Atf4 (activating transcription factor 4)

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Gene: Atf4 (activating transcription factor 4) Chinchilla lanigera

Analyze

Symbol:

Atf4

Name:

activating transcription factor 4

RGD ID:

8835135

Description:

ENCODES a protein that exhibits cAMP response element binding protein binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN bone mineralization (ortholog); cellular calcium ion homeostasis (ortholog); cellular response to amino acid starvation (ortholog); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); borna disease (ortholog); fatty liver disease (ortholog); FOUND IN ATF1-ATF4 transcription factor complex (ortholog); ATF4-CREB1 transcription factor complex (ortholog); centrosome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cyclic AMP-dependent transcription factor ATF-4

RGD Orthologs

Human

Mouse

Rat

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	25,406,589 - 25,412,218 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	25,406,589 - 25,408,727 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenylosuccinase lyase deficiency (ISO)

borna disease (ISO)

fatty liver disease (ISO)

Hypoxia (ISO)

invasive ductal carcinoma (ISO)

Necrosis (ISO)

prostate carcinoma (ISO)

prostatic hypertrophy (ISO)

pulmonary venoocclusive disease (ISO)

Spinal Cord Injuries (ISO)

Zika fever (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone mineralization (ISO)

cellular calcium ion homeostasis (ISO)

cellular response to amino acid starvation (ISO)

cellular response to dopamine (ISO)

cellular response to glucose starvation (ISO)

cellular response to leucine starvation (ISO)

cellular response to oxidative stress (ISO)

cellular response to oxygen-glucose deprivation (ISO)

circadian regulation of gene expression (ISO)

circadian rhythm (ISO)

embryonic hemopoiesis (ISO)

endoplasmic reticulum unfolded protein response (ISO)

gamma-aminobutyric acid signaling pathway (ISO)

gluconeogenesis (ISO)

HRI-mediated signaling (ISO)

integrated stress response signaling (ISO)

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (ISO)

L-asparagine metabolic process (ISO)

lens fiber cell morphogenesis (ISO)

mRNA transcription by RNA polymerase II (ISO)

negative regulation of cold-induced thermogenesis (ISO)

negative regulation of oxidative stress-induced neuron death (ISO)

negative regulation of potassium ion transport (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

neuron differentiation (ISO)

PERK-mediated unfolded protein response (ISO)

positive regulation of biomineral tissue development (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of gene expression (ISO)

positive regulation of neuron apoptotic process (ISO)

positive regulation of sodium-dependent phosphate transport (ISO)

positive regulation of transcription by RNA polymerase I (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress (ISO)

positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress (ISO)

positive regulation of vascular associated smooth muscle cell apoptotic process (ISO)

positive regulation of vascular endothelial growth factor production (ISO)

regulation of DNA-templated transcription (ISO)

regulation of osteoblast differentiation (ISO)

regulation of synaptic plasticity (ISO)

regulation of transcription by RNA polymerase II (ISO)

response to endoplasmic reticulum stress (ISO)

response to manganese-induced endoplasmic reticulum stress (ISO)

response to nutrient levels (ISO)

response to toxic substance (ISO)

transcription by RNA polymerase II (ISO)

Cellular Component

ATF1-ATF4 transcription factor complex (ISO)

ATF4-CREB1 transcription factor complex (ISO)

centrosome (ISO)

CHOP-ATF4 complex (ISO)

cytoplasm (ISO)

dendrite membrane (ISO)

Lewy body core (ISO)

neuron projection (ISO)

nuclear periphery (ISO)

nucleus (ISO)

protein-containing complex (ISO)

RNA polymerase II transcription regulator complex (ISO)

transcription regulator complex (ISO)

Molecular Function

cAMP response element binding protein binding (ISO)

DNA binding (ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor binding (ISO)

general transcription initiation factor binding (ISO)

identical protein binding (ISO)

leucine zipper domain binding (ISO)

promoter-specific chromatin binding (ISO)

protein binding (ISO)

protein C-terminus binding (ISO)

protein heterodimerization activity (ISO)

protein kinase binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

transcription cis-regulatory region binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endoplasmic reticulum stress - the unfolded protein response pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations

Genomics

Comparative Map Data

Atf4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	25,406,589 - 25,412,218 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	25,406,589 - 25,408,727 (+)	NCBI	ChiLan1.0	ChiLan1.0

ATF4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	39,520,559 - 39,522,686 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	22	39,519,695 - 39,522,683 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	39,916,564 - 39,918,691 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	38,246,515 - 38,248,637 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	22	38,241,068 - 38,243,191	NCBI
Celera	22	23,718,625 - 23,720,747 (+)	NCBI
Cytogenetic Map	22	q13.1	NCBI
HuRef	22	22,881,158 - 22,883,280 (+)	NCBI		HuRef
CHM1_1	22	39,875,308 - 39,877,431 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	39,991,189 - 39,993,317 (+)	NCBI

Atf4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	80,139,385 - 80,141,746 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	15	80,139,385 - 80,141,742 (+)	Ensembl
GRCm38	15	80,255,184 - 80,257,545 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	80,255,184 - 80,257,541 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	80,085,614 - 80,087,971 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	15	80,082,756 - 80,084,759 (+)	NCBI			mm8
Celera	15	82,372,526 - 82,374,883 (+)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	37.85	NCBI

Atf4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	111,804,135 - 111,806,457 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	7	111,804,183 - 111,806,446 (+)	Ensembl
Rnor_6.0	7	121,480,723 - 121,482,781 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	121,480,723 - 121,482,772 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	121,468,275 - 121,470,587 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	118,537,718 - 118,538,994	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	118,571,947 - 118,573,223	NCBI
Cytogenetic Map	7	q34	NCBI

ATF4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	22	38,246,337 - 38,249,333 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	38,248,094 - 38,249,249 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	22	20,426,743 - 20,428,892 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

ATF4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	25,528,880 - 25,531,018 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	25,528,874 - 25,530,993 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	25,464,741 - 25,466,879 (-)	NCBI
ROS_Cfam_1.0	10	26,280,612 - 26,282,756 (-)	NCBI
ROS_Cfam_1.0 Ensembl	10	26,280,619 - 26,282,738 (-)	Ensembl
UMICH_Zoey_3.1	10	25,995,219 - 25,997,329 (-)	NCBI
UNSW_CanFamBas_1.0	10	26,314,765 - 26,316,875 (-)	NCBI
UU_Cfam_GSD_1.0	10	26,490,223 - 26,492,367 (-)	NCBI

Atf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	9,104,066 - 9,105,487 (-)	NCBI
SpeTri2.0	NW_004936492	2,114,478 - 2,115,969 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATF4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	8,738,880 - 8,745,225 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	8,742,964 - 8,745,752 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	6,042,584 - 6,044,651 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATF4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	22,092,046 - 22,094,184 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	19	22,091,667 - 22,095,230 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666045	103,557,595 - 103,561,018 (-)	NCBI	Vero_WHO_p1.0

Atf4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	8,822,740 - 8,825,032 (-)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624752	8,822,955 - 8,825,019 (-)	NCBI	HetGla_female_1.0		hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005379299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01014405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01240104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCLAT00000025449 ⟹ ENSCLAP00000025203

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955413	25,406,589 - 25,412,218 (+)	Ensembl

RefSeq Acc Id:

XM_005379299 ⟹ XP_005379356

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955413	25,406,589 - 25,408,727 (+)	NCBI

Sequence:

show sequence

GAGGCAGTAGTGCCTGCGGCAGCATTGGCTCTTGCAGCGGCGGCAGTAGCATCAGGCTCTGCAG
CGGCACCCCCCAGCGGCTTAAGCCATGGCGCTTTTCACGGCATCCAGCAGCAGCGTTGCTGTAA
CCGACAAAGACATCTTCGAATTAAGCACATTCCTCGATTCCAGCAAAGCCCCCCAGCATGGCCG
AGATGAGCTTCCTGAGCAGCGAGGTGTTGGGGGGGGACTTGATGTCCCCCTTCGACCAGTCGGG
TTTGGGGGCTGAAGAAAGCTTAGGTCTCTTAGATGACTACCTGGAGGTGGCCAAGCACTTCAAA
CCTCATGGGTTCTCCAGCGACAAGGCTAAGGCGGGCTCCTCCGATTGGCTGGCTGTGGATGAGT
TGGTCAGTGCCTCGGACACCGGCAAGGAGGATGCCTTCTCTGGGACAGATTGGATGTTGGAGAA
AATGGATCTGAAGGAGTTCGATTTTGATGCCCTGTTGAACGTAGATGACCTGGAAACCATGCCA
GATGAGCTTTTGGCCACGTTGGATGACACATGTGATCTCTTTGCCCCAGTAGTCCAGGAGACTA
ATGAGGAGCCCCCCCAGGCAGTGAACCCCATTGGCCATCTTCCAGAAAGTTTAACACAAACTGA
CCAGGTTGCCCCTTTCACCTTCTTGCAACCTTTCCCCCTTTCCCCGGGGGTTCTGTCCTCCACT
CCAGATCATTCCTTCAGCTTAGAGTTAGGCAGTGAGGTGGATATCTCTGAAGGAGATAGGAAAT
CTGACTCTATTGCTTACATTACCTTGGTTCCTCAGTGTTTAAAGGAGGAGGATGCCCCCTCAGA
TAATGACAGTGGCGTCTGTATGAGCCCTGAGTCCTACCCTGGTTCTCCCCAGCACAGCCCCTCT
ACCTCCAGGGGCTCTCCAAATAGGAGCTTGCCATCTCCAGGTGTCCCCTACGCCCGTCCCAAAC
CCTATGATCCCCCCGGAGAGAAGATGGTAGCGGCCAAAGTTAAGGGTGAAAAGCTGGATAAGAA
ACTGAAAAAAATGGAACAAAACAAGACAGCAGCCACCAGGTACCGCCAGAAGAAGCGAGCAGAG
CAAGAGGCCCTCACTGGCGAATGTAAAGAACTGGAAAAGAAAAATGAGGCCCTGAAAGAGAAAG
CAGATTCTCTGGCCAAGGAGATTCAATATCTGAAAGATCTGATAGAAGAGGTCCGCAAAGCCAG
GGGGAAGAAGAGGGTCCCTTAGGGTAGTCAGGAATGCTATGTGCTCGTACATAGGTGTCTTGCG
CTGAAGCTGTGTTGTAATAAATTATTTTGTAGTGAAAGTGCCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005379356	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_005379356 ⟸ XM_005379299

- Sequence:

show sequence

MAEMSFLSSEVLGGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSDWLAV
DELVSASDTGKEDAFSGTDWMLEKMDLKEFDFDALLNVDDLETMPDELLATLDDTCDLFAPVVQ
ETNEEPPQAVNPIGHLPESLTQTDQVAPFTFLQPFPLSPGVLSSTPDHSFSLELGSEVDISEGD
RKSDSIAYITLVPQCLKEEDAPSDNDSGVCMSPESYPGSPQHSPSTSRGSPNRSLPSPGVPYAR
PKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKRAEQEALTGECKELEKKNEALK
EKADSLAKEIQYLKDLIEEVRKARGKKRVP

hide sequence

RefSeq Acc Id:

ENSCLAP00000025203 ⟸ ENSCLAT00000025449

Protein Domains

bZIP

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000017308	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSCLAP00000025203	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000025449	ENTREZGENE, UniProtKB/TrEMBL
InterPro	ATF4	UniProtKB/TrEMBL
	bZIP	UniProtKB/TrEMBL
	bZIP_sf	UniProtKB/TrEMBL
NCBI Gene	Atf4	ENTREZGENE
PANTHER	PTHR13044:SF32	UniProtKB/TrEMBL
Pfam	bZIP_1	UniProtKB/TrEMBL
PROSITE	BZIP	UniProtKB/TrEMBL
	BZIP_BASIC	UniProtKB/TrEMBL
SMART	BRLZ	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57959	UniProtKB/TrEMBL
UniProt	A0A8C2W9H9_CHILA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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