Ttl (tubulin tyrosine ligase) - Rat Genome Database

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Gene: Ttl (tubulin tyrosine ligase) Chinchilla lanigera
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Symbol: Ttl
Name: tubulin tyrosine ligase
RGD ID: 8784743
Description: ENCODES a protein that exhibits tubulin-tyrosine ligase activity (ortholog); INVOLVED IN microtubule cytoskeleton organization (ortholog); positive regulation of mitotic cell cycle (ortholog); post-translational protein modification (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN spindle microtubule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tubulin--tyrosine ligase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,743,751 - 1,774,512 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,747,217 - 1,774,512 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Ttl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,743,751 - 1,774,512 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,747,217 - 1,774,512 (-)NCBIChiLan1.0ChiLan1.0
TTL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382112,482,156 - 112,541,739 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2112,482,156 - 112,541,739 (+)EnsemblGRCh38hg38GRCh38
GRCh372113,239,733 - 113,299,316 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362112,956,214 - 113,006,694 (+)NCBINCBI36Build 36hg18NCBI36
Build 342112,956,128 - 113,006,212NCBI
Celera2106,625,279 - 106,675,764 (+)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2105,693,725 - 105,744,724 (+)NCBIHuRef
CHM1_12113,243,890 - 113,294,368 (+)NCBICHM1_1
T2T-CHM13v2.02112,908,795 - 112,968,389 (+)NCBIT2T-CHM13v2.0
Ttl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392128,907,867 - 128,938,203 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2128,907,862 - 128,938,203 (+)EnsemblGRCm39 Ensembl
GRCm382129,065,947 - 129,096,283 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,065,942 - 129,096,283 (+)EnsemblGRCm38mm10GRCm38
MGSCv372128,891,683 - 128,922,019 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362128,757,430 - 128,785,190 (+)NCBIMGSCv36mm8
Celera2130,293,491 - 130,323,607 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.65NCBI
Ttl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83136,752,025 - 136,781,758 (+)NCBIGRCr8
mRatBN7.23116,298,813 - 116,328,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,298,797 - 116,328,538 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3120,196,066 - 120,222,520 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03128,791,655 - 128,818,105 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03126,452,127 - 126,478,585 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03121,596,773 - 121,626,581 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,596,791 - 121,624,048 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03128,388,189 - 128,417,974 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,671,419 - 116,697,989 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13116,576,991 - 116,603,562 (+)NCBI
Celera3115,124,248 - 115,150,813 (+)NCBICelera
Cytogenetic Map3q36NCBI
TTL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21215,591,253 - 15,632,233 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A15,594,017 - 15,635,068 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A89,526,022 - 89,567,068 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A113,505,416 - 113,546,896 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,505,416 - 113,546,896 (+)Ensemblpanpan1.1panPan2
TTL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11736,735,836 - 36,770,292 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1736,735,788 - 36,767,016 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1736,504,890 - 36,539,300 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01737,511,436 - 37,545,848 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1737,511,409 - 37,545,835 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11736,649,169 - 36,683,745 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01736,703,448 - 36,738,023 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01736,917,312 - 36,951,900 (+)NCBIUU_Cfam_GSD_1.0
Ttl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,096,219 - 82,130,048 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936783989,269 - 1,025,690 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936783989,269 - 1,024,537 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl343,977,265 - 44,022,635 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1343,980,634 - 44,022,611 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2345,574,533 - 45,617,612 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TTL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11415,500,417 - 15,540,252 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1415,500,520 - 15,538,184 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660804,140,168 - 4,186,856 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474912,549,969 - 12,595,490 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474912,550,017 - 12,595,397 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000007781   ⟹   ENSCLAP00000007662
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554701,743,751 - 1,774,512 (-)Ensembl
RefSeq Acc Id: XM_005400605   ⟹   XP_005400662
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554701,747,217 - 1,774,512 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013522827   ⟹   XP_013378281
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554701,747,217 - 1,774,512 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005400662 (Get FASTA)   NCBI Sequence Viewer  
  XP_013378281 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000007662
  ENSCLAP00000007662.1
RefSeq Acc Id: XP_005400662   ⟸   XM_005400605
- Peptide Label: isoform X2
- UniProtKB: A0A8C2V0U2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013378281   ⟸   XM_013522827
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000007662   ⟸   ENSCLAT00000007781


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005372 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000007781 ENTREZGENE
  ENSCLAT00000007781.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.11480 UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/TrEMBL
InterPro TTL/TTLL_fam UniProtKB/TrEMBL
NCBI Gene Ttl ENTREZGENE
PANTHER TUBULIN--TYROSINE LIGASE UniProtKB/TrEMBL
  TUBULIN--TYROSINE LIGASE UniProtKB/TrEMBL
Pfam TTL UniProtKB/TrEMBL
PROSITE TTL UniProtKB/TrEMBL
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/TrEMBL
UniProt A0A8C2V0U2 ENTREZGENE, UniProtKB/TrEMBL