Mknk2 (MAPK interacting serine/threonine kinase 2) - Rat Genome Database

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Gene: Mknk2 (MAPK interacting serine/threonine kinase 2) Chinchilla lanigera
Analyze
Symbol: Mknk2
Name: MAPK interacting serine/threonine kinase 2
RGD ID: 8774690
Description: ENCODES a protein that exhibits ATP binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cellular response to arsenic-containing substance (ortholog); extrinsic apoptotic signaling pathway in absence of ligand (ortholog); hemopoiesis (ortholog); PARTICIPATES IN p38 MAPK signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH cyclic hematopoiesis (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN nuclear body (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MAP kinase interacting serine/threonine kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,048,128 - 6,062,913 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,048,346 - 6,061,579 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mknk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,048,128 - 6,062,913 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,048,346 - 6,061,579 (+)NCBIChiLan1.0ChiLan1.0
MKNK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,037,471 - 2,051,244 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,037,465 - 2,051,244 (-)EnsemblGRCh38hg38GRCh38
GRCh37192,037,470 - 2,051,243 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,988,470 - 2,002,243 (-)NCBINCBI36Build 36hg18NCBI36
Build 34191,988,469 - 2,002,233NCBI
Celera191,972,223 - 1,985,996 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,809,368 - 1,822,963 (-)NCBIHuRef
CHM1_1192,037,373 - 2,051,145 (-)NCBICHM1_1
T2T-CHM13v2.0192,010,542 - 2,024,317 (-)NCBIT2T-CHM13v2.0
Mknk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,501,152 - 80,512,264 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,501,161 - 80,513,946 (-)EnsemblGRCm39 Ensembl
GRCm381080,665,318 - 80,676,293 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,665,327 - 80,678,112 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,128,072 - 80,134,721 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,068,456 - 80,075,105 (-)NCBIMGSCv36mm8
Celera1081,683,709 - 81,690,357 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Mknk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,690,385 - 9,701,527 (+)NCBIGRCr8
mRatBN7.279,039,771 - 9,050,832 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,039,728 - 9,050,827 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,918,241 - 11,929,263 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,793,754 - 13,804,776 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,659,834 - 11,670,885 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,908,107 - 11,919,161 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,908,107 - 11,919,156 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,075,381 - 12,086,471 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,550,040 - 10,561,100 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,550,039 - 10,561,095 (+)NCBI
Celera77,222,443 - 7,233,496 (+)NCBICelera
Cytogenetic Map7q11NCBI
MKNK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,417,727 - 6,431,445 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,648,480 - 5,662,190 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,045,316 - 1,059,023 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,018,822 - 2,032,429 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,018,822 - 2,032,429 (-)Ensemblpanpan1.1panPan2
MKNK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,966,656 - 56,978,414 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,965,800 - 56,974,073 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,761,516 - 56,773,096 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02057,699,409 - 57,711,005 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,698,709 - 57,709,803 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,756,543 - 56,768,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,236,165 - 57,247,743 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,436,941 - 57,448,534 (+)NCBIUU_Cfam_GSD_1.0
Mknk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,645,852 - 216,657,922 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,178,890 - 1,188,896 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,176,861 - 1,188,931 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MKNK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,510,303 - 76,522,883 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,510,302 - 76,522,885 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,245,674 - 77,254,490 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MKNK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,836,009 - 1,851,325 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl61,835,993 - 1,851,039 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660816,889,976 - 6,905,278 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mknk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248286,788,069 - 6,801,370 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000016695   ⟹   ENSCLAP00000016531
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554956,048,128 - 6,062,913 (+)Ensembl
RefSeq Acc Id: XM_005405932   ⟹   XP_005405989
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554956,048,346 - 6,061,579 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005405934   ⟹   XP_005405991
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554956,048,346 - 6,061,579 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005405989 (Get FASTA)   NCBI Sequence Viewer  
  XP_005405991 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000016531
  ENSCLAP00000016531.1
RefSeq Acc Id: XP_005405991   ⟸   XM_005405934
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005405989   ⟸   XM_005405932
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VLI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000016531   ⟸   ENSCLAT00000016695
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011365 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000016695 ENTREZGENE
  ENSCLAT00000016695.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Mknk2 ENTREZGENE
PANTHER MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2VLI1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 Mknk2  MAPK interacting serine/threonine kinase 2    MAP kinase interacting serine/threonine kinase 2  Symbol and/or name change 5135510 APPROVED