Azin2 (antizyme inhibitor 2) - Rat Genome Database

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Gene: Azin2 (antizyme inhibitor 2) Chinchilla lanigera
Analyze
Symbol: Azin2
Name: antizyme inhibitor 2
RGD ID: 8835185
Description: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). [provided by RefSeq, Sep 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Adc; arginine decarboxylase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545211,303,499 - 11,330,555 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545211,304,345 - 11,330,370 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:19956990   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Azin2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545211,303,499 - 11,330,555 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545211,304,345 - 11,330,370 (+)NCBIChiLan1.0ChiLan1.0
AZIN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38133,081,153 - 33,166,795 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl133,081,104 - 33,123,492 (+)EnsemblGRCh38hg38GRCh38
GRCh37133,546,754 - 33,589,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36133,319,301 - 33,358,582 (+)NCBINCBI36Build 36hg18NCBI36
Celera131,816,917 - 31,856,199 (+)NCBICelera
Cytogenetic Map1p35.1NCBI
HuRef131,662,672 - 31,701,953 (+)NCBIHuRef
CHM1_1133,662,239 - 33,701,504 (+)NCBICHM1_1
T2T-CHM13v2.0132,941,046 - 33,025,345 (+)NCBIT2T-CHM13v2.0
Azin2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394128,824,026 - 128,856,250 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4128,824,026 - 128,856,235 (-)EnsemblGRCm39 Ensembl
GRCm384128,930,233 - 128,962,456 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4128,930,233 - 128,962,442 (-)EnsemblGRCm38mm10GRCm38
MGSCv374128,609,390 - 128,639,661 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364128,434,450 - 128,464,721 (-)NCBIMGSCv36mm8
Celera4127,269,823 - 127,300,290 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map462.48NCBI
Azin2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,568,187 - 146,594,777 (-)NCBIGRCr8
mRatBN7.25141,281,310 - 141,310,415 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,281,249 - 141,310,397 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5143,981,604 - 144,008,307 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05145,751,428 - 145,778,134 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05145,751,282 - 145,777,336 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,120,128 - 147,148,576 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,120,129 - 147,148,291 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05150,852,122 - 150,878,525 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,100,546 - 148,110,453 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5139,766,112 - 139,793,390 (-)NCBICelera
Cytogenetic Map5q36NCBI
AZIN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21193,707,944 - 193,747,394 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11192,830,125 - 192,869,587 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,365,430 - 32,404,880 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1133,550,140 - 33,629,953 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl133,550,140 - 33,589,402 (+)Ensemblpanpan1.1panPan2
AZIN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,288,554 - 68,323,710 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,286,195 - 68,323,710 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha264,868,938 - 64,903,660 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0268,852,964 - 68,887,963 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,853,095 - 68,887,963 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,665,607 - 65,700,276 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0266,688,183 - 66,722,680 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0267,680,112 - 67,714,721 (-)NCBIUU_Cfam_GSD_1.0
Azin2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505850,116,873 - 50,148,699 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647415,941,620 - 15,973,745 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647415,941,655 - 15,973,481 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AZIN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl689,345,862 - 89,385,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1689,346,860 - 89,385,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2683,490,513 - 83,529,154 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AZIN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12099,757,861 - 99,804,671 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603316,893,178 - 16,935,047 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Azin2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476416,145,308 - 16,175,000 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476416,145,696 - 16,177,588 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000014868   ⟹   ENSCLAP00000014709
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545211,303,499 - 11,330,555 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000014869   ⟹   ENSCLAP00000014710
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545211,304,345 - 11,330,370 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000014870   ⟹   ENSCLAP00000014711
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545211,304,629 - 11,330,555 (+)Ensembl
RefSeq Acc Id: NM_001293750   ⟹   NP_001280679
RefSeq Status: REVIEWED
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545211,304,345 - 11,330,370 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013519440   ⟹   XP_013374894
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545211,304,633 - 11,329,983 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013519441   ⟹   XP_013374895
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545211,307,142 - 11,330,370 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001280679 (Get FASTA)   NCBI Sequence Viewer  
  XP_013374894 (Get FASTA)   NCBI Sequence Viewer  
  XP_013374895 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000014709
  ENSCLAP00000014709.1
  ENSCLAP00000014710
  ENSCLAP00000014710.1
  ENSCLAP00000014711.1
Reference Protein Sequences
RefSeq Acc Id: NP_001280679   ⟸   NM_001293750
- UniProtKB: A0A8C2VF95 (UniProtKB/TrEMBL),   A0A8C2VFA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013374894   ⟸   XM_013519440
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VFA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013374895   ⟸   XM_013519441
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VKQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000014709   ⟸   ENSCLAT00000014868
RefSeq Acc Id: ENSCLAP00000014710   ⟸   ENSCLAT00000014869
RefSeq Acc Id: ENSCLAP00000014711   ⟸   ENSCLAT00000014870
Protein Domains
Orn/DAP/Arg decarboxylase 2 C-terminal   Orn/DAP/Arg decarboxylase 2 N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010152 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000014868 ENTREZGENE
  ENSCLAT00000014868.1 UniProtKB/TrEMBL
  ENSCLAT00000014869 ENTREZGENE
  ENSCLAT00000014869.1 UniProtKB/TrEMBL
  ENSCLAT00000014870.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.10 UniProtKB/TrEMBL
InterPro Ala_racemase/Decarboxylase_C UniProtKB/TrEMBL
  De-COase2_C UniProtKB/TrEMBL
  De-COase2_N UniProtKB/TrEMBL
  Orn/DAP/Arg_de-COase UniProtKB/TrEMBL
  Orn_de-COase UniProtKB/TrEMBL
  PLP-binding_barrel UniProtKB/TrEMBL
NCBI Gene Azin2 ENTREZGENE
PANTHER PTHR11482 UniProtKB/TrEMBL
  PTHR11482:SF4 UniProtKB/TrEMBL
Pfam Orn_Arg_deC_N UniProtKB/TrEMBL
  Orn_DAP_Arg_deC UniProtKB/TrEMBL
PRINTS ODADCRBXLASE UniProtKB/TrEMBL
  ORNDCRBXLASE UniProtKB/TrEMBL
Superfamily-SCOP SSF50621 UniProtKB/TrEMBL
  SSF51419 UniProtKB/TrEMBL
UniProt A0A8C2VF95 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VFA3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VKQ5 ENTREZGENE, UniProtKB/TrEMBL