Orai1 (ORAI calcium release-activated calcium modulator 1)

Gene: Orai1 (ORAI calcium release-activated calcium modulator 1) Chinchilla lanigera

Analyze

Symbol:

Orai1

Name:

ORAI calcium release-activated calcium modulator 1

RGD ID:

8779981

Description:

ENCODES a protein that exhibits calcium channel activity (ortholog); identical protein binding (ortholog); store-operated calcium channel activity (ortholog); INVOLVED IN calcineurin-NFAT signaling cascade (ortholog); calcium ion import (ortholog); calcium ion transmembrane transport (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH congenital structural myopathy (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN basolateral plasma membrane (ortholog); growth cone (ortholog); membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

calcium release-activated calcium channel protein 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	6,731,949 - 6,775,545 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955482	6,731,949 - 6,746,095 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital structural myopathy (ISO)

genetic disease (ISO)

hypertension (ISO)

immunodeficiency 9 (ISO)

Neoplasm Metastasis (ISO)

tubular aggregate myopathy 1 (ISO)

tubular aggregate myopathy 2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcineurin-NFAT signaling cascade (ISO)

calcium ion import (ISO)

calcium ion transmembrane transport (ISO)

ion channel modulating, G protein-coupled receptor signaling pathway (ISO)

ligand-gated ion channel signaling pathway (ISO)

mammary gland epithelium development (ISO)

phospholipase C-activating G protein-coupled receptor signaling pathway (ISO)

positive regulation of calcium ion transport (ISO)

positive regulation of insulin secretion (ISO)

regulation of calcium ion transport (ISO)

store-operated calcium entry (ISO)

Cellular Component

basolateral plasma membrane (ISO)

growth cone (ISO)

membrane (ISO)

membrane raft (ISO)

plasma membrane (ISO)

plasma membrane raft (ISO)

protein-containing complex (ISO)

Molecular Function

calcium channel activity (ISO)

identical protein binding (ISO)

protein binding (ISO)

store-operated calcium channel activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium transport pathway (ISO)

calcium/calcium-mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Orai1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	6,731,949 - 6,775,545 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955482	6,731,949 - 6,746,095 (-)	NCBI	ChiLan1.0	ChiLan1.0

ORAI1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	121,626,530 - 121,643,109 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	121,626,509 - 121,643,218 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	122,064,455 - 122,079,946 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	120,548,858 - 120,564,322 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	121,703,577 - 121,719,069 (+)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	119,077,074 - 119,092,406 (+)	NCBI		HuRef
CHM1_1	12	122,032,834 - 122,048,313 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	121,619,725 - 121,636,322 (+)	NCBI		T2T-CHM13v2.0

Orai1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	123,153,078 - 123,168,515 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	123,153,137 - 123,168,519 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	123,015,074 - 123,030,452 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	123,015,074 - 123,030,456 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	123,465,083 - 123,480,461 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	123,275,691 - 123,290,773 (+)	NCBI		MGSCv36	mm8
Celera	5	120,110,246 - 120,125,811 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	62.72	NCBI

Orai1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	39,195,139 - 39,209,030 (-)	NCBI		GRCr8
mRatBN7.2	12	33,533,151 - 33,548,361 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	33,534,344 - 33,548,405 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	34,713,038 - 34,727,066 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	35,324,404 - 35,338,430 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	34,376,303 - 34,390,334 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	38,981,903 - 38,995,570 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	38,981,927 - 38,995,570 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	40,878,296 - 40,879,065 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	34,631,248 - 34,646,316 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	34,494,636 - 34,509,704 (-)	NCBI
Celera	12	35,214,491 - 35,228,150 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

LOC100987781
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	129,715,796 - 129,730,170 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	129,712,187 - 129,726,546 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	119,229,069 - 119,243,435 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	122,601,227 - 122,614,990 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

ORAI1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	7,584,276 - 7,599,667 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	7,584,880 - 7,599,401 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	7,743,828 - 7,758,883 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	7,836,101 - 7,851,163 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	7,836,598 - 7,881,528 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	7,767,621 - 7,782,778 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	7,857,940 - 7,873,138 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	7,813,894 - 7,829,022 (-)	NCBI		UU_Cfam_GSD_1.0

Orai1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	156,736,358 - 156,749,328 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936558	2,730,098 - 2,743,062 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ORAI1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	31,011,644 - 31,027,993 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	31,012,212 - 31,028,008 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	32,817,278 - 32,818,011 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Sscrofa10.2	14	32,882,749 - 32,883,075 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ORAI1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	116,997,375 - 117,012,115 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	116,997,636 - 117,011,737 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	127,968,411 - 127,985,052 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Orai1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	22,071,404 - 22,085,976 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	22,071,373 - 22,085,180 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005403114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01057413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01095542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01082823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000015018 ⟹ ENSCLAP00000014859

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955482	6,731,949 - 6,775,545 (-)	Ensembl

RefSeq Acc Id:

XM_005403114 ⟹ XP_005403171

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955482	6,731,949 - 6,746,095 (-)	NCBI

Sequence:

show sequence

GGCGTATGCAAATCACTCCGGGGCGGCGGCCAATCGTGGCGCGCGCCGAGAGTCCAGGCCCGGG
ACCGGACGGTGGCTGGCGTGCTGGCTCGCGTCGCGGCTGGCCTGGGTCTCTGGCGAGCTGCGCC
GCAAGCCGGTCTGCAGCCGCTTGCTCGACCTCCTCTTCCCGTGCGGCCGGCTGGGTGAGGCCGG
GCCCGCGGCGGGGGGCAGGCGGAGGTGCCGCGGGCCGCCGCCGCTGCCGCGTGCTCCATGCATC
CGGAGCCCGCCCCGCCCCCGAGCAGCAGCAGCAGTCCGGAGCTTCCCCTCGGCGGTGGCAGCGG
GAGCAGCCGGAGCCGTCGCCACAGTGCGGACGGGGAGCCCCCGGGGTCTCCGCCGCCGCCCGCC
GTCAGCTACCCGGACTGGGTCGGCCAGAGCTACTACTCCGAGGTGATGAGTCTCAACGAGCACT
CGATGCAGGCGCTGTCCTGGCGCAAACTCTACTTGAGTCGCGCCAAGCTCAAAGCCTCCAGCCG
GACCTCGGCGCTGCTCTCCGGCTTCGCCATGGTGGCCATGGTGGAGGTGCAGCTGGACGCCGAG
CATGACTACCCGCCGGGGCTGCTCATCGCCTTCAGCGCCTGCACCACGGTGCTGGTGGCTGTGC
ACCTGTTCGCACTCATGATCAGCACCTGCATCCTGCCCAACATCGAGGCGGTGAGCAACGTGCA
CAACCTCAACTCGGTCAAGGAGTCGCCCCACGAGCGCATGCATCGCCACATCGAGCTGGCCTGG
GCCTTCTCCACTGTCATCGGCACGCTGCTCTTCCTGGCCGAGGTCGTGCTGCTCTGCTGGGTCA
AGTTCCTGCCGCTCAAGAAGCAGCCGGGCCAGCCTCGCCCCACCAGCAAGCCGCCTGCCGCTGA
CATGGCAGCCAACATCAGCAGCGGAATCACACCGGGCCAGGCGGCGGCCATCGCCTCCACCACC
ATCATGGTCCCCTTCGGCCTGGTCTTCATCGTCTTTGCCGTGCACTTCTACCGCTCACTGGTCA
GCCACAAGACGGACCGACAGTTCCAGGAGCTCAACGAGCTGGCCGAGTTCGCGCGCCTGCAGGA
CCAGCTGGACCACAGAGGGGACCACCCGCTGACGCCCGGCAGCCACTATGCCTGAGCCTGCCGG
GCCCAGGCACTGAGGCCTGCACGCCCTTCCTTCCTGGTGGCCTTGACCCACGCCAGCTCAGGGG
CGCCTGCGCGGGGCCCTGGCTCCGCGGGCACAGAGAGGCAGGAAGAGGCTTTCGAAAAAGGGAC
TGCACCTTGAGACTTTGCTCAGAGAGAATAAGCACTTCCTGTTCTTCCAGGGCCAGAGAGAGGA
CAGATGCTCTCTTTGTCCCCTCCCTCCACCCCCATGTCATTGCCACCCAGATGCTTCTGTCCCC
GCCTCCCTCCCCACTTGGTGGTGTGTATGTGTGTGTGTGTGTGTGTGTGTGCGTGCGTGTGCGT
GAACATAGAAATATACTACTAAGGGACACCTCC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005403171	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000014859
	ENSCLAP00000014859.1

RefSeq Acc Id:

XP_005403171 ⟸ XM_005403114

- UniProtKB:

A0A8C2VFY3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MHPEPAPPPSSSSSPELPLGGGSGSSRSRRHSADGEPPGSPPPPAVSYPDWVGQSYYSEVMSLN
EHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDAEHDYPPGLLIAFSACTTVLV
AVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLC
WVKFLPLKKQPGQPRPTSKPPAADMAANISSGITPGQAAAIASTTIMVPFGLVFIVFAVHFYRS
LVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA

hide sequence

RefSeq Acc Id:

ENSCLAP00000014859 ⟸ ENSCLAT00000015018

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000010246	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000015018	ENTREZGENE
	ENSCLAT00000015018.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.140.140	UniProtKB/TrEMBL
InterPro	CRAC_channel	UniProtKB/TrEMBL
	Orai_sf	UniProtKB/TrEMBL
NCBI Gene	Orai1	ENTREZGENE
PANTHER	CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1	UniProtKB/TrEMBL
	PTHR31501	UniProtKB/TrEMBL
Pfam	Orai-1	UniProtKB/TrEMBL
UniProt	A0A8C2VFY3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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