Sipa1 (signal-induced proliferation-associated 1) - Rat Genome Database

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Gene: Sipa1 (signal-induced proliferation-associated 1) Chinchilla lanigera
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Symbol: Sipa1
Name: signal-induced proliferation-associated 1
RGD ID: 8825299
Description: ENCODES a protein that exhibits GTPase activator activity (ortholog); INVOLVED IN cellular response to water deprivation (ortholog); regulation of cell cycle (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); Autoinflammatory Disease, Familial, Behcet-Like-3 (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: signal-induced proliferation-associated protein 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,615,440 - 19,627,088 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,615,440 - 19,627,195 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Sipa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,615,440 - 19,627,088 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,615,440 - 19,627,195 (-)NCBIChiLan1.0ChiLan1.0
SIPA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,638,101 - 65,650,912 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,638,101 - 65,650,918 (+)EnsemblGRCh38hg38GRCh38
GRCh371165,405,572 - 65,418,383 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,162,171 - 65,174,965 (+)NCBINCBI36Build 36hg18NCBI36
Build 341165,164,167 - 65,174,965NCBI
Celera1162,732,306 - 62,745,096 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,732,561 - 61,745,380 (+)NCBIHuRef
CHM1_11165,289,517 - 65,302,326 (+)NCBICHM1_1
T2T-CHM13v2.01165,632,271 - 65,645,082 (+)NCBIT2T-CHM13v2.0
Sipa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,701,211 - 5,713,758 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,701,213 - 5,713,735 (-)EnsemblGRCm39 Ensembl
GRCm38195,651,185 - 5,663,722 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,651,185 - 5,663,707 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,651,185 - 5,663,707 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,651,194 - 5,663,620 (-)NCBIMGSCv36mm8
Celera195,520,784 - 5,533,298 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.34NCBI
Sipa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,367,867 - 212,379,952 (-)NCBIGRCr8
mRatBN7.21202,938,532 - 202,950,672 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,938,580 - 202,950,591 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,291,365 - 211,300,621 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,384,175 - 218,393,436 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,075,220 - 211,084,481 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,006,305 - 221,018,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,006,340 - 221,015,929 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,941,623 - 227,953,709 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,276,451 - 208,285,639 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,429,903 - 208,439,092 (-)NCBI
Celera1200,474,523 - 200,483,784 (-)NCBICelera
Cytogenetic Map1q43NCBI
SIPA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2966,867,872 - 66,880,744 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,910,631 - 67,923,523 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01160,997,292 - 61,010,155 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11164,332,322 - 64,345,177 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,335,136 - 64,344,955 (+)Ensemblpanpan1.1panPan2
SIPA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,560,551 - 51,571,291 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,560,551 - 51,568,885 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,169,066 - 50,179,806 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01852,597,850 - 52,608,590 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,597,850 - 52,606,184 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11851,697,698 - 51,708,437 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,271,817 - 51,282,555 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01852,062,171 - 52,072,909 (-)NCBIUU_Cfam_GSD_1.0
Sipa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,371,001 - 7,382,901 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365993,813,596 - 3,822,170 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365993,813,350 - 3,825,319 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIPA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,606,626 - 6,618,566 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,606,613 - 6,618,556 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,760,347 - 5,770,847 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIPA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,588,221 - 8,601,310 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl18,586,685 - 8,598,455 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038105,884,061 - 105,897,031 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sipa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,745,168 - 20,757,219 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476720,745,125 - 20,757,243 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000022999   ⟹   ENSCLAP00000022790
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542219,615,440 - 19,627,088 (-)Ensembl
RefSeq Acc Id: XM_005384470   ⟹   XP_005384527
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542219,615,440 - 19,627,195 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513855   ⟹   XP_013369309
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542219,615,440 - 19,627,088 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513856   ⟹   XP_013369310
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542219,615,440 - 19,627,171 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513857   ⟹   XP_013369311
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542219,615,440 - 19,627,193 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513858   ⟹   XP_013369312
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542219,615,697 - 19,627,088 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005384527   ⟸   XM_005384470
- Peptide Label: isoform X2
- UniProtKB: A0A8C2W418 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013369311   ⟸   XM_013513857
- Peptide Label: isoform X2
- UniProtKB: A0A8C2W418 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013369310   ⟸   XM_013513856
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W418 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013369309   ⟸   XM_013513855
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W418 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013369312   ⟸   XM_013513858
- Peptide Label: isoform X3
- UniProtKB: A0A8C2W418 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000022790   ⟸   ENSCLAT00000022999
Protein Domains
PDZ   Rap-GAP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000015627 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000022999 ENTREZGENE
  ENSCLAT00000022999.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  3.40.50.11210 UniProtKB/TrEMBL
  6.10.140.210 UniProtKB/TrEMBL
InterPro PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Rap/Ran-GAP_sf UniProtKB/TrEMBL
  Rap/Ran_GAP_dom UniProtKB/TrEMBL
  Rap1_Ran_GAP UniProtKB/TrEMBL
NCBI Gene Sipa1 ENTREZGENE
PANTHER RAP GTPASE-ACTIVATING PROTEIN UniProtKB/TrEMBL
  SIGNAL-INDUCED PROLIFERATION-ASSOCIATED PROTEIN 1 UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
  Rap-GAP_dimer UniProtKB/TrEMBL
  Rap_GAP UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/TrEMBL
  RAPGAP UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
Superfamily-SCOP SSF111347 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
UniProt A0A8C2W418 ENTREZGENE, UniProtKB/TrEMBL