Rapgef2 (Rap guanine nucleotide exchange factor 2) - Rat Genome Database

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Gene: Rapgef2 (Rap guanine nucleotide exchange factor 2) Chinchilla lanigera
Analyze
Symbol: Rapgef2
Name: Rap guanine nucleotide exchange factor 2
RGD ID: 8850129
Description: ENCODES a protein that exhibits beta-1 adrenergic receptor binding (ortholog); cAMP binding (ortholog); cGMP binding (ortholog); INVOLVED IN adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); blood vessel development (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ortholog); PARTICIPATES IN adenosine signaling pathway; ASSOCIATED WITH familial adult myoclonic epilepsy 7 (ortholog); genetic disease (ortholog); Myoclonic Epilepsies (ortholog); FOUND IN apical plasma membrane (ortholog); bicellular tight junction (ortholog); cell-cell junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Rap guanine nucleotide exchange factor (GEF) 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547112,670,764 - 12,815,430 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547112,670,837 - 12,838,910 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rapgef2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547112,670,764 - 12,815,430 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547112,670,837 - 12,838,910 (+)NCBIChiLan1.0ChiLan1.0
RAPGEF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384159,103,079 - 159,360,173 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4159,103,013 - 159,360,174 (+)EnsemblGRCh38hg38GRCh38
GRCh374160,024,231 - 160,281,325 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364160,408,448 - 160,500,752 (+)NCBINCBI36Build 36hg18NCBI36
Celera4157,529,482 - 157,621,655 (+)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4155,939,342 - 156,031,440 (+)NCBIHuRef
CHM1_14160,165,501 - 160,257,796 (+)NCBICHM1_1
T2T-CHM13v2.04162,453,893 - 162,710,940 (+)NCBIT2T-CHM13v2.0
Rapgef2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39378,969,818 - 79,194,681 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl378,969,823 - 79,193,824 (-)EnsemblGRCm39 Ensembl
GRCm38379,062,511 - 79,286,545 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl379,062,516 - 79,286,517 (-)EnsemblGRCm38mm10GRCm38
MGSCv37378,866,450 - 78,949,797 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36379,148,443 - 79,372,981 (-)NCBIMGSCv36mm8
MGSCv36379,728,293 - 79,956,813 (-)NCBIMGSCv36mm8
Celera379,094,490 - 79,178,178 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map334.91NCBI
Rapgef2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82166,505,868 - 166,728,139 (-)NCBIGRCr8
mRatBN7.22164,207,513 - 164,322,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2164,207,513 - 164,244,247 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2171,425,256 - 171,539,995 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02169,440,712 - 169,555,299 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02164,049,532 - 164,164,134 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02177,836,191 - 178,057,378 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2177,836,202 - 178,057,157 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02197,171,946 - 197,285,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42170,472,420 - 170,587,987 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12170,422,533 - 170,512,880 (-)NCBI
Celera2158,305,258 - 158,419,241 (-)NCBICelera
Cytogenetic Map2q33NCBI
RAPGEF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23156,967,271 - 157,228,616 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14157,322,566 - 157,584,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04151,419,402 - 151,680,769 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14163,316,387 - 163,489,514 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4163,316,396 - 163,487,495 (+)Ensemblpanpan1.1panPan2
RAPGEF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11556,133,094 - 56,353,609 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1556,174,578 - 56,352,569 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1556,473,491 - 56,715,382 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01556,855,560 - 57,097,663 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1556,855,619 - 57,097,663 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11556,092,734 - 56,334,363 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01556,190,343 - 56,432,335 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01556,504,459 - 56,746,362 (+)NCBIUU_Cfam_GSD_1.0
Rapgef2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530133,800,312 - 33,963,070 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365765,583,805 - 5,746,671 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365765,583,847 - 5,746,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl848,021,604 - 48,277,454 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1848,183,518 - 48,277,476 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2850,390,322 - 50,684,115 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17105,672,583 - 105,883,544 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7105,624,608 - 105,884,366 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603785,337,825 - 85,597,514 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgef2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248483,968,362 - 4,182,885 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248483,968,845 - 4,184,740 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000021360   ⟹   ENSCLAP00000021159
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495547112,670,764 - 12,815,430 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000021361   ⟹   ENSCLAP00000021160
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495547112,670,764 - 12,815,430 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000021362   ⟹   ENSCLAP00000021161
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495547112,670,764 - 12,815,430 (+)Ensembl
RefSeq Acc Id: XM_013522900   ⟹   XP_013378354
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495547112,670,837 - 12,838,910 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013378354 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021159.1
  ENSCLAP00000021160
  ENSCLAP00000021160.1
  ENSCLAP00000021161.1
Reference Protein Sequences
RefSeq Acc Id: XP_013378354   ⟸   XM_013522900
- UniProtKB: A0A8C2VV81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000021160   ⟸   ENSCLAT00000021361
RefSeq Acc Id: ENSCLAP00000021159   ⟸   ENSCLAT00000021360
RefSeq Acc Id: ENSCLAP00000021161   ⟸   ENSCLAT00000021362
Protein Domains
Cyclic nucleotide-binding   N-terminal Ras-GEF   PDZ   Ras-associating   Ras-GEF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014491 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021360.1 UniProtKB/TrEMBL
  ENSCLAT00000021361 ENTREZGENE
  ENSCLAT00000021361.1 UniProtKB/TrEMBL
  ENSCLAT00000021362.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  RA_dom UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene Rapgef2 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE RAS GEF UniProtKB/TrEMBL
  CYTOSKELETON-ASSOCIATED PROTEIN 4 UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
  PF00788 UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PS50200 UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
  SM00314 UniProtKB/TrEMBL
Superfamily-SCOP SSF48366 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF51206 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8C2VV81 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VVL3_CHILA UniProtKB/TrEMBL
  A0A8C2YT12_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Rapgef2  Rap guanine nucleotide exchange factor 2    Rap guanine nucleotide exchange factor (GEF) 2  Symbol and/or name change 5135510 APPROVED