Fbp1 (fructose-bisphosphatase 1) - Rat Genome Database

Name: Fbp1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Fbp1 (fructose-bisphosphatase 1) Chinchilla lanigera

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Symbol:

Fbp1

Name:

fructose-bisphosphatase 1

RGD ID:

8829652

Description:

ENCODES a protein that exhibits AMP binding (ortholog); fructose 1,6-bisphosphate 1-phosphatase activity (ortholog); identical protein binding (ortholog); INVOLVED IN cellular hyperosmotic salinity response (ortholog); cellular hypotonic salinity response (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN fructose and mannose metabolic pathway; fructose-1,6-bisphosphatase deficiency pathway; fructosuria pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Baker-Winegrad Disease (ortholog); Colonic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

fructose-1,6-bisphosphatase 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	21,536,667 - 21,569,433 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	21,537,337 - 21,569,174 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

Baker-Winegrad Disease (ISO)

Colonic Neoplasms (ISO)

fructose-1,6-bisphosphatase deficiency (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

hiatus hernia (ISO)

Parkinson's disease (ISO)

schizophrenia (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular hyperosmotic salinity response (ISO)

cellular hypotonic salinity response (ISO)

cellular response to cAMP (ISO)

cellular response to insulin stimulus (ISO)

cellular response to magnesium ion (ISO)

cellular response to phorbol 13-acetate 12-myristate (ISO)

cellular response to raffinose (ISO)

cellular response to xenobiotic stimulus (ISO)

dephosphorylation (ISO)

fructose 6-phosphate metabolic process (ISO)

gluconeogenesis (ISO)

negative regulation of cell growth (ISO)

negative regulation of glycolytic process (ISO)

negative regulation of Ras protein signal transduction (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

regulation of gluconeogenesis (ISO)

response to nutrient levels (ISO)

Cellular Component

cytoplasm (ISO)

extracellular space (ISO)

nucleus (ISO)

Molecular Function

AMP binding (ISO)

fructose 1,6-bisphosphate 1-phosphatase activity (ISO)

identical protein binding (ISO)

metal ion binding (ISO)

monosaccharide binding (ISO)

protein binding (ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

fructose and mannose metabolic pathway (ISO)

fructose-1,6-bisphosphatase deficiency pathway (ISO)

fructosuria pathway (ISO)

gluconeogenesis pathway (ISO)

glycogen storage disease type Ia pathway (ISO)

glycogen storage disease type Ib pathway (ISO)

glycolysis/gluconeogenesis pathway (ISO)

hereditary fructose intolerance syndrome pathway (ISO)

pentose phosphate pathway (ISO)

phosphoenolpyruvate carboxykinase deficiency pathway (ISO)

ribose 5-phosphate isomerase deficiency pathway (ISO)

transaldolase deficiency pathway (ISO)

triosephosphate isomerase deficiency pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Fbp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	21,536,667 - 21,569,433 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	21,537,337 - 21,569,174 (-)	NCBI	ChiLan1.0	ChiLan1.0

FBP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	94,603,133 - 94,640,263 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	94,603,133 - 94,640,249 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	97,365,415 - 97,402,545 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	96,405,236 - 96,441,624 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	94,444,977 - 94,481,358	NCBI
Celera	9	67,806,446 - 67,843,550 (-)	NCBI		Celera
Cytogenetic Map	9	q22.32	NCBI
HuRef	9	66,974,069 - 67,011,150 (-)	NCBI		HuRef
CHM1_1	9	97,511,867 - 97,548,958 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	106,772,462 - 106,809,573 (-)	NCBI		T2T-CHM13v2.0

Fbp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	63,012,567 - 63,036,112 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	63,012,567 - 63,036,096 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	62,864,753 - 62,888,298 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	62,864,753 - 62,888,282 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	62,966,113 - 62,989,596 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	62,874,376 - 62,897,859 (-)	NCBI		MGSCv36	mm8
Celera	13	64,525,124 - 64,552,462 (-)	NCBI		Celera
Cytogenetic Map	13	B3	NCBI
cM Map	13	32.74	NCBI

Fbp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	2,212,941 - 2,235,749 (+)	NCBI		GRCr8
mRatBN7.2	17	2,207,271 - 2,230,076 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	2,208,031 - 2,230,071 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	2,226,670 - 2,248,706 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	3,769,275 - 3,791,309 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	2,224,130 - 2,246,168 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	396,175 - 417,480 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	396,180 - 417,480 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	391,323 - 412,426 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	7,795,717 - 7,818,041 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	7,795,716 - 7,818,038 (+)	NCBI
Celera	17	294,875 - 316,917 (-)	NCBI		Celera
RH 3.4 Map	17	5.6	RGD
Cytogenetic Map	17	p14	NCBI

FBP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	44,817,885 - 44,855,493 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	44,820,279 - 44,857,884 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	65,695,082 - 65,731,628 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	93,825,142 - 93,860,968 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	93,825,150 - 93,860,968 (-)	Ensembl	panpan1.1		panPan2

FBP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	72,099,886 - 72,125,266 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	72,099,881 - 72,125,224 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	72,861,998 - 72,887,376 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	72,404,539 - 72,429,921 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	72,404,165 - 72,429,918 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	72,215,481 - 72,240,826 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	71,981,002 - 72,006,401 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	72,686,298 - 72,711,910 (+)	NCBI		UU_Cfam_GSD_1.0

Fbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	4,327,489 - 4,353,383 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936626	3,555,762 - 3,581,659 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936626	3,555,835 - 3,581,651 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FBP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	27,588,570 - 27,622,674 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	27,588,609 - 27,622,225 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	31,712,560 - 31,829,432 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FBP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	108,452,856 - 108,484,052 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	108,453,156 - 108,483,775 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	96,849,781 - 96,881,775 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fbp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624753	16,016,022 - 16,048,104 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624753	16,019,546 - 16,048,096 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005384677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01023124	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01023125	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01023126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01189663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000025270 ⟹ ENSCLAP00000025026

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955422	21,536,667 - 21,569,433 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000025271 ⟹ ENSCLAP00000025027

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955422	21,537,569 - 21,551,993 (-)	Ensembl

RefSeq Acc Id:

XM_005384677 ⟹ XP_005384734

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955422	21,537,337 - 21,569,174 (-)	NCBI

Sequence:

show sequence

TAGGTTCTCCTGGGACGCGCCCGCAGGGACTCGGCAGCCTGGCGGGTGGCGCTGCAACCTCTGC
GCAGGGCCGTGCGTGCGTCCTCCTGCCGCCCAGCACCTGTCGCGCTCACCTGCCCGCACCTGTG
GCGCTCGCTCGCAGCCCCCATCTATCGCCCGCACCTGCACTCCTGCACCTGCAGCCCTACACCT
GCGGACCGGCCCAGCATGGCGGATCAAGCGCCCTTCGACACAGACATCAGCACCCTGACCCGCT
TCGTCATGGAAGAGGGCAGGAAGGCTCGCGGCACTGGCGAGCTGACCCAGCTGCTCAACTCGCT
CTGCACCGCGGTCAAAGCCATCTCCTCCGCGGTGCGCAAGGCGGGCATCGCGCATCTCTATGGC
ATTGCTGGCTCCACCAACGTGACAGGTGATCAGGTCAAGAAGCTGGATGTCCTCTCCAACGATC
TGGTTATGAACATGCTAAAGTCATCCTTCGCCACCTGTGTTCTTGTGTCCGAAGAAGATAAACA
CGCCATAATCGTAGAACCTGAGAAAAGGGGTAAATATGTGGTCTGCTTTGATCCCCTTGATGGC
TCTTCCAACATCGACTGCCTGGTGTCCATTGGAACCATTTTTGGCATCTACAGAAAGAAATCTA
CTGATGAGCCTTCCGAGAAGGATGCCCTGCAAGCAGGCCGGAGCCTGGTGGCAGCTGGTTATGC
CCTCTATGGCAGCGCCACCATGCTGGTTCTCGCCATGGACAGTGGTGTCAACTGCTTCATGCTG
GACCCGGCCATCGGGGAATTCATTTTGGTGGACAGGAATGTGAAGATCAAGAAGAAAGGTAATA
TCTATAGCCTTAATGAAGGCTACGCCAAGGACTTTGACCCTGCCATCACTGAGTACATCCAGAG
GAAGAAGTTTCCTTCAGATAATTCAGCTCCCTACGGGGCCCGGTATGTGGGCTCCATGGTGGCT
GATGTGCACCGCACTTTGGTCTACGGAGGGATCTTTCTATACCCTGCTAACAAGAAAAGCCCCA
ATGGGAAGTTGAGACTACTGTATGAATGTAACCCAATGGCCTTTGTCATGGAGAAGGCAGGGGG
ACTGGCCACAACAGGCAAAGAAGCTATATTAGACATCGTTCCCACCGATATCCACCAGCGAGCG
CCAGTCATCCTGGGGTCCCCTGACGATGTGAGGGAGTTCCTGGAGATCTACAAGAAGCACTCTG
CCAAATGAAGAGCTGGTCTTGTCCTCATCCCAAAGAGTTGCCTCACACAGCACTAACCCATTCT
GACCGTGCATTCTATGTTCCTAGCCAGCAGACGAAATGCACAGATATTTTTACCATCTAATGCA
CTCTAATGCCTGGTGCTACCTAACCCAAATGCTATCTCCATAATATCACTGGTGGGAAAGATAT
ATGTTGAGCAGAGGGAGGAGAAATAAACATATTCTTCCTTTAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005384734	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000025026
	ENSCLAP00000025026.1
	ENSCLAP00000025027.1

RefSeq Acc Id:

XP_005384734 ⟸ XM_005384677

- UniProtKB:

A0A8C2W539 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADQAPFDTDISTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGST
NVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNID
CLVSIGTIFGIYRKKSTDEPSEKDALQAGRSLVAAGYALYGSATMLVLAMDSGVNCFMLDPAIG
EFILVDRNVKIKKKGNIYSLNEGYAKDFDPAITEYIQRKKFPSDNSAPYGARYVGSMVADVHRT
LVYGGIFLYPANKKSPNGKLRLLYECNPMAFVMEKAGGLATTGKEAILDIVPTDIHQRAPVILG
SPDDVREFLEIYKKHSAK

hide sequence

Ensembl Acc Id:

ENSCLAP00000025027 ⟸ ENSCLAT00000025271

Ensembl Acc Id:

ENSCLAP00000025026 ⟸ ENSCLAT00000025270

Protein Domains

Fructose-1-6-bisphosphatase class 1 C-terminal Fructose-1-6-bisphosphatase class I N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000017181	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000025270	ENTREZGENE
	ENSCLAT00000025270.1	UniProtKB/TrEMBL
	ENSCLAT00000025271.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.190.80	UniProtKB/TrEMBL
	Fructose-1,6-Bisphosphatase, subunit A, domain 1	UniProtKB/TrEMBL
InterPro	FBPase_C_dom	UniProtKB/TrEMBL
	FBPase_class-1	UniProtKB/TrEMBL
	FBPase_N	UniProtKB/TrEMBL
	FBPtase	UniProtKB/TrEMBL
	Fructose_bisphosphatase_AS	UniProtKB/TrEMBL
NCBI Gene	Fbp1	ENTREZGENE
PANTHER	FRUCTOSE-1,6-BISPHOSPHATASE 1	UniProtKB/TrEMBL
	PTHR11556	UniProtKB/TrEMBL
Pfam	FBPase	UniProtKB/TrEMBL
	FBPase_C	UniProtKB/TrEMBL
PIRSF	FBPtase	UniProtKB/TrEMBL
	FBPtase_SBPase	UniProtKB/TrEMBL
PRINTS	F16BPHPHTASE	UniProtKB/TrEMBL
PROSITE	FBPASE	UniProtKB/TrEMBL
Superfamily-SCOP	Carbohydrate phosphatase	UniProtKB/TrEMBL
UniProt	A0A8C2W539	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2YUV9_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Fbp1	fructose-bisphosphatase 1		fructose-1,6-bisphosphatase 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB