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Gene: Trh (thyrotropin releasing hormone) Chinchilla lanigera

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Symbol:

Trh

Name:

thyrotropin releasing hormone

RGD ID:

8854456

Description:

ENCODES a protein that exhibits thyrotropin-releasing hormone activity (ortholog); INVOLVED IN adult walking behavior (ortholog); eating behavior (ortholog); histamine metabolic process (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); alkaptonuria (ortholog); amnestic disorder (ortholog); FOUND IN secretory granule (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

thyrotropin-releasing hormone

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955429	17,487,275 - 17,489,385 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

alkaptonuria (ISO)

amnestic disorder (ISO)

Bradycardia (ISO)

Cardiac Arrhythmias (ISO)

Catalepsy (ISO)

Developmental Disabilities (ISO)

endometriosis (ISO)

hypertension (ISO)

Hypothermia (ISO)

hypothyroidism (ISO)

immunodeficiency 21 (ISO)

learning disability (ISO)

narcolepsy (ISO)

Pain (ISO)

Post-Head Injury Coma (ISO)

Primary Lymphedema with Myelodysplasia (ISO)

respiratory failure (ISO)

stereotypic movement disorder (ISO)

Stupor (ISO)

Tachycardia (ISO)

Thyrotropin-Releasing Hormone Deficiency (ISO)

Tremor (ISO)

Unconsciousness (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult walking behavior (ISO)

eating behavior (ISO)

histamine metabolic process (ISO)

negative regulation of feeding behavior (ISO)

negative regulation of glutamate secretion (ISO)

positive regulation of gamma-aminobutyric acid secretion (ISO)

positive regulation of insulin secretion (ISO)

response to corticosterone (ISO)

response to ethanol (ISO)

response to glucose (ISO)

response to hypoxia (ISO)

Cellular Component

secretory granule (ISO)

Molecular Function

protein binding (ISO)

thyrotropin-releasing hormone activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Trh
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955429	17,487,275 - 17,489,385 (-)	NCBI	ChiLan1.0	ChiLan1.0

TRH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	129,974,720 - 129,977,935 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	129,974,688 - 129,977,935 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	129,693,563 - 129,696,778 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	131,176,253 - 131,179,470 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	131,176,260 - 131,179,478	NCBI
Celera	3	128,120,232 - 128,123,896 (+)	NCBI		Celera
Cytogenetic Map	3	q22.1	NCBI
HuRef	3	127,076,564 - 127,080,109 (+)	NCBI		HuRef
CHM1_1	3	129,656,247 - 129,659,792 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	132,718,521 - 132,721,736 (+)	NCBI		T2T-CHM13v2.0

Trh
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	92,219,042 - 92,221,631 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	92,219,042 - 92,221,631 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	92,242,061 - 92,244,650 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	92,242,061 - 92,244,650 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	92,192,056 - 92,194,642 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	92,207,565 - 92,209,391 (-)	NCBI		MGSCv36	mm8
Celera	6	94,137,673 - 94,140,256 (-)	NCBI		Celera
Cytogenetic Map	6	D1	NCBI
cM Map	6	41.03	NCBI

Trh
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	126,299,236 - 126,301,762 (-)	NCBI		GRCr8
mRatBN7.2	4	124,742,111 - 124,777,094 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	124,742,111 - 124,744,637 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	130,209,920 - 130,212,447 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	125,984,348 - 125,986,875 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	124,608,890 - 124,611,417 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	124,110,716 - 124,113,242 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	124,110,716 - 124,113,242 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	189,116,103 - 189,151,296 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	126,425,212 - 126,427,670 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	126,670,058 - 126,672,508 (-)	NCBI
Celera	4	113,659,987 - 113,662,513 (-)	NCBI		Celera
RH 3.4 Map	4	736.33	RGD
Cytogenetic Map	4	q34	NCBI

TRH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	127,905,957 - 127,911,897 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	127,910,679 - 127,916,625 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	127,037,069 - 127,041,299 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	134,383,016 - 134,386,541 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	134,383,016 - 134,387,736 (+)	Ensembl	panpan1.1		panPan2

TRH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	5,219,495 - 5,222,914 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	5,219,594 - 5,222,866 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	5,256,400 - 5,324,009 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	5,240,648 - 5,307,811 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	5,240,655 - 5,244,046 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	4,958,873 - 5,026,447 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	5,309,588 - 5,376,738 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	5,293,272 - 5,360,877 (-)	NCBI		UU_Cfam_GSD_1.0

Trh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404942	18,283,064 - 18,286,124 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936602	623,535 - 626,445 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936602	623,542 - 626,337 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	69,364,093 - 69,365,493 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	69,362,892 - 69,366,183 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	76,784,937 - 76,833,534 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	51,075,814 - 51,079,852 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	51,076,157 - 51,078,236 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	115,412,012 - 115,415,595 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trh
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624872	866,365 - 868,739 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624872	866,370 - 868,624 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005387079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013515365	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01028858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01103008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005387079 ⟹ XP_005387136

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955429	17,487,275 - 17,489,385 (-)	NCBI

Sequence:

show sequence

AGCGCTGGCAGCAGACAACTCGCCCGACCAGGACAGCACCCGGACTGGACCCTCCACCCTCCAG
CCTTGGCCCCGGATCCTCTGCAGACGCCGTGATGCATGGCCCTTGGTGGCCCCTTTCCCTGATC
CTGATCCTGACCAGTGTCCCGAGGGGCCATGCCCAGCAAGAAGCAGCGATGGAGGCTGAGGGTC
CTGGCCTAGACCTCCTGCGGCAGGCAGAGCGCCTACTCCTCCTCCGGGAAGACCTCCAGGGGCT
GCCAGGGGCGCCCATCGAGCATGAGTCCCAGCTCTCGCAGCCCGACTGGCTTTCGAAGCGCCAG
CACCCAGGTAAAAGGGAGGAGGACACTGAGGAGAGGCCTCAAGAAGAGGAGGAGGAAGTGGGTA
CCGTGGGGCTCCACAAGCGGCAGCACCCTGGCCGGCGCTCACCCTGGCTGGAGTACCCGGTCAC
CAAGAGGCAGCACCCAGGCCGAAGGCTGGTAGATCCCCTCAGCCAGAGGAGCTGGGAAGAGGAC
GTGGAGGAGGACAGAGAGGGGGCACCGCTGCCCGAGAAGCGCCAACACCCCGGCAAGAGGGCCC
CAGGAGGGCTGTGTGGGCCCTGGGGTGCCTGTGGCCAAGCCAGCCTCCTGCTGGGGCTCCTGGA
TGACCTGAGTCGGGGCCAGGGGGCCCAGGAGAAGCGGCAGCACCCAGGGCGGCGAGCATCCTGG
GCTAGGGAGCCCCTGGAAGCGTGAGCCTCGCTTCCTGTGTATAGAGTTGGGGTCCAGGACACCT
GAGCCCTGTGTGCCCCAGCTCTTCTCAGCCCCCAGCCCCTCCTTAGACCCCACCGCACACCTGA
GCCCTTCCTTCAGGGACGCAACAGCCAGCCAAGAAGGGAAACCCACACTGCCCATACCTGAGCC
CCTTTCTTCCACGTCGTCTAAGGAGCCCCATAGAGAGCAGGCGCCAGGATGTCCATGCCCAGCT
CCTGTCCCCTGCTGCATGCGGCCAGACTCTCAGCGTGCGCCCTGCCCCAGCCCCAGTTCTGGCT
TCCCGGGCTCCTCCTGTGGGTGGGCAGAGCCTCTCCGTGCTGCAATCTCTGGGGATATTGGTCT
GGGAAACTCCAGCGCTGCTGGTGGCTGTGAGCACAGATGAGTTTGGGAACAGACATCACCCTAG
AAGACCTGGCTCCTGTGTAACCCTCTAGGCACCCTGCCCTGTCCACAAGAGTCACCCCTAATGA
CAATAAAGTGCCCACTGGACCGTC

hide sequence

RefSeq Acc Id:

XM_013515365 ⟹ XP_013370819

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955429	17,487,275 - 17,489,344 (-)	NCBI

Sequence:

show sequence

GGACTGGACCCTCCACCCTCCAGCCTTGGCCCCGGATCCTCTGCAGGTGGGACCCCCGACCCTC
AGCCCACAGGACCCTGGCTCCTGGCCCCTGACTCGAGACGCCGTGATGCATGGCCCTTGGTGGC
CCCTTTCCCTGATCCTGATCCTGACCAGTGTCCCGAGGGGCCATGCCCAGCAAGAAGCAGCGAT
GGAGGCTGAGGGTCCTGGCCTAGACCTCCTGCGGCAGGCAGAGCGCCTACTCCTCCTCCGGGAA
GACCTCCAGGGGCTGCCAGGGGCGCCCATCGAGCATGAGTCCCAGCTCTCGCAGCCCGACTGGC
TTTCGAAGCGCCAGCACCCAGGTAAAAGGGAGGAGGACACTGAGGAGAGGCCTCAAGAAGAGGA
GGAGGAAGTGGGTACCGTGGGGCTCCACAAGCGGCAGCACCCTGGCCGGCGCTCACCCTGGCTG
GAGTACCCGGTCACCAAGAGGCAGCACCCAGGCCGAAGGCTGGTAGATCCCCTCAGCCAGAGGA
GCTGGGAAGAGGACGTGGAGGAGGACAGAGAGGGGGCACCGCTGCCCGAGAAGCGCCAACACCC
CGGCAAGAGGGCCCCAGGAGGGCTGTGTGGGCCCTGGGGTGCCTGTGGCCAAGCCAGCCTCCTG
CTGGGGCTCCTGGATGACCTGAGTCGGGGCCAGGGGGCCCAGGAGAAGCGGCAGCACCCAGGGC
GGCGAGCATCCTGGGCTAGGGAGCCCCTGGAAGCGTGAGCCTCGCTTCCTGTGTATAGAGTTGG
GGTCCAGGACACCTGAGCCCTGTGTGCCCCAGCTCTTCTCAGCCCCCAGCCCCTCCTTAGACCC
CACCGCACACCTGAGCCCTTCCTTCAGGGACGCAACAGCCAGCCAAGAAGGGAAACCCACACTG
CCCATACCTGAGCCCCTTTCTTCCACGTCGTCTAAGGAGCCCCATAGAGAGCAGGCGCCAGGAT
GTCCATGCCCAGCTCCTGTCCCCTGCTGCATGCGGCCAGACTCTCAGCGTGCGCCCTGCCCCAG
CCCCAGTTCTGGCTTCCCGGGCTCCTCCTGTGGGTGGGCAGAGCCTCTCCGTGCTGCAATCTCT
GGGGATATTGGTCTGGGAAACTCCAGCGCTGCTGGTGGCTGTGAGCACAGATGAGTTTGGGAAC
AGACATCACCCTAGAAGACCTGGCTCCTGTGTAACCCTCTAGGCACCCTGCCCTGTCCACAAGA
GTCACCCCTAATGACAATAAAGTGCCCACTGGACCGTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005387136	(Get FASTA)	NCBI Sequence Viewer
	XP_013370819	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005387136 ⟸ XM_005387079

- Sequence:

show sequence

MHGPWWPLSLILILTSVPRGHAQQEAAMEAEGPGLDLLRQAERLLLLREDLQGLPGAPIEHESQ
LSQPDWLSKRQHPGKREEDTEERPQEEEEEVGTVGLHKRQHPGRRSPWLEYPVTKRQHPGRRLV
DPLSQRSWEEDVEEDREGAPLPEKRQHPGKRAPGGLCGPWGACGQASLLLGLLDDLSRGQGAQE
KRQHPGRRASWAREPLEA

hide sequence

RefSeq Acc Id:

XP_013370819 ⟸ XM_013515365

- Sequence:

show sequence

MHGPWWPLSLILILTSVPRGHAQQEAAMEAEGPGLDLLRQAERLLLLREDLQGLPGAPIEHESQ
LSQPDWLSKRQHPGKREEDTEERPQEEEEEVGTVGLHKRQHPGRRSPWLEYPVTKRQHPGRRLV
DPLSQRSWEEDVEEDREGAPLPEKRQHPGKRAPGGLCGPWGACGQASLLLGLLDDLSRGQGAQE
KRQHPGRRASWAREPLEA

hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Trh	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Trh	thyrotropin releasing hormone		thyrotropin-releasing hormone	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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