Loricrin (loricrin cornified envelope precursor protein)

Gene: Loricrin (loricrin cornified envelope precursor protein) Chinchilla lanigera

Analyze

Symbol:

Loricrin

Name:

loricrin cornified envelope precursor protein

RGD ID:

8878585

Description:

ENCODES a protein that exhibits structural constituent of cytoskeleton (ortholog); structural constituent of skin epidermis (ortholog); INVOLVED IN keratinocyte differentiation (ortholog); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); immunodeficiency 42 (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog); cytoplasmic side of plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Lor

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955592	167,139 - 169,638 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

immunodeficiency 42 (ISO)

MHC class II deficiency (ISO)

parathyroid carcinoma (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Skin Neoplasms (ISO)

squamous cell carcinoma (ISO)

Vohwinkel Syndrome, Variant Form (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

keratinocyte differentiation (ISO)

Cellular Component

cornified envelope (ISO)

cytoplasm (ISO)

cytoplasmic side of plasma membrane (ISO)

Molecular Function

protein binding (ISO)

structural constituent of cytoskeleton (ISO)

structural constituent of skin epidermis (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data

Loricrin
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955592	167,139 - 169,638 (-)	NCBI	ChiLan1.0	ChiLan1.0

LORICRIN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	153,259,687 - 153,262,124 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	153,259,687 - 153,262,124 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	153,232,163 - 153,234,600 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	151,498,803 - 151,501,224 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	150,046,475 - 150,047,671	NCBI
Celera	1	126,303,436 - 126,305,857 (+)	NCBI		Celera
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	124,595,566 - 124,597,999 (+)	NCBI		HuRef
CHM1_1	1	154,627,959 - 154,630,380 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	152,396,903 - 152,399,352 (+)	NCBI		T2T-CHM13v2.0

Loricrin
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	91,987,578 - 91,990,447 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	91,987,578 - 91,990,449 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	92,080,271 - 92,083,142 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	92,080,271 - 92,083,142 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	91,884,193 - 91,887,064 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	92,166,209 - 92,169,067 (-)	NCBI		MGSCv36	mm8
Celera	3	92,123,831 - 92,126,702 (-)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI
cM Map	3	40.14	NCBI

Loricrin
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	180,253,674 - 180,256,572 (-)	NCBI		GRCr8
mRatBN7.2	2	177,558,062 - 177,560,960 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	177,558,252 - 177,559,807 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	185,120,471 - 185,123,369 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	183,102,235 - 183,105,133 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	177,763,534 - 177,766,432 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	191,984,455 - 191,990,713 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	191,984,773 - 191,986,170 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	212,877,186 - 212,882,693 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	184,953,538 - 184,955,283 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	172,680,893 - 172,687,160 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

LORICRIN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	96,580,323 - 96,581,568 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	96,315,995 - 96,317,311 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	128,607,506 - 128,608,808 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

LORICRIN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	61,994,297 - 61,995,591 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	61,460,176 - 61,463,150 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	63,144,507 - 63,147,606 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	17	61,893,634 - 61,896,464 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	61,944,715 - 61,947,725 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	62,703,311 - 62,706,427 (+)	NCBI		UU_Cfam_GSD_1.0

LORICRIN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	96,304,070 - 96,305,110 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	96,303,835 - 96,308,016 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	105,206,034 - 105,209,187 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LORICRIN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	10,494,570 - 10,497,944 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	9,966,739 - 9,968,274 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Loricrin
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624885	675,955 - 677,391 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005414606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01076300	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCC01001286	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005414606 ⟹ XP_005414663

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955592	167,139 - 169,638 (-)	NCBI

Sequence:

show sequence

TCAATAGATGAGTCAGGATAGGCAAAGAGTATAAAACCTCAGGAGTTCCAGTGCTTCTCACATC
GCCAGCAACTCCTCTCCTCACTCACCCTCCCTGGTGCTTTGGGGTGCCCTTCCTCCTCAGACAA
GATGTCTCACCAGAAAAAGCAGCCCACTCCCTACCCTCCAATTATTTGCAAGACCTCTGGCGGT
GGAGGCGGTGGCGGCGGCGGCGGCGGCGGCGGCTCCAGCTGCGGCGGCGGCGGCAGCTCTAGCT
GTGGAGGTGGCTACTCCGGCGGCGGTTCCAGCTGTGGAGGGGGCGGTAGCTCCGGAGGAGGCAT
CAAGTACTCGGGCGGCGGAGGCGGCGGCGGCGGCGGTGGCTCCAGCTGCGGCGGCGGCTACTCC
GGGGGCGGCGGCGGCTCCAGCTGTGGCGGCGGCTACTCCGGCGGCGGTTCCAGCTGTGGGGGTG
GCTCCTCCGGGGGCGGTGGCGGTGGGTCTTCCAGCCAGCATTATCAGAGCCAGAGCTACGGCGG
CGGTTCTTCCGGGGGCGGTTCCAGTTGCGGCGGCGGTTCTTCCGGGGGCGGTTCCGGTTGCGGC
GGCGGCTCTTCCGGGGGCGGGTCTTCCGGCCAGCATTACCAGTGCCAGAGCTACGGTGGCGGCT
CCTCAGGGGGCGGTTCCAGTTGCGGCGGCGGCTCTTCCGGGGGCGGCGGCTCTAGCTGTGGCGG
GGGCTCCTCTGGAGGCGGCGGCGGCGGCGGCTCCTCTGGCCAGCATTACCAGTGCCAGAGCTAC
GGCGGCTCCTCCGGGGGCGGTTCCGGTTGCGGCGGGGGCTCTGGAGGCGGCGGCGGCTCTGGCT
GTGGCGGGGGCTCTGGAGGTGGCGGCGGCTCCTCTGGCCAGCATTACCAGTGCCAGAGCTACGG
CGGCTCCTCCGGGGGCGGTTCCGGTTGCGGCGGCGGCTACTCTGGAGGCGGCGGCGGCTCTAGC
TGTGGCGGGGGCTCTGGAGGTGGCGGCGGCTCCTCAAGCCAGCATTACCAGTGCCAGAGCTACG
GCGGCTCCTCTGGGGGCGGTTCCGGTTGCGGCGGCGGCTCTTCCGGGGGCGGCTCCAGCTGCGG
TGGGGGTTCCTCTGGGGGCAGCGGCTGCGGAGGGGGTTCCTCTGGGGGCGGGGGCGGCTCCAGC
TGCGGAGGTGGCTCCTCTGGCGGCGGCTCGTCTAGCGGTGGCAAGGGCATCCCAATCTGTCACC
AGACCCAGCAGAAGCAGGCGCCTAGCTGGCCATGCAAATAAGGCCCCCTGGATGCCGCGGAGAC
AAAGGAGCTGGAGGTGTTCTCCGTGGGCACCGATGGGCTTAATGTTCTCTTGATACTGCTCAAG
GTTTCCAAATTTTTTGGTGTCTCTACCTACCTAGAAGAAGCCATCGAGTTCTCAAAATGCATCT
CATTCTGCAGTTTTTCCTTCTTAGTTTCTGTATGACTACCTCCAATTCCAGTGCCTCTTCAATC
AATAAATTTTGCAGTTCATGAGAA

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Protein Sequences


Protein RefSeqs	XP_005414663	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005414663 ⟸ XM_005414606

- Sequence:

show sequence

MSHQKKQPTPYPPIICKTSGGGGGGGGGGGGGSSCGGGGSSSCGGGYSGGGSSCGGGGSSGGGI
KYSGGGGGGGGGGSSCGGGYSGGGGGSSCGGGYSGGGSSCGGGSSGGGGGGSSSQHYQSQSYGG
GSSGGGSSCGGGSSGGGSGCGGGSSGGGSSGQHYQCQSYGGGSSGGGSSCGGGSSGGGGSSCGG
GSSGGGGGGGSSGQHYQCQSYGGSSGGGSGCGGGSGGGGGSGCGGGSGGGGGSSGQHYQCQSYG
GSSGGGSGCGGGYSGGGGGSSCGGGSGGGGGSSSQHYQCQSYGGSSGGGSGCGGGSSGGGSSCG
GGSSGGSGCGGGSSGGGGGSSCGGGSSGGGSSSGGKGIPICHQTQQKQAPSWPCK

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Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Lor	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-10-22	Loricrin	loricrin cornified envelope precursor protein	Lor	loricrin	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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