Dis3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease) - Rat Genome Database

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Gene: Dis3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease) Chinchilla lanigera
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Symbol: Dis3
Name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
RGD ID: 8804705
Description: ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); endonuclease activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN CUT catabolic process (ortholog); RNA catabolic process (ortholog); RNA processing (ortholog); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH chromosome 13q14 deletion syndrome (ortholog); Joubert syndrome 33 (ortholog); multiple myeloma (ortholog); FOUND IN cytosol (ortholog); nuclear exosome (RNase complex) (ortholog); nucleolus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DIS3 mitotic control homolog; exosome complex exonuclease RRP44
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540433,897,237 - 33,924,069 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540433,897,681 - 33,924,069 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dis3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540433,897,237 - 33,924,069 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540433,897,681 - 33,924,069 (+)NCBIChiLan1.0ChiLan1.0
DIS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381372,752,169 - 72,781,900 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1372,752,169 - 72,782,096 (-)EnsemblGRCh38hg38GRCh38
GRCh371373,326,307 - 73,356,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361372,227,541 - 72,254,007 (-)NCBINCBI36Build 36hg18NCBI36
Build 341372,227,541 - 72,254,007NCBI
Celera1354,228,002 - 54,254,806 (-)NCBICelera
Cytogenetic Map13q21.33NCBI
HuRef1354,026,857 - 54,053,683 (-)NCBIHuRef
CHM1_11373,297,230 - 73,324,057 (-)NCBICHM1_1
T2T-CHM13v2.01371,973,643 - 72,003,383 (-)NCBIT2T-CHM13v2.0
Dis3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391499,314,070 - 99,337,217 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1499,312,642 - 99,337,206 (-)EnsemblGRCm39 Ensembl
GRCm381499,076,634 - 99,099,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1499,075,206 - 99,099,770 (-)EnsemblGRCm38mm10GRCm38
MGSCv371499,475,853 - 99,498,989 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361497,960,404 - 97,982,874 (-)NCBIMGSCv36mm8
Celera1497,752,393 - 97,775,528 (-)NCBICelera
Cytogenetic Map14E2.2NCBI
cM Map1449.25NCBI
Dis3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81582,231,922 - 82,258,299 (-)NCBIGRCr8
mRatBN7.21575,820,040 - 75,850,450 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1575,823,436 - 75,850,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1579,808,848 - 79,835,406 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01580,885,466 - 80,912,024 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01577,833,009 - 77,859,568 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01583,466,330 - 83,494,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1583,466,428 - 83,494,423 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01586,975,865 - 87,005,393 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41582,855,389 - 82,881,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11582,871,188 - 82,897,665 (-)NCBI
Celera1575,064,436 - 75,090,827 (-)NCBICelera
Cytogenetic Map15q21NCBI
DIS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21474,335,657 - 74,362,392 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11372,931,207 - 72,953,629 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01353,982,914 - 54,011,076 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11372,760,610 - 72,787,325 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1372,760,610 - 72,787,325 (-)Ensemblpanpan1.1panPan2
DIS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12226,908,502 - 26,935,368 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2226,909,409 - 26,935,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2226,761,433 - 26,791,766 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02227,236,965 - 27,267,364 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2227,236,861 - 27,266,597 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12226,899,065 - 26,929,340 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02226,938,509 - 26,968,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02227,009,909 - 27,040,201 (-)NCBIUU_Cfam_GSD_1.0
Dis3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945132,665,787 - 132,687,976 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365118,082,406 - 8,108,233 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365118,082,909 - 8,105,203 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,044,508 - 45,075,963 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,046,040 - 45,075,973 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21149,594,714 - 49,614,004 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DIS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1351,890,033 - 51,916,628 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl351,888,707 - 51,916,643 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660467,984,139 - 8,013,994 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dis3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475127,760,776 - 27,785,613 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475127,760,665 - 27,786,403 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000004916   ⟹   ENSCLAP00000004825
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540433,897,237 - 33,924,069 (+)Ensembl
RefSeq Acc Id: XM_005374190   ⟹   XP_005374247
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540433,897,681 - 33,924,069 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005374191   ⟹   XP_005374248
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540433,897,681 - 33,924,069 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001234968
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540433,897,681 - 33,924,069 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005374247 (Get FASTA)   NCBI Sequence Viewer  
  XP_005374248 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000004825
  ENSCLAP00000004825.1
RefSeq Acc Id: XP_005374248   ⟸   XM_005374191
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005374247   ⟸   XM_005374190
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UY21 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000004825   ⟸   ENSCLAT00000004916
Protein Domains
PIN   RNB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003424 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000004916 ENTREZGENE
  ENSCLAT00000004916.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
  2.40.50.690 UniProtKB/TrEMBL
  2.40.50.700 UniProtKB/TrEMBL
  5'-nuclease UniProtKB/TrEMBL
InterPro Dis3_CSD2 UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  PIN-like_dom_sf UniProtKB/TrEMBL
  PIN_dom UniProtKB/TrEMBL
  RNase_II/R UniProtKB/TrEMBL
  RNase_II/R_CS UniProtKB/TrEMBL
  RNR_Ribonuclease UniProtKB/TrEMBL
  Rrp44_CSD1 UniProtKB/TrEMBL
  RRP44_S1 UniProtKB/TrEMBL
NCBI Gene Dis3 ENTREZGENE
PANTHER EXOSOME COMPLEX EXONUCLEASE RRP44 UniProtKB/TrEMBL
  RIBONUCLEASE UniProtKB/TrEMBL
Pfam OB_Dis3 UniProtKB/TrEMBL
  PIN_4 UniProtKB/TrEMBL
  RNB UniProtKB/TrEMBL
  Rrp44_CSD1 UniProtKB/TrEMBL
  Rrp44_S1 UniProtKB/TrEMBL
PROSITE RIBONUCLEASE_II UniProtKB/TrEMBL
SMART PINc UniProtKB/TrEMBL
  RNB UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/TrEMBL
  SSF88723 UniProtKB/TrEMBL
UniProt A0A8C2UY21 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Dis3  DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease    DIS3 mitotic control homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED