Lxn (latexin) - Rat Genome Database

Name: Lxn
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Lxn (latexin) Chinchilla lanigera

Analyze

Symbol:

Lxn

Name:

latexin

RGD ID:

8891048

Description:

ENCODES a protein that exhibits metalloendopeptidase inhibitor activity (ortholog); INVOLVED IN detection of temperature stimulus involved in sensory perception of pain (ortholog); ASSOCIATED WITH Chromosomal Instability (ortholog); genetic disease (ortholog); melanoma (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LXN (latexin)	NCBI	Ortholog
Mus musculus (house mouse):	Lxn (latexin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Lxn (latexin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LXN (latexin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LXN (latexin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lxn (latexin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LXN (latexin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LXN (latexin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lxn (latexin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955448	9,414,721 - 9,421,575 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955448	9,414,721 - 9,421,575 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chromosomal Instability (ISO)

genetic disease (ISO)

melanoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

detection of temperature stimulus involved in sensory perception of pain (ISO)

Molecular Function

metalloendopeptidase inhibitor activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Lxn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955448	9,414,721 - 9,421,575 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955448	9,414,721 - 9,421,575 (-)	NCBI	ChiLan1.0	ChiLan1.0

LXN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	158,666,414 - 158,672,648 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	158,645,822 - 158,672,648 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	158,384,203 - 158,390,437 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	159,866,900 - 159,873,176 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	159,866,907 - 159,873,184	NCBI
Celera	3	156,806,788 - 156,813,067 (-)	NCBI		Celera
Cytogenetic Map	3	q25.32	NCBI
HuRef	3	155,780,049 - 155,786,328 (-)	NCBI		HuRef
CHM1_1	3	158,347,170 - 158,353,449 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	161,440,336 - 161,446,570 (-)	NCBI		T2T-CHM13v2.0

Lxn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	67,365,332 - 67,371,240 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	67,365,331 - 67,371,259 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	67,457,999 - 67,463,907 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	67,457,998 - 67,463,926 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	67,261,921 - 67,267,829 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	67,545,928 - 67,551,836 (-)	NCBI		MGSCv36	mm8
Celera	3	67,584,098 - 67,590,006 (-)	NCBI		Celera
Cytogenetic Map	3	E1	NCBI
cM Map	3	30.98	NCBI

Lxn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	154,037,604 - 154,043,473 (-)	NCBI		GRCr8
mRatBN7.2	2	151,727,556 - 151,733,426 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	151,727,102 - 151,733,460 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	158,844,126 - 158,849,894 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	156,894,624 - 156,900,393 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	151,527,375 - 151,533,143 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	164,628,565 - 164,634,434 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	164,628,566 - 164,634,434 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	183,977,968 - 183,983,837 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	157,310,036 - 157,315,905 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	157,259,999 - 157,265,868 (-)	NCBI
Celera	2	146,097,077 - 146,102,946 (-)	NCBI		Celera
Cytogenetic Map	2	q32	NCBI

LXN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	156,608,664 - 156,617,760 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	156,613,379 - 156,619,970 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	155,692,283 - 155,698,605 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	163,743,319 - 163,749,614 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	163,743,319 - 163,749,614 (-)	Ensembl	panpan1.1		panPan2

LXN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	51,962,877 - 51,968,447 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	51,962,873 - 51,969,172 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	51,772,677 - 51,778,236 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	52,601,679 - 52,609,457 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	52,603,873 - 52,610,212 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	52,182,014 - 52,189,772 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	52,234,990 - 52,242,749 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	52,520,422 - 52,528,212 (-)	NCBI		UU_Cfam_GSD_1.0

Lxn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	84,460,719 - 84,466,968 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936519	5,266,664 - 5,273,245 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936519	5,266,988 - 5,273,227 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LXN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	98,435,320 - 98,441,785 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	98,435,318 - 98,441,823 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	106,728,207 - 106,734,674 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LXN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	32,170,100 - 32,177,239 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	32,171,183 - 32,180,384 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	4,734,054 - 4,740,325 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lxn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	36,379,576 - 36,388,760 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	36,382,179 - 36,388,785 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005393103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01041473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01191214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000003774 ⟹ ENSCLAP00000003698

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955448	9,414,721 - 9,421,575 (-)	Ensembl

RefSeq Acc Id:

XM_005393103 ⟹ XP_005393160

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955448	9,414,721 - 9,421,575 (-)	NCBI

Sequence:

show sequence

GCTCCCAGACACAGGGAGCACGGCGCACAGAGCTGCTTCCAGGAAGGAGGAAGCGGGGAGAAGG
AGCCGAGTCCAGCGCACTCCCAGCCCGAGCCAGGCGTCGCCCTTCCGCAGGAGCTCCGCGGCAG
GCGGCAGAGCGCGCCTGCACCCTCCCGATAAGCCGGAGCAGCCCGCGCTCTCCCCATGGAAATC
TCGCCCAACCACTACGCAGCCTCCAGGGCGGCCTCGGTGGCGGAGAGCTGCATCAACTACCAGC
AAGGGAGCCCCCACAAAGTGTTCCTGGTGCAGGCTGTACAGCAGGCCCGCAAGGAGGATATTCC
AGGAAGAGGACACAAATACCACCTTAAATTTTCTGTGGAAGAAATTATCCAAAAACAAGTTACA
GTGAACTGCACTGCTGAAGTACTTTACCCTCCAGTGGGACAAGGCTCTGCACCAGAAGTCAACT
TCACATTTGAAGGAGACATTGGGAAGAACCCGGATGAAGAAGATAACACATTTTATCAAAGACT
CAAGTCCATGAAGGAACCACTAGAAGCACAAAATATTCCAGATAGTTTTGGAAATGTACCTCCA
CAGATGAAGCCAGTTCGACACTTAGCCTGGGTTGCCTGTGGTTATATAATATGGCAGAATTCTA
CTGAAGACACATGGTATAAAATGGTAAAAATTCAAACTGTCAAGCAAGTGCAAAGAAATGATGA
CTTTATTGAATTAGACTATACCATTCTACTTCATGACATTGCTTCGCAGGAGATTACTCCTTGG
CAGATGCAAGTTCTTTGGCATCCACAGTATGGTACAAAGGTAAAACACAGTAACCGTCTCCCAA
AAGAAACACTGGAATAAACAAAGACCCTGCATGGAGATGACACCTAACAACGCCTCTGGACGAT
GTGTGTGCCAGTCTTCCCCGGTATCTAGTCTAAGGGGCCAAACAAATCCCCAAGTGTCACTTCG
TACAATATCTTATCTACATATATTCCATAAAAGAGGTGTCCCTACCTAGAAATGTGTTCAGAAC
AGTAAAAATGCTATGTGTATCCCATAATACAGTTTTACTTTCAGCCTCATAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005393160	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000003698
	ENSCLAP00000003698.1

RefSeq Acc Id:

XP_005393160 ⟸ XM_005393103

- UniProtKB:

A0A8C2UPQ3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEISPNHYAASRAASVAESCINYQQGSPHKVFLVQAVQQARKEDIPGRGHKYHLKFSVEEIIQK
QVTVNCTAEVLYPPVGQGSAPEVNFTFEGDIGKNPDEEDNTFYQRLKSMKEPLEAQNIPDSFGN
VPPQMKPVRHLAWVACGYIIWQNSTEDTWYKMVKIQTVKQVQRNDDFIELDYTILLHDIASQEI
TPWQMQVLWHPQYGTKVKHSNRLPKETLE

hide sequence

RefSeq Acc Id:

ENSCLAP00000003698 ⟸ ENSCLAT00000003774

Protein Domains

Latexin C-terminal Latexin N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000002640	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000003774	ENTREZGENE
	ENSCLAT00000003774.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.450.10	UniProtKB/TrEMBL
InterPro	Cystatin_sf	UniProtKB/TrEMBL
	Latexin_C	UniProtKB/TrEMBL
	Latexin_N	UniProtKB/TrEMBL
	Prot_inh_latexin	UniProtKB/TrEMBL
NCBI Gene	Lxn	ENTREZGENE
PANTHER	LATEXIN	UniProtKB/TrEMBL
	PTHR28591	UniProtKB/TrEMBL
Pfam	Latexin	UniProtKB/TrEMBL
	Latexin_C	UniProtKB/TrEMBL
PIRSF	Prot_inh_latexin	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54403	UniProtKB/TrEMBL
UniProt	A0A8C2UPQ3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD