Psma1 (proteasome 20S subunit alpha 1)

Gene: Psma1 (proteasome 20S subunit alpha 1) Chinchilla lanigera

Analyze

Symbol:

Psma1

Name:

proteasome 20S subunit alpha 1

RGD ID:

8870678

Description:

ENCODES a protein that exhibits lipopolysaccharide binding (ortholog); INVOLVED IN negative regulation of inflammatory response to antigenic stimulus (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

proteasome (prosome, macropain) subunit, alpha type, 1; proteasome subunit alpha 1; proteasome subunit alpha type-1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	29,665,335 - 29,679,922 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	29,667,417 - 29,679,510 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of inflammatory response to antigenic stimulus (ISO)

Cellular Component

centrosome (ISO)

cytoplasm (ISO)

nucleoplasm (ISO)

nucleus (ISO)

proteasome complex (ISO)

proteasome core complex (ISO)

Molecular Function

lipopolysaccharide binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Psma1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	29,665,335 - 29,679,922 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	29,667,417 - 29,679,510 (-)	NCBI	ChiLan1.0	ChiLan1.0

PSMA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	14,504,876 - 14,643,662 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	14,504,874 - 14,643,635 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	14,526,422 - 14,665,208 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	14,482,998 - 14,621,739 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	14,482,998 - 14,621,739	NCBI
Celera	11	14,651,494 - 14,790,271 (-)	NCBI		Celera
Cytogenetic Map	11	p15.2	NCBI
HuRef	11	14,207,557 - 14,313,706 (-)	NCBI		HuRef
CHM1_1	11	14,525,354 - 14,664,092 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	14,600,152 - 14,738,957 (-)	NCBI		T2T-CHM13v2.0

Psma1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	113,863,785 - 113,875,351 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	113,863,841 - 113,875,353 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	114,264,550 - 114,276,116 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	114,264,606 - 114,276,118 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	121,408,064 - 121,419,630 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	114,055,789 - 114,067,280 (-)	NCBI		MGSCv36	mm8
Celera	7	114,225,919 - 114,237,486 (-)	NCBI		Celera
Cytogenetic Map	7	F1	NCBI
cM Map	7	59.32	NCBI

Psma1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	177,876,838 - 177,887,857 (-)	NCBI		GRCr8
mRatBN7.2	1	168,442,421 - 168,453,440 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	168,440,936 - 168,453,472 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	176,771,846 - 176,782,862 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	183,957,918 - 183,968,934 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	176,671,909 - 176,682,943 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	183,733,567 - 183,744,586 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	183,733,567 - 183,744,586 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	190,708,745 - 190,719,764 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	172,237,763 - 172,248,782 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	172,373,871 - 172,384,891 (-)	NCBI
Celera	1	166,294,949 - 166,305,966 (-)	NCBI		Celera
Cytogenetic Map	1	q34	NCBI

PSMA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	16,886,092 - 17,024,783 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	16,846,932 - 16,985,649 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	14,607,557 - 14,746,207 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	14,298,860 - 14,314,780 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	14,298,860 - 14,314,780 (-)	Ensembl	panpan1.1		panPan2

LOC102152879
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	24,114,023 - 24,116,951 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	24,089,251 - 24,090,279 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	24,283,760 - 24,285,132 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	30	24,209,220 - 24,210,232 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	24,291,908 - 24,293,280 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	24,435,997 - 24,437,025 (+)	NCBI		UU_Cfam_GSD_1.0

Psma1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	48,161,083 - 48,173,283 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936528	4,195,072 - 4,209,558 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936528	4,195,072 - 4,207,263 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PSMA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	44,648,247 - 44,757,440 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	44,740,102 - 44,755,296 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	47,966,027 - 47,981,201 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PSMA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	50,360,667 - 50,376,024 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	147,903,641 - 147,919,508 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Psma1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	6,380,060 - 6,392,373 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624766	6,380,057 - 6,392,408 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005380332	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01015711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCB01002979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000023797 ⟹ ENSCLAP00000023573

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955414	29,665,335 - 29,679,922 (-)	Ensembl

RefSeq Acc Id:

XM_005380332 ⟹ XP_005380389

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955414	29,667,417 - 29,679,510 (-)	NCBI

Sequence:

show sequence

CACACAAACGGCCCGTTGTTTGTTTGCTTTTCTGTAACCTACTTCTTCTCAGTTATACAATTCC
CCAAATCTCTGCGGACAGTGAAGGAGAGGTTGAGAGGCACAAGGAGAACACCCGGTGTCGCAGC
AGGGGTCTCGAGGCCGTCTATCCATAGGGATGAGAAACTGGCGCGAATCTGCAATACTCGGAAT
CTCGCTGAGGCTACAAGAAGGGTAATACAACAGGATACACAGCAGATCTGCTTAGCTGCTGCTC
CAAACCCAGGTTTTCCCGCCAATCTCAGTTTTGTACTTTCCAAGGCCCCGCCCACACCCGCGAG
GCGCGCTGGGAGGTTTGAGAGTCCGCAAACCCAGACACCTTATCGATATCTCTGGAATGGACTG
CCCTACCCTGCGCCGCCGCCGTCAAAATCCCACAGACCTCTCGGTCGATCGCCGAGCGGAAGTT
TCGACAGCTCTCCTCGATTCGCCGCTTTGCAGGAGGCTCGTAGCCTGGTCCGCGCCCGAACTAT
GTTTCGTAACCAGTATGATAATGATGTCACTGTTTGGAGCCCTCAGGGCAGGATTCATCAAATT
GAATATGCAATGGAAGCTGTTAAACAAGGTTCTGCCACAGTTGGTCTGAAATCAAAAACCCATG
CAGTGTTGGTTGCATTGAAGAGGGCACAGTCAGAGCTTGCAGCTCACCAGAAAAAAATTCTCCA
TGTTGACAACCATATTGGTATCTCTATTGCGGGACTTACTGCTGATGCTAGACTCTTATGTAAT
TTTATGCGACAGGAGTGTTTGGATTCCAGATTCGTATTTGACAGGCCACTTCCTGTGTCTCGTC
TTGTATCTCTAATTGGAAGCAAGACCCAGATACCAACACAGCGGTATGGCCGGAGACCATATGG
TGTTGGGCTGCTTATTGCTGGTTATGATGATATGGGCCCTCACATTTTCCAGACCTGTCCATCT
GCTAACTATTTTGACTGCAGAGCTATGTCTATTGGAGCCCGTTCTCAATCAGCTCGTACTTACT
TGGAGAGACATATGTCTGAATTTATGGAGTGCAATTTAAATGAACTGGTTAAGCATGGTCTGCG
TGCCTTAAGAGAGACACTTCCTGCAGAGCAGGACCTGACTACTAAGAATGTTTCCATTGGAATT
GTTGGTAAAGACTTGGAATTCACGATCTATGATGATGATGATGTGTCTCCATTCCTGGAAGGTC
TTGAAGAAAGACCACAGAGAAAGGCACAGCCTGCACAACCTGCGGATGAACCTGCAGAAAAAGC
TGATGAACCAATGGAACATTAGTAAACCAGTCTCTGTGTGTCGTCAGATATGTAAGAATGCAGG
AACACATACTGATGACAGTAATCTATACTTTGAACCAAAAGATGCAGAGTGTGGAATTGGTATG
TTTTAGGAATCAGTCCAGATATGTTTTTTCCAACCAACCTCCCTGAAACCATATAATGAGGTGC
AGTTTTCTTTAAGGGGGTCTGTATAATCATTTTCTAAAAAGTATAGGTATACCAATGTTTTTAT
ATGAAGAAAATAGTGTCTTTGCAGTTTTAAAGACAACTGTGAAATAAAACTGTTTCACTTCC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005380389	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000023573
	ENSCLAP00000023573.1

RefSeq Acc Id:

XP_005380389 ⟸ XM_005380332

- UniProtKB:

A0A8C2W101 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKIL
HVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPY
GVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGL
RALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQRKAQPAQPADEPAEK
ADEPMEH

hide sequence

RefSeq Acc Id:

ENSCLAP00000023573 ⟸ ENSCLAT00000023797

Protein Domains

Proteasome alpha-type subunits

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000016167	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000023797	ENTREZGENE
	ENSCLAT00000023797.1	UniProtKB/TrEMBL
Gene3D-CATH	3.60.20.10	UniProtKB/TrEMBL
InterPro	Ntn_hydrolases_N	UniProtKB/TrEMBL
	Proteasome_alpha-type	UniProtKB/TrEMBL
	Proteasome_alpha1	UniProtKB/TrEMBL
	Proteasome_asu_N	UniProtKB/TrEMBL
	Proteasome_sua/b	UniProtKB/TrEMBL
NCBI Gene	Psma1	ENTREZGENE
PANTHER	PROTEASOME SUBUNIT ALPHA/BETA	UniProtKB/TrEMBL
	PTHR11599:SF12	UniProtKB/TrEMBL
Pfam	Proteasome	UniProtKB/TrEMBL
	Proteasome_A_N	UniProtKB/TrEMBL
PROSITE	PROTEASOME_ALPHA_1	UniProtKB/TrEMBL
	PROTEASOME_ALPHA_2	UniProtKB/TrEMBL
SMART	Proteasome_A_N	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56235	UniProtKB/TrEMBL
UniProt	A0A8C2W101	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-09-03	Psma1	proteasome 20S subunit alpha 1	Psma1	proteasome subunit alpha 1	Symbol and/or name change	5135510	APPROVED
2015-08-25	Psma1	proteasome subunit alpha 1		proteasome (prosome, macropain) subunit, alpha type, 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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