35,231,398 - 35,253,746 (-)	Ensembl	panpan1.1		panPan2

MBIP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	14,883,317 - 14,908,664 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	14,886,638 - 14,908,610 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	14,683,507 - 14,706,043 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	14,995,192 - 15,017,515 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	14,995,207 - 15,033,731 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	14,694,145 - 14,716,345 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	14,760,525 - 14,783,054 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	15,050,548 - 15,073,089 (-)	NCBI		UU_Cfam_GSD_1.0

Mbip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	46,810,825 - 46,833,000 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936494	10,313,442 - 10,338,950 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936494	10,315,416 - 10,338,893 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MBIP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	63,659,232 - 63,687,552 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	63,659,223 - 63,684,545 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	68,669,766 - 68,695,106 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MBIP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	13,100,914 - 13,123,017 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	13,102,520 - 13,122,977 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	2,095,680 - 2,117,775 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mbip
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624838	508,732 - 528,161 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624838	508,660 - 527,306 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005377166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01010095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01124465	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000014752 ⟹ ENSCLAP00000014594

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955409	24,821,884 - 24,848,125 (+)	Ensembl

RefSeq Acc Id:

XM_005377166 ⟹ XP_005377223

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955409	24,821,884 - 24,848,125 (+)	NCBI

Sequence:

show sequence

TGTTACGTCATCCCAAAGCGACAAAAGCATGGTGGGGGTAGGGTTGTGATTGTACCTCGGTGGT
GTTAGGGGCCTCTTGCGAAGGTGTCATGGCTGCTACCACGGATCCTAGTCACCCCAACAGCAGT
GACAAGAGTCTAGAGCGAAGCTGCAGCCCCAACCTCTCCCGAGAGGTCCTGTGCGAAATCTTTC
GCTCCCTGCACACCTTGTCTGGACAGCTTAACCTCAGAGATGATGTGGTGAAAATTACAATCGA
TTGGGACAAGCTCCAGAGCCTCTCGGCATTCCAGCCTGCATTGCTCTTTAGAGCACTTGAACAA
CACATTTTACATTTACAGCCTTTTTTAGCAAAACTTCAGCCTGTGATTAAAGAGGAGAATTCAG
CTACCATTGAAGAGATAGGAAAAACAGAAGCAGGGAACCAGAATGAACTAAATGCCAAATTTCC
CACTGGTGACCAACAAGAAGAAGAAAAGCACAAAGATGGTGATTTAGGTGATGTGAAAAAGACA
CAAATCCATTTTGATCCAGAAGTAGTTCAAATAAAGGCTGGAAAAGCAGAAATTGACAGAAGAA
TATCTGCATTTATCGAAAGAAAGCAAGCTGAAATCAATGAAAACAACGTCAGGGAATTTTGTAA
TGTTATTGATTGTAATCAAGAAAATAGTTGTGCAAGAACTGATGCCATTTTTACCCCTTACCCT
GGATTTAAAAGTCATGTAAAAGTTTCTAGAGTTGTAAATACGTATGGACCACAAACTAGACCTG
AAGGAATTCAGGGATCAGGTCATAAATCTAACAGCATGCATCGAGATTGTGGCAATCAGGCTGT
AGAAGAACGACTACAGAATATTGAAGCTCACTTGCGATTGCAGTCAGGTGGTCCAGTGCCAAGA
GACATTTATCAGAGAATTAAAAAACTTGAAGATAAAATCCTTGAATTGGAAGGCATGTCTCCTG
AATATTTTCAGTCTGTGAACTTTCCTGGAAAAAGAAGAAAAGTTCAGCCACCACAGCAGAACTA
TTCACTGGCTGAACTTGATGAGAAAATTAGTGCCCTCAAACAAGCCCTGCTCAGAAAATCAAGA
GAAGCAGAATCTACGGCAATTCACTACTTTCCGTTAAAAATGCCTCTCATTCTTGTCATTTTAC
TTTTTTATATAAATATGTGTAACTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005377223	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000014594
	ENSCLAP00000014594.1

RefSeq Acc Id:

XP_005377223 ⟸ XM_005377166

- UniProtKB:

A0A8C2YPW8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAATTDPSHPNSSDKSLERSCSPNLSREVLCEIFRSLHTLSGQLNLRDDVVKITIDWDKLQSLS
AFQPALLFRALEQHILHLQPFLAKLQPVIKEENSATIEEIGKTEAGNQNELNAKFPTGDQQEEE
KHKDGDLGDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQEN
SCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIQGSGHKSNSMHRDCGNQAVEERLQNIE
AHLRLQSGGPVPRDIYQRIKKLEDKILELEGMSPEYFQSVNFPGKRRKVQPPQQNYSLAELDEK
ISALKQALLRKSREAESTAIHYFPLKMPLILVILLFYINMCN

hide sequence

RefSeq Acc Id:

ENSCLAP00000014594 ⟸ ENSCLAT00000014752

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000010075	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000014752	ENTREZGENE
	ENSCLAT00000014752.1	UniProtKB/TrEMBL
NCBI Gene	Mbip	ENTREZGENE
UniProt	A0A8C2YPW8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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