Dync2li1 (dynein cytoplasmic 2 light intermediate chain 1)

Gene: Dync2li1 (dynein cytoplasmic 2 light intermediate chain 1) Chinchilla lanigera

Analyze

Symbol:

Dync2li1

Name:

dynein cytoplasmic 2 light intermediate chain 1

RGD ID:

8861228

Description:

ENCODES a protein that exhibits dynein heavy chain binding (ortholog); INVOLVED IN cilium assembly (ortholog); determination of left/right symmetry (ortholog); intraciliary transport involved in cilium assembly (ortholog); ASSOCIATED WITH asphyxiating thoracic dystrophy (ortholog); asphyxiating thoracic dystrophy 1 (ortholog); genetic disease (ortholog); FOUND IN apical part of cell (ortholog); axoneme (ortholog); centrosome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cytoplasmic dynein 2 light intermediate chain 1; dynein, cytoplasmic 2, light intermediate chain 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	10,928,343 - 10,961,194 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955441	10,928,577 - 10,961,194 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asphyxiating thoracic dystrophy (ISO)

asphyxiating thoracic dystrophy 1 (ISO)

genetic disease (ISO)

hemorrhagic disease (ISO)

Lynch syndrome (ISO)

Short-Rib Thoracic Dysplasia 15 with Polydactyly (ISO)

short-rib thoracic dysplasia 6 with or without polydactyly (ISO)

sitosterolemia (ISO)

Sitosterolemia 1 (ISO)

Sitosterolemia 2 (ISO)

thrombocytopenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cilium assembly (ISO)

determination of left/right symmetry (ISO)

intraciliary transport involved in cilium assembly (ISO)

regulation of cilium assembly (ISO)

Cellular Component

apical part of cell (ISO)

axoneme (ISO)

centrosome (ISO)

ciliary basal body (ISO)

ciliary transition zone (ISO)

cytoplasm (ISO)

cytoplasmic dynein complex (ISO)

cytosol (ISO)

motile cilium (ISO)

Molecular Function

dynein heavy chain binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Dync2li1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	10,928,343 - 10,961,194 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955441	10,928,577 - 10,961,194 (+)	NCBI	ChiLan1.0	ChiLan1.0

DYNC2LI1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	43,774,039 - 43,828,347 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	43,774,039 - 43,810,010 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	44,001,178 - 44,055,486 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	43,854,686 - 43,890,653 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	43,839,914 - 43,875,885 (+)	NCBI		Celera
Cytogenetic Map	2	p21	NCBI
HuRef	2	43,737,874 - 43,773,845 (+)	NCBI		HuRef
CHM1_1	2	43,930,576 - 43,966,546 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	43,779,369 - 43,833,678 (+)	NCBI		T2T-CHM13v2.0

Dync2li1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	84,933,903 - 84,962,996 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	84,933,924 - 84,963,016 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	84,626,475 - 84,655,568 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	84,626,496 - 84,655,588 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	85,025,836 - 85,054,908 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	84,534,823 - 84,563,894 (+)	NCBI		MGSCv36	mm8
Celera	17	88,993,647 - 89,022,328 (+)	NCBI		Celera
Cytogenetic Map	17	E4	NCBI
cM Map	17	55.02	NCBI

Dync2li1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	15,745,350 - 15,778,166 (-)	NCBI		GRCr8
mRatBN7.2	6	9,992,537 - 10,025,355 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	9,992,541 - 10,025,336 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	10,287,813 - 10,320,761 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	10,597,204 - 10,630,152 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	10,112,319 - 10,148,463 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	7,900,962 - 7,933,795 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	7,900,972 - 7,933,796 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	7,837,898 - 7,869,293 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	7,993,577 - 8,025,670 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	7,993,576 - 8,025,669 (+)	NCBI
Celera	6	9,714,091 - 9,746,141 (-)	NCBI		Celera
Cytogenetic Map	6	q12	NCBI

DYNC2LI1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	82,595,156 - 82,649,760 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	82,599,634 - 82,653,716 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	43,858,368 - 43,912,262 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	44,706,777 - 44,760,757 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	44,706,777 - 44,742,724 (+)	Ensembl	panpan1.1		panPan2

DYNC2LI1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	46,231,433 - 46,270,102 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	46,231,460 - 46,290,382 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	46,093,044 - 46,131,740 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	47,109,916 - 47,148,612 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	47,109,962 - 47,148,583 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	46,818,280 - 46,856,971 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	47,108,466 - 47,146,902 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	47,291,618 - 47,330,309 (+)	NCBI		UU_Cfam_GSD_1.0

Dync2li1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	36,690,889 - 36,720,417 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936508	8,118,589 - 8,149,035 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936508	8,119,733 - 8,149,022 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DYNC2LI1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	96,654,415 - 96,703,237 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	96,656,099 - 96,703,282 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	142,093,233 - 142,093,545 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DYNC2LI1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	63,441,948 - 63,481,460 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	63,440,155 - 63,481,479 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	48,407,629 - 48,448,000 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dync2li1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	25,245,890 - 25,283,706 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	25,245,792 - 25,298,397 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005390934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01037096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01037097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01037098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01006691	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000006860 ⟹ ENSCLAP00000006750

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955441	10,928,343 - 10,961,194 (+)	Ensembl

RefSeq Acc Id:

XM_005390934 ⟹ XP_005390991

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955441	10,928,577 - 10,961,194 (+)	NCBI

Sequence:

show sequence

GTTGCTGTTGAAGATGAGACTTTAGAAAGAGCACCGAAAACTACATTTCCCATGATGCCATTCT
TTAGCACGCATGCGACCACGCCCTCGTTGCCACGGGAACTGAGGAGCCTACGTTCTTGGTTCAT
CCTGCCGCTCTCGGTTCGCGGGGTACCGGGCTGGGCCGCACGCCGAGCACTCCGCGTTTGCGGG
CCTGTCACGATGCCCAGTGAAACTCTCTGGGAAATTGCAAAAGCTGAAGTGGAAAAGAGAGGAA
GTAATGGAAATGAAGGCGATGGCGTTGAAAGTGGAGAAAAGTCTGTCTTCTTCATTGGCAGTAA
AAATGGGGGAAAGACTACTATAATTCTAAGGTGTCTTGACAGGGACGAGCCAGCAAAGCCAACC
TTAGCTTTGGAATATACGTATGGAAGAAGAGCAAAAGGACATAACACACCGAAAGATATCGCTC
ATTTTTGGGAACTGGGTGGAGGAACCTCTTTATTGGACTTAATCAGCATACCCATCACAAGTGA
CACTTTGCGGACATTTTCTATTGTTCTTGTTCTGGATCTTTCAAAACCTAATGACCTTTGGCCA
ACCATGGAAAATCTGTTGCAAGCCACAAGAAGCCATGTAGATAAAGTGATCATGAAACTGGGAA
GGACAAATTCTAAATCAGCTTCTGAAATGAGACAGAAGATATGGAGTAACATGCAGAAGGAACA
TCCCGATCGTGAGTTAATTGACCCATTTCCAGTACCTCTGGTCATAATTGGAAGTAAATATGAT
ATTTTTCAGGATTTTGACTCTGAGAAGAGAAAAGTAATATGCAAGACACTTCGATTTGTTGCAC
ATTATTATGGAGCATCATTGATGTTTACCAGTAAATCAGAAGCTCTATTACTAAAAATACGTGG
AGTTATCAACCAGTTGGCATTTGGCGTCGATAAAAGCAGATCGATCTGTGTGGATCAGAATAAA
CCACTGTTTATCACTGCAGGAATGGATTCTTTATGTCAGATAGGTCCTCCCCCTGTTCCTGATA
ACGACATTGGAAAGTTTCATGCCCACACACCAATGGAGTTGTGGAAAAAAGTGTATGAACAGCT
CTTTCCACCAAAGAGCATGCGCACACTGAAAGATGCCAGGGACCCCGCGCGAGACCCTCAGTAT
GCCGAAAGCGACGTGGACGAGATGAGGGTTCAGAAGGATCAGGAACTGGAGCAGTACAAGAGAA
ATGCTTCCAAGTCTTGGAAACAGATTGATCTTGACTTTTGAGCCTTACTCAGCTATTATATTGA
TTTTTCTTTTCTTTCCCAAGTTCAAGTAAGATTATTTTATTAATTAACTATTGTGGCAATCCGT
GAAGAAAGTTAAGAGATGTGACTGGTTAGAGCAAAAGCTCGATTTTCTCTAATGTGACTCCTTT
CTGGATGCTCTGAAGTCTTTTAAAAGGGAAAAATATTCATGAGAAGCCACTTTGAAGATATCAA
TATGTAATACAACCACCATTGTTAATTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005390991	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000006750
	ENSCLAP00000006750.1

RefSeq Acc Id:

XP_005390991 ⟸ XM_005390934

- UniProtKB:

A0A8C2V1E2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMPFFSTHATTPSLPRELRSLRSWFILPLSVRGVPGWAARRALRVCGPVTMPSETLWEIAKAEV
EKRGSNGNEGDGVESGEKSVFFIGSKNGGKTTIILRCLDRDEPAKPTLALEYTYGRRAKGHNTP
KDIAHFWELGGGTSLLDLISIPITSDTLRTFSIVLVLDLSKPNDLWPTMENLLQATRSHVDKVI
MKLGRTNSKSASEMRQKIWSNMQKEHPDRELIDPFPVPLVIIGSKYDIFQDFDSEKRKVICKTL
RFVAHYYGASLMFTSKSEALLLKIRGVINQLAFGVDKSRSICVDQNKPLFITAGMDSLCQIGPP
PVPDNDIGKFHAHTPMELWKKVYEQLFPPKSMRTLKDARDPARDPQYAESDVDEMRVQKDQELE
QYKRNASKSWKQIDLDF

hide sequence

RefSeq Acc Id:

ENSCLAP00000006750 ⟸ ENSCLAT00000006860

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000004757	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000006860	ENTREZGENE
	ENSCLAT00000006860.1	UniProtKB/TrEMBL
InterPro	DYNC2LI1	UniProtKB/TrEMBL
	Dynein_light_int_chain	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
NCBI Gene	Dync2li1	ENTREZGENE
PANTHER	CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1	UniProtKB/TrEMBL
	PTHR13236	UniProtKB/TrEMBL
Pfam	DLIC	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8C2V1E2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Dync2li1	dynein cytoplasmic 2 light intermediate chain 1		dynein, cytoplasmic 2, light intermediate chain 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM