Tnfsf14 (TNF superfamily member 14)

Gene: Tnfsf14 (TNF superfamily member 14) Chinchilla lanigera

Analyze

Symbol:

Tnfsf14

Name:

TNF superfamily member 14

RGD ID:

8891245

Description:

ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); identical protein binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); positive regulation of myoblast differentiation (ortholog); positive regulation of myoblast fusion (ortholog); ASSOCIATED WITH genetic disease (ortholog); mucolipidosis type IV (ortholog); multiple sclerosis (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand superfamily member 14; tumor necrosis factor superfamily member 14

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	2,829,402 - 2,835,335 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	2,829,314 - 2,834,826 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

mucolipidosis type IV (ISO)

multiple sclerosis (ISO)

rheumatoid arthritis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to mechanical stimulus (ISO)

positive regulation of myoblast differentiation (ISO)

positive regulation of myoblast fusion (ISO)

positive regulation of non-canonical NF-kappaB signal transduction (ISO)

positive regulation of T cell chemotaxis (ISO)

T cell chemotaxis (ISO)

T cell costimulation (ISO)

Molecular Function

cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ISO)

identical protein binding (ISO)

protein binding (ISO)

signaling receptor binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Tnfsf14
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	2,829,402 - 2,835,335 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	2,829,314 - 2,834,826 (+)	NCBI	ChiLan1.0	ChiLan1.0

TNFSF14
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	6,661,253 - 6,670,588 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	6,661,253 - 6,670,588 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	6,661,264 - 6,670,599 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	6,615,560 - 6,621,599 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	6,615,565 - 6,621,599	NCBI
Celera	19	6,604,701 - 6,612,155 (-)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	6,425,122 - 6,432,649 (-)	NCBI		HuRef
CHM1_1	19	6,663,409 - 6,670,848 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	6,650,888 - 6,660,217 (-)	NCBI		T2T-CHM13v2.0

Tnfsf14
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	57,496,437 - 57,501,182 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	57,496,492 - 57,501,177 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	57,189,474 - 57,194,181 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	57,189,492 - 57,194,177 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	57,328,915 - 57,333,612 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	56,874,827 - 56,889,591 (-)	NCBI		MGSCv36	mm8
Celera	17	61,538,038 - 61,542,735 (-)	NCBI		Celera
Cytogenetic Map	17	D	NCBI
cM Map	17	29.71	NCBI

Tnfsf14
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	2,155,270 - 2,160,100 (-)	NCBI		GRCr8
mRatBN7.2	9	2,068,295 - 2,073,128 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	2,069,104 - 2,073,216 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	2,497,352 - 2,501,003 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	7,846,726 - 7,850,377 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	6,802,581 - 6,806,232 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	9,761,363 - 9,765,461 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	9,761,536 - 9,765,186 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	8,768,631 - 8,772,649 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	6,447,405 - 6,451,055 (+)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

TNFSF14
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	11,074,535 - 11,081,518 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	10,299,977 - 10,306,862 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	5,691,648 - 5,700,935 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	6,614,372 - 6,621,763 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	6,614,378 - 6,621,763 (-)	Ensembl	panpan1.1		panPan2

TNFSF14
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	53,604,101 - 53,607,522 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	53,603,709 - 53,607,522 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	53,351,781 - 53,355,064 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	54,258,226 - 54,261,513 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	54,258,091 - 54,261,536 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	53,325,114 - 53,328,394 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	53,773,591 - 53,776,865 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	54,002,586 - 54,005,871 (+)	NCBI		UU_Cfam_GSD_1.0

Tnfsf14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	213,854,848 - 213,859,307 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	3,976,492 - 3,979,825 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	3,976,492 - 3,979,825 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TNFSF14
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	72,473,477 - 72,483,989 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	72,478,178 - 72,483,885 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	72,993,336 - 72,998,023 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TNFSF14
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	6,235,641 - 6,241,706 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	6,236,193 - 6,241,311 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	1,755,097 - 1,764,021 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tnfsf14
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624828	3,763,849 - 3,770,500 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005405702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01061803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01207122	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000012914 ⟹ ENSCLAP00000012766

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955495	2,829,402 - 2,835,335 (+)	Ensembl

RefSeq Acc Id:

XM_005405702 ⟹ XP_005405759

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955495	2,829,314 - 2,834,826 (+)	NCBI

Sequence:

show sequence

TCTGCAGCGCGCAAAGCCCAGAGCGTTGGGCAACTGCGGTTTCCTCTGAGCCCCAGAGCTCAGG
CGCCGGGGCCCCATCTGCTGGGGCATGGAGGACACGGCTGTGCGGCCCTCGGTGTTTGTGGTGG
AAGGACAGACGGACATCCCGTTCAGGAGGCTGGGGCCCAGCCGCAAGCAAAGGTGCTGCAGCCC
TGCCCGGGTGGGCCTCGGGCTCCTGCTGCTGCTCCTGGGGGCTGCACTGGCTGCCCAGGGCTGG
TTCTTGCTGCAGCTGTACTGGCGTCTGGAGGAGATGGTGGCCCGCCTGCCGGACCAAGATGCAG
GGTCCTGGGAGAAGTCCGTACAAGAGCGGAGATCCCACCAGACCAACCCAGCAGCGCACCTTAC
AGGAGCCAACTCCAGCTTGACGGGCAGTGGCGGCCCCCTGCTGTGGGAGTCCCAGCTGGGCCTG
GCCTTCCTGAGGGGCCTCAGCTACCGCAATGGGGCCCTGGTGACCACCAAGGCCGGCTACTATT
ACATCTACTCGAAAGTGCAGCTGGGTGGTGTGGGCTGTCCCCAGGGGCTGGCCAGCGGCCTCCC
GGTCACCCACGGGCTCTACAAGCGCACGCCCCGCTACCCCGAGGAGCTGGAGCTGCTGGTCAGC
CGGCGGTCACCCTGTGGACGGGCAAACAGCTCCCGCGTCTGGTGGGACAGCAGCTTCCTGGGCG
GCGTGGTGCACCTGGAGGTGGGAGAGGAGGTGATCGTCCGGGTGCCCGATGAGCGTCTGGTCCG
CCTGCGCGATGGTACTCGGTCCTACTTCGGCGCTTTCATGGTGTGAGGAAGGAGAGATGCGGAA
GGAGACACCTCAGAGGTCCCGCAGTGGACGGGCAATCTGGCCACGGAGATCTTGGGGGGGCCTC
CCAGGGAGCTCAAAACCTGGCAGGTGGACAGCTGGGTGGACACCTCCTGGGACCATGATCTCAA
CACCTTGAGTGGCTGAAGACCCAGCAGGCCCTTTTGAGGGGCCCGCCCCCCAGCTTCAGACCTT
GCCATGGACGATTCTACTGACAAAGACCTGGAGCAGGGACACTGGAGACTTGGGGGTCTCTAGA
CCCTCGAGTGTGACATCCGGCTGATTTGCCTGATATTCAGGAAGACGGGATGAGGGACGGGTAT
TTATACTTTTCTTCCCAAAGAAAGTGGGATTCCAGGGATTTGGGTTGGAGACTGGCAACCGTGT
GGCTCTCCCTACTGTCTGTCACAAGCAGGGCCAGGGGCACGTTTGTCATCAGGGCCGGTCCACG
TGCAGAGCCTGGCCCAGTGCCATGTACAACCACAGTGAAGCCTCATGGCTGTGTGGCGTGGACC
TTCCCTGGGGACCATGGTGTACACGGTCCCACCGTGGTGGATTTCCAGCTGCCGAGGTGGCCTC
AGCCCGTTGGCCGTGTCTTGTCACTGCTGGGCACACCCAGCCCACGGGGGTGCCGCTGCCATGC
CCCTGCCACACAGGAAGTGCTTGCTGAGGGTACGAAAGGAGCGAAGGATGACTCGACAGTCACA
CCTGCCTTGTCACGGAGAATCCATGACCATCACAGGAAACGGCACACACAGCTCACAGGTGGCA
CCAAACACCCCCAGCCACCCTCCCAGGGGGTCAGAGGCACATTTGCTCACGCTCACCACTGTGG
ACTTCCACACACCAGGTCACTGTCAGAACTGGTGACCCACGTGGGGTCACAATGACAAACATCT
CATACACCGGGCCTGAGGGTCCTTCCCAGCCAGGACCGACACATCCTGGCTTAGGACTAGACCT
TGCCTGCGGCCCGAGGGCCCCTCGACCACTGGCCTTTGAAATAAACAACAAACAGTTGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005405759	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000012766
	ENSCLAP00000012766.1

RefSeq Acc Id:

XP_005405759 ⟸ XM_005405702

- UniProtKB:

A0A8C2VAN9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEDTAVRPSVFVVEGQTDIPFRRLGPSRKQRCCSPARVGLGLLLLLLGAALAAQGWFLLQLYWR
LEEMVARLPDQDAGSWEKSVQERRSHQTNPAAHLTGANSSLTGSGGPLLWESQLGLAFLRGLSY
RNGALVTTKAGYYYIYSKVQLGGVGCPQGLASGLPVTHGLYKRTPRYPEELELLVSRRSPCGRA
NSSRVWWDSSFLGGVVHLEVGEEVIVRVPDERLVRLRDGTRSYFGAFMV

hide sequence

RefSeq Acc Id:

ENSCLAP00000012766 ⟸ ENSCLAT00000012914

Protein Domains

TNF family profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000008813	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000012914	ENTREZGENE
	ENSCLAT00000012914.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.40	UniProtKB/TrEMBL
InterPro	TNF_dom	UniProtKB/TrEMBL
	Tumour_necrosis_fac-like_dom	UniProtKB/TrEMBL
NCBI Gene	Tnfsf14	ENTREZGENE
PANTHER	TUMOR NECROSIS FACTOR FAMILY MEMBER	UniProtKB/TrEMBL
	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14	UniProtKB/TrEMBL
Pfam	TNF	UniProtKB/TrEMBL
PROSITE	TNF_2	UniProtKB/TrEMBL
SMART	TNF	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49842	UniProtKB/TrEMBL
UniProt	A0A8C2VAN9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-08	Tnfsf14	TNF superfamily member 14		tumor necrosis factor superfamily member 14	Symbol and/or name change	5135510	APPROVED
2016-08-16	Tnfsf14	tumor necrosis factor superfamily member 14		tumor necrosis factor (ligand) superfamily, member 14	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD