Eya3 (EYA transcriptional coactivator and phosphatase 3) - Rat Genome Database

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Gene: Eya3 (EYA transcriptional coactivator and phosphatase 3) Chinchilla lanigera
Analyze
Symbol: Eya3
Name: EYA transcriptional coactivator and phosphatase 3
RGD ID: 8872680
Description: ENCODES a protein that exhibits chromatin binding (ortholog); histone H2AXY142 phosphatase activity (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN double-strand break repair (ortholog); positive regulation of DNA repair (ortholog); response to ionizing radiation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN centrosome (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: eyes absent homolog 3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554527,150,886 - 7,255,159 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554527,148,762 - 7,273,886 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Eya3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554527,150,886 - 7,255,159 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554527,148,762 - 7,273,886 (-)NCBIChiLan1.0ChiLan1.0
EYA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,970,344 - 28,088,610 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,970,344 - 28,088,637 (-)EnsemblGRCh38hg38GRCh38
GRCh37128,296,855 - 28,415,121 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,173,406 - 28,287,718 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,999,126 - 28,099,273NCBI
Celera126,696,435 - 26,810,762 (-)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef126,552,221 - 26,670,901 (-)NCBIHuRef
CHM1_1128,412,382 - 28,530,637 (-)NCBICHM1_1
T2T-CHM13v2.0127,812,178 - 27,930,443 (-)NCBIT2T-CHM13v2.0
Eya3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,366,303 - 132,452,076 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,366,298 - 132,452,076 (+)EnsemblGRCm39 Ensembl
GRCm384132,639,025 - 132,724,765 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,638,987 - 132,724,765 (+)EnsemblGRCm38mm10GRCm38
MGSCv374132,194,961 - 132,280,678 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,911,122 - 131,996,839 (+)NCBIMGSCv36mm8
Celera4130,800,983 - 130,886,901 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map465.68NCBI
Eya3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,090,535 - 150,218,855 (+)NCBIGRCr8
mRatBN7.25144,806,523 - 144,934,522 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,806,577 - 144,934,518 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,554,161 - 147,632,926 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,323,743 - 149,402,508 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,311,255 - 149,391,185 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,833,754 - 150,915,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,787,043 - 150,913,757 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,501,246 - 154,582,998 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,427,552 - 152,507,813 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15152,439,701 - 152,546,295 (-)NCBI
Celera5143,279,068 - 143,358,777 (+)NCBICelera
Cytogenetic Map5q36NCBI
EYA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21198,763,927 - 198,883,142 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,880,844 - 198,000,070 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,230,623 - 27,349,355 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,270,116 - 28,386,878 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl128,270,116 - 28,386,878 (-)Ensemblpanpan1.1panPan2
EYA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,313,412 - 72,417,729 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,328,362 - 72,414,058 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,891,457 - 68,995,289 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,873,523 - 72,977,951 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,873,590 - 72,977,551 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,700,796 - 69,805,085 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,711,314 - 70,815,575 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,707,748 - 71,811,729 (+)NCBIUU_Cfam_GSD_1.0
Eya3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505846,367,002 - 46,470,598 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,191,389 - 12,295,458 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,191,391 - 12,295,380 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EYA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,095,409 - 85,185,799 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,095,409 - 85,185,856 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2678,635,980 - 78,683,700 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EYA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,720,487 - 104,840,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20104,720,482 - 104,840,883 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603311,633,751 - 11,754,343 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eya3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476411,821,609 - 11,898,144 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476411,820,993 - 11,932,183 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000013037   ⟹   ENSCLAP00000012888
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554527,150,886 - 7,255,159 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000013038   ⟹   ENSCLAP00000012889
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554527,150,886 - 7,255,159 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000013039   ⟹   ENSCLAP00000012890
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554527,151,971 - 7,225,485 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000013040   ⟹   ENSCLAP00000012891
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554527,151,971 - 7,204,929 (-)Ensembl
RefSeq Acc Id: XM_005394937   ⟹   XP_005394994
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554527,148,762 - 7,254,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005394938   ⟹   XP_005394995
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554527,148,762 - 7,254,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005394939   ⟹   XP_005394996
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554527,148,762 - 7,254,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005394940   ⟹   XP_005394997
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554527,148,762 - 7,254,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013519541   ⟹   XP_013374995
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554527,148,762 - 7,273,886 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013519542   ⟹   XP_013374996
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554527,148,762 - 7,218,518 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005394997   ⟸   XM_005394940
- Peptide Label: isoform X3
- UniProtKB: A0A8C2YP34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005394994   ⟸   XM_005394937
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YP35 (UniProtKB/TrEMBL),   A0A8C2YP34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005394996   ⟸   XM_005394939
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YP35 (UniProtKB/TrEMBL),   A0A8C2YP34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005394995   ⟸   XM_005394938
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YP35 (UniProtKB/TrEMBL),   A0A8C2YP34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013374995   ⟸   XM_013519541
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YP35 (UniProtKB/TrEMBL),   A0A8C2YP34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013374996   ⟸   XM_013519542
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YP34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000012888   ⟸   ENSCLAT00000013037
RefSeq Acc Id: ENSCLAP00000012889   ⟸   ENSCLAT00000013038
RefSeq Acc Id: ENSCLAP00000012890   ⟸   ENSCLAT00000013039
RefSeq Acc Id: ENSCLAP00000012891   ⟸   ENSCLAT00000013040


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000008901 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000013037 ENTREZGENE
  ENSCLAT00000013037.1 UniProtKB/TrEMBL
  ENSCLAT00000013038 ENTREZGENE
  ENSCLAT00000013038.1 UniProtKB/TrEMBL
  ENSCLAT00000013039 ENTREZGENE
  ENSCLAT00000013039.1 UniProtKB/TrEMBL
  ENSCLAT00000013040.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.12350 UniProtKB/TrEMBL
InterPro EYA_dom UniProtKB/TrEMBL
  EYA_dom_metazoan UniProtKB/TrEMBL
  EYA_dom_sf UniProtKB/TrEMBL
  EYA_fam UniProtKB/TrEMBL
NCBI Gene Eya3 ENTREZGENE
PANTHER PTHR10190 UniProtKB/TrEMBL
  PTHR10190:SF5 UniProtKB/TrEMBL
Pfam Hydrolase UniProtKB/TrEMBL
UniProt A0A8C2VBG7_CHILA UniProtKB/TrEMBL
  A0A8C2YP34 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YP35 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Eya3  EYA transcriptional coactivator and phosphatase 3    eyes absent homolog 3 (Drosophila)  Symbol and/or name change 5135510 APPROVED