Tmprss6 (transmembrane serine protease 6)

Gene: Tmprss6 (transmembrane serine protease 6) Chinchilla lanigera

Analyze

Symbol:

Tmprss6

Name:

transmembrane serine protease 6

RGD ID:

8874406

Description:

INVOLVED IN BMP signaling pathway (ortholog); intracellular iron ion homeostasis (ortholog); membrane protein proteolysis (ortholog); ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN extracellular space (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

transmembrane protease serine 6; transmembrane protease, serine 6

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	23,580,530 - 23,612,276 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	23,579,946 - 23,615,277 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenylosuccinase lyase deficiency (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

genetic disease (ISO)

iron deficiency anemia (ISO)

microcytic anemia (ISO)

myoclonic dystonia 26 (ISO)

neurodegeneration with brain iron accumulation 2A (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

BMP signaling pathway (ISO)

intracellular iron ion homeostasis (ISO)

membrane protein proteolysis (ISO)

multicellular organismal-level iron ion homeostasis (ISO)

negative regulation of BMP signaling pathway (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

self proteolysis (ISO)

Cellular Component

extracellular space (ISO)

plasma membrane (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Tmprss6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	23,580,530 - 23,612,276 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	23,579,946 - 23,615,277 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMPRSS6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	37,065,436 - 37,110,536 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	37,065,436 - 37,109,713 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	37,461,476 - 37,505,753 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	35,791,425 - 35,829,639 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	35,785,978 - 35,824,193	NCBI
Celera	22	21,262,809 - 21,300,772 (-)	NCBI		Celera
Cytogenetic Map	22	q12.3	NCBI
HuRef	22	20,426,706 - 20,464,791 (-)	NCBI		HuRef
CHM1_1	22	37,420,983 - 37,458,920 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	37,525,034 - 37,570,488 (-)	NCBI		T2T-CHM13v2.0

Tmprss6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	78,323,867 - 78,352,848 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	78,323,867 - 78,352,834 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	78,439,667 - 78,468,648 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	78,439,667 - 78,468,634 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	78,270,097 - 78,299,064 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	78,266,931 - 78,295,735 (-)	NCBI		MGSCv36	mm8
Celera	15	79,902,371 - 79,931,350 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	37.49	NCBI

Tmprss6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	111,871,504 - 111,902,127 (-)	NCBI		GRCr8
mRatBN7.2	7	109,991,008 - 110,021,626 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	109,985,931 - 110,021,624 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	111,741,252 - 111,771,803 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	113,964,790 - 113,995,347 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	113,932,869 - 113,963,426 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	119,659,323 - 119,689,953 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	119,659,324 - 119,689,938 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	119,649,831 - 119,680,259 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	116,391,730 - 116,419,671 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	116,425,992 - 116,456,922 (-)	NCBI
Celera	7	106,329,190 - 106,359,893 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

TMPRSS6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	46,921,683 - 46,967,316 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	49,610,237 - 49,655,886 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	17,979,094 - 18,032,590 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	35,815,051 - 35,867,818 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	35,815,051 - 35,859,940 (-)	Ensembl	panpan1.1		panPan2

TMPRSS6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	27,393,650 - 27,435,893 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	27,397,123 - 27,435,908 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	27,353,491 - 27,390,639 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	28,190,798 - 28,228,167 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	28,190,967 - 28,228,124 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	27,912,441 - 27,949,753 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	28,221,179 - 28,258,351 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	28,399,083 - 28,436,250 (+)	NCBI		UU_Cfam_GSD_1.0

Tmprss6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	10,804,553 - 10,838,236 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	3,819,309 - 3,848,075 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	3,819,347 - 3,848,372 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMPRSS6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	10,663,635 - 10,705,471 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	10,663,491 - 10,704,583 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	8,263,703 - 8,304,970 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMPRSS6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	19,771,303 - 19,811,751 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	19,771,952 - 19,806,420 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	106,017,797 - 106,057,808 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmprss6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	10,693,634 - 10,727,269 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	10,693,895 - 10,727,269 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013511592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013511593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01014332	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01014333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01155445	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01356744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000024745 ⟹ ENSCLAP00000024510

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955413	23,580,530 - 23,612,276 (-)	Ensembl

RefSeq Acc Id:

XM_013511592 ⟹ XP_013367046

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955413	23,579,946 - 23,615,277 (-)	NCBI

Sequence:

show sequence

GCCTGTTTACCTGTGCTCAGTCCCGGTGCCGTCCTGGACCCGGCAGGAGGCCCATGGAGCCCAG
GGCCACAGGCCACAGAGGACAAGGGCCAGACACCCCAGCCATGGCTCTGGGCCATTGATCCACC
CGCAGGCCAGCCTGGTGGGGGTGGAGAAACCTTGGCCTGGACAAACAGAGCTGCCGAGGCCTGT
GTGTGGGACCGCCACCCACCTCCCACTCCAGGAGGATGCCGAGGGCCGAGGCCCCCCAGCTCGC
CGGCGGGCAGGGTGACGGAGGCGACGGTGAGGAAGCGGAGCCCGAGGGGATGTTTAAGGCCTCC
AAGAGGAAAGCCCGGGACTACATGTGCCTGGCGCCCCTGTGGCTGGCTCTGGTTGTGCTGGCTT
CAGTGGGGGTGATGCTCTGGTATTTCCTAGGGTACAGGGCCGAGGTGACCGTCAGCCAGGTGTA
CGCAGGCAGCCTCCGGGTGCTCAATCGTCACTTCTCCCAGGACCTTGCCCGCCGAGAGTCCAGC
ACCTTCCGCAGTGAGACTGCCAAAGCCCAGAGGATGCTTAAAGAACTCATCGCCAGCACCCGCC
TGGGTACTTACTACAACTCCAGCTCTGTCTACTCCTTCGGGGAGGGACCTCTCACTTGCTTCTT
CTGGTTCATCTTGCAAATCCCGGAGCATCTCCGGCCCACGCTGAGCCCCGAGATGGTGCAGGTG
CTGCTGGTGGAGGAGCTGCTGTCCGCTGCCAACAGCTCGGCCCCCGTCTCCTACGTGGCCGAGT
ATGAGGTGGACCCCGAGGGTCTGGTGATCCTGGAAGCCAGCGTGAAAGACATAGTCGCACTGAA
TTCCACGCTGGGCTGTTACCGCTACAGCTACGTAGGCCAGGGCCAGGCCCTGCGGCTGAAGGGC
CCCGACTACCTGGCCTCCAGCTGCCTGTGGCACCTGCAGGGCCCCCAGGAGCTCATGCTCAAGG
TACGGCTGGAGTGGACCCTGGCTGAGTGCCGCGACCGCCTGGCCATGTACGACGCAGCCGGGCC
ACTGGAAAAGAAGCTCATCACCTCGGTCTACGGCTGCAGTCGCCAGGAGCCGGTGGTGGAGGTG
CTGGCCTCAGGCCCCGTCATGGCGGTGGTGTGGAAGAAGGGTCTGCACAGCTACGTGGACCCCT
TCATGCTCTCTGTGCAGCCCGTGGCTTTCCAAGCCTGCCAGGTGAACCTGACACTAGAGGGCCG
GCTGGACCCGCAGGGTGCCCTGAGCACCCCCTACTTCCCCAGCTACTACTCTCCCAGCACCCAC
TGCTCCTGGCATCTCACGGTGCCGTCTCTGGACTATGGCTTGGCCCTCTGGTTTGATGCCTATG
CTCTGCGGAGACAGAAGTATGGCCTGCCGTGCACTCAGGGACAGTGGACGATACAGAACAGGAG
CCGGTCAGGGACTGTGACTAAAAGGAAGGAGAAACGCCGTGATGTGACTCGAGCCTGTGCCATT
GGGGTGCCAGGCTGCCGGTGTGACTTCAGGCTGTGCGGCTTGCGCACCCTGCAGCCCTACGCTG
AGAGGATCCCTGTGGTGGCCACGGCTGGCATCACCATCAACTTCACATCGCAGAGCTCCCTGAC
AGGGCCGGGCGTGCGGGTGCACTACAGCCTGTACAACCAGTCGGACCCCTGCCCTGGTGAGTTC
CTCTGCTCCGTGAATGGACTCTGTGTCCCCGCCTGCGACGGGATCAAGGACTGCCCCAACGGCC
TGGATGAGAGAAACTGCGTTTGCAGAGCCACATTCCAGTGCCAAGAAGACAGCACGTGCATCCC
CCTGTCCCGAGTCTGTGACCAGCAGCCTGACTGTCTCAACAGCAGCGATGAGGAGCATTGCCAA
GAAGGAGTGCCTTGTGGGACCTTCACCTTCCGGTGTGAGGACCGCAGCTGTGTGCGGAAGCCCA
ACCCGCAGTGTGACGGGCAGTCGGACTGCAGGGATGGCTCGGATGAGCGCCACTGTGACTGTGG
CCTCCAGGGCCCCTCCAGCCGCATCGTGGGCGGGGCCGTGTCCTCTGAGGGCGAGTGGCCGTGG
CAGGCCAGCCTACAGGTTCGCGGCCGACACATCTGCGGGGGCGCCCTCGTCGCTGACCGCTGGG
TGATCACAGCTGCCCACTGTTTCCAGGAGGACGGCATGGCCAACCCAGCGCTGTGGACCGTGTT
CCTGGGCAAGATGCGGCAGAACGCCCGCTGGCCTGGCGAGGTGTCTTTCAAGGTGAGCCGCCTG
CTCCTGCACCCGTACCACGAGGAGGACAGCCACGACTATGACGTGGCCCTGCTGCAGCTCGACC
ACCCGGTGGTGCGCTCGGCCACTGTCCGCCCTGTCTGCCTGCCTGCACGCTCCCACTTCTTCGA
GCCCGGCCTGCATTGCTGGATCACGGGTTGGGGTGCCCTGCGAGAGGGCGGCCCCACCAGCAAT
GTCCTGCAGAAAGTGGATGTGCAGCTGGTTGCACAGGACTTGTGCAGTGAGGCCTATCACTACC
AGGTGACACCGCGCATGCTGTGTGCTGGCTACCGCAAGGGCAAGAAGGATGCGTGCCAGGGTGA
CTCCGGCGGCCCGCTGGTGTGCAAGGAGCCCAGTGGCCGCTGGTTCCTGGCGGGGCTGGTCAGC
TGGGGCCTGGGCTGTGGCCGGCCCAACTACTTTGGCGTCTACACTCGCATCACAGGTGTGATCG
GCTGGATCCGGCAGGCGCTGACCTGAGGTGCTGTGAGCCAGGGGCACCTCCTGGACAGAGTGTA
CAGGGTGCCCGCCAGGCAGACGAACAAGTATTCTGGGGGCAAGTGGCCCTGCGGAGGCAGGAGG
TGGCATCCTGTCCCCACCATGCCTCAGTGACTGCACAAGAGGGCGAGGACCATCAGCCTGTGGT
CAGGACCTCCTGGGGGCCCAGGTCCAATGGGCCAGACCGGTGGGGGGTCACACCCAGCGCTGTC
ACCTCCCAGTCGATCCTCTTGGTCTCGTCTTTTTCCTTGCTTCACACTGTCTTGGGGGCACTCA
GCAGGACGGTGCAGCTCTCTGACCCAGGAAGAAGCGTCAAGCCCCCTGCTCCAGGCAGAGCCCG
GATGTGGATGCACAGCACTGGCTCTGGAGCAGATCCCAGCCTCTGCCCCACCCTGGGGAGTGGG
AGGTGCTCCTGCCAGAGCGGAACCTTAAGGCCCTGGGAAGCCAAGTGGGCAGCTGCTGCCATAA
GCCAAAGGGTGGGATGGCCTCTGCTGGAGAGTCCCGCCCATCCCTGCCGCCAGTCTAGAAGGGC
AGCTCACTCAAGGAATAAAGCGCCTGACCAGTGA

hide sequence

RefSeq Acc Id:

XM_013511593 ⟹ XP_013367047

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955413	23,579,946 - 23,615,277 (-)	NCBI

Sequence:

show sequence

GCCTGTTTACCTGTGCTCAGTCCCGGTGCCGTCCTGGACCCGGCAGGAGGCCCATGGAGCCCAG
GGCCACAGGCCACAGAGGACAAGGGCCAGACACCCCAGCCATGGCTCTGGGCCATTGATCCACC
CGCAGGCCAGCCTGGTGGGGGTGGAGAAACCTTGGCCTGGACAAACAGAGCTGCCGAGGCCTGT
GTGTGGGACCGCCACCCACCTCCCACTCCAGGAGGATGCCGAGGGCCGAGGCCCCCCAGCTCGC
CGGCGGGCAGGGTGACGGAGGCGACGGTGAGGAAGCGGAGCCCGAGGGGATGTTTAAGGCCTCC
AAGAGGAAAGCCCGGGACTACATGTGCCTGGCGCCCCTGTGGCTGGCTCTGGTTGTGCTGGCTT
CAGTGGGGGTGATGCTCTGGTATTTCCTAGGGTACAGGGCCGAGGTGACCGTCAGCCAGGTGTA
CGCAGGCAGCCTCCGGGTGCTCAATCGTCACTTCTCCCAGGACCTTGCCCGCCGAGAGTCCAGC
ACCTTCCGCAGTGAGACTGCCAAAGCCCAGAGGATGCTTAAAGAACTCATCGCCAGCACCCGCC
TGGGTACTTACTACAACTCCAGCTCTGTCTACTCCTTCGGGGAGGGACCTCTCACTTGCTTCTT
CTGGTTCATCTTGCAAATCCCGGAGCATCTCCGGCCCACGCTGAGCCCCGAGATGGTGCAGGTG
CTGCTGGTGGAGGAGCTGCTGTCCGCTGCCAACAGCTCGGCCCCCGTCTCCTACGTGGCCGAGT
ATGAGGTGGACCCCGAGGGTCTGGTGATCCTGGAAGCCAGCGTGAAAGACATAGTCGCACTGAA
TTCCACGCTGGGCTGTTACCGCTACAGCTACGTAGGCCAGGGCCAGGCCCTGCGGCTGAAGGGC
CCCGACTACCTGGCCTCCAGCTGCCTGTGGCACCTGCAGGGCCCCCAGGAGCTCATGCTCAAGG
TACGGCTGGAGTGGACCCTGGCTGAGTGCCGCGACCGCCTGGCCATGTACGACGCAGCCGGGCC
ACTGGAAAAGAAGCTCATCACCTCGGTCTACGGCTGCAGTCGCCAGGAGCCGGTGGTGGAGGTG
CTGGCCTCAGGCCCCGTCATGGCGGTGGTGTGGAAGAAGGGTCTGCACAGCTACGTGGACCCCT
TCATGCTCTCTGTGCAGCCCGTGGCTTTCCAAGCCTGCCAGGTGAACCTGACACTAGAGGGCCG
GCTGGACCCGCAGGGTGCCCTGAGCACCCCCTACTTCCCCAGCTACTACTCTCCCAGCACCCAC
TGCTCCTGGCATCTCACGGTGCCGTCTCTGGACTATGGCTTGGCCCTCTGGTTTGATGCCTATG
CTCTGCGGAGACAGAAGTATGGCCTGCCGTGCACTCAGGGACAGTGGACGATACAGAACAGGAG
GCTGTGCGGCTTGCGCACCCTGCAGCCCTACGCTGAGAGGATCCCTGTGGTGGCCACGGCTGGC
ATCACCATCAACTTCACATCGCAGAGCTCCCTGACAGGGCCGGGCGTGCGGGTGCACTACAGCC
TGTACAACCAGTCGGACCCCTGCCCTGGTGAGTTCCTCTGCTCCGTGAATGGACTCTGTGTCCC
CGCCTGCGACGGGATCAAGGACTGCCCCAACGGCCTGGATGAGAGAAACTGCGTTTGCAGAGCC
ACATTCCAGTGCCAAGAAGACAGCACGTGCATCCCCCTGTCCCGAGTCTGTGACCAGCAGCCTG
ACTGTCTCAACAGCAGCGATGAGGAGCATTGCCAAGAAGGAGTGCCTTGTGGGACCTTCACCTT
CCGGTGTGAGGACCGCAGCTGTGTGCGGAAGCCCAACCCGCAGTGTGACGGGCAGTCGGACTGC
AGGGATGGCTCGGATGAGCGCCACTGTGACTGTGGCCTCCAGGGCCCCTCCAGCCGCATCGTGG
GCGGGGCCGTGTCCTCTGAGGGCGAGTGGCCGTGGCAGGCCAGCCTACAGGTTCGCGGCCGACA
CATCTGCGGGGGCGCCCTCGTCGCTGACCGCTGGGTGATCACAGCTGCCCACTGTTTCCAGGAG
GACGGCATGGCCAACCCAGCGCTGTGGACCGTGTTCCTGGGCAAGATGCGGCAGAACGCCCGCT
GGCCTGGCGAGGTGTCTTTCAAGGTGAGCCGCCTGCTCCTGCACCCGTACCACGAGGAGGACAG
CCACGACTATGACGTGGCCCTGCTGCAGCTCGACCACCCGGTGGTGCGCTCGGCCACTGTCCGC
CCTGTCTGCCTGCCTGCACGCTCCCACTTCTTCGAGCCCGGCCTGCATTGCTGGATCACGGGTT
GGGGTGCCCTGCGAGAGGGCGGCCCCACCAGCAATGTCCTGCAGAAAGTGGATGTGCAGCTGGT
TGCACAGGACTTGTGCAGTGAGGCCTATCACTACCAGGTGACACCGCGCATGCTGTGTGCTGGC
TACCGCAAGGGCAAGAAGGATGCGTGCCAGGGTGACTCCGGCGGCCCGCTGGTGTGCAAGGAGC
CCAGTGGCCGCTGGTTCCTGGCGGGGCTGGTCAGCTGGGGCCTGGGCTGTGGCCGGCCCAACTA
CTTTGGCGTCTACACTCGCATCACAGGTGTGATCGGCTGGATCCGGCAGGCGCTGACCTGAGGT
GCTGTGAGCCAGGGGCACCTCCTGGACAGAGTGTACAGGGTGCCCGCCAGGCAGACGAACAAGT
ATTCTGGGGGCAAGTGGCCCTGCGGAGGCAGGAGGTGGCATCCTGTCCCCACCATGCCTCAGTG
ACTGCACAAGAGGGCGAGGACCATCAGCCTGTGGTCAGGACCTCCTGGGGGCCCAGGTCCAATG
GGCCAGACCGGTGGGGGGTCACACCCAGCGCTGTCACCTCCCAGTCGATCCTCTTGGTCTCGTC
TTTTTCCTTGCTTCACACTGTCTTGGGGGCACTCAGCAGGACGGTGCAGCTCTCTGACCCAGGA
AGAAGCGTCAAGCCCCCTGCTCCAGGCAGAGCCCGGATGTGGATGCACAGCACTGGCTCTGGAG
CAGATCCCAGCCTCTGCCCCACCCTGGGGAGTGGGAGGTGCTCCTGCCAGAGCGGAACCTTAAG
GCCCTGGGAAGCCAAGTGGGCAGCTGCTGCCATAAGCCAAAGGGTGGGATGGCCTCTGCTGGAG
AGTCCCGCCCATCCCTGCCGCCAGTCTAGAAGGGCAGCTCACTCAAGGAATAAAGCGCCTGACC
AGTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013367046	(Get FASTA)	NCBI Sequence Viewer
	XP_013367047	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000024510
	ENSCLAP00000024510.1

RefSeq Acc Id:	XP_013367047 ⟸ XM_013511593
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C2W3W0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPRAEAPQLAGGQGDGGDGEEAEPEGMFKASKRKARDYMCLAPLWLALVVLASVGVMLWYFLGY RAEVTVSQVYAGSLRVLNRHFSQDLARRESSTFRSETAKAQRMLKELIASTRLGTYYNSSSVYS FGEGPLTCFFWFILQIPEHLRPTLSPEMVQVLLVEELLSAANSSAPVSYVAEYEVDPEGLVILE ASVKDIVALNSTLGCYRYSYVGQGQALRLKGPDYLASSCLWHLQGPQELMLKVRLEWTLAECRD RLAMYDAAGPLEKKLITSVYGCSRQEPVVEVLASGPVMAVVWKKGLHSYVDPFMLSVQPVAFQA CQVNLTLEGRLDPQGALSTPYFPSYYSPSTHCSWHLTVPSLDYGLALWFDAYALRRQKYGLPCT QGQWTIQNRRLCGLRTLQPYAERIPVVATAGITINFTSQSSLTGPGVRVHYSLYNQSDPCPGEF LCSVNGLCVPACDGIKDCPNGLDERNCVCRATFQCQEDSTCIPLSRVCDQQPDCLNSSDEEHCQ EGVPCGTFTFRCEDRSCVRKPNPQCDGQSDCRDGSDERHCDCGLQGPSSRIVGGAVSSEGEWPW QASLQVRGRHICGGALVADRWVITAAHCFQEDGMANPALWTVFLGKMRQNARWPGEVSFKVSRL LLHPYHEEDSHDYDVALLQLDHPVVRSATVRPVCLPARSHFFEPGLHCWITGWGALREGGPTSN VLQKVDVQLVAQDLCSEAYHYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKEPSGRWFLAGLVS WGLGCGRPNYFGVYTRITGVIGWIRQALT hide sequence

RefSeq Acc Id:	XP_013367046 ⟸ XM_013511592
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2W3W0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPRAEAPQLAGGQGDGGDGEEAEPEGMFKASKRKARDYMCLAPLWLALVVLASVGVMLWYFLGY RAEVTVSQVYAGSLRVLNRHFSQDLARRESSTFRSETAKAQRMLKELIASTRLGTYYNSSSVYS FGEGPLTCFFWFILQIPEHLRPTLSPEMVQVLLVEELLSAANSSAPVSYVAEYEVDPEGLVILE ASVKDIVALNSTLGCYRYSYVGQGQALRLKGPDYLASSCLWHLQGPQELMLKVRLEWTLAECRD RLAMYDAAGPLEKKLITSVYGCSRQEPVVEVLASGPVMAVVWKKGLHSYVDPFMLSVQPVAFQA CQVNLTLEGRLDPQGALSTPYFPSYYSPSTHCSWHLTVPSLDYGLALWFDAYALRRQKYGLPCT QGQWTIQNRSRSGTVTKRKEKRRDVTRACAIGVPGCRCDFRLCGLRTLQPYAERIPVVATAGIT INFTSQSSLTGPGVRVHYSLYNQSDPCPGEFLCSVNGLCVPACDGIKDCPNGLDERNCVCRATF QCQEDSTCIPLSRVCDQQPDCLNSSDEEHCQEGVPCGTFTFRCEDRSCVRKPNPQCDGQSDCRD GSDERHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALVADRWVITAAHCFQEDG MANPALWTVFLGKMRQNARWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSATVRPV CLPARSHFFEPGLHCWITGWGALREGGPTSNVLQKVDVQLVAQDLCSEAYHYQVTPRMLCAGYR KGKKDACQGDSGGPLVCKEPSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVIGWIRQALT hide sequence

RefSeq Acc Id:

ENSCLAP00000024510 ⟸ ENSCLAT00000024745

Protein Domains

CUB Peptidase S1 SEA

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000016826	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000024745	ENTREZGENE
	ENSCLAT00000024745.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	2.60.120.290	UniProtKB/TrEMBL
	3.30.70.960	UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/TrEMBL
InterPro	CUB_dom	UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/TrEMBL
	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	SEA_dom	UniProtKB/TrEMBL
	SEA_dom_sf	UniProtKB/TrEMBL
	Sperma_CUB_dom_sf	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
NCBI Gene	Tmprss6	ENTREZGENE
PANTHER	ACROSIN-RELATED	UniProtKB/TrEMBL
	LOW QUALITY PROTEIN: TRANSMEMBRANE PROTEASE SERINE 6	UniProtKB/TrEMBL
Pfam	Ldl_recept_a	UniProtKB/TrEMBL
	SEA	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	CUB	UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/TrEMBL
	SEA	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
SMART	LDLa	UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49854	UniProtKB/TrEMBL
	SSF50494	UniProtKB/TrEMBL
	SSF57424	UniProtKB/TrEMBL
	SSF82671	UniProtKB/TrEMBL
UniProt	A0A8C2W3W0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-23	Tmprss6	transmembrane serine protease 6		transmembrane protease, serine 6	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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