Atf4 (activating transcription factor 4) - Rat Genome Database

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Gene: Atf4 (activating transcription factor 4) Chinchilla lanigera
Analyze
Symbol: Atf4
Name: activating transcription factor 4
RGD ID: 8835135
Description: ENCODES a protein that exhibits cAMP response element binding protein binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN bone mineralization (ortholog); cellular calcium ion homeostasis (ortholog); cellular response to amino acid starvation (ortholog); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); borna disease (ortholog); fatty liver disease (ortholog); FOUND IN ATF1-ATF4 transcription factor complex (ortholog); ATF4-CREB1 transcription factor complex (ortholog); centrosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cyclic AMP-dependent transcription factor ATF-4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,406,589 - 25,412,218 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,406,589 - 25,408,727 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bone mineralization  (ISO)
cellular calcium ion homeostasis  (ISO)
cellular response to amino acid starvation  (ISO)
cellular response to dopamine  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to leucine starvation  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to oxygen-glucose deprivation  (ISO)
circadian regulation of gene expression  (ISO)
circadian rhythm  (ISO)
embryonic hemopoiesis  (ISO)
endoplasmic reticulum unfolded protein response  (ISO)
gamma-aminobutyric acid signaling pathway  (ISO)
gluconeogenesis  (ISO)
HRI-mediated signaling  (ISO)
integrated stress response signaling  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
L-asparagine metabolic process  (ISO)
lens fiber cell morphogenesis  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of oxidative stress-induced neuron death  (ISO)
negative regulation of potassium ion transport  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron differentiation  (ISO)
PERK-mediated unfolded protein response  (ISO)
positive regulation of biomineral tissue development  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of sodium-dependent phosphate transport  (ISO)
positive regulation of transcription by RNA polymerase I  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of osteoblast differentiation  (ISO)
regulation of synaptic plasticity  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to manganese-induced endoplasmic reticulum stress  (ISO)
response to nutrient levels  (ISO)
response to toxic substance  (ISO)
transcription by RNA polymerase II  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations

Genomics

Comparative Map Data
Atf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,406,589 - 25,412,218 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,406,589 - 25,408,727 (+)NCBIChiLan1.0ChiLan1.0
ATF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,520,559 - 39,522,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2239,519,695 - 39,522,683 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,916,564 - 39,918,691 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,246,515 - 38,248,637 (+)NCBINCBI36hg18NCBI36
Build 342238,241,068 - 38,243,191NCBI
Celera2223,718,625 - 23,720,747 (+)NCBI
Cytogenetic Map22q13.1NCBI
HuRef2222,881,158 - 22,883,280 (+)NCBIHuRef
CHM1_12239,875,308 - 39,877,431 (+)NCBICHM1_1
T2T-CHM13v2.02239,991,189 - 39,993,317 (+)NCBI
Atf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,139,385 - 80,141,746 (+)NCBIGRCm39mm39
GRCm39 Ensembl1580,139,385 - 80,141,742 (+)Ensembl
GRCm381580,255,184 - 80,257,545 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1580,255,184 - 80,257,541 (+)EnsemblGRCm38mm10GRCm38
MGSCv371580,085,614 - 80,087,971 (+)NCBIGRCm37mm9NCBIm37
MGSCv361580,082,756 - 80,084,759 (+)NCBImm8
Celera1582,372,526 - 82,374,883 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Atf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27111,804,135 - 111,806,457 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl7111,804,183 - 111,806,446 (+)Ensembl
Rnor_6.07121,480,723 - 121,482,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,480,723 - 121,482,772 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,468,275 - 121,470,587 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,537,718 - 118,538,994NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17118,571,947 - 118,573,223NCBI
Cytogenetic Map7q34NCBI
ATF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12238,246,337 - 38,249,333 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,248,094 - 38,249,249 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02220,426,743 - 20,428,892 (+)NCBIMhudiblu_PPA_v0panPan3
ATF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,528,880 - 25,531,018 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,528,874 - 25,530,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,464,741 - 25,466,879 (-)NCBI
ROS_Cfam_1.01026,280,612 - 26,282,756 (-)NCBI
ROS_Cfam_1.0 Ensembl1026,280,619 - 26,282,738 (-)Ensembl
UMICH_Zoey_3.11025,995,219 - 25,997,329 (-)NCBI
UNSW_CanFamBas_1.01026,314,765 - 26,316,875 (-)NCBI
UU_Cfam_GSD_1.01026,490,223 - 26,492,367 (-)NCBI
Atf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,104,066 - 9,105,487 (-)NCBI
SpeTri2.0NW_0049364922,114,478 - 2,115,969 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,738,880 - 8,745,225 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.158,742,964 - 8,745,752 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,042,584 - 6,044,651 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11922,092,046 - 22,094,184 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1922,091,667 - 22,095,230 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045103,557,595 - 103,561,018 (-)NCBIVero_WHO_p1.0
Atf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247528,822,740 - 8,825,032 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247528,822,955 - 8,825,019 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000025449   ⟹   ENSCLAP00000025203
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541325,406,589 - 25,412,218 (+)Ensembl
RefSeq Acc Id: XM_005379299   ⟹   XP_005379356
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541325,406,589 - 25,408,727 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005379356 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005379356   ⟸   XM_005379299
- Sequence:
RefSeq Acc Id: ENSCLAP00000025203   ⟸   ENSCLAT00000025449
Protein Domains
bZIP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000017308 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000025203 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000025449 ENTREZGENE, UniProtKB/TrEMBL
InterPro ATF4 UniProtKB/TrEMBL
  bZIP UniProtKB/TrEMBL
  bZIP_sf UniProtKB/TrEMBL
NCBI Gene Atf4 ENTREZGENE
PANTHER PTHR13044:SF32 UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/TrEMBL
SMART BRLZ UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/TrEMBL
UniProt A0A8C2W9H9_CHILA UniProtKB/TrEMBL