Mark4 (microtubule affinity regulating kinase 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mark4 (microtubule affinity regulating kinase 4) Chinchilla lanigera
Analyze
Symbol: Mark4
Name: microtubule affinity regulating kinase 4
RGD ID: 8811142
Description: ENCODES a protein that exhibits cytoskeletal anchor activity (ortholog); gamma-tubulin binding (ortholog); microtubule binding (ortholog); INVOLVED IN cilium organization (ortholog); microtubule bundle formation (ortholog); microtubule cytoskeleton organization (ortholog); FOUND IN centrosome (ortholog); ciliary basal body (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MAP/microtubule affinity-regulating kinase 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555552,286,365 - 2,315,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555552,284,615 - 2,315,152 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mark4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555552,286,365 - 2,315,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555552,284,615 - 2,315,152 (+)NCBIChiLan1.0ChiLan1.0
MARK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,251,271 - 45,305,284 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,079,288 - 45,305,284 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,754,529 - 45,808,542 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,446,682 - 50,500,381 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,446,681 - 50,500,381NCBI
Celera1942,560,416 - 42,614,109 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,186,730 - 42,240,375 (+)NCBIHuRef
CHM1_11945,757,812 - 45,811,842 (+)NCBICHM1_1
T2T-CHM13v2.01948,077,944 - 48,131,959 (+)NCBIT2T-CHM13v2.0
Mark4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,159,027 - 19,193,255 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,158,700 - 19,192,746 (-)EnsemblGRCm39 Ensembl
GRCm38719,425,102 - 19,459,330 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,424,775 - 19,458,821 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,011,424 - 20,043,843 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,584,597 - 18,617,016 (-)NCBIMGSCv36mm8
Celera716,832,468 - 16,864,312 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.78NCBI
Mark4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,203,352 - 88,239,858 (-)NCBIGRCr8
mRatBN7.2179,075,353 - 79,108,882 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,068,904 - 79,108,556 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,464,089 - 84,497,076 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,022,035 - 93,055,153 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,219,187 - 86,252,174 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,335,517 - 80,367,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,335,526 - 80,367,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,601,789 - 81,633,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,776,358 - 78,809,172 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,537,656 - 73,568,075 (-)NCBICelera
Cytogenetic Map1q21NCBI
MARK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,412,240 - 51,464,569 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,283,626 - 53,335,977 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,200,080 - 42,252,432 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,800,366 - 50,851,832 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,800,366 - 50,851,832 (+)Ensemblpanpan1.1panPan2
MARK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,222,760 - 110,248,745 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,222,754 - 110,247,411 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,704,511 - 109,734,401 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01110,752,887 - 110,782,763 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,748,595 - 110,783,360 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,428,494 - 110,458,379 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,062,832 - 110,092,741 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,932,199 - 110,962,137 (-)NCBIUU_Cfam_GSD_1.0
Mark4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,416,894 - 17,442,402 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,762,869 - 1,788,821 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,764,239 - 1,789,745 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,665,918 - 51,700,552 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,665,923 - 51,700,553 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MARK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,710,593 - 38,761,548 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,710,467 - 38,760,561 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607318,304,443 - 18,358,991 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mark4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249072,184,729 - 2,212,666 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249072,184,702 - 2,212,673 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000002992   ⟹   ENSCLAP00000002934
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555552,286,365 - 2,315,146 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000002993   ⟹   ENSCLAP00000002935
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555552,286,534 - 2,313,603 (+)Ensembl
RefSeq Acc Id: XM_005412505   ⟹   XP_005412562
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555552,286,371 - 2,315,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005412506   ⟹   XP_005412563
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555552,284,615 - 2,315,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005412507   ⟹   XP_005412564
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555552,285,160 - 2,315,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005412508   ⟹   XP_005412565
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555552,286,503 - 2,315,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005412509   ⟹   XP_005412566
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555552,286,371 - 2,313,702 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005412563   ⟸   XM_005412506
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005412564   ⟸   XM_005412507
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005412566   ⟸   XM_005412509
- Peptide Label: isoform X5
- UniProtKB: A0A8C2UM45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005412562   ⟸   XM_005412505
- Peptide Label: isoform X1
- UniProtKB: A0A8C2US33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005412565   ⟸   XM_005412508
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSCLAP00000002935   ⟸   ENSCLAT00000002993
Ensembl Acc Id: ENSCLAP00000002934   ⟸   ENSCLAT00000002992
Protein Domains
KA1   Protein kinase   UBA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002104 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000002992 ENTREZGENE
  ENSCLAT00000002992.1 UniProtKB/TrEMBL
  ENSCLAT00000002993 ENTREZGENE
  ENSCLAT00000002993.1 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
  Kinase associated domain 1, KA1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro KA1/Ssp2_C UniProtKB/TrEMBL
  KA1_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MARK1-4_cat UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
NCBI Gene Mark4 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  MAP/MICROTUBULE AFFINITY-REGULATING KINASE 4 UniProtKB/TrEMBL
Pfam KA1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
PROSITE KA1 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2UM45 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2US33 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Mark4  microtubule affinity regulating kinase 4    MAP/microtubule affinity-regulating kinase 4  Symbol and/or name change 5135510 APPROVED