Inpp5k (inositol polyphosphate-5-phosphatase K) - Rat Genome Database

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Gene: Inpp5k (inositol polyphosphate-5-phosphatase K) Chinchilla lanigera
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Symbol: Inpp5k
Name: inositol polyphosphate-5-phosphatase K
RGD ID: 8833200
Description: ENCODES a protein that exhibits inositol bisphosphate phosphatase activity (ortholog); inositol trisphosphate phosphatase activity (ortholog); phosphatidylinositol phosphate 5-phosphatase activity (ortholog); INVOLVED IN cellular response to cAMP (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to hormone stimulus (ortholog); ASSOCIATED WITH congenital muscular dystrophy with cataracts and intellectual disability (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inositol polyphosphate 5-phosphatase K
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,651,902 - 1,673,893 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,651,422 - 1,674,402 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cAMP  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
dephosphorylation  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glucose homeostasis  (ISO)
in utero embryonic development  (ISO)
inositol phosphate dephosphorylation  (ISO)
negative regulation by host of viral transcription  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of dephosphorylation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of glucose transmembrane transport  (ISO)
negative regulation of glycogen (starch) synthase activity  (ISO)
negative regulation of glycogen biosynthetic process  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein targeting to membrane  (ISO)
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate  (ISO)
negative regulation of stress fiber assembly  (ISO)
phosphatidylinositol dephosphorylation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of renal water transport  (ISO)
positive regulation of urine volume  (ISO)
protein localization to plasma membrane  (ISO)
regulation of glycogen biosynthetic process  (ISO)
response to insulin  (ISO)
ruffle assembly  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations

Genomics

Comparative Map Data
Inpp5k
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,651,902 - 1,673,893 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,651,422 - 1,674,402 (+)NCBIChiLan1.0ChiLan1.0
INPP5K
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,494,577 - 1,516,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl171,494,577 - 1,516,742 (-)EnsemblGRCh38hg38GRCh38
GRCh37171,397,871 - 1,419,906 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,344,621 - 1,366,704 (-)NCBINCBI36Build 36hg18NCBI36
Celera171,413,368 - 1,435,621 (-)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,298,037 - 1,320,343 (-)NCBIHuRef
CHM1_1171,406,563 - 1,428,873 (-)NCBICHM1_1
T2T-CHM13v2.0171,383,334 - 1,405,368 (-)NCBIT2T-CHM13v2.0
Inpp5k
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,519,893 - 75,539,691 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,521,814 - 75,539,697 (+)EnsemblGRCm39 Ensembl
GRCm381175,629,067 - 75,648,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,630,988 - 75,648,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv371175,444,522 - 75,462,367 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,447,215 - 75,465,060 (+)NCBIMGSCv36mm8
Celera1183,140,156 - 83,157,894 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.92NCBI
Inpp5k
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21060,474,262 - 60,495,813 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,475,897 - 60,496,773 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01063,775,639 - 63,796,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,776,378 - 63,795,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,209,340 - 64,228,728 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,953,425 - 62,971,016 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,967,047 - 62,984,638 (+)NCBI
Celera1059,503,324 - 59,523,140 (+)NCBICelera
Cytogenetic Map10q24NCBI
INPP5K
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1171,377,310 - 1,399,373 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,377,312 - 1,399,373 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0171,477,511 - 1,499,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
INPP5K
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1945,660,445 - 45,680,407 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl945,660,446 - 45,680,363 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha944,812,547 - 44,832,619 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0946,488,250 - 46,508,538 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl946,487,348 - 46,508,366 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1945,258,657 - 45,278,900 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0945,553,108 - 45,573,180 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0945,606,572 - 45,626,642 (-)NCBIUU_Cfam_GSD_1.0
Inpp5k
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560244,763,537 - 44,785,099 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365387,641,485 - 7,662,033 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INPP5K
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,718,491 - 47,738,475 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,717,898 - 47,738,540 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,602,564 - 49,623,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
INPP5K
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,171,059 - 1,192,241 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl161,170,899 - 1,191,965 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605920,795,694 - 20,817,596 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inpp5k
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,214,916 - 4,236,563 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247864,213,430 - 4,236,930 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000009088   ⟹   ENSCLAP00000008960
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554811,651,902 - 1,673,893 (+)Ensembl
RefSeq Acc Id: XM_013503399   ⟹   XP_013358853
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554811,651,422 - 1,674,402 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013503400   ⟹   XP_013358854
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554811,654,008 - 1,674,402 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013358853 (Get FASTA)   NCBI Sequence Viewer  
  XP_013358854 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013358853   ⟸   XM_013503399
- Peptide Label: isoform X1
- UniProtKB: A0A8C2V6N9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013358854   ⟸   XM_013503400
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000008960   ⟸   ENSCLAT00000009088
Protein Domains
IPPc


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006255 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000008960 ENTREZGENE
  ENSCLAP00000008960.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000009088 ENTREZGENE
  ENSCLAT00000009088.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.10.10 UniProtKB/TrEMBL
InterPro Endo/exonu/phosph_ase_sf UniProtKB/TrEMBL
  IPPc UniProtKB/TrEMBL
  SKICH UniProtKB/TrEMBL
NCBI Gene Inpp5k ENTREZGENE
Pfam SKICH UniProtKB/TrEMBL
SMART IPPc UniProtKB/TrEMBL
Superfamily-SCOP SSF56219 UniProtKB/TrEMBL
UniProt A0A8C2V6N9 ENTREZGENE, UniProtKB/TrEMBL