Gcg (glucagon) - Rat Genome Database

Name: Gcg
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Gcg (glucagon) Chinchilla lanigera

Analyze

Symbol:

Gcg

Name:

glucagon

RGD ID:

8840939

Description:

ENCODES a protein that exhibits gastric inhibitory polypeptide receptor binding (ortholog); glucagon receptor binding (ortholog); hormone activity (ortholog); INVOLVED IN positive regulation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN forkhead class A signaling pathway; glucagon signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); Alzheimer's disease (ortholog); Anorexia (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

RGD Orthologs

Human

Mouse

Rat

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GCG (glucagon)	NCBI	Ortholog
Mus musculus (house mouse):	Gcg (glucagon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Gcg (glucagon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GCG (glucagon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GCG (glucagon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gcg (glucagon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GCG (glucagon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GCG (glucagon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gcg (glucagon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955449	11,708,152 - 11,716,429 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955449	11,708,152 - 11,716,429 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aberrant Crypt Foci (ISO)

Alzheimer's disease (ISO)

Anorexia (ISO)

autistic disorder (ISO)

Bradycardia (ISO)

Catalepsy (ISO)

colitis (ISO)

Colonic Neoplasms (ISO)

Coma (ISO)

congestive heart failure (ISO)

Constipation (ISO)

Experimental Diabetes Mellitus (ISO)

familial hyperlipidemia (ISO)

genetic disease (ISO)

heart disease (ISO)

hyperglycemia (ISO)

hyperinsulinism (ISO)

Hyperkinesis (ISO)

hypertension (ISO)

Hypotension (ISO)

Hypothermia (ISO)

Myocardial Reperfusion Injury (ISO)

obesity (ISO)

Poisoning (ISO)

prediabetes syndrome (ISO)

Sinus Tachycardia (ISO)

Spasm (ISO)

stomach disease (ISO)

Tachycardia (ISO)

Taste Disorders (ISO)

type 2 diabetes mellitus (ISO)

vascular disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ISO)

cellular response to glucagon stimulus (ISO)

gluconeogenesis (ISO)

glucose homeostasis (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of appetite (ISO)

negative regulation of execution phase of apoptosis (ISO)

negative regulation of intrinsic apoptotic signaling pathway (ISO)

positive regulation of adenylate cyclase activity (IDA)

positive regulation of bicellular tight junction assembly (ISO)

positive regulation of calcium ion import (ISO)

positive regulation of ERK1 and ERK2 cascade (ISO)

positive regulation of gluconeogenesis (ISO)

positive regulation of histone H3-K4 methylation (ISO)

positive regulation of insulin secretion involved in cellular response to glucose stimulus (ISO)

positive regulation of peptidyl-serine phosphorylation (ISO)

positive regulation of peptidyl-threonine phosphorylation (ISO)

positive regulation of protein binding (ISO)

positive regulation of protein kinase activity (ISO)

protein kinase A signaling (ISO)

regulation of insulin secretion (ISO)

response to activity (ISO)

response to L-arginine (ISO)

Cellular Component

cytoplasm (ISO)

extracellular space (ISO)

plasma membrane (ISO)

Molecular Function

gastric inhibitory polypeptide receptor binding (ISO)

glucagon receptor binding (ISO)

hormone activity (ISO)

identical protein binding (ISO)

protein binding (ISO)

receptor ligand activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

forkhead class A signaling pathway (ISO)

glucagon signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	Purification of peptide hormones from chinchilla pancreas by chemical assay.	Eng J, etal., Peptides. 1990 Jul-Aug;11(4):683-5.

Genomics

Comparative Map Data

Gcg
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955449	11,708,152 - 11,716,429 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955449	11,708,152 - 11,716,429 (+)	NCBI	ChiLan1.0	ChiLan1.0

GCG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	162,142,882 - 162,152,247 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	162,142,882 - 162,152,404 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	162,999,392 - 163,008,757 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	162,707,634 - 162,717,003 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	162,824,894 - 162,834,264	NCBI
Celera	2	156,609,679 - 156,619,210 (-)	NCBI		Celera
Cytogenetic Map	2	q24.2	NCBI
HuRef	2	154,881,734 - 154,891,273 (-)	NCBI		HuRef
CHM1_1	2	163,005,267 - 163,014,802 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	162,599,534 - 162,608,895 (-)	NCBI		T2T-CHM13v2.0

Gcg
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	62,304,874 - 62,313,997 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	62,304,874 - 62,313,994 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	62,474,530 - 62,483,653 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	62,474,530 - 62,483,650 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	62,312,587 - 62,321,710 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	62,275,369 - 62,284,492 (-)	NCBI		MGSCv36	mm8
Celera	2	64,164,668 - 64,173,806 (-)	NCBI		Celera
Cytogenetic Map	2	C1.3	NCBI
cM Map	2	35.85	NCBI

Gcg
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	47,113,914 - 47,122,929 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	47,113,914 - 47,122,929 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	50,468,582 - 50,477,739 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	59,052,116 - 59,061,273 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	56,825,210 - 56,834,365 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	48,442,635 - 48,451,650 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	48,442,635 - 48,451,650 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	55,108,272 - 55,117,287 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	44,433,180 - 44,438,004 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	44,329,550 - 44,334,376 (-)	NCBI
Celera	3	46,755,241 - 46,764,256 (-)	NCBI		Celera
RH 3.4 Map	3	602.83	RGD
Cytogenetic Map	3	q21	NCBI

GCG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	2B	64,850,018 - 64,856,247 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	49,436,379 - 49,446,559 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	166,804,877 - 166,814,374 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	166,806,016 - 166,811,155 (-)	Ensembl	panpan1.1		panPan2

GCG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	7,544,637 - 7,554,171 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	7,544,637 - 7,554,021 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	7,688,385 - 7,697,769 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	7,676,373 - 7,685,875 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	7,676,373 - 7,685,757 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	7,695,095 - 7,704,477 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	7,736,177 - 7,745,567 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	7,843,487 - 7,852,871 (-)	NCBI		UU_Cfam_GSD_1.0

Gcg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	124,701,669 - 124,710,958 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	16,906,658 - 16,916,045 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936469	16,906,658 - 16,916,045 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GCG
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	68,800,560 - 68,810,242 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	68,800,557 - 68,810,268 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	76,292,316 - 76,302,025 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GCG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	47,550,097 - 47,560,610 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666040	151,966,064 - 151,975,601 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gcg
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	3,362,234 - 3,370,536 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624732	3,361,897 - 3,370,020 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005393317	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013518788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01042092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCLAT00000003717 ⟹ ENSCLAP00000003643

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955449	11,708,152 - 11,716,429 (+)	Ensembl

RefSeq Acc Id:

XM_005393317 ⟹ XP_005393374

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955449	11,708,152 - 11,716,429 (+)	NCBI

Sequence:

show sequence

CACAGTGGGCTGGCCCGCTAAGCGCTCCACCTATTCCGCACCACACCCTACCAGCAGAAGGCAG
CAAAAATGAAGAGCATTTACTTTGTGGCTGGATTGTTTATAATGCTGGTACAAGGCAGCTGGCA
ACGTTCCCTTCAAGACACAGAGGAGAATCCCAGATCTTTCTCAGCTTCCCGAGCAGACGTGCTG
GATGATCCAGACCAGATGAATGAAGACAAGCGTCATTCACAGGGCACATTCACCAGTGACTATA
GCAAGCACCTGGACTCCAGGTATGCTCAAGAGTTTGTGCAGTGGCTGATGAACACCAAGAGGAA
CAGGAATAACATTGCCAAACGTCATGATGAATTTGAGAGACATGCTGAAGGGACCTTTACTAGC
GATGTCAGTTCTTATTTGGAAGGCCAAGCTGCAAAAGAATTCATTGCTTGGCTGGTGAAAGGCC
GAGGAAGACGAGACTTTCCAGAAGAAGTCACCATTGTTGAAGAACTCCGCCGCAGACATGCTGA
TGGTTCTTTCTCAGATGAGATGAACACCGTTCTTGACAATCTTGCCACCAGGGACTTTATCAAC
TGGCTGATTCAGACCAAAATCACTGACAGGAAATAAGTGGGTCATTATTCAAGACCATCTTCAC
ATCGCCTGCCATCCACTTAGGATG

hide sequence

RefSeq Acc Id:

XM_013518788 ⟹ XP_013374242

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955449	11,708,152 - 11,715,855 (+)	NCBI

Sequence:

show sequence

CACAGTGGGCTGGCCCGCTAAGCGCTCCACCTATTCCGCACCACACCCTACCAGCAGAAGGCAG
CAAAAATGAAGAGCATTTACTTTGTGGCTGGATTGTTTATAATGCTGGTACAAGGCAGCTGGCA
ACGTTCCCTTCAAGACACAGAGGAGAATCCCAGATCTTTCTCAGCTTCCCGAGCAGACGTGCTG
GATGATCCAGACCAGATGAATGAAGACAAGCGTCATTCACAGGGCACATTCACCAGTGACTATA
GCAAGCACCTGGACTCCAGGTATGCTCAAGAGTTTGTGCAGTGGCTGATGAACACCAAGAGGAA
CAGGAATAACATTGCCAAACGTCATGATGAATTTGAGAGACATGCTGAAGGGACCTTTACTAGC
GATGTCAGTTCTTATTTGGAAGGCCAAGCTGCAAAAGAATTCATTGCTTGGCTGGTGAAAGGCC
GAGGAAGACGAGACTTTCCAGAAGAAGTCACCATTGTTGAAGAACTCCGCCGCAGACATGCTGA
TGGTTCTTTCTCAGATGAGATGAACACCGTTCTTGACAATCTTGCCACCAGGGACTTTATCAAC
TGGCTGATTCAGACCAAAATCACTGACAGGTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005393374	(Get FASTA)	NCBI Sequence Viewer
	XP_013374242	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_005393374 ⟸ XM_005393317
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2UNV1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKSIYFVAGLFIMLVQGSWQRSLQDTEENPRSFSASRADVLDDPDQMNEDKRHSQGTFTSDYSK HLDSRYAQEFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG RRDFPEEVTIVEELRRRHADGSFSDEMNTVLDNLATRDFINWLIQTKITDRK hide sequence

RefSeq Acc Id:	XP_013374242 ⟸ XM_013518788
- Peptide Label:	isoform X2
- Sequence:	show sequence MKSIYFVAGLFIMLVQGSWQRSLQDTEENPRSFSASRADVLDDPDQMNEDKRHSQGTFTSDYSK HLDSRYAQEFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG RRDFPEEVTIVEELRRRHADGSFSDEMNTVLDNLATRDFINWLIQTKITDR hide sequence

RefSeq Acc Id:

ENSCLAP00000003643 ⟸ ENSCLAT00000003717

Protein Domains

Glucagon / GIP / secretin / VIP family

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000002597	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSCLAP00000003643	ENTREZGENE
	ENSCLAP00000003643.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000003717	ENTREZGENE
	ENSCLAT00000003717.1	UniProtKB/TrEMBL
Gene3D-CATH	6.10.250.590	UniProtKB/TrEMBL
InterPro	Glucagon	UniProtKB/TrEMBL
	Glucagon_GIP_secretin_VIP	UniProtKB/TrEMBL
NCBI Gene	Gcg	ENTREZGENE
PANTHER	PRO-GLUCAGON	UniProtKB/TrEMBL
	PTHR11418	UniProtKB/TrEMBL
Pfam	Hormone_2	UniProtKB/TrEMBL
PROSITE	GLUCAGON	UniProtKB/TrEMBL
SMART	GLUCA	UniProtKB/TrEMBL
UniProt	A0A8C2UNV1	ENTREZGENE, UniProtKB/TrEMBL

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InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

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Imported Annotations - PID (archival)