Etv2 (ETS variant transcription factor 2)

Gene: Etv2 (ETS variant transcription factor 2) Chinchilla lanigera

Analyze

Symbol:

Etv2

Name:

ETS variant transcription factor 2

RGD ID:

8874082

Description:

ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN blastocyst development (ortholog); blood vessel morphogenesis (ortholog); BMP signaling pathway (ortholog); ASSOCIATED WITH Aortic Remodeling (ortholog); Brugada syndrome 5 (ortholog); dystonia (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ETS translocation variant 2; ETS variant 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	4,857,595 - 4,860,531 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	4,857,023 - 4,859,926 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aortic Remodeling (ISO)

Brugada syndrome 5 (ISO)

dystonia (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 75 (ISO)

limb ischemia (ISO)

polydactyly (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blastocyst development (ISO)

blood vessel morphogenesis (ISO)

BMP signaling pathway (ISO)

erythrocyte differentiation (ISO)

hemopoiesis (ISO)

in utero embryonic development (ISO)

mesoderm formation (ISO)

Notch signaling pathway (ISO)

placenta development (ISO)

positive regulation of endothelial cell differentiation (ISO)

positive regulation of gene expression (ISO)

positive regulation of mesoderm development (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

Wnt signaling pathway (ISO)

Molecular Function

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Etv2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	4,857,595 - 4,860,531 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	4,857,023 - 4,859,926 (+)	NCBI	ChiLan1.0	ChiLan1.0

ETV2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	35,641,745 - 35,644,871 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	35,641,745 - 35,644,871 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	36,132,647 - 36,135,773 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	40,824,487 - 40,827,613 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	32,846,129 - 32,849,256 (+)	NCBI		Celera
Cytogenetic Map	19	q13.12	NCBI
HuRef	19	32,637,910 - 32,641,036 (+)	NCBI		HuRef
CHM1_1	19	36,134,179 - 36,137,305 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	38,186,718 - 38,189,844 (+)	NCBI		T2T-CHM13v2.0

Etv2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	30,333,041 - 30,335,934 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	30,333,041 - 30,335,277 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	30,633,616 - 30,636,509 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	30,633,616 - 30,635,852 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	31,418,635 - 31,420,871 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	30,342,378 - 30,344,612 (-)	NCBI		MGSCv36	mm8
Celera	7	25,225,816 - 25,227,677 (-)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	18.92	NCBI

Etv2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	95,017,980 - 95,021,582 (-)	NCBI		GRCr8
mRatBN7.2	1	85,890,562 - 85,894,025 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	85,890,559 - 85,893,431 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	1	89,091,239 - 89,094,570 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	89,091,239 - 89,094,530 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	90,246,861 - 90,250,074 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	85,684,698 - 85,686,914 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	85,762,809 - 85,765,732 (-)	NCBI
Celera	1	80,262,333 - 80,264,853 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

ETV2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	41,638,278 - 41,641,458 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	43,621,733 - 43,624,908 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	32,571,829 - 32,575,083 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	41,307,864 - 41,311,004 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	41,307,864 - 41,311,004 (+)	Ensembl	panpan1.1		panPan2

ETV2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	116,971,238 - 116,974,831 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	116,971,365 - 116,985,796 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	116,376,575 - 116,379,674 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	117,574,597 - 117,577,707 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	117,574,598 - 117,577,031 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	117,137,602 - 117,140,703 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	116,761,500 - 116,764,598 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	117,817,402 - 117,820,510 (-)	NCBI		UU_Cfam_GSD_1.0

Etv2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	10,971,607 - 10,974,730 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936570	671,152 - 673,768 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ETV2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	45,087,100 - 45,089,626 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	45,085,984 - 45,089,592 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	40,543,308 - 40,546,424 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ETV2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	30,552,780 - 30,556,374 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	30,553,931 - 30,556,355 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	8,348,216 - 8,351,726 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Etv2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	7,984,884 - 7,988,296 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	7,985,662 - 7,989,063 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013522386	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01051923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01048409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000016827 ⟹ ENSCLAP00000016663

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955468	4,857,595 - 4,860,531 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000016828 ⟹ ENSCLAP00000016664

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955468	4,857,595 - 4,860,531 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000016829 ⟹ ENSCLAP00000016665

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955468	4,857,615 - 4,859,873 (+)	Ensembl

RefSeq Acc Id:

XM_013522386 ⟹ XP_013377840

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955468	4,857,023 - 4,859,926 (+)	NCBI

Sequence:

show sequence

GCTGGGGACGCGGGGAATCTGGCCGGAAATCCCTCTTCCTGTTGCAGATAAGCCTGGCGCAGCC
TAGCTGACCCCTGGCCCTCCTTCCACCTCCCATGTCGCAGGATCAAGTCCCCAAGACGGAGAAC
CTGTCCACTCTGCCCAGCCCCCATCACCTCATAAACACTCCCGGCCCCTGTCCCCCGCCTTGCC
CAGCCCGCTGTTCCCCAAGCCACTCCTGCACCAGGACAGCTCCAGAGGCTGCATCCCTGATGCC
GGGGGGCGCGGCGCGGCTCCGCCCCCGGACCTGCAACTTGACCCAGGCTGCGACCCCTTGCTCT
GACGTCTTGGAAAATTCCCCCCTGCCCAGGTCCCGGGGGGAGGGGGTGCACGGTATGAAATGGG
GCTGAGACCCCCGGTTGGGGACAGAGGAACCCGCTGGAGATCATTCCAAACGAGCGCCTATGGA
CGTGTGGAGCTGCGATGAGACCCCGCCACAGGAAGTGCCTGCAGGGAACAAGCTGGCAGGGCTG
GAAGGAACCGAATTTGGCTTCTATTTCCCTGAACTAGAACTCCAAGCGGACACACCGACAAGCG
AAACATGCTGGAAAGGGTTCCCGGAGCTAAACTGGAGCCCCGCGTTACCACATCCAGAATATGC
ATGGGGAGCAGATCTCGGCCCTCAGGCCCCTACGTGGTCCAGAGATTGGACAGATATGGCGCAA
AACGCCTCGGACCCTTGCAACCTCGTCTTTCAGACCCTGGAGCCGGCCCTCCCCGGCCCAGGCC
ACGCCCCCGACGCTGGTTCCGGAGGGGCGGCGGGCCAGAACAGTGCCACCTCGTGGTCTCACGC
CCAGGCCGCCAGGAGCACGGCGAGCTGCGACTATTCTGTCGTGCCCAACGGCGCCACCTACTGG
GACAATGGCTTCTACGGGGACCCTCGCGCGGACTATACCATGTCGTGGGGCGACCCTGCGGGTT
CGGACCGTACCACCTCGTGGAGTCTCGGGCTGCATGGAGATTGCAGCCTCTCTTCGAACGGGTA
CCGGAGTTCAGCTCTCACCACCTCCTCCGAACCGAGGCCGCAGCCCGACCGTGCCACCTCGACT
CGTTACCCCAAAACGAACCACCACCGAGGTCCCATTCAGCTGTGGCAGTTTCTCCTGGAGCTAC
TGCACGACGGGGCGCGTAGCAGCTGCATCCGCTGGACTGGCAACAGCCGCGAGTTCCAGCTGTG
CGACCCCAAAGAGGTGGCGCGGCTGTGGGGCGAGCGCAAGAGGAAGCCGGGCATGAATTACGAG
AAGCTGAGCCGGGGTCTGCGTTACTACTACCGCCGCGACATCGTGCAAAAGAGCGGTGGGCGCA
AGTACACGTACCGCTTCGGGGGCCGCGTGCCTGGTTTGGCCTGTTCGGACTGATCGAGGGTCGG
GCAGGGAGCAGAGACCCAATAAAATATCCTGCCAAACTGTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013377840	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000016663.1
	ENSCLAP00000016664
	ENSCLAP00000016664.1
	ENSCLAP00000016665.1

RefSeq Acc Id:

XP_013377840 ⟸ XM_013522386

- UniProtKB:

A0A8C2VNU5 (UniProtKB/TrEMBL), A0A8C2VLT6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDVWSCDETPPQEVPAGNKLAGLEGTEFGFYFPELELQADTPTSETCWKGFPELNWSPALPHPE
YAWGADLGPQAPTWSRDWTDMAQNASDPCNLVFQTLEPALPGPGHAPDAGSGGAAGQNSATSWS
HAQAARSTASCDYSVVPNGATYWDNGFYGDPRADYTMSWGDPAGSDRTTSWSLGLHGDCSLSSN
GYRSSALTTSSEPRPQPDRATSTRYPKTNHHRGPIQLWQFLLELLHDGARSSCIRWTGNSREFQ
LCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVQKSGGRKYTYRFGGRVPGLACSD

hide sequence

RefSeq Acc Id:

ENSCLAP00000016665 ⟸ ENSCLAT00000016829

RefSeq Acc Id:

ENSCLAP00000016664 ⟸ ENSCLAT00000016828

RefSeq Acc Id:

ENSCLAP00000016663 ⟸ ENSCLAT00000016827

Protein Domains

ETS

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000011446	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000016827.1	UniProtKB/TrEMBL
	ENSCLAT00000016828	ENTREZGENE
	ENSCLAT00000016828.1	UniProtKB/TrEMBL
	ENSCLAT00000016829.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
InterPro	Ets_dom	UniProtKB/TrEMBL
	ETS_fam	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	Etv2	ENTREZGENE
PANTHER	ETS TRANSLOCATION VARIANT 2	UniProtKB/TrEMBL
	PTHR11849	UniProtKB/TrEMBL
Pfam	Ets	UniProtKB/TrEMBL
PRINTS	ETSDOMAIN	UniProtKB/TrEMBL
PROSITE	ETS_DOMAIN_1	UniProtKB/TrEMBL
	ETS_DOMAIN_2	UniProtKB/TrEMBL
	ETS_DOMAIN_3	UniProtKB/TrEMBL
SMART	ETS	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
UniProt	A0A8C2VLT6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2VNU5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2VRH5_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-11-26	Etv2	ETS variant transcription factor 2	Etv2	ETS variant 2	Symbol and/or name change	5135510	APPROVED
2016-08-03	Etv2	ETS variant 2		ets variant 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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