Commd1 (copper metabolism domain containing 1)

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Gene: Commd1 (copper metabolism domain containing 1) Chinchilla lanigera

Analyze

Symbol:

Commd1

Name:

copper metabolism domain containing 1

RGD ID:

8824283

Description:

ENCODES a protein that exhibits copper ion binding (ortholog); identical protein binding (ortholog); phosphatidic acid binding (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); copper ion homeostasis (ortholog); Golgi to plasma membrane transport (ortholog); ASSOCIATED WITH allergic disease (ortholog); Chronic Hepatitis (ortholog); Copper-Overload Cirrhosis (ortholog); FOUND IN Cul2-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

COMM domain-containing protein 1; copper metabolism (Murr1) domain containing 1

RGD Orthologs

Human

Mouse

Rat

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	21,927,079 - 22,050,371 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	21,962,837 - 22,067,745 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic disease (ISO)

Chronic Hepatitis (ISO)

Copper-Overload Cirrhosis (ISO)

Dog Diseases (ISO)

liver cirrhosis (ISO)

schizophrenia (ISO)

Wilson disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cholesterol homeostasis (ISO)

copper ion homeostasis (ISO)

Golgi to plasma membrane transport (ISO)

low-density lipoprotein particle clearance (ISO)

negative regulation of hypoxia-inducible factor-1alpha signaling pathway (ISO)

negative regulation of NF-kappaB transcription factor activity (ISO)

negative regulation of protein localization to cell surface (ISO)

negative regulation of sodium ion transmembrane transport (ISO)

nucleotide-excision repair (ISO)

plasma membrane to endosome transport (ISO)

positive regulation of cholesterol import (ISO)

positive regulation of endosome to plasma membrane protein transport (ISO)

positive regulation of protein localization to cell surface (ISO)

positive regulation of protein ubiquitination (ISO)

protein destabilization (ISO)

regulation of plasma lipoprotein particle levels (ISO)

regulation of proteasomal ubiquitin-dependent protein catabolic process (ISO)

Cellular Component

Cul2-RING ubiquitin ligase complex (ISO)

cytoplasm (ISO)

cytosol (ISO)

early endosome (ISO)

endosome (ISO)

nucleoplasm (ISO)

nucleus (ISO)

recycling endosome (ISO)

Molecular Function

copper ion binding (ISO)

identical protein binding (ISO)

phosphatidic acid binding (ISO)

phosphatidylinositol-3,4,5-trisphosphate binding (ISO)

phosphatidylinositol-3,4-bisphosphate binding (ISO)

phosphatidylinositol-3,5-bisphosphate binding (ISO)

phosphatidylinositol-4,5-bisphosphate binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

sodium channel inhibitor activity (ISO)

References

References - curated


1.	Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations

Genomics

Comparative Map Data

Commd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	21,927,079 - 22,050,371 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	21,962,837 - 22,067,745 (-)	NCBI	ChiLan1.0	ChiLan1.0

COMMD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	61,888,724 - 62,147,247 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	61,888,391 - 62,136,066 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	62,115,526 - 62,368,321 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	61,986,307 - 62,216,709 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	62,044,453 - 62,274,855	NCBI
Celera	2	61,977,700 - 62,207,946 (+)	NCBI
Cytogenetic Map	2	p15	NCBI
HuRef	2	61,871,871 - 62,101,672 (+)	NCBI		HuRef
CHM1_1	2	62,045,803 - 62,293,462 (+)	NCBI		CHM1_1

Commd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	22,849,728 - 22,934,539 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	11	22,846,136 - 22,932,382 (-)	Ensembl
GRCm38	11	22,899,728 - 22,984,539 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	22,896,136 - 22,982,382 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	22,799,728 - 22,882,284 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	11	22,799,728 - 22,882,284 (-)	NCBI			mm8
Celera	11	25,035,441 - 25,117,915 (-)	NCBI		Celera
Cytogenetic Map	11	A3.2	NCBI
cM Map	11	14.22	NCBI

Commd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	96,880,463 - 96,984,494 (-)	NCBI
Rnor_6.0 Ensembl	14	107,664,255 - 107,760,191 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	14	107,664,321 - 107,759,974 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	14	107,804,733 - 107,835,993 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	14	107,724,470 - 107,726,728 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	103,571,472 - 103,667,692 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	14	95,868,544 - 95,965,715 (-)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

COMMD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	63,121,490 - 63,349,256 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	63,121,521 - 63,349,131 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2A	61,970,830 - 62,216,677 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

COMMD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	61,886,281 - 62,059,610 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	61,886,281 - 62,059,591 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	61,775,492 - 61,947,762 (+)	NCBI
ROS_Cfam_1.0	10	62,894,268 - 63,067,243 (+)	NCBI
UMICH_Zoey_3.1	10	62,578,128 - 62,750,820 (+)	NCBI
UNSW_CanFamBas_1.0	10	62,882,129 - 63,053,837 (+)	NCBI
UU_Cfam_GSD_1.0	10	63,177,646 - 63,350,655 (+)	NCBI
Dog Cytomap	10	q26	NCBI

Commd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	21,150,249 - 21,324,134 (-)	NCBI
SpeTri2.0	NW_004936491	7,247,160 - 7,421,039 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COMMD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	79,770,565 - 79,913,975 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	79,770,315 - 79,913,969 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	83,605,344 - 83,748,646 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

COMMD1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	44,839,460 - 45,068,764 (-)	NCBI
ChlSab1.1 Ensembl	14	44,839,542 - 45,068,586 (-)	Ensembl
Vero_WHO_p1.0	NW_023666045	66,766,475 - 66,997,250 (+)	NCBI

Commd1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624762	11,302,730 - 11,407,074 (-)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013514647	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01024921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024924	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024927	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024928	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024930	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01056265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01125496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCLAT00000019538 ⟹ ENSCLAP00000019349

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955424	21,927,079 - 22,050,371 (-)	Ensembl

RefSeq Acc Id:

XM_013514647 ⟹ XP_013370101

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955424	21,962,837 - 22,067,745 (-)	NCBI

Sequence:

show sequence

CGGCCGCGCTCAGCTGCTGGGGGCGGGGTCTTCGCCGACCATGGCGGTGGAGCTGGAGGCAAGC
AAGTCCCTGAGCGGGCTGCTGAGCGGCCTGGCTCAGGACGCTTTCCACGGGCACCCGGGCATCA
CAGAGGAGCTGCTGCGGAGCCAACTTTATCCAGAGGTGTCCCCCGAAGAGTTCCGCCCGTTCCT
GGCGAAAATGAGGGGCATTCTGAAGGAATCGAACTTGGGACCTTGCCCTTGCCAGTCCATTGCA
TCTGCAGACATGGATTTCAATCAGTTGGAGGCATTCTTAACTGCGCAAACTAAAAAGCAAGGTG
GGATCACATCTGACCAAGCGGCTGTTATTTCCAAATTCTGGAAGAGCCACAAGACAAAAATCCG
AGAGAGCCTTGTGAACCAGAGCTGCTGGGAGAGTGGACTCCGGGGCCTGAGCTGGAGGGTTGAT
GGCAAGTCTCAGTCGAGGCACTCGGCTCAGATCCACACCCCTGTTGCCCTAGTAGAGCTGGAAT
TCGGGAAACGTGGCCAGGAGTCTGAATTTCTGTGTTTGGAATTTGATGAGGTGAAGGTCAACCA
AATACTGAAGAAGCTCTCAGAGGTAGAAGAAAGTATCAATGCACTGATGCAACCAGCCTAACTG
AAGACGATGTAGGAAAGAGTTGGAATTATAAAGCAAAGGTGTTAATGATCTCACCCACTTTCAC
AGTCCTGTTCCCCCACTGGTATTAAATCCTCAGTGTCAAATCCT

hide sequence

Protein Sequences


Protein RefSeqs	XP_013370101	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_013370101 ⟸ XM_013514647

- Sequence:

show sequence

MAVELEASKSLSGLLSGLAQDAFHGHPGITEELLRSQLYPEVSPEEFRPFLAKMRGILKESNLG
PCPCQSIASADMDFNQLEAFLTAQTKKQGGITSDQAAVISKFWKSHKTKIRESLVNQSCWESGL
RGLSWRVDGKSQSRHSAQIHTPVALVELEFGKRGQESEFLCLEFDEVKVNQILKKLSEVEESIN
ALMQPA

hide sequence

RefSeq Acc Id:

ENSCLAP00000019349 ⟸ ENSCLAT00000019538

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000013262	Ensembl, ENTREZGENE
Ensembl Protein	ENSCLAP00000019349	ENTREZGENE
Ensembl Transcript	ENSCLAT00000019538	ENTREZGENE
NCBI Gene	Commd1	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Commd1	copper metabolism domain containing 1		copper metabolism (Murr1) domain containing 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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