Trex2 (three prime repair exonuclease 2)

Gene: Trex2 (three prime repair exonuclease 2) Chinchilla lanigera

Analyze

Symbol:

Trex2

Name:

three prime repair exonuclease 2

RGD ID:

8890226

Description:

ENCODES a protein that exhibits 3'-5'-DNA exonuclease activity (ortholog); DNA binding (ortholog); magnesium ion binding (ortholog); INVOLVED IN DNA metabolic process (ortholog); ASSOCIATED WITH adrenoleukodystrophy (ortholog); autistic disorder (ortholog); Barth syndrome (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955580	207,903 - 209,426 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955580	207,903 - 209,426 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

autistic disorder (ISO)

Barth syndrome (ISO)

cerebral creatine deficiency syndrome 1 (ISO)

dyskeratosis congenita (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

Experimental Diabetes Mellitus (ISO)

favism (ISO)

genetic disease (ISO)

immunodeficiency 33 (ISO)

intellectual disability (ISO)

paraplegia (ISO)

periventricular nodular heterotopia (ISO)

Splenomegaly (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA metabolic process (ISO)

Molecular Function

3'-5'-DNA exonuclease activity (ISO)

DNA binding (ISO)

magnesium ion binding (ISO)

molecular adaptor activity (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Trex2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955580	207,903 - 209,426 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955580	207,903 - 209,426 (-)	NCBI	ChiLan1.0	ChiLan1.0

TREX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	153,444,473 - 153,446,056 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	153,444,473 - 153,470,587 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	152,709,931 - 152,711,514 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	152,363,372 - 152,365,139 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	152,231,024 - 152,231,735	NCBI
Celera	X	152,943,888 - 152,945,655 (-)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	141,369,186 - 141,370,953 (-)	NCBI		HuRef
CHM1_1	X	152,584,603 - 152,586,370 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	151,718,056 - 151,719,639 (-)	NCBI		T2T-CHM13v2.0

Trex2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	72,477,311 - 72,478,949 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	72,477,311 - 72,478,950 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	73,433,705 - 73,435,343 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	73,433,705 - 73,435,344 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	70,679,044 - 70,680,682 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	69,686,425 - 69,688,050 (-)	NCBI		MGSCv36	mm8
Celera	X	64,687,545 - 64,689,183 (-)	NCBI		Celera
Cytogenetic Map	X	A7.3	NCBI
cM Map	X	37.31	NCBI

Trex2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	156,303,203 - 156,304,811 (-)	NCBI		GRCr8
mRatBN7.2	X	151,151,862 - 151,153,470 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	151,151,864 - 151,153,479 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	153,293,024 - 153,294,632 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	156,856,235 - 156,857,843 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	154,528,068 - 154,529,676 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	157,374,305 - 157,375,913 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	157,374,305 - 157,375,913 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	153,122,389 - 153,123,997 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	159,334,472 - 159,336,080 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	136,736,131 - 136,737,739 (+)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

TREX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	153,484,903 - 153,485,860 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	153,488,507 - 153,489,464 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	142,995,051 - 142,998,178 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	152,881,479 - 152,884,584 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

TREX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	121,263,341 - 121,265,009 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	121,258,646 - 121,264,555 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	106,593,265 - 106,595,819 (-)	NCBI		Dog10K_Boxer_Tasha

Trex2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	118,580,535 - 118,584,104 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936809	318,548 - 319,258 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936809	317,655 - 319,293 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TREX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	124,234,738 - 124,238,598 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	124,234,736 - 124,244,193 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	141,798,112 - 141,800,794 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TREX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	127,878,891 - 127,882,019 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666065	65,740,629 - 65,743,712 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trex2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624946	187,056 - 210,497 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624946	187,147 - 188,805 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005414119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01075591	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01123808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000003865 ⟹ ENSCLAP00000003789

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955580	207,903 - 209,426 (-)	Ensembl

RefSeq Acc Id:

XM_005414119 ⟹ XP_005414176

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955580	207,903 - 209,426 (-)	NCBI

Sequence:

show sequence

AGCCGCTGATTAAAGGCCGCCTGGAGCAGCCCGTGCGGAGACAGGTGCCAGCAGCCAGCAGCTC
AGGACGCCAGCCAGCTCCTGCTCTAGCTTCAGGCCCTGTCCCTGTGAGAAGACCACCATGTCTG
AGCTGCCCCCGGCCGCGACCTTTGTCTTTCTGGACCTGGAAGCCACTGGGCTCCCCAGCATGGA
CCCAGAGATTGCAGAGATCTCCCTTTTTGCTGTGCACCGCTCCTCCCTGGAAAATCCAGAACGT
GGCGAGTCTGGAGCCCCTGTGCTCCCCCGCATCCTGGATAAGCTCACACTGTGCATGAGCCCGC
AACGGCCCTTCACTGCCAAGGCCAGCGAGATTACCGGCCTGAGCAGTGAGGGCCTGGCACAGTG
CCGGAAGGCCGGCTTTGACAGCGCCGTGGTGCGGAGCCTGCAGGCCTTCCTGAGCCGCCAGGAG
GGCCCCATCTGCCTCGTGGCCCACAACGGCTTTGATTACGACTTCCCCCTGCTGTGCACGGAGC
TACAGCGCCTGGGTGCCCACCTGCCCCAGGACACTGTCTGCCTGGACACGCTGCCGGCACTGCG
GGGCCTGGACCGCGCCCACAGCCATGGCACCCGGGCTCAGGGCCGCAAGGGCTACAGCCTGGGC
AGCCTGTTCCACCGCTACTTCGGGGCTGAGCCGAGTGCAGCGCATTCTGCCGAGGGTGACGTAC
ACACGCTGCTGCTCATCTTCCTGCACCGTGCCACTGAGCTGCTTGCCTGGGCTGACGAGCAGGC
CCGCAGCTGGCTGCACATTGAACCCATGTACCTGCCGCCCGATGGCCCACACAGCGAGGCCTGA
CCACTCGCTCCTTCGCTGGCTTCCTCACCTGGCCCAGCTCAAGCCTGCAGCTGGCCCAGACTGG
GACCTTGCTGCACCTCTGCCTGGCCCTGCCCAGTGGAGAGCCCTGGACCCATGCACCTGCCAGG
CTGCTGGCCTGCCTTACCTCTGGACAGCTTGTGAACCCAGCAATCTGCTCTTCCCGACCCCTTC
CTTTCCTGTTTATCAATAAACATCAATTTCTCACCAGCTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005414176	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000003789
	ENSCLAP00000003789.1

RefSeq Acc Id:

XP_005414176 ⟸ XM_005414119

- UniProtKB:

A0A8C2UQT7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSELPPAATFVFLDLEATGLPSMDPEIAEISLFAVHRSSLENPERGESGAPVLPRILDKLTLCM
SPQRPFTAKASEITGLSSEGLAQCRKAGFDSAVVRSLQAFLSRQEGPICLVAHNGFDYDFPLLC
TELQRLGAHLPQDTVCLDTLPALRGLDRAHSHGTRAQGRKGYSLGSLFHRYFGAEPSAAHSAEG
DVHTLLLIFLHRATELLAWADEQARSWLHIEPMYLPPDGPHSEA

hide sequence

RefSeq Acc Id:

ENSCLAP00000003789 ⟸ ENSCLAT00000003865

Protein Domains

Exonuclease

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000002698	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000003865	ENTREZGENE
	ENSCLAT00000003865.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.420.10	UniProtKB/TrEMBL
InterPro	Exonuclease_RNaseT/DNA_pol3	UniProtKB/TrEMBL
	RNaseH-like_sf	UniProtKB/TrEMBL
	RNaseH_sf	UniProtKB/TrEMBL
	TREX1/2	UniProtKB/TrEMBL
NCBI Gene	Trex2	ENTREZGENE
PANTHER	PTHR13058	UniProtKB/TrEMBL
	PTHR13058:SF24	UniProtKB/TrEMBL
Pfam	RNase_T	UniProtKB/TrEMBL
SMART	EXOIII	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53098	UniProtKB/TrEMBL
UniProt	A0A8C2UQT7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar