Syngap1 (synaptic Ras GTPase activating protein 1) - Rat Genome Database

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Gene: Syngap1 (synaptic Ras GTPase activating protein 1) Chinchilla lanigera
Analyze
Symbol: Syngap1
Name: synaptic Ras GTPase activating protein 1
RGD ID: 8792970
Description: ENCODES a protein that exhibits GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN axonogenesis (ortholog); dendrite development (ortholog); maintenance of postsynaptic specialization structure (ortholog); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); autosomal dominant intellectual developmental disorder 5 (ortholog); autosomal dominant nocturnal frontal lobe epilepsy (ortholog); FOUND IN dendritic shaft (ortholog); glutamatergic synapse (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ras/Rap GTPase-activating protein SynGAP
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,950,602 - 1,979,251 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,950,559 - 1,981,004 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Syngap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,950,602 - 1,979,251 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,950,559 - 1,981,004 (+)NCBIChiLan1.0ChiLan1.0
SYNGAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,418,167 - 33,453,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,419,661 - 33,453,689 (+)EnsemblGRCh38hg38GRCh38
GRCh37633,387,842 - 33,421,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,495,825 - 33,529,444 (+)NCBINCBI36Build 36hg18NCBI36
Celera634,942,270 - 34,975,892 (+)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef633,129,996 - 33,162,361 (+)NCBIHuRef
CHM1_1633,389,741 - 33,423,358 (+)NCBICHM1_1
T2T-CHM13v2.0633,239,529 - 33,275,052 (+)NCBIT2T-CHM13v2.0
Syngap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,160,186 - 27,191,408 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,160,227 - 27,191,408 (+)EnsemblGRCm39 Ensembl
GRCm381726,941,212 - 26,972,434 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,941,253 - 26,972,434 (+)EnsemblGRCm38mm10GRCm38
MGSCv371727,078,397 - 27,107,590 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,669,086 - 26,698,234 (+)NCBIMGSCv36mm8
Celera1727,478,075 - 27,507,298 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.6NCBI
Syngap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,028,226 - 5,058,519 (+)NCBIGRCr8
mRatBN7.2205,026,366 - 5,056,659 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,026,364 - 5,056,672 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,751,876 - 5,782,170 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,113,613 - 5,143,907 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,591,920 - 5,622,090 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,535,434 - 5,564,657 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,535,432 - 5,564,437 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,594,614 - 7,623,865 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,178,523 - 5,208,449 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,191,049 - 5,207,973 (+)NCBI
Celera206,608,780 - 6,637,810 (+)NCBICelera
Cytogenetic Map20p12NCBI
SYNGAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,905,069 - 47,938,759 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,772,255 - 43,805,902 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,999,408 - 33,033,067 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,111,285 - 34,144,490 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,110,652 - 34,144,490 (+)Ensemblpanpan1.1panPan2
SYNGAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,829,274 - 2,862,888 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,829,306 - 2,851,432 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,910,079 - 2,943,658 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,162,881 - 3,194,514 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,162,894 - 3,194,511 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,828,036 - 2,861,597 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,909,144 - 2,942,686 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,007,257 - 3,040,837 (+)NCBIUU_Cfam_GSD_1.0
Syngap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,485,483 - 38,513,743 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,445,775 - 25,474,899 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,446,524 - 25,474,793 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYNGAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,723,588 - 29,753,933 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,723,745 - 29,752,351 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,341,195 - 34,373,397 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SYNGAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,612,777 - 38,646,382 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,617,679 - 38,646,192 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,268,732 - 33,302,381 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Syngap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,366,912 - 23,396,575 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,367,585 - 23,396,643 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000015669   ⟹   ENSCLAP00000015507
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554371,950,602 - 1,979,251 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000015670   ⟹   ENSCLAP00000015508
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554371,961,923 - 1,979,251 (+)Ensembl
RefSeq Acc Id: XM_013516981   ⟹   XP_013372435
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554371,950,559 - 1,981,004 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516982   ⟹   XP_013372436
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554371,950,559 - 1,981,004 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516983   ⟹   XP_013372437
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554371,950,559 - 1,981,004 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516984   ⟹   XP_013372438
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554371,950,559 - 1,979,193 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516985   ⟹   XP_013372439
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554371,950,559 - 1,979,193 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516986   ⟹   XP_013372440
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554371,950,559 - 1,979,185 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013372435   ⟸   XM_013516981
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VHD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013372436   ⟸   XM_013516982
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VHD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013372437   ⟸   XM_013516983
- Peptide Label: isoform X3
- UniProtKB: A0A8C2VHD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013372439   ⟸   XM_013516985
- Peptide Label: isoform X5
- UniProtKB: A0A8C2VHD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013372438   ⟸   XM_013516984
- Peptide Label: isoform X4
- UniProtKB: A0A8C2VHD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013372440   ⟸   XM_013516986
- Peptide Label: isoform X6
- UniProtKB: A0A8C2VHD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000015507   ⟸   ENSCLAT00000015669
RefSeq Acc Id: ENSCLAP00000015508   ⟸   ENSCLAT00000015670
Protein Domains
C2   PH   Ras-GAP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010661 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000015669 ENTREZGENE
  ENSCLAT00000015669.1 UniProtKB/TrEMBL
  ENSCLAT00000015670.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DUF3498 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Ras_GTPase UniProtKB/TrEMBL
  RasGAP_CS UniProtKB/TrEMBL
  RasGAP_dom UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  SynGAP_PH UniProtKB/TrEMBL
NCBI Gene Syngap1 ENTREZGENE
PANTHER PTHR10194 UniProtKB/TrEMBL
  RAS/RAP GTPASE-ACTIVATING PROTEIN SYNGAP UniProtKB/TrEMBL
Pfam DUF3498 UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  RasGAP UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_1 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_2 UniProtKB/TrEMBL
SMART RasGAP UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
UniProt A0A8C2VHD0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VP87_CHILA UniProtKB/TrEMBL