Nek7 (NIMA related kinase 7) - Rat Genome Database

Name: Nek7
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Nek7 (NIMA related kinase 7) Chinchilla lanigera

Analyze

Symbol:

Nek7

Name:

NIMA related kinase 7

RGD ID:

8817020

Description:

ENCODES a protein that exhibits molecular function activator activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cellular response to potassium ion (ortholog); positive regulation of NLRP3 inflammasome complex assembly (ortholog); positive regulation of telomere capping (ortholog); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); parathyroid carcinoma (ortholog); FOUND IN cytoplasm (ortholog); microtubule organizing center (ortholog); nucleoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

NIMA-related kinase 7; serine/threonine-protein kinase Nek7

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	34,626,494 - 34,717,546 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	34,575,292 - 34,714,024 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

parathyroid carcinoma (ISO)

Weight Gain (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to potassium ion (ISO)

positive regulation of NLRP3 inflammasome complex assembly (ISO)

positive regulation of telomere capping (ISO)

positive regulation of telomere maintenance via telomerase (ISO)

regulation of mitotic cell cycle (ISO)

Cellular Component

cytoplasm (ISO)

microtubule organizing center (ISO)

nucleoplasm (ISO)

nucleus (ISO)

Molecular Function

molecular function activator activity (ISO)

protein binding (ISO)

protein serine/threonine kinase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Nek7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	34,626,494 - 34,717,546 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	34,575,292 - 34,714,024 (+)	NCBI	ChiLan1.0	ChiLan1.0

NEK7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	198,156,998 - 198,322,420 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	198,156,994 - 198,322,420 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	198,126,128 - 198,291,550 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	196,468,306 - 196,555,392 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	194,933,338 - 195,020,426	NCBI
Celera	1	171,248,701 - 171,414,114 (+)	NCBI		Celera
Cytogenetic Map	1	q31.3	NCBI
HuRef	1	169,281,535 - 169,446,709 (+)	NCBI		HuRef
CHM1_1	1	199,548,440 - 199,713,855 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	197,416,379 - 197,581,805 (+)	NCBI		T2T-CHM13v2.0

Nek7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	138,411,575 - 138,547,481 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	138,410,613 - 138,547,879 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	138,483,837 - 138,619,757 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	138,482,875 - 138,620,141 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	140,381,291 - 140,516,273 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	140,301,125 - 140,436,107 (-)	NCBI		MGSCv36	mm8
Celera	1	141,116,690 - 141,252,989 (-)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	60.82	NCBI

Nek7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	52,573,730 - 52,700,869 (-)	NCBI		GRCr8
mRatBN7.2	13	50,022,212 - 50,149,374 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	50,022,218 - 50,149,296 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	52,633,583 - 52,702,078 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	53,921,489 - 53,989,987 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	51,188,092 - 51,257,283 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	55,485,759 - 55,617,534 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	55,488,531 - 55,561,750 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	60,515,259 - 60,641,914 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	51,679,191 - 51,942,636 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	51,696,338 - 51,802,947 (-)	NCBI
Celera	13	50,308,775 - 50,377,141 (-)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

NEK7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	51,064,827 - 51,230,182 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	51,024,328 - 51,189,816 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	173,752,892 - 173,918,258 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	178,063,721 - 178,228,197 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	178,138,925 - 178,228,197 (+)	Ensembl	panpan1.1		panPan2

NEK7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	4,557,754 - 4,755,912 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	4,555,231 - 4,704,955 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	4,242,787 - 4,401,020 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	4,244,695 - 4,403,399 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	4,244,697 - 4,401,233 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	4,191,041 - 4,349,354 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	4,291,900 - 4,450,309 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	4,323,524 - 4,481,976 (-)	NCBI		UU_Cfam_GSD_1.0

Nek7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	76,450,900 - 76,580,386 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936567	5,685,125 - 5,808,499 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936567	5,685,619 - 5,815,094 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NEK7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	20,966,651 - 21,124,271 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	20,966,660 - 21,124,283 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	25,627,135 - 25,785,075 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NEK7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	31,111,332 - 31,257,445 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	31,110,616 - 31,257,374 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	32,000,563 - 32,147,161 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nek7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624798	2,116,900 - 2,198,999 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624798	2,116,888 - 2,283,061 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005375133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01006508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01006509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01006510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01090871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCB01021956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000017660 ⟹ ENSCLAP00000017488

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955406	34,626,494 - 34,717,546 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000017661 ⟹ ENSCLAP00000017489

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955406	34,627,241 - 34,712,859 (+)	Ensembl

RefSeq Acc Id:

XM_005375133 ⟹ XP_005375190

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955406	34,575,292 - 34,714,024 (+)	NCBI

Sequence:

show sequence

CTCCTCGGGGATGCCGGGATGTTTACACTCCTGACAGCGGCGGCCGCGCGAGGAGGAGCGGGAG
CCGCGGGAGGATGGGCCGCCGCTAGCTTCGCTCCGGGGCCGCACCTCGCTGTGCGCTGGGTGGG
TGCCCGCGCTGCAGCTTCCGCGGGGGCGGCGCGGCGGGAGGTGGCCGAGCGGCTCGGGCCGCGC
AGTCTCGCCCCCGGCCCAGTGGGCCTTTCCGCGGCGCGCCGGGCCGCGCTGCCCGCTCGCGGCG
TCTCTCGAGGGCGGGGATCGGAACCCTCGCAACTTCCTGAGTTTTAAAGTTTCTGTTGCTTCAA
ACAATGGATGAACAATCACAAGGAATGCAGGGGCCACTTGTTCCTCAGTTCCAGCCACAGAAGG
CCTTACGACCGGATATGGGTTATAATACATTAGCCAACTTTCGAATAGAAAAGAAAATTGGTCG
TGGACAATTTAGTGAAGTTTATAGAGCATCTTGTCTCTTGGATGGAGTACCAGTAGCTTTAAAA
AAAGTGCAGATATTTGATTTAATGGATGCCAAAGCACGTGCTGATTGCATTAAAGAAATAGATC
TCCTCAAGCAACTCAACCATCCAAATGTAATTAAATATTATGCATCATTCATTGAAGATAACGA
ACTAAACATAGTTTTGGAATTAGCAGATGCTGGTGATCTATCCAGAATGATAAAGCATTTTAAA
AAACAGAAGAGGCTGATCCCTGAAAGAACCGTGTGGAAGTACTTTGTTCAGCTCTGCAGCGCGC
TGGAGCACATGCATTCGCGCAGAGTCATGCACAGAGATATAAAGCCAGCTAATGTGTTCATTAC
AGCCACTGGGGTGGTAAAGCTTGGAGATCTTGGGCTTGGTCGGTTTTTCAGTTCCAAAACCACA
GCTGCACATTCTTTAGTGGGTACACCTTATTACATGTCTCCAGAGAGAATACATGAAAATGGAT
ACAACTTCAAATCTGACATCTGGTCTCTTGGCTGTCTACTGTATGAGATGGCTGCATTACAGAG
TCCTTTCTATGGTGACAAAATGAATTTATACTCACTGTGTAAGAAGATAGAACAGTGTGACTAC
CCACCTCTTCCTTCAGATCACTATTCAGAAGAACTGCGACAGTTAGTTAATATGTGCATCAACC
CGGATCCAGAGAAGCGACCAGACATCACCTATGTGTATGATGTAGCAAAAAGGATGCACGCATG
CACTGCAAGCAGCTAAACACGCAAAATCATGAAGAGCATAACCAAAATAATTTAAAGTATTTTG
TGCAGATCATACCTCCCCGTTCTTGTCTGGGTGTTAAGATTAATATTTCAGAGCTAATGTTCTT
TGAATCCTTAACCAGTTTTCATATCAGCTTCATCTTGTACCAGTCTAAGTCACCTTCTTGCAAA
CCCAAAATGACTTCGAGGTAACCAAGCTGCATGTTAGCAAAGAACGTGGTTCAGGACAGTAGTC
GCCGAAGGTTTTTGACTGAGAGTTACTATATTTTTTTTTATTAATACGTGTTTGCAGTACACTT
TTTGATGGTAAATTGTACTTAGAGTGTCAGTGCCAAATAACAAGGTTGCATCCTGTAGACATCA
AGGTAGATGCGAAACCTGAGGAAATACTTGCTGATCCACCACAAAGGGAATGTAGAGTTTTCTT
AATTGTAATTGCCATAAGTTTAGGGAACTAGGTGTTTTCAAAATTGTATATGATATTTTATACT
TTCTGTCTTGAAAATGTGTCTTTAGGAATGATTTAAACATTCTGAAAACTTACAAATCTGAATA
TTTGACTTGTTTGCTTTTTGTAGTCACTTATGGACATTTAATTTGAAGTGTACATCTTAGCTCT
TCTGCATTATCACTGTCAGATATAATTCTTATAATAATTGTAAGCATAAACTAGTTGATAAACA
TTTAGATTCTTAGCTTATACATTCAAAATGCATTTATCAAATGTGAAAAGATTGGGGGCAAAAT
GTGAGTCAGACACTGAAGAGTCTATTATTTTAATAGCTTTGATATTCTATTTACATTAAAATGG
TATAAATGAATCCATTTAAAAAGTGGTTAAGGATTTCTTTGGCTGGTTTGATAGTTTTTAAAGT
TGCACGTTGCTCAAGGCTTTTTGTTTATTGTTTGTATGTACATTTGAAAAATACTCTGAATAAT
CTTACAGTACTATATTTCAGTTTCTTTATAAGTCTAAATGTATTTTAACTCATAATTGTACACT
ATAATGTAAGCATATGTTTTTATTGAAGATTTTATTAAAGTTCTGATTGGTCCCCTTCAGAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005375190	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000017488
	ENSCLAP00000017488.1
	ENSCLAP00000017489.1

RefSeq Acc Id:

XP_005375190 ⟸ XM_005375133

- UniProtKB:

A0A8C2YRA4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDEQSQGMQGPLVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRASCLLDGVPVALKK
VQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKK
QKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTA
AHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYP
PLPSDHYSEELRQLVNMCINPDPEKRPDITYVYDVAKRMHACTASS

hide sequence

RefSeq Acc Id:

ENSCLAP00000017488 ⟸ ENSCLAT00000017660

RefSeq Acc Id:

ENSCLAP00000017489 ⟸ ENSCLAT00000017661

Protein Domains

Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000012012	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000017660	ENTREZGENE
	ENSCLAT00000017660.1	UniProtKB/TrEMBL
	ENSCLAT00000017661.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	Nek7	ENTREZGENE
PANTHER	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE NEK7	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PIRSF	Integrin-linked_kinase	UniProtKB/TrEMBL
PRINTS	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
UniProt	A0A8C2YR97_CHILA	UniProtKB/TrEMBL
	A0A8C2YRA4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Nek7	NIMA related kinase 7		NIMA-related kinase 7	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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