Bmpr1a (bone morphogenetic protein receptor type 1A) - Rat Genome Database

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Pathways
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Gene: Bmpr1a (bone morphogenetic protein receptor type 1A) Chinchilla lanigera
Analyze
Symbol: Bmpr1a
Name: bone morphogenetic protein receptor type 1A
RGD ID: 8823269
Description: ENCODES a protein that exhibits ATP binding (ortholog); BMP binding (ortholog); BMP receptor activity (ortholog); INVOLVED IN angiogenesis (ortholog); anterior/posterior pattern specification (ortholog); atrioventricular node cell development (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1 (ortholog); bone development disease (ortholog); breast cancer (ortholog); FOUND IN caveola (ortholog); cell surface (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type IA
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555105,905,008 - 5,936,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555105,812,571 - 5,936,312 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
anterior/posterior pattern specification  (ISO)
atrioventricular node cell development  (ISO)
atrioventricular valve development  (ISO)
BMP signaling pathway  (ISO)
cardiac conduction system development  (ISO)
cardiac right ventricle morphogenesis  (ISO)
cartilage development  (ISO)
cellular response to BMP stimulus  (ISO)
central nervous system neuron differentiation  (ISO)
chondrocyte differentiation  (ISO)
developmental growth  (ISO)
dorsal aorta morphogenesis  (ISO)
dorsal/ventral axis specification  (ISO)
dorsal/ventral pattern formation  (ISO)
ectoderm development  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic morphogenesis  (ISO)
embryonic organ development  (ISO)
endocardial cushion formation  (ISO)
endocardial cushion morphogenesis  (ISO)
endoderm development  (ISO)
epithelial cell proliferation  (ISO)
fibrous ring of heart morphogenesis  (ISO)
heart development  (ISO)
heart formation  (ISO)
heart morphogenesis  (ISO)
hindlimb morphogenesis  (ISO)
immune response  (ISO)
in utero embryonic development  (ISO)
lateral mesoderm development  (ISO)
lung development  (ISO)
mesendoderm development  (ISO)
mesoderm formation  (ISO)
mitral valve morphogenesis  (ISO)
Mullerian duct regression  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of muscle cell differentiation  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
nervous system development  (ISO)
neural crest cell development  (ISO)
neural plate mediolateral regionalization  (ISO)
neural plate pattern specification  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
osteoblast differentiation  (ISO)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (ISO)
paraxial mesoderm development  (ISO)
paraxial mesoderm structural organization  (ISO)
pattern specification process  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
pituitary gland development  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cardiac ventricle development  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta2 production  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of cardiac muscle cell apoptotic process  (ISO)
regulation of cardiac muscle cell proliferation  (ISO)
regulation of cellular senescence  (ISO)
regulation of endothelial cell differentiation  (ISO)
regulation of endothelial cell proliferation  (ISO)
regulation of lateral mesodermal cell fate specification  (ISO)
regulation of neural crest cell differentiation  (ISO)
regulation of neural crest cell fate specification  (ISO)
roof of mouth development  (ISO)
somatic stem cell population maintenance  (ISO)
somitogenesis  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
tricuspid valve morphogenesis  (ISO)
ventricular compact myocardium morphogenesis  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Bmpr1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555105,905,008 - 5,936,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555105,812,571 - 5,936,312 (+)NCBIChiLan1.0ChiLan1.0
BMPR1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381086,755,763 - 86,932,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1086,756,596 - 86,932,825 (+)EnsemblGRCh38hg38GRCh38
GRCh371088,516,376 - 88,687,726 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361088,506,376 - 88,674,925 (+)NCBINCBI36Build 36hg18NCBI36
Build 341088,506,375 - 88,674,924NCBI
Celera1082,519,484 - 82,687,979 (+)NCBICelera
Cytogenetic Map10q23.2NCBI
HuRef1082,370,811 - 82,538,774 (+)NCBIHuRef
CHM1_11088,798,078 - 88,966,382 (+)NCBICHM1_1
T2T-CHM13v2.01087,639,833 - 87,816,596 (+)NCBIT2T-CHM13v2.0
Bmpr1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391434,133,018 - 34,225,335 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1434,132,691 - 34,225,298 (-)EnsemblGRCm39 Ensembl
GRCm381434,411,061 - 34,503,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,410,734 - 34,503,341 (-)EnsemblGRCm38mm10GRCm38
MGSCv371435,224,254 - 35,315,732 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361433,240,160 - 33,331,638 (-)NCBIMGSCv36mm8
Celera1430,676,409 - 30,725,958 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.81NCBI
Bmpr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,740,751 - 9,786,861 (-)NCBIGRCr8
mRatBN7.2169,736,390 - 9,829,825 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,736,630 - 9,780,616 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx169,756,712 - 9,800,677 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,901,424 - 10,945,388 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,751,786 - 9,795,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,758,278 - 10,852,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,758,527 - 10,802,512 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0169,084,569 - 9,127,943 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41610,061,943 - 10,105,854 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11610,061,941 - 10,105,852 (-)NCBI
Celera165,436,477 - 5,480,314 (+)NCBICelera
Cytogenetic Map16p15NCBI
BMPR1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2898,749,056 - 98,920,091 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11098,750,184 - 98,925,412 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01083,185,040 - 83,353,239 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11086,742,248 - 86,912,912 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1086,837,469 - 86,912,912 (+)Ensemblpanpan1.1panPan2
BMPR1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1434,499,898 - 34,582,481 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl434,517,492 - 34,578,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha434,508,865 - 34,570,053 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0434,801,402 - 34,942,941 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl434,769,955 - 34,941,813 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1434,723,326 - 34,784,614 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0434,892,537 - 34,953,583 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0435,397,828 - 35,459,419 (+)NCBIUU_Cfam_GSD_1.0
Bmpr1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721343,941,218 - 44,004,913 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493680448,947 - 115,412 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493680452,435 - 115,289 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMPR1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1487,742,459 - 87,891,790 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11487,743,270 - 87,891,790 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21495,239,745 - 95,280,923 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMPR1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1944,944,463 - 45,108,832 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl944,941,460 - 45,027,275 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660485,049,884 - 5,217,543 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmpr1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624841219,133 - 265,397 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624841218,642 - 304,744 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000000997   ⟹   ENSCLAP00000000960
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555105,905,008 - 5,936,312 (+)Ensembl
RefSeq Acc Id: XM_005407907   ⟹   XP_005407964
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555105,812,571 - 5,936,312 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005407964 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000000960
  ENSCLAP00000000960.1
Reference Protein Sequences
RefSeq Acc Id: XP_005407964   ⟸   XM_005407907
- UniProtKB: A0A8C2UNG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000000960   ⟸   ENSCLAT00000000997
Protein Domains
GS   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000000743 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000000997 ENTREZGENE
  ENSCLAT00000000997.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.60.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Activin_recp UniProtKB/TrEMBL
  GS_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/TrEMBL
NCBI Gene Bmpr1a ENTREZGENE
PANTHER BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A UniProtKB/TrEMBL
  PTHR23255 UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  TGF_beta_GS UniProtKB/TrEMBL
PRINTS ACTIVIN2R UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  PS51256 UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  SM00467 UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
  SSF57302 UniProtKB/TrEMBL
UniProt A0A8C2UNG6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Bmpr1a  bone morphogenetic protein receptor type 1A    bone morphogenetic protein receptor, type IA  Symbol and/or name change 5135510 APPROVED