Terf2ip (TERF2 interacting protein)

Gene: Terf2ip (TERF2 interacting protein) Chinchilla lanigera

Analyze

Symbol:

Terf2ip

Name:

TERF2 interacting protein

RGD ID:

8812874

Description:

ENCODES a protein that exhibits telomeric DNA binding (ortholog); INVOLVED IN negative regulation of DNA recombination at telomere (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); protection from non-homologous end joining at telomere (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); male germ cell nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

telomeric repeat-binding factor 2-interacting protein 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	1,917,767 - 1,925,044 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	1,917,902 - 1,924,482 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of DNA recombination at telomere (ISO)

positive regulation of canonical NF-kappaB signal transduction (ISO)

protection from non-homologous end joining at telomere (ISO)

regulation of DNA-templated transcription (ISO)

regulation of double-strand break repair via homologous recombination (ISO)

telomere maintenance via telomere lengthening (ISO)

telomeric loop formation (ISO)

Cellular Component

chromosome, telomeric region (ISO)

cytoplasm (ISO)

male germ cell nucleus (ISO)

nucleus (ISO)

Molecular Function

protein binding (ISO)

telomeric DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Terf2ip
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	1,917,767 - 1,925,044 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	1,917,902 - 1,924,482 (-)	NCBI	ChiLan1.0	ChiLan1.0

TERF2IP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	75,760,050 - 75,914,672 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	75,647,773 - 75,761,872 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	75,681,602 - 75,691,340 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	74,239,185 - 74,248,829 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	74,239,184 - 74,248,829	NCBI
Celera	16	59,975,980 - 59,985,684 (+)	NCBI		Celera
Cytogenetic Map	16	q23.1	NCBI
HuRef	16	61,435,312 - 61,445,016 (+)	NCBI		HuRef
CHM1_1	16	77,206,325 - 77,364,191 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	81,808,326 - 81,966,242 (+)	NCBI		T2T-CHM13v2.0

Terf2ip
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	112,737,991 - 112,747,160 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	112,738,030 - 112,747,160 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	112,011,359 - 112,020,528 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	112,011,398 - 112,020,528 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	114,535,259 - 114,544,428 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	114,898,078 - 114,907,132 (+)	NCBI		MGSCv36	mm8
Celera	8	116,240,716 - 116,249,885 (+)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	58.29	NCBI

Terf2ip
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	56,886,211 - 56,893,300 (+)	NCBI		GRCr8
mRatBN7.2	19	39,976,965 - 39,984,055 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	39,976,906 - 39,984,064 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	46,840,498 - 46,847,586 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	47,493,834 - 47,500,922 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	49,743,110 - 49,750,199 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	44,231,317 - 44,238,406 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	44,231,251 - 44,238,404 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	55,037,928 - 55,044,773 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	41,946,621 - 41,954,910 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	41,951,501 - 41,959,790 (+)	NCBI
Celera	19	39,337,396 - 39,344,484 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

TERF2IP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	85,365,677 - 85,375,227 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	91,288,270 - 91,297,800 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	56,216,920 - 56,226,612 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	75,565,090 - 75,574,701 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	75,565,184 - 75,573,882 (+)	Ensembl	panpan1.1		panPan2

Terf2ip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	35,269,446 - 35,276,971 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	24,312,101 - 24,320,543 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	24,312,140 - 24,319,492 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TERF2IP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	12,014,243 - 12,057,448 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	12,047,409 - 12,057,451 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	11,888,301 - 11,898,336 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TERF2IP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	61,133,028 - 61,142,713 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	61,133,173 - 61,141,896 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	14,917,275 - 14,926,965 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Terf2ip
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	11,327,467 - 11,337,496 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	11,327,473 - 11,337,489 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005403434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01058073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01235374	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000016207 ⟹ ENSCLAP00000016043

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955484	1,917,767 - 1,925,044 (-)	Ensembl

RefSeq Acc Id:

XM_005403434 ⟹ XP_005403491

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955484	1,917,902 - 1,924,482 (-)	NCBI

Sequence:

show sequence

CAGGCGCAGTGTGAGCTCCGTGGCTGTCAGAGCGACTTCCGCAAGGGCTCCCTCTAGGAAGCGC
TTGTCTCCGGGCGGCTGCTGTGGTGCCGGGCGTCAGACATGGCGGAGGCGCTGGAGATGGGCAA
AGACCCCAACGGGCCCACCCATTCCTCTACTCTGTTCGTGAGGGCAGACGGGAGCCCGCTGTCG
TTCTACGTGCGGCCCAGCCCGGCCAAGCGCCGGCTGTCCACGCTGATCCTGCACGGCGGCGGCA
CCGTGTGCCGCGTGCAGGAGCCCGGGGCGGTGCTGCTGGCCCAGCCGGGGGAAGCGCTGGCCGA
GGCCTCGGGCGACTTCATCTCCACGCAGTACATCCTGGACTGCGTGGAGCGCAACGAGAGGCTG
GAAATGGAAGCCTATCGGCTGCGCGCCGCCTCGGCGGGCGAGCAGGCTGCGGAGTCCAAGCCCG
GCGCCGCGGGCGAGGGCGCCGCCGAGCGCGAGCCGCAGCCGCTCCCGGGGCGCGTGGCCTTCAC
GGACGCGGACGACGTGGCCATCCTGACCTACGTGAAGGAGCACGCGCGCTCGCCCAGCTCGGTC
ACCGGCAACGCCCTGTGGAAAGCGATGGAGAAGGGCGCGCTCACGCAGCACTCGTGGCAGGCCA
TGAAGGACCGCTACCTCAAGCACCTGCGCGGCCAGGAGCACAAGTACCTGCTGGGGGACGCGCC
CGTGAGCCCCTCTTCGCAGAAGCTCAAGAGGAAGGCGGAGCAGGACCCCGAGGCTGCGGACAGC
GGGGAACCACAGAATAAGAGAACTCCAGACTTGCCTGAAGAAGAATATGTGAAAGAAGAGACTG
GGAAAAATGAAGAAACAGTAAAAAAAATGCTTGTAGAAACCACCCAGGACTTTGGGGAAGTTGT
GGTTAATGAGAGCTCTGATTTTGAAATCCACATAACTATGTGTGATGATGACCCTCCCACACCA
GAAGAAGACTTAGAAACACAGCCTGATGAGGAGGAAGAAGAAAAACTTTCTTCACCAGAGGTGG
GAGCTGCCATTAAGATTATCCGGCAATTAATGGAAAAGTTTAACTTGGATCTATCAACAGTCAC
ACAGGCCTTCCTAAAAAATAGTGGTGAGTTGGAGGCTACCTCCTCCTTTTTAGAGTCTGGTCGG
AGAGCAGATGGGTACCCCATTTGGTCCCGGCAAGATGACTTAGATTTGCAAAAAAATGATGAAG
CTACCAGAGAGGCTTTAGTCAAAAAATTTGGTGCTCAGAATGTAGCTCGGAGGATTGAATTCCG
AAAAAAATAATTAGCAAGGTAATGAGAAAAGAAAAAAACCATGAACAGTTGTGACCTGTGAACT
TCAAAAAGTTCTTACATTGAAACTGACATTTATCTTCTGACCAATGCTGCTATCATTCTGTGAG
TCTCAGTTTCTGTAGCCAAGCAGAGTTATGTAGGAGGATAAAAGTCAAAGAAATTGGATATATT
TAGAGTTGTCCCTGGAAAGTATCAGTGTGTTTAAGAAAGGAAAATCTGAACCAGAGAAGTCGAT
CTACTAGGTAGTAATCCTTTGCTGGAATGGGAGCCCTGCTGTGCTAGTGAGAAGGAGCTTAGTG
ACAGAGTCAAAGAAAGAAAATCAGGACCATAGGTCTTTCCACATAGCTTGAGTAAAGAGCCTCC
TGTCCTTTGCCAGAAGTTTGTCAGATCATAGTAGATTCAAATCCAAGAATCTAGAAAAATGGAA
ATTTATAATAAAAGGCCTTGAACATGGAGTGTCCCAAACCATTCCATTCCCAAGGAGCTCTAAA
TTTCTAGAATGTTTTGAAAATTGCATATTTGCTTTGCTAACTTAGTATTCAGGGCCCCTGTTCT
TTGGCTATTGTTTTCTTGGAGCACTTCTGAGTCAGGTCTCTAGTATATGTCTCTACCTGACACT
CAGTTCTGTTTCAAACGCAGACAAACCCCCAGAGTCTCAAGAACTATCTCTATTAATAGTAATG
TGGTTTTTAAACGTCAATTGTGCATAGCTTTGTGCTAAAGATTGTGTTAGACTTAAAAATTCAT
GAATTGGTTCTTTGTTGTGTTTTCATTATTGAAAATAAATAAAACTTTGAATCTTTTAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005403491	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000016043
	ENSCLAP00000016043.1

RefSeq Acc Id:

XP_005403491 ⟸ XM_005403434

- UniProtKB:

A0A8C2VNS0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEALEMGKDPNGPTHSSTLFVRADGSPLSFYVRPSPAKRRLSTLILHGGGTVCRVQEPGAVLL
AQPGEALAEASGDFISTQYILDCVERNERLEMEAYRLRAASAGEQAAESKPGAAGEGAAEREPQ
PLPGRVAFTDADDVAILTYVKEHARSPSSVTGNALWKAMEKGALTQHSWQAMKDRYLKHLRGQE
HKYLLGDAPVSPSSQKLKRKAEQDPEAADSGEPQNKRTPDLPEEEYVKEETGKNEETVKKMLVE
TTQDFGEVVVNESSDFEIHITMCDDDPPTPEEDLETQPDEEEEEKLSSPEVGAAIKIIRQLMEK
FNLDLSTVTQAFLKNSGELEATSSFLESGRRADGYPIWSRQDDLDLQKNDEATREALVKKFGAQ
NVARRIEFRKK

hide sequence

RefSeq Acc Id:

ENSCLAP00000016043 ⟸ ENSCLAT00000016207

Protein Domains

BRCT Rap1 Myb TRF2-interacting telomeric protein/Rap1 C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000011045	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000016207	ENTREZGENE
	ENSCLAT00000016207.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.2170	UniProtKB/TrEMBL
	3.40.50.10190	UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/TrEMBL
InterPro	BRCT_dom	UniProtKB/TrEMBL
	BRCT_dom_sf	UniProtKB/TrEMBL
	Homeobox-like_sf	UniProtKB/TrEMBL
	Rap1_C	UniProtKB/TrEMBL
	Rap1_C_sf	UniProtKB/TrEMBL
	Rap1_Myb_dom	UniProtKB/TrEMBL
	TE2IP/Rap1	UniProtKB/TrEMBL
NCBI Gene	Terf2ip	ENTREZGENE
PANTHER	PTHR16466	UniProtKB/TrEMBL
	TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1	UniProtKB/TrEMBL
Pfam	BRCT_2	UniProtKB/TrEMBL
	Myb_DNA-bind_2	UniProtKB/TrEMBL
	Rap1_C	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	A0A8C2VNS0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Terf2ip	TERF2 interacting protein		telomeric repeat binding factor 2, interacting protein	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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