Grk5 (G protein-coupled receptor kinase 5)

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Gene: Grk5 (G protein-coupled receptor kinase 5) Chinchilla lanigera

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Symbol:

Grk5

Name:

G protein-coupled receptor kinase 5

RGD ID:

8797552

Description:

ENCODES a protein that exhibits beta-adrenergic receptor kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN desensitization of G protein-coupled receptor signaling pathway (ortholog); fat cell differentiation (ortholog); negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH Alzheimer's disease (ortholog); cardiovascular system disease (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN cytosol (ortholog); nuclear membrane (ortholog); nuclear speck (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955551	44,156 - 254,534 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955551	43,918 - 255,118 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

cardiovascular system disease (ISO)

Cocaine-Related Disorders (ISO)

congestive heart failure (ISO)

hypertension (ISO)

Inflammation (ISO)

liver disease (ISO)

obstructive lung disease (ISO)

Parkinson's disease (ISO)

rheumatoid arthritis (ISO)

Sepsis (ISO)

Temporomandibular Joint Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

desensitization of G protein-coupled receptor signaling pathway (ISO)

fat cell differentiation (ISO)

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

negative regulation of apoptotic process (ISO)

oligodendrocyte differentiation (ISO)

positive regulation of cell population proliferation (ISO)

protein autophosphorylation (ISO)

regulation of cell cycle (ISO)

regulation of G protein-coupled receptor signaling pathway (ISO)

response to cocaine (ISO)

tachykinin receptor signaling pathway (ISO)

Cellular Component

cytosol (ISO)

nuclear membrane (ISO)

nuclear speck (ISO)

plasma membrane (ISO)

Molecular Function

beta-adrenergic receptor kinase activity (ISO)

protein binding (ISO)

protein serine/threonine kinase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via muscarinic acetylcholine receptor (ISO)

angiotensin II signaling pathway via AT1 receptor (ISO)

dopamine signaling pathway via D1 family of receptors (ISO)

dopamine signaling pathway via D2 family of receptors (ISO)

epinephrine signaling pathway via adrenergic receptor beta (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Grk5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955551	44,156 - 254,534 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955551	43,918 - 255,118 (+)	NCBI	ChiLan1.0	ChiLan1.0

GRK5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	119,207,571 - 119,459,745 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	119,207,571 - 119,459,745 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	120,967,083 - 121,219,257 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	120,957,187 - 121,205,121 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	120,957,186 - 121,205,120	NCBI
Celera	10	114,696,799 - 114,943,133 (+)	NCBI		Celera
Cytogenetic Map	10	q26.11	NCBI
HuRef	10	114,596,405 - 114,842,644 (+)	NCBI		HuRef
CHM1_1	10	121,251,583 - 121,499,541 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	120,102,994 - 120,355,311 (+)	NCBI		T2T-CHM13v2.0

Grk5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	60,877,995 - 61,084,406 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	60,878,187 - 61,084,406 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	60,889,560 - 61,095,968 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	60,889,749 - 61,095,968 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	60,965,652 - 61,168,459 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	60,945,139 - 61,147,005 (+)	NCBI		MGSCv36	mm8
Celera	19	63,189,741 - 63,294,504 (+)	NCBI		Celera
Cytogenetic Map	19	D3	NCBI
cM Map	19	56.52	NCBI

Grk5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	270,014,314 - 270,208,294 (+)	NCBI		GRCr8
mRatBN7.2	1	260,028,269 - 260,223,699 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	260,028,242 - 260,218,701 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	268,234,940 - 268,425,947 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	274,940,966 - 275,131,956 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	267,595,271 - 267,786,197 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	282,265,371 - 282,467,842 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	282,265,370 - 282,462,605 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	289,603,922 - 289,802,914 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	267,495,534 - 267,693,144 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	267,706,618 - 267,904,229 (+)	NCBI
Celera	1	255,668,943 - 255,859,242 (+)	NCBI		Celera
Cytogenetic Map	1	q55	NCBI

GRK5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	131,064,338 - 131,314,329 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	131,069,692 - 131,319,683 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	115,776,236 - 116,026,221 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	119,200,901 - 119,448,006 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	119,200,688 - 119,450,809 (+)	Ensembl	panpan1.1		panPan2

GRK5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	29,424,350 - 29,636,552 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	29,424,593 - 29,632,741 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	29,566,413 - 29,778,694 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	29,955,098 - 30,167,121 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	29,955,134 - 30,165,427 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	29,509,598 - 29,721,404 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	29,529,525 - 29,741,448 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	29,723,728 - 29,936,023 (+)	NCBI		UU_Cfam_GSD_1.0

Grk5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	16,730,225 - 16,924,264 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936486	8,720,036 - 8,831,075 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936486	8,720,036 - 8,830,472 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GRK5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	129,113,603 - 129,347,152 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	129,113,933 - 129,351,135 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	140,638,292 - 140,875,396 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GRK5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	111,996,780 - 112,249,247 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	111,996,599 - 112,244,570 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	73,269,146 - 73,517,028 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Grk5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	27,375,149 - 27,600,210 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624737	27,379,114 - 27,600,132 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005412154	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005412155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01072649	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01072650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01072651	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01085529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000002637 ⟹ ENSCLAP00000002584

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955551	44,156 - 254,534 (+)	Ensembl

RefSeq Acc Id:

XM_005412154 ⟹ XP_005412211

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955551	228,757 - 255,118 (+)	NCBI

Sequence:

show sequence

GCCTGCGATGGACTGTGTTCATCTTTATATTGTCCCTCCAAGGAAACAGGCCCAGGTGGCCAAG
GGATGTCACCATGCTCAACAGGGGCTCCCTGATGAGCTGGACCATGGTGTGCAGCTCCTTGTGA
CTGTGAGCACGTGCATACTCAGTCACTTCTGGCCACAACCTCAGGCCACAGGAGGTATGAGACT
CAGAAGAGCCACCTACCTCTGTGACATCACACAGCTTGTAAGTGGCAAAGCCGGAAATCTCCCC
CTAAGTCTGAGCTCCGCACCTTCTCACCCAGCCATCTCCCCATGCTGCTGGACACTGTCCACAT
GGCCCAGGCCAGGCGTGGGGGCGGGAGGCGGATGGACACACACGAGGTCCCCAGTTTTCATTGC
TGAAGTCAGCCGAGACCTGGTGTCCCAGACAGAGGCCAAGCTCCTGCAGAGACCCTGTAAAGAG
CTGTTTTCTGCCTGTGCGCAGTCTGTCCACGACTACCTGAGGGGCGATCCGTTCCACGAATACC
TGGACAGCATGTATTTTGACCGCTTTCTCCAGTGGAAGTGGTTGGAGAGGCAACCGGTGACTAA
AAACACTTTCAGGCAGTACCGAGTGCTGGGGAAAGGGGGCTTCGGGGAGGTCTGTGCCTGCCAG
GTTCGGGCCACAGGTAAAATGTATGCCTGCAAGCGCTTGGAGAAGAAGAGGATCAAAAAGAGAA
AAGGGGAGTCCATGGCGCTCAATGAGAAGCAGATTCTTGAGAAGGTCAACAGCCAGTTTGTGGT
CAACCTGGCCTACGCCTATGAGACCAAGGATGCGCTGTGCCTGGTCCTGACCATCATGAACGGG
GGCGACCTGAAGTTCCACATCTACAACATGGGGAACCCAGGCTTCGAGGAGGAGCGAGCCTTGT
TTTACGCTGCGGAGATCCTCTGTGGCTTGGAGGACCTGCATCGCGAGAACACTGTCTACAGAGA
CCTGAAACCCGAAAACATCCTGTTGGATGATTATGGCCACATCAGGATCTCGGACCTGGGCCTG
GCCGTGAAGATCCCCGAGGGAGACCTGATCCGTGGCCGGGTGGGCACCGTTGGCTACATGGCTC
CGGAGGTCCTGAACAACCAGCGATATGGCCTGAGCCCCGACTACTGGGGCCTAGGCTGCCTCAT
CTATGAGATGATCGAGGGCCAGTCGCCGTTCCGGGGCCGCAAGGAGAAGGTGAAGCGGGAGGAG
GTGGACCGCCGCGTCTTGGAGACTGAGGAGGTGTACTCGCACAAGTTCTCCGAGGAGGCCAAGT
CCATCTGCAGGATGCTGCTCACCAAAGACGCAAAGCAGAGGCTGGGCTGTCAGGAGGAGGGCGC
AGCCGAGGTCAAGAGGCACCCCTTCTTCCGGAACATGAACTTCAAGCGCTTGGAGGCCGGAATG
CTGGACCCTCCCTTCATTCCGGATCCGCGAGCCGTGTATTGTAAGGATGTCCTGGACATCGAGC
AGTTCTCCACCGTGAAAGGCGTCAACTTGGACCACACGGATGACGACTTCTACTCCAAGTTCTC
CACAGGCTCCGTGTCCATCCCATGGCAGAATGAGATGATAGAAACAGAATGCTTTAAAGAGCTG
AACGTGTTTGGACCTGATGGTACCCTCTCATCGGACCTGAACCGAAGTCAGCCTCCCGAACCAC
CGAAGAAAGGGCTGCTCCAAAGACTCTTCCGGCGTCAGCATCAGAACAATTCCAAGAGTGCGCC
CAATTCCAAGACCAGTCACAACCACCACATAAATTCAAACCACATCAGCTCGAACTCCACTGGA
AGCAGCTAGTTTCAGCTCTGGCCTTGACGTCCACAGCGAAACCAGCCCAGACCTTCTATTGGGA
AGCAGAACTTGTGGCCAAAGGGGCTTCCGCTCGGCTGGAGGGCCAGCAGAGCCCAGGAGCTGGG
AAAGGAGACCACCCACCCCCTCTACAAGCCTCGAGCTTTCTCAAAGAAATTTCCACTCAGGTCT
GTTTTCCAAGGCAGCCCCATGCCGGGGTGGATTGGATTTGCCCTCGTTGACGTTGCAATAGAAA
CCCAGTGAGATTCAACAACTTGCACGTATTTTAATAGCGTCCTAACTAGAACTGAATTTTGTCT
TTATTATTTTTAAAGAAAAGTTTTGTAAATTTCTCTATTGTCTCAGTTTACATTTTGTATATTT
GTATTTAAATGAAAGTCAGACTTTGAGGGTGTATATTTTCTGTGCAGCCACTGTTAAGCCATGT
GTTTTAAGACATTCTAGGGGGAAGGGATTTACCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGA
AAATGTGACTCCAGACTTCCAAGCCTCAAATGAGAAAATGTTTTTATTAAATGTAGAAAATCTT
TCACCTTTCACCTTTAA

hide sequence

RefSeq Acc Id:

XM_005412155 ⟹ XP_005412212

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955551	43,918 - 255,118 (+)	NCBI

Sequence:

show sequence

GGGTGGGGGGAGAGTGTTGAGGGAGGGGGGAGGGGGGACACAGAGGGAGGAAGAAGCGGCGGCG
GCGGCTTCTCTGTGCAGAGGGGGAAAACTCGAGGGCTCGGAGCAGGAATAATGCGGTAGGCGAG
GCGGGCTGCTGGCTCCCGGCTCTGGCAGCAGCGGCGGCGGCCCGAGCAGCGGCAGCACCCAGGC
GCTGACAGCCCGGCCGGCCGGCTCCCTCGCTGACCGCGGACTGTCAATGGAGCTGGAAAACATC
GTGGCCAACACGGTCTTGCTGAAAGCCCGGGAAGGGGGCGGAGGAAAGCGCAAAGGGAAAAGCA
AGAAGTGGAAGGAAATCCTGAAGTTCCCTCACATCAGCCAGTGTGAAGACCTGCGAAGGACTAT
AGACAGAGATTACTGCAGTTTATGTGACAAGCAGCCTATCGGGCGGCTGCTTTTCCGACAGTTC
TGCGAAACCCGGCCTGGGCTGGAGTGCTACATTCAGTTCCTGGACTCAGTGGCAGAATATGAAG
TTACTCCAGATGAAAAACTGGGAGAGAAAGGGAAGGAAATTATGACCAAGTACCTCACCCCAAA
GTCCCCAGTTTTCATTGCTGAAGTCAGCCGAGACCTGGTGTCCCAGACAGAGGCCAAGCTCCTG
CAGAGACCCTGTAAAGAGCTGTTTTCTGCCTGTGCGCAGTCTGTCCACGACTACCTGAGGGGCG
ATCCGTTCCACGAATACCTGGACAGCATGTATTTTGACCGCTTTCTCCAGTGGAAGTGGTTGGA
GAGGCAACCGGTGACTAAAAACACTTTCAGGCAGTACCGAGTGCTGGGGAAAGGGGGCTTCGGG
GAGGTCTGTGCCTGCCAGGTTCGGGCCACAGGTAAAATGTATGCCTGCAAGCGCTTGGAGAAGA
AGAGGATCAAAAAGAGAAAAGGGGAGTCCATGGCGCTCAATGAGAAGCAGATTCTTGAGAAGGT
CAACAGCCAGTTTGTGGTCAACCTGGCCTACGCCTATGAGACCAAGGATGCGCTGTGCCTGGTC
CTGACCATCATGAACGGGGGCGACCTGAAGTTCCACATCTACAACATGGGGAACCCAGGCTTCG
AGGAGGAGCGAGCCTTGTTTTACGCTGCGGAGATCCTCTGTGGCTTGGAGGACCTGCATCGCGA
GAACACTGTCTACAGAGACCTGAAACCCGAAAACATCCTGTTGGATGATTATGGCCACATCAGG
ATCTCGGACCTGGGCCTGGCCGTGAAGATCCCCGAGGGAGACCTGATCCGTGGCCGGGTGGGCA
CCGTTGGCTACATGGCTCCGGAGGTCCTGAACAACCAGCGATATGGCCTGAGCCCCGACTACTG
GGGCCTAGGCTGCCTCATCTATGAGATGATCGAGGGCCAGTCGCCGTTCCGGGGCCGCAAGGAG
AAGGTGAAGCGGGAGGAGGTGGACCGCCGCGTCTTGGAGACTGAGGAGGTGTACTCGCACAAGT
TCTCCGAGGAGGCCAAGTCCATCTGCAGGATGCTGCTCACCAAAGACGCAAAGCAGAGGCTGGG
CTGTCAGGAGGAGGGCGCAGCCGAGGTCAAGAGGCACCCCTTCTTCCGGAACATGAACTTCAAG
CGCTTGGAGGCCGGAATGCTGGACCCTCCCTTCATTCCGGATCCGCGAGCCGTGTATTGTAAGG
ATGTCCTGGACATCGAGCAGTTCTCCACCGTGAAAGGCGTCAACTTGGACCACACGGATGACGA
CTTCTACTCCAAGTTCTCCACAGGCTCCGTGTCCATCCCATGGCAGAATGAGATGATAGAAACA
GAATGCTTTAAAGAGCTGAACGTGTTTGGACCTGATGGTACCCTCTCATCGGACCTGAACCGAA
GTCAGCCTCCCGAACCACCGAAGAAAGGGCTGCTCCAAAGACTCTTCCGGCGTCAGCATCAGAA
CAATTCCAAGAGTGCGCCCAATTCCAAGACCAGTCACAACCACCACATAAATTCAAACCACATC
AGCTCGAACTCCACTGGAAGCAGCTAGTTTCAGCTCTGGCCTTGACGTCCACAGCGAAACCAGC
CCAGACCTTCTATTGGGAAGCAGAACTTGTGGCCAAAGGGGCTTCCGCTCGGCTGGAGGGCCAG
CAGAGCCCAGGAGCTGGGAAAGGAGACCACCCACCCCCTCTACAAGCCTCGAGCTTTCTCAAAG
AAATTTCCACTCAGGTCTGTTTTCCAAGGCAGCCCCATGCCGGGGTGGATTGGATTTGCCCTCG
TTGACGTTGCAATAGAAACCCAGTGAGATTCAACAACTTGCACGTATTTTAATAGCGTCCTAAC
TAGAACTGAATTTTGTCTTTATTATTTTTAAAGAAAAGTTTTGTAAATTTCTCTATTGTCTCAG
TTTACATTTTGTATATTTGTATTTAAATGAAAGTCAGACTTTGAGGGTGTATATTTTCTGTGCA
GCCACTGTTAAGCCATGTGTTTTAAGACATTCTAGGGGGAAGGGATTTACCAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAGAAAATGTGACTCCAGACTTCCAAGCCTCAAATGAGAAAATGTTTTTA
TTAAATGTAGAAAATCTTTCACCTTTCACCTTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005412211	(Get FASTA)	NCBI Sequence Viewer
	XP_005412212	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000002584
	ENSCLAP00000002584.1

RefSeq Acc Id:	XP_005412212 ⟸ XM_005412155
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C2UP20 (UniProtKB/TrEMBL)
- Sequence:	show sequence MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGR LLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAEVSRDLVSQ TEAKLLQRPCKELFSACAQSVHDYLRGDPFHEYLDSMYFDRFLQWKWLERQPVTKNTFRQYRVL GKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETK DALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLD DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSP FRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICRMLLTKDAKQRLGCQEEGAAEVKRHPFF RNMNFKRLEAGMLDPPFIPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQ NEMIETECFKELNVFGPDGTLSSDLNRSQPPEPPKKGLLQRLFRRQHQNNSKSAPNSKTSHNHH INSNHISSNSTGSS hide sequence

RefSeq Acc Id:

XP_005412211 ⟸ XM_005412154

- Peptide Label:

isoform X1

- Sequence:

show sequence

MDCVHLYIVPPRKQAQVAKGCHHAQQGLPDELDHGVQLLVTVSTCILSHFWPQPQATGGMRLRR
ATYLCDITQLVSGKAGNLPLSLSSAPSHPAISPCCWTLSTWPRPGVGAGGGWTHTRSPVFIAEV
SRDLVSQTEAKLLQRPCKELFSACAQSVHDYLRGDPFHEYLDSMYFDRFLQWKWLERQPVTKNT
FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL
AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLK
PENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYE
MIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICRMLLTKDAKQRLGCQEEGAAE
VKRHPFFRNMNFKRLEAGMLDPPFIPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTG
SVSIPWQNEMIETECFKELNVFGPDGTLSSDLNRSQPPEPPKKGLLQRLFRRQHQNNSKSAPNS
KTSHNHHINSNHISSNSTGSS

hide sequence

Ensembl Acc Id:

ENSCLAP00000002584 ⟸ ENSCLAT00000002637

Protein Domains

AGC-kinase C-terminal Protein kinase RGS

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000001870	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000002637	ENTREZGENE
	ENSCLAT00000002637.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.167.10	UniProtKB/TrEMBL
	6.10.250.2260	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	AGC-kinase_C	UniProtKB/TrEMBL
	GPCR_kinase	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	RGS	UniProtKB/TrEMBL
	RGS_sf	UniProtKB/TrEMBL
	RGS_subdomain_2	UniProtKB/TrEMBL
NCBI Gene	Grk5	ENTREZGENE
PANTHER	G PROTEIN-COUPLED RECEPTOR KINASE 5	UniProtKB/TrEMBL
	G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
	RGS	UniProtKB/TrEMBL
PRINTS	GPCRKINASE	UniProtKB/TrEMBL
PROSITE	AGC_KINASE_CTER	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	RGS	UniProtKB/TrEMBL
SMART	RGS	UniProtKB/TrEMBL
	S_TK_X	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48097	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
UniProt	A0A8C2UP20	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - CTD

RGD Manual Annotations