Unc119 (unc-119 lipid binding chaperone)

Gene: Unc119 (unc-119 lipid binding chaperone) Chinchilla lanigera

Analyze

Symbol:

Unc119

Name:

unc-119 lipid binding chaperone

RGD ID:

8781154

Description:

ENCODES a protein that exhibits lipid binding (ortholog); INVOLVED IN lipoprotein transport (ortholog); mitotic cytokinesis (ortholog); negative regulation of caveolin-mediated endocytosis (ortholog); ASSOCIATED WITH cone-rod dystrophy (ortholog); Cone-Rod Dystrophy 24 (ortholog); genetic disease (ortholog); FOUND IN centrosome (ortholog); intercellular bridge (ortholog); spindle midzone (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

unc-119 homolog

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955481	4,597,839 - 4,603,313 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955481	4,597,839 - 4,603,313 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cone-rod dystrophy (ISO)

Cone-Rod Dystrophy 24 (ISO)

genetic disease (ISO)

idiopathic CD4-positive T-lymphocytopenia (ISO)

immunodeficiency 13 (ISO)

macular degeneration (ISO)

retinitis pigmentosa (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

lipoprotein transport (ISO)

mitotic cytokinesis (ISO)

negative regulation of caveolin-mediated endocytosis (ISO)

negative regulation of clathrin-dependent endocytosis (ISO)

Cellular Component

centrosome (ISO)

intercellular bridge (ISO)

spindle midzone (ISO)

spindle pole (ISO)

Molecular Function

lipid binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Unc119
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955481	4,597,839 - 4,603,313 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955481	4,597,839 - 4,603,313 (+)	NCBI	ChiLan1.0	ChiLan1.0

UNC119
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	28,546,707 - 28,552,628 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	28,546,708 - 28,552,631 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	26,873,725 - 26,879,646 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	23,897,852 - 23,903,770 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	23,897,852 - 23,903,770	NCBI
Celera	17	23,732,750 - 23,738,671 (-)	NCBI		Celera
Cytogenetic Map	17	q11.2	NCBI
HuRef	17	23,082,548 - 23,088,469 (-)	NCBI		HuRef
CHM1_1	17	26,935,427 - 26,941,348 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	29,489,330 - 29,495,251 (-)	NCBI		T2T-CHM13v2.0

Unc119
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	78,234,321 - 78,239,990 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	78,234,308 - 78,239,990 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	78,343,495 - 78,349,164 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	78,343,482 - 78,349,164 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	78,157,024 - 78,162,658 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	78,159,717 - 78,165,351 (+)	NCBI		MGSCv36	mm8
Celera	11	87,975,604 - 87,981,238 (+)	NCBI		Celera
Cytogenetic Map	11	B5	NCBI
cM Map	11	46.74	NCBI

Unc119
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	63,735,927 - 63,741,404 (+)	NCBI		GRCr8
mRatBN7.2	10	63,237,862 - 63,243,339 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	63,237,903 - 63,243,339 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	67,870,234 - 67,875,633 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	67,375,583 - 67,380,982 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	62,846,688 - 62,852,088 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	65,606,919 - 65,612,324 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	65,606,898 - 65,612,324 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	66,026,840 - 66,032,239 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	64,285,993 - 64,291,392 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	64,299,615 - 64,305,015 (-)	NCBI
Celera	10	62,215,606 - 62,221,005 (+)	NCBI		Celera
Cytogenetic Map	10	q25	NCBI

UNC119
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	35,907,677 - 35,913,612 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	37,787,803 - 37,793,737 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	28,223,428 - 28,229,361 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	28,729,569 - 28,732,229 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

UNC119
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	42,754,575 - 42,760,337 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	42,754,887 - 42,760,482 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	41,911,236 - 41,917,005 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	43,573,537 - 43,579,307 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	43,573,540 - 43,579,444 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	42,356,587 - 42,362,351 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	42,649,035 - 42,654,797 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	42,726,501 - 42,732,272 (-)	NCBI		UU_Cfam_GSD_1.0

Unc119
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	41,894,288 - 41,900,215 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936538	4,772,283 - 4,778,137 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936538	4,772,236 - 4,778,149 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UNC119
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	44,801,267 - 44,807,339 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	44,801,265 - 44,807,334 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	46,785,656 - 46,791,681 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UNC119
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	22,315,900 - 22,321,806 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666075	7,804,980 - 7,810,919 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Unc119
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624786	1,134,162 - 1,141,474 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624786	1,134,508 - 1,140,831 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005402748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01056944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01056945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01050087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000023314 ⟹ ENSCLAP00000023095

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955481	4,597,839 - 4,603,313 (+)	Ensembl

RefSeq Acc Id:

XM_005402748 ⟹ XP_005402805

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955481	4,597,839 - 4,603,313 (+)	NCBI

Sequence:

show sequence

TGCGGACGCTCCCCCTTCCTCCGGCTCCAGCCGGCGCAGGCGACGGTGGCGGTAGCAGCGAGCC
ACGGGCGGCCCGGCGGGGCGAGGCCATGAAGGTGAAGAAGGGCGCCAGCGGGGCCAGGGCGGGG
GCGGAGCCCGCTCCTGGAGCTTCGGGCCTGAGCGTAGAACCCCCGCCGGGTCCGCAAGCGGAAT
CTGAATCAGAGTCCGAGTCGGAGCCAGAGCCAGGCCTGGGGCCCAGGCCGGGGCCGCTGCAGGG
AAAGCAACCCATCGGGCCCGAGGATGTGCTGGGGCTGCAGCGGATCACGGGCGACTACTTGTGC
TCCCCCGAGGAGAATATCTACAAGATCGACTTCGTCAGGTTCAAGATCCGGGACATGGACTCAG
GCACTGTTCTCTTTGAAATCAAGAAGCCCCCTGCTTCAGAACGGTTGCCCATCAACCGGCGGGA
CCTGGACCCCAATGCTGGGCGCTTTGTCCGCTACCAGTTCACACCTGCCTTTCTCCGCCTGAGG
CAGGTGGGAGCCACGGTGGAGTTCACAGTGGGAGACAAGCCCGTGAACAACTTCCGCATGATCG
AGAGGCACTACTTCCGGAACCAGCTGCTCAAAAGCTTTGACTTCCACTTTGGCTTCTGCATTCC
CAGCAGCAAAAACACCTGCGAGCACATCTATGACTTTCCCCCTCTGTCGGAGGAGCTGATCAGC
GAGATGATCCGTCACCCATATGAGACACAGTCTGACAGCTTCTACTTCGTGGATGACCGGCTGG
TGATGCACAATAAAGCAGACTATTCCTACAGTGGGACACCCTGACCCCCCAAACTGCTCCCCAC
CCCAGGAGGCTCTGGCCTGGGCCCTCAGCTGTGACCTCTCCAAACTCACCTTTCAGCCCCAGAT
CTTCTGCGTGGGGTATGCTCCAGAAGACCTGGACCCAGAGTCAGTGTTGGGAAGAAGGGTACCT
CGTGTCCCCAGGCCAAGCCCTGACATCCCTGGGGCCTGGTCTGTGGGTTGAATGGTAGGGAGCT
GTTTACCTCCGTGTCCTTTTAGGCCTCCTGTGAGAGGATCAACCAGGACTTCCAGACAGTCTAG
CTCGGCCCTTTGGGGCTCCAGTTTCATAATACTGTTTCCGGCTCCAGGCTGTGACGAGGTCAGG
ACGAGGATCCATTCTCTGTCCCGTCAGCCATATCCAGGGCATTTAGAGTTGTAAGTTCTCAGAC
AAAGGTCCACAGGGGAAGTGGGCCTCAGCTCCCCAACTCTCCCATCAGGGGCCACGACATTGCC
TGAGATGTGGGGGGACCAGCCCAGGTTTCATCCTGTGCTAGGAACTGGACCAACTGTATATAGT
TTTCAATAAACTCCTTTTCTGTTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005402805	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000023095
	ENSCLAP00000023095.1

RefSeq Acc Id:

XP_005402805 ⟸ XM_005402748

- UniProtKB:

A0A8C2YTY0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKVKKGASGARAGAEPAPGASGLSVEPPPGPQAESESESESEPEPGLGPRPGPLQGKQPIGPED
VLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPASERLPINRRDLDPNAGRF
VRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFHFGFCIPSSKNTCEH
IYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSGTP

hide sequence

RefSeq Acc Id:

ENSCLAP00000023095 ⟸ ENSCLAT00000023314

Protein Domains

GMP phosphodiesterase delta subunit

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015855	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000023314	ENTREZGENE
	ENSCLAT00000023314.1	UniProtKB/TrEMBL
Gene3D-CATH	2.70.50.40	UniProtKB/TrEMBL
InterPro	Ig_E-set	UniProtKB/TrEMBL
	PDED_dom	UniProtKB/TrEMBL
	PDED_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Unc119	ENTREZGENE
PANTHER	PTHR12951:SF5	UniProtKB/TrEMBL
	RETINAL PROTEIN 4	UniProtKB/TrEMBL
Pfam	GMP_PDE_delta	UniProtKB/TrEMBL
Superfamily-SCOP	SSF81296	UniProtKB/TrEMBL
UniProt	A0A8C2YTY0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-25	Unc119	unc-119 lipid binding chaperone		unc-119 homolog (C. elegans)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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