Upf1 (UPF1 RNA helicase and ATPase) - Rat Genome Database

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Gene: Upf1 (UPF1 RNA helicase and ATPase) Chinchilla lanigera
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Symbol: Upf1
Name: UPF1 RNA helicase and ATPase
RGD ID: 8856738
Description: ENCODES a protein that exhibits ATP hydrolysis activity (ortholog); chromatin binding (ortholog); double-stranded DNA helicase activity (ortholog); INVOLVED IN 3'-UTR-mediated mRNA destabilization (ortholog); cell cycle phase transition (ortholog); DNA repair (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Developmental Disease (ortholog); dextro-looped transposition of the great arteries (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: regulator of nonsense transcripts 1; UPF1 regulator of nonsense transcripts homolog (yeast); UPF1, RNA helicase and ATPase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555242,798,336 - 2,913,176 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555242,798,336 - 2,814,063 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Upf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555242,798,336 - 2,913,176 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555242,798,336 - 2,814,063 (-)NCBIChiLan1.0ChiLan1.0
UPF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,831,959 - 18,868,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,831,959 - 18,868,230 (+)EnsemblGRCh38hg38GRCh38
GRCh371918,942,768 - 18,979,039 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,803,744 - 18,840,039 (+)NCBINCBI36Build 36hg18NCBI36
Build 341918,803,787 - 18,840,038NCBI
Celera1918,847,541 - 18,883,840 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1918,507,089 - 18,543,390 (+)NCBIHuRef
CHM1_11918,942,555 - 18,978,848 (+)NCBICHM1_1
T2T-CHM13v2.01918,967,570 - 19,003,847 (+)NCBIT2T-CHM13v2.0
Upf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,784,143 - 70,806,418 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl870,784,175 - 70,805,928 (-)EnsemblGRCm39 Ensembl
GRCm38870,331,493 - 70,353,423 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,331,525 - 70,353,278 (-)EnsemblGRCm38mm10GRCm38
MGSCv37872,855,421 - 72,877,172 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,260,514 - 73,282,268 (-)NCBIMGSCv36mm8
Celera872,887,999 - 72,909,735 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Upf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81619,110,531 - 19,131,327 (+)NCBIGRCr8
mRatBN7.21619,076,594 - 19,097,365 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1619,076,322 - 19,096,568 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01620,824,888 - 20,845,632 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,824,864 - 20,845,243 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,677,403 - 20,698,177 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1619,266,888 - 19,287,629 (+)NCBICelera
Cytogenetic Map16p14NCBI
UPF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,693,196 - 23,729,529 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,699,421 - 22,735,743 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01918,269,878 - 18,306,199 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11919,293,020 - 19,315,295 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1919,292,725 - 19,313,224 (+)Ensemblpanpan1.1panPan2
UPF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,234,411 - 44,271,129 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,236,264 - 44,270,916 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,149,222 - 44,185,842 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02044,720,750 - 44,757,369 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2044,720,766 - 44,757,522 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12043,958,032 - 43,994,646 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,368,223 - 44,404,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02044,643,707 - 44,680,326 (-)NCBIUU_Cfam_GSD_1.0
Upf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118202,920,305 - 202,956,549 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,468,116 - 2,505,688 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365962,469,444 - 2,505,688 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UPF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl258,975,023 - 59,013,495 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1258,975,013 - 59,013,546 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2258,558,438 - 58,561,969 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UPF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1617,291,189 - 17,328,768 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl617,291,175 - 17,330,193 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660741,996,616 - 2,034,083 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Upf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,910,315 - 1,933,655 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,909,995 - 1,935,370 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000005792   ⟹   ENSCLAP00000005691
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555242,798,336 - 2,814,065 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000005793   ⟹   ENSCLAP00000005692
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555242,799,930 - 2,913,176 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000005794   ⟹   ENSCLAP00000005693
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555242,799,930 - 2,814,581 (-)Ensembl
RefSeq Acc Id: XM_013507221   ⟹   XP_013362675
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555242,798,336 - 2,814,063 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013507222   ⟹   XP_013362676
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555242,798,336 - 2,814,063 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013507223   ⟹   XP_013362677
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555242,798,336 - 2,814,063 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013507224   ⟹   XP_013362678
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555242,798,336 - 2,814,063 (-)NCBI
Sequence:
RefSeq Acc Id: XP_013362678   ⟸   XM_013507224
- Peptide Label: isoform X4
- UniProtKB: A0A8C2UXG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362677   ⟸   XM_013507223
- Peptide Label: isoform X3
- UniProtKB: A0A8C2UXG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362676   ⟸   XM_013507222
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UXG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362675   ⟸   XM_013507221
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UXG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000005693   ⟸   ENSCLAT00000005794
Ensembl Acc Id: ENSCLAP00000005692   ⟸   ENSCLAT00000005793
Ensembl Acc Id: ENSCLAP00000005691   ⟸   ENSCLAT00000005792
Protein Domains
UPF1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000004037 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000005792 ENTREZGENE
  ENSCLAT00000005792.1 UniProtKB/TrEMBL
  ENSCLAT00000005793.1 UniProtKB/TrEMBL
  ENSCLAT00000005794.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.30.230 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  6.10.140.1240 UniProtKB/TrEMBL
InterPro DNA2/NAM7-like UniProtKB/TrEMBL
  DNA2/NAM7-like_C UniProtKB/TrEMBL
  DNA2/NAM7_AAA_11 UniProtKB/TrEMBL
  Helicase/UvrB_N UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  SF1_C_Upf1 UniProtKB/TrEMBL
  UPF1_1B_dom UniProtKB/TrEMBL
  UPF1_CH/ZBD UniProtKB/TrEMBL
NCBI Gene Upf1 ENTREZGENE
PANTHER PTHR10887 UniProtKB/TrEMBL
  REGULATOR OF NONSENSE TRANSCRIPTS 1 UniProtKB/TrEMBL
Pfam AAA_11 UniProtKB/TrEMBL
  AAA_12 UniProtKB/TrEMBL
  ResIII UniProtKB/TrEMBL
  UPF1_1B_dom UniProtKB/TrEMBL
  UPF1_Zn_bind UniProtKB/TrEMBL
PROSITE UPF1_CH_RICH UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C2UW59_CHILA UniProtKB/TrEMBL
  A0A8C2UXG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UZS5_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 Upf1  UPF1 RNA helicase and ATPase    UPF1, RNA helicase and ATPase  Symbol and/or name change 5135510 APPROVED
2016-08-03 Upf1  UPF1, RNA helicase and ATPase    UPF1 regulator of nonsense transcripts homolog (yeast)  Symbol and/or name change 5135510 APPROVED