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Gene: Lpcat3 (lysophosphatidylcholine acyltransferase 3) Chinchilla lanigera

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Symbol:

Lpcat3

Name:

lysophosphatidylcholine acyltransferase 3

RGD ID:

8830637

Description:

ENCODES a protein that exhibits 1-acylglycerophosphocholine O-acyltransferase activity (ortholog); 1-acylglycerophosphoethanolamine O-acyltransferase activity (ortholog); 1-acylglycerophosphoserine O-acyltransferase activity (ortholog); INVOLVED IN chylomicron assembly (ortholog); endoplasmic reticulum membrane organization (ortholog); intestinal stem cell homeostasis (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 21 (ortholog); Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); Klippel-Feil syndrome 3 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

lysophospholipid acyltransferase 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	4,571,028 - 4,605,097 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	4,571,028 - 4,605,097 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy 21 (ISO)

Hyperphosphatemic Familial Tumoral Calcinosis 1 (ISO)

Klippel-Feil syndrome 3 (ISO)

lymphoproliferative syndrome 2 (ISO)

peroxisome biogenesis disorder 2B (ISO)

Temtamy syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chylomicron assembly (ISO)

endoplasmic reticulum membrane organization (ISO)

intestinal stem cell homeostasis (ISO)

negative regulation of inflammatory response (ISO)

negative regulation of response to endoplasmic reticulum stress (ISO)

phosphatidylcholine acyl-chain remodeling (ISO)

phosphatidylethanolamine acyl-chain remodeling (ISO)

phosphatidylserine acyl-chain remodeling (ISO)

positive regulation of intestinal cholesterol absorption (ISO)

positive regulation of triglyceride transport (ISO)

regulation of cholesterol biosynthetic process (ISO)

regulation of plasma lipoprotein particle levels (ISO)

very-low-density lipoprotein particle assembly (ISO)

Cellular Component

endoplasmic reticulum membrane (ISO)

Molecular Function

1-acylglycerophosphocholine O-acyltransferase activity (ISO)

1-acylglycerophosphoethanolamine O-acyltransferase activity (ISO)

1-acylglycerophosphoserine O-acyltransferase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Lpcat3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	4,571,028 - 4,605,097 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	4,571,028 - 4,605,097 (-)	NCBI	ChiLan1.0	ChiLan1.0

LPCAT3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	6,976,185 - 7,018,476 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	6,976,185 - 7,018,477 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	7,085,347 - 7,125,780 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	6,955,608 - 6,996,103 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	8,706,367 - 8,748,731 (-)	NCBI		Celera
Cytogenetic Map	12	p13.31	NCBI
HuRef	12	6,943,813 - 6,986,151 (-)	NCBI		HuRef
CHM1_1	12	7,084,301 - 7,124,856 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	6,989,663 - 7,031,946 (-)	NCBI		T2T-CHM13v2.0

Lpcat3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	124,639,887 - 124,681,142 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	124,639,990 - 124,681,381 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	124,663,094 - 124,704,716 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	124,663,027 - 124,704,418 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	124,613,122 - 124,654,734 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	124,628,747 - 124,669,798 (+)	NCBI		MGSCv36	mm8
Celera	6	126,344,780 - 126,386,441 (+)	NCBI		Celera
Cytogenetic Map	6	F2	NCBI
cM Map	6	59.17	NCBI

Lpcat3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	159,154,690 - 159,196,176 (+)	NCBI		GRCr8
mRatBN7.2	4	157,468,397 - 157,509,889 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	157,468,290 - 157,509,880 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	163,691,494 - 163,738,379 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	159,474,396 - 159,521,285 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	158,121,481 - 158,162,851 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	157,181,722 - 157,222,997 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	157,181,795 - 157,222,996 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	224,199,925 - 224,240,593 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	160,786,349 - 160,827,556 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	161,031,284 - 161,072,491 (+)	NCBI
Celera	4	146,207,013 - 146,248,552 (+)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

LPCAT3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	12,542,261 - 12,583,945 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	12,539,020 - 12,580,609 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	7,107,925 - 7,149,982 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	7,024,015 - 7,065,945 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	7,024,015 - 7,065,945 (-)	Ensembl	panpan1.1		panPan2

LPCAT3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	38,028,438 - 38,068,854 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	38,028,120 - 38,068,502 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	8,547,836 - 8,588,333 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	38,380,888 - 38,421,451 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	38,380,568 - 38,424,143 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	38,255,853 - 38,296,355 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	38,296,886 - 38,337,321 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	8,026,597 - 8,067,116 (-)	NCBI		UU_Cfam_GSD_1.0

Lpcat3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	102,132,454 - 102,185,140 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936709	799,961 - 851,585 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936709	800,197 - 852,659 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LPCAT3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	63,708,020 - 63,746,103 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	63,707,674 - 63,746,369 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	66,143,944 - 66,182,458 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LPCAT3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	7,009,911 - 7,051,391 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	7,005,701 - 7,051,605 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	1,165,941 - 1,207,838 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lpcat3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624860	3,611,300 - 3,642,686 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624860	3,611,300 - 3,642,682 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005378854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01013621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01076822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000023075 ⟹ ENSCLAP00000022863

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955413	4,571,028 - 4,605,097 (-)	Ensembl

RefSeq Acc Id:

XM_005378854 ⟹ XP_005378911

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955413	4,571,028 - 4,605,097 (-)	NCBI

Sequence:

show sequence

GTGCGGTCACCGCGCCGCGCGCTCCGGCCCTTTCCAATCGGGGCGGCCCCGGCTCCAGGCCCCG
CCCGCGCCTCACGGGCCCTTGTCACTCTCTGTCACTCTCGGCCGAGTCACCTTTGCCTTACAAA
CGCCCGGGCCCGCCCGCTTCCTACCTTGCCGCGCTAGGCCCCGCCCCCACGCCGTCTGACCAAT
CGGTGGCGGGGCCCGGCGGCCGGGGCGGGCCCGCGGCCAATGCGCACGCCGTGGGCGGGCCCCC
GGCCGGAATTGGGGGTGAAGCTCCAGCGGCTTGCCCACAATCGGGGCGCTGGGAGCCGGGGGTC
CCTGGGGCCCGCCCGCAGTTAAGATGGCGTCCGCGGTGGAGGGGGACGTGTGGACCGCGGCGGG
GCTGAGCTGGGAGCTGCGGCCGGGGCTGGAGGAGCTGAGCTTGAACAAGTTGGCGACGTCCCTG
GGCGCGTCGGAGCAGGCGCTGCGGCTCATCATCTCCATCTTCCTGGGTTACCCCTTGGCTCTGT
TTTACCGGCATTACCTTTTCTACAAGGACAGCTACCTCATCCATCTGTTCCATGCGTTCACCGG
TCTCTCCATCGCTTACTTTAACTTTGGGTGCCAGTTCTACCACTCCCTGCTCTGTATTGTGCTT
CAGTTCCTCATCCTCCGACTGATGGGCCGCACCGTCACTGCCGTCCTCACCACCTTTTGCTTGC
AGATGGCCTATCTTCTTGCTGGATATTATTACACTGCCACAGGCAACTACGATATCAAGTGGAC
GATGCCACACTGTGTCCTGACGTTGAAGCTGATCGGTTTGGCTGTTGACTACTTTGATGGAGGC
AAAGAGGAGAGCTCCTTGACCGCTGAGCAGCAGAAGTATGCCTTCCGTGGCGTCCCTTCCCTGC
TGGAAGTTGCTGGTTTCTCCTACTTCTACGGGGCATTCTTGGTAGGTCCCCAGTTCTCCATGAA
CCACTACATGAAGCTGGTGCAGGGGAAGCTGACGGACACACCAGGGAAGATGCCAAACAGCACC
ATACCTGCTCTCAAGCGCCTGAGCCTGGGCCTTATCTACCTGGTGGGTCACACGCTGCTCAGCC
CGCACATCACAGAGGACTACCTGCTCTCTGAGGACTACGAAAACCGCTCTTTCTGGTTCCGCTG
CATGTACATGCTGATCTGGGGCAAGTTTGTGCTGTACAAATACGTCACCTGTTGGCTGGTCACA
GAAGGAGTGTGCATCTTGACGGGGCTGGGCTTCAATGGCTTTGGAGAAGACGGAAAAGCCAAGT
GGGATGCCTGTGCCAACATGAAGGTGTGGCTCTTTGAGACAACTCCCCAATTCAACGGCACCAT
CGCCTCCTTCAACATCAACACGAACGCCTGGGTGGCCCGTTACTTCTTCAAACGCCTCAAGTTC
CTTGGAAATAAACAACTGTCCCATGGTCTCTCATTGCTGTTCCTGGCCCTCTGGCATGGCCTCC
ACTCAGGATACCTGGTCTGCTTCCAGATGGAGTTCCTCATCATTATTGTGGAAAAGCAGGTTGC
CGCCCTCATCCAAAACAGTCCAGCCCTCAGCAGCCTCGCCAACATCACTGCCCTGCAGCCCTTG
TTCTACGTGGTACAGCAGACCATCCACTGGCTCTTCATGGGCTACTCCATGACCGCCTTCTGCC
TCTTCACGTGGGACAAGTGGTTTAAGGTATATAAATCTGTCTACTTTCTCGGCCACGTCTTCTT
CTTGAGCCTACTATTCACACTGCCTTACATCCGCAAAGCATTGGTGCCAAGGAAAGAGAAGTTA
AAGAAGACAGAATAATCGGTTTCTCTGGTGGCCTAAAGCAGGACTGGTGCAGAAACTACTCGGC
CCTTTTTCACAGCACTCCCTCATCCAGCGCACAGAAAGCCAGGGAGACGGAAGCCGTGTGCTCC
CAGCTGTGCCTCTGCTGCGGCGGCCAAAGGGGAGGCTTTTGTGGGAGGAGTGGGGGGCCTCGTC
CCCCTTACTCCCCCATGCACGTTGCCTTATCTCTCCCCTCCAGCCGGGACTCTGCTGTTCTTCT
GCCAATTTCCTAGGACTGTCTGTGCCACCGCCCCCATGGGGGAGGAGAGGGTACGCGGCCCCAC
CTGCTCCACTTTTCTATCTTGGAACTGTACCAGATAAAATCACTTCTGTTTGTGGGTTTTTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005378911	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000022863
	ENSCLAP00000022863.1

RefSeq Acc Id:

XP_005378911 ⟸ XM_005378854

- UniProtKB:

A0A8C2VZA7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASAVEGDVWTAAGLSWELRPGLEELSLNKLATSLGASEQALRLIISIFLGYPLALFYRHYLFY
KDSYLIHLFHAFTGLSIAYFNFGCQFYHSLLCIVLQFLILRLMGRTVTAVLTTFCLQMAYLLAG
YYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDGGKEESSLTAEQQKYAFRGVPSLLEVAGFSY
FYGAFLVGPQFSMNHYMKLVQGKLTDTPGKMPNSTIPALKRLSLGLIYLVGHTLLSPHITEDYL
LSEDYENRSFWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILTGLGFNGFGEDGKAKWDACANMK
VWLFETTPQFNGTIASFNINTNAWVARYFFKRLKFLGNKQLSHGLSLLFLALWHGLHSGYLVCF
QMEFLIIIVEKQVAALIQNSPALSSLANITALQPLFYVVQQTIHWLFMGYSMTAFCLFTWDKWF
KVYKSVYFLGHVFFLSLLFTLPYIRKALVPRKEKLKKTE

hide sequence

Ensembl Acc Id:

ENSCLAP00000022863 ⟸ ENSCLAT00000023075

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015685	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000023075	ENTREZGENE
	ENSCLAT00000023075.1	UniProtKB/TrEMBL
InterPro	LPLAT_7/PORCN-like	UniProtKB/TrEMBL
	MBOAT_fam	UniProtKB/TrEMBL
NCBI Gene	Lpcat3	ENTREZGENE
PANTHER	LYSOPHOSPHOLIPID ACYLTRANSFERASE 5	UniProtKB/TrEMBL
	PORCUPINE	UniProtKB/TrEMBL
Pfam	MBOAT	UniProtKB/TrEMBL
UniProt	A0A8C2VZA7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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