Mllt10 (MLLT10 histone lysine methyltransferase DOT1L cofactor) - Rat Genome Database

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Gene: Mllt10 (MLLT10 histone lysine methyltransferase DOT1L cofactor) Chinchilla lanigera
Analyze
Symbol: Mllt10
Name: MLLT10 histone lysine methyltransferase DOT1L cofactor
RGD ID: 8796185
Description: ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); nucleosome binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH acute monocytic leukemia (ortholog); acute myeloid leukemia (ortholog); genetic disease (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MLLT10, histone lysine methyltransferase DOT1L cofactor; myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554296,999,333 - 7,163,990 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554296,999,333 - 7,163,988 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Mllt10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554296,999,333 - 7,163,990 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554296,999,333 - 7,163,988 (-)NCBIChiLan1.0ChiLan1.0
MLLT10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381021,533,756 - 21,743,630 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1021,524,646 - 21,743,630 (+)EnsemblGRCh38hg38GRCh38
GRCh371021,822,685 - 22,032,559 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361021,863,108 - 22,072,560 (+)NCBINCBI36Build 36hg18NCBI36
Build 341021,863,107 - 22,072,560NCBI
Celera1021,495,732 - 21,720,297 (+)NCBICelera
Cytogenetic Map10p12.31NCBI
HuRef1021,476,633 - 21,694,284 (+)NCBIHuRef
CHM1_11021,823,893 - 22,033,408 (+)NCBICHM1_1
T2T-CHM13v2.01021,552,866 - 21,762,703 (+)NCBIT2T-CHM13v2.0
Mllt10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39218,059,971 - 18,217,201 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl218,060,048 - 18,217,199 (+)EnsemblGRCm39 Ensembl
GRCm38218,055,160 - 18,212,390 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl218,055,237 - 18,212,388 (+)EnsemblGRCm38mm10GRCm38
MGSCv37217,976,898 - 18,134,017 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36217,973,025 - 18,130,144 (+)NCBIMGSCv36mm8
Celera217,952,297 - 18,109,815 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map212.84NCBI
Mllt10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81785,729,964 - 85,857,791 (+)NCBIGRCr8
mRatBN7.21780,821,870 - 80,949,349 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1780,822,556 - 80,949,345 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1784,294,521 - 84,421,795 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01788,129,933 - 88,257,195 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01782,153,817 - 82,279,445 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01784,847,660 - 84,981,134 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1784,881,414 - 84,979,543 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01786,574,897 - 86,705,158 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41792,246,466 - 92,389,861 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11792,257,298 - 92,400,692 (+)NCBI
Celera1780,112,286 - 80,232,138 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
MLLT10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2834,209,484 - 34,430,504 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11034,214,798 - 34,435,518 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01021,686,507 - 21,907,247 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11022,135,281 - 22,284,382 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1021,994,975 - 22,282,737 (+)Ensemblpanpan1.1panPan2
MLLT10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1211,349,864 - 11,607,194 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl211,349,856 - 11,596,398 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha210,042,564 - 10,291,025 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.029,598,648 - 9,848,677 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl29,597,996 - 9,847,891 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.128,911,703 - 9,160,725 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.028,996,500 - 9,245,212 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.029,172,316 - 9,421,340 (-)NCBIUU_Cfam_GSD_1.0
Mllt10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934421,594,099 - 21,783,693 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365206,176,599 - 6,366,428 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365206,176,784 - 6,366,436 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLLT10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1053,072,056 - 53,314,862 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11053,072,056 - 53,315,351 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21058,733,136 - 58,799,017 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Mllt10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247966,762,118 - 6,948,816 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247966,762,304 - 6,949,126 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000016951   ⟹   ENSCLAP00000016787
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554296,999,333 - 7,163,990 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000016952   ⟹   ENSCLAP00000016788
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554297,000,880 - 7,136,311 (-)Ensembl
RefSeq Acc Id: XM_013515398   ⟹   XP_013370852
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554296,999,333 - 7,163,988 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013515399   ⟹   XP_013370853
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554296,999,333 - 7,163,988 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013515400   ⟹   XP_013370854
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554296,999,333 - 7,163,988 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013515401   ⟹   XP_013370855
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554296,999,333 - 7,163,988 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013515402   ⟹   XP_013370856
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554296,999,333 - 7,163,988 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013370856   ⟸   XM_013515402
- Peptide Label: isoform X5
- UniProtKB: A0A8C2VQF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013370855   ⟸   XM_013515401
- Peptide Label: isoform X4
- UniProtKB: A0A8C2VQF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013370854   ⟸   XM_013515400
- Peptide Label: isoform X3
- UniProtKB: A0A8C2VQF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013370853   ⟸   XM_013515399
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VQF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013370852   ⟸   XM_013515398
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VQF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000016788   ⟸   ENSCLAT00000016952
RefSeq Acc Id: ENSCLAP00000016787   ⟸   ENSCLAT00000016951
Protein Domains
PHD-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011519 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000016951 ENTREZGENE
  ENSCLAT00000016951.1 UniProtKB/TrEMBL
  ENSCLAT00000016952.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro AF10-like_CC UniProtKB/TrEMBL
  AF10_ePHD UniProtKB/TrEMBL
  EPHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene Mllt10 ENTREZGENE
PANTHER PHD FINGER PROTEINS UniProtKB/TrEMBL
  PROTEIN AF-10 UniProtKB/TrEMBL
Pfam zf-HC5HC2H_2 UniProtKB/TrEMBL
PROSITE EPHD UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
SMART PHD UniProtKB/TrEMBL
UniProt A0A8C2VK29_CHILA UniProtKB/TrEMBL
  A0A8C2VQF0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 Mllt10  MLLT10 histone lysine methyltransferase DOT1L cofactor    MLLT10, histone lysine methyltransferase DOT1L cofactor  Symbol and/or name change 5135510 APPROVED
2017-05-16 Mllt10  MLLT10, histone lysine methyltransferase DOT1L cofactor    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10  Symbol and/or name change 5135510 APPROVED
2015-08-25 Mllt10  myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10  Symbol and/or name change 5135510 APPROVED