Eps15 (epidermal growth factor receptor pathway substrate 15) - Rat Genome Database

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Gene: Eps15 (epidermal growth factor receptor pathway substrate 15) Chinchilla lanigera
Analyze
Symbol: Eps15
Name: epidermal growth factor receptor pathway substrate 15
RGD ID: 8841814
Description: ENCODES a protein that exhibits identical protein binding (ortholog); polyubiquitin modification-dependent protein binding (ortholog); ubiquitin binding (ortholog); INVOLVED IN clathrin coat assembly (ortholog); endocytic recycling (ortholog); Golgi to endosome transport (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; Notch signaling pathway; FOUND IN aggresome (ortholog); AP-2 adaptor complex (ortholog); apical plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: epidermal growth factor receptor substrate 15
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554647,569,566 - 7,688,098 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554647,569,570 - 7,688,098 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Eps15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554647,569,566 - 7,688,098 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554647,569,570 - 7,688,098 (+)NCBIChiLan1.0ChiLan1.0
EPS15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38151,354,263 - 51,519,266 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl151,354,263 - 51,519,328 (-)EnsemblGRCh38hg38GRCh38
GRCh37151,819,935 - 51,984,938 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36151,592,523 - 51,757,583 (-)NCBINCBI36Build 36hg18NCBI36
Build 34151,531,955 - 51,697,016NCBI
Celera150,106,464 - 50,271,514 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef149,937,536 - 50,064,736 (-)NCBIHuRef
CHM1_1151,937,379 - 52,102,411 (-)NCBICHM1_1
T2T-CHM13v2.0151,234,162 - 51,399,178 (-)NCBIT2T-CHM13v2.0
Eps15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394109,137,372 - 109,245,014 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4109,137,465 - 109,245,014 (+)EnsemblGRCm39 Ensembl
GRCm384109,280,175 - 109,387,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4109,280,268 - 109,387,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv374108,952,880 - 109,060,422 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364108,778,235 - 108,883,626 (+)NCBIMGSCv36mm8
Celera4107,626,627 - 107,727,939 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map451.29NCBI
Eps15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85129,274,487 - 129,374,856 (+)NCBIGRCr8
mRatBN7.25124,045,865 - 124,146,221 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5124,045,926 - 124,146,221 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5126,662,232 - 126,762,454 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05128,385,293 - 128,485,514 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05128,436,588 - 128,536,804 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05128,923,809 - 129,022,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5128,923,934 - 129,022,054 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05132,763,094 - 132,861,698 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45130,639,805 - 130,739,014 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15130,645,030 - 130,744,240 (+)NCBI
Celera5122,775,022 - 122,873,141 (+)NCBICelera
Cytogenetic Map5q34-q35NCBI
EPS15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21175,347,708 - 175,512,679 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11174,488,255 - 174,653,230 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0150,598,692 - 50,763,585 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1152,097,387 - 52,223,533 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl152,097,387 - 52,223,533 (-)Ensemblpanpan1.1panPan2
EPS15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1159,834,285 - 9,895,755 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl159,787,260 - 9,893,540 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,904,456 - 10,047,227 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0159,877,844 - 10,020,742 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl159,877,855 - 10,020,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1159,689,665 - 9,832,450 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0159,778,543 - 9,921,371 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,794,994 - 9,938,012 (+)NCBIUU_Cfam_GSD_1.0
Eps15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505865,928,976 - 66,023,422 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365229,438,929 - 9,486,781 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPS15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6160,653,917 - 160,801,288 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16160,653,818 - 160,792,516 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26148,356,480 - 148,494,390 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPS15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12081,439,017 - 81,599,626 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2081,439,025 - 81,602,710 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603335,638,865 - 35,801,433 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eps15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248591,584,024 - 1,754,395 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000007276   ⟹   ENSCLAP00000007163
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554647,569,566 - 7,688,098 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000007277   ⟹   ENSCLAP00000007164
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554647,569,570 - 7,685,681 (+)Ensembl
RefSeq Acc Id: XM_005398604   ⟹   XP_005398661
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554647,569,570 - 7,688,098 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013521700   ⟹   XP_013377154
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554647,569,570 - 7,688,098 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013521701   ⟹   XP_013377155
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554647,569,570 - 7,688,098 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013521702   ⟹   XP_013377156
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554647,569,570 - 7,685,621 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005398661   ⟸   XM_005398604
- Peptide Label: isoform X3
- UniProtKB: A0A8C2YLD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013377154   ⟸   XM_013521700
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YLD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013377155   ⟸   XM_013521701
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YLD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013377156   ⟸   XM_013521702
- Peptide Label: isoform X4
- UniProtKB: A0A8C2YLD0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000007164   ⟸   ENSCLAT00000007277
Ensembl Acc Id: ENSCLAP00000007163   ⟸   ENSCLAT00000007276
Protein Domains
EF-hand   EH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005042 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000007276 ENTREZGENE
  ENSCLAT00000007276.1 UniProtKB/TrEMBL
  ENSCLAT00000007277 ENTREZGENE
  ENSCLAT00000007277.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  EH_dom UniProtKB/TrEMBL
  UIM_dom UniProtKB/TrEMBL
NCBI Gene Eps15 ENTREZGENE
PANTHER EH DOMAIN UniProtKB/TrEMBL
  EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE 15 UniProtKB/TrEMBL
Pfam EF-hand_4 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PS50031 UniProtKB/TrEMBL
  UIM UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
  SM00027 UniProtKB/TrEMBL
  UIM UniProtKB/TrEMBL
Superfamily-SCOP Myosin rod fragments UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
UniProt A0A8C2YLD0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YLD1_CHILA UniProtKB/TrEMBL