Terf1 (telomeric repeat binding factor 1)

Gene: Terf1 (telomeric repeat binding factor 1) Chinchilla lanigera

Analyze

Symbol:

Terf1

Name:

telomeric repeat binding factor 1

RGD ID:

8766065

Description:

ENCODES a protein that exhibits ankyrin repeat binding (ortholog); DNA binding, bending (ortholog); double-stranded telomeric DNA binding (ortholog); INVOLVED IN meiotic telomere clustering (ortholog); negative regulation of DNA replication (ortholog); negative regulation of establishment of protein localization to telomere (ortholog); ASSOCIATED WITH breast cancer (ortholog); genetic disease (ortholog); squamous cell carcinoma (ortholog); FOUND IN chromosome, telomeric region (ortholog); fibrillar center (ortholog); nuclear body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

telomeric repeat binding factor (NIMA-interacting) 1; telomeric repeat-binding factor 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955444	7,103,552 - 7,150,323 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955444	7,103,282 - 7,149,450 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast cancer (ISO)

genetic disease (ISO)

squamous cell carcinoma (ISO)

stomach cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

meiotic telomere clustering (ISO)

negative regulation of DNA replication (ISO)

negative regulation of establishment of protein localization to telomere (ISO)

negative regulation of establishment of RNA localization to telomere (ISO)

negative regulation of telomere maintenance via telomerase (ISO)

negative regulation of telomeric D-loop disassembly (ISO)

positive regulation of shelterin complex assembly (ISO)

response to xenobiotic stimulus (ISO)

telomere capping (ISO)

telomere maintenance (ISO)

telomere maintenance via telomerase (ISO)

telomeric D-loop disassembly (ISO)

telomeric loop formation (ISO)

Cellular Component

chromosome, telomeric region (ISO)

fibrillar center (ISO)

nuclear body (ISO)

nuclear telomere cap complex (ISO)

nucleolus (ISO)

nucleus (ISO)

shelterin complex (ISO)

spindle (ISO)

Molecular Function

ankyrin repeat binding (ISO)

DNA binding, bending (ISO)

double-stranded telomeric DNA binding (ISO)

G-rich strand telomeric DNA binding (ISO)

identical protein binding (ISO)

microtubule binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

telomerase activity (ISO)

telomeric DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Terf1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955444	7,103,552 - 7,150,323 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955444	7,103,282 - 7,149,450 (-)	NCBI	ChiLan1.0	ChiLan1.0

TERF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	73,008,864 - 73,048,123 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	73,008,856 - 73,048,123 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	73,921,099 - 73,960,358 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	74,083,661 - 74,122,281 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	74,083,662 - 74,122,281	NCBI
Celera	8	69,918,262 - 69,957,163 (+)	NCBI		Celera
Cytogenetic Map	8	q21.11	NCBI
HuRef	8	69,411,980 - 69,450,876 (+)	NCBI		HuRef
CHM1_1	8	73,973,943 - 74,012,842 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	73,437,901 - 73,477,172 (+)	NCBI		T2T-CHM13v2.0

Terf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	15,875,634 - 15,914,283 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	15,875,870 - 15,914,276 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	15,805,546 - 15,844,052 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	15,805,646 - 15,844,052 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	15,795,739 - 15,833,510 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	15,790,872 - 15,828,643 (+)	NCBI		MGSCv36	mm8
Celera	1	15,750,793 - 15,788,563 (+)	NCBI		Celera
Cytogenetic Map	1	A3	NCBI
cM Map	1	4.88	NCBI

Terf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	8,226,345 - 8,255,614 (-)	NCBI		GRCr8
mRatBN7.2	5	3,443,103 - 3,472,377 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	3,443,106 - 3,472,340 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	5,560,595 - 5,589,792 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	7,199,479 - 7,228,676 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	6,896,804 - 6,926,212 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	2,853,455 - 2,882,731 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	2,853,459 - 2,882,668 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	2,843,150 - 2,872,418 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	2,556,918 - 2,586,086 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	2,556,917 - 2,586,086 (-)	NCBI
Celera	5	3,039,138 - 3,068,345 (-)	NCBI		Celera
Cytogenetic Map	5	q11	NCBI

TERF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	88,753,525 - 88,792,513 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	64,383,202 - 64,422,226 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	69,545,115 - 69,583,997 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	71,192,716 - 71,231,648 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

TERF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	21,664,378 - 21,701,491 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	21,664,186 - 21,700,495 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	21,929,296 - 21,966,341 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	21,773,860 - 21,811,415 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	21,773,883 - 21,811,414 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	21,832,463 - 21,869,553 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	21,868,610 - 21,906,117 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	22,149,876 - 22,187,001 (+)	NCBI		UU_Cfam_GSD_1.0

Terf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	57,612,694 - 57,639,199 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936648	1,809,395 - 1,835,890 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TERF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	62,797,000 - 62,831,454 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	62,797,244 - 62,831,459 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	68,341,702 - 68,375,863 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TERF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	68,608,830 - 68,647,220 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	68,608,844 - 68,648,171 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	72,734,995 - 72,774,562 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Terf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624744	18,121,687 - 18,156,989 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624744	18,120,677 - 18,156,920 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013518223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01038891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01038892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01038893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01038894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01038895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01038896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01318609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000002942 ⟹ ENSCLAP00000002885

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955444	7,103,552 - 7,150,323 (-)	Ensembl

RefSeq Acc Id:

XM_013518223 ⟹ XP_013373677

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955444	7,103,282 - 7,149,450 (-)	NCBI

Sequence:

show sequence

GCCGGGAGATAACCCCCGCGGGCGCGCTAGGGGGCGCTCGCAGGCGCGAGAGGACCAACATGGC
GGACGACGGCGCCTTCTCGGCTGCGAGCCCGGGCGGGCGTGCCGCTGAGGGCGATGCGGACGCC
GCGGCGCCGGAGCCGACGGGGAAGGCGAGCGGCGAGCAGGAGCACGTAGACTGCCAGGAGCTGC
TGGACTGCCAGGTGGAGTGCGAGGCCCCCGCGGCGGCGGAGGCGGAGGCGGCGGACGTGGTGGC
GAGGGCCGAGGCCGTGGCAGCCGGCTGGATGCTGGATTTCCTGTGCCTGTCGCTGTGCCGGGCG
TTCTGCGACGGCCGCTCCGAGGACTTCCAGCGCATCCGCGACAGCGCCGAGGCTATTATTCATG
GACTCTCTAGTCTTACATCTGATCAGTTGAGAACCATTTACATATGCCAGTTTTTGACAAGAAT
TGCAGCAGGAAAATCCCTTGATGCACAATTTGAAAGTGATGAGCGAATTACACCCTTGGAATCG
GCTCTGATGATTTGGACTTCAGTTGAAAAACAGCATGACAAACTTCATGAAGAAATACAAAATT
TAATTAAAATTCAGGCTGTAGCTGTTTGTATGGAGCATGGCAGTTTTAAGGAAGCAGAAGAAGT
TTTTGAAAGAATATTTGGCGACCCATATTGTCACACGTCATTGGAAAGGAAATTGCTTATGGTA
ATCTCTCAGAAAGATCCATATCACTCCTTTTTTCAACACTTCAGCTACAACCACATGATGGAGA
AAATTAGAAGTTACGTGAATTCTATGCTAAGGGAAAAGTCATCAACTTTTCTAATGAAGGCAGC
AATAAAAGTAGTGGAGAGTGAGAAAACAAGAATAGTAACTTCTCAAGATAAACCCAGTGGTGAT
GATGATGAAGCAGAAACGGAAGCTCATTTGATTGAAGGAAAAAGGTCTCACAGCAACATCTTCT
TACCTAAATTGGAACAAAGAAGCTGTCAGCAAGATCTTAATAAGAAAGAGAGAGTGGGAATTCT
TCAAAGTGGAAGAAAGGCAAACAGAAGAGACGCTAAAAGATGTTCTTCCACAAATCAACCAGTA
ACCCAGGAAAAACAGCGAGCCAGGAAAAGACAGCCATGGCTTTGGGAAGAAGACAAGAATTTGA
AATCTGGTGTGAGGAAGTACGGAGAGGGAAACTGGACTAAAATACTGTTACGTTACAAATTCAA
CAACCGCACCAGTGTCATGCTGAAAGACAGGTGGAGGACCATGAAAAAGCTAAAGCTGATTTGC
TCAGACAGTGAAGACTGAAGGTGATTGTCAGAGTTTGATAAAAGGACAGTTAAATATTTTGTTT
ACTGTATTATATTTGGAACTCGCTGGTCATTGAGGTATGTTAAAACCCTTGTTTAATTTATTTT
TGTCAGTTTAGTGAGGGTGTGTGCTGTCAAGTTACATGCCATCAGCTTATTCTTCAAGAATCTG
TCTGACAAAATGTAAATACATTGAACTCTACCCAGATCTAATACCCAATCCCCAAATTCTGTCC
CAATAAAAAATTTAAAACCTAATGGAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013373677	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000002885
	ENSCLAP00000002885.1

RefSeq Acc Id:

XP_013373677 ⟸ XM_013518223

- UniProtKB:

A0A8C2UPP8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADDGAFSAASPGGRAAEGDADAAAPEPTGKASGEQEHVDCQELLDCQVECEAPAAAEAEAADV
VARAEAVAAGWMLDFLCLSLCRAFCDGRSEDFQRIRDSAEAIIHGLSSLTSDQLRTIYICQFLT
RIAAGKSLDAQFESDERITPLESALMIWTSVEKQHDKLHEEIQNLIKIQAVAVCMEHGSFKEAE
EVFERIFGDPYCHTSLERKLLMVISQKDPYHSFFQHFSYNHMMEKIRSYVNSMLREKSSTFLMK
AAIKVVESEKTRIVTSQDKPSGDDDEAETEAHLIEGKRSHSNIFLPKLEQRSCQQDLNKKERVG
ILQSGRKANRRDAKRCSSTNQPVTQEKQRARKRQPWLWEEDKNLKSGVRKYGEGNWTKILLRYK
FNNRTSVMLKDRWRTMKKLKLICSDSED

hide sequence

RefSeq Acc Id:

ENSCLAP00000002885 ⟸ ENSCLAT00000002942

Protein Domains

HTH myb-type Myb-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000002076	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000002942	ENTREZGENE
	ENSCLAT00000002942.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.210	UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/TrEMBL
	Myb_dom	UniProtKB/TrEMBL
	SANT/Myb	UniProtKB/TrEMBL
	Telomere_rpt-bd_fac_dimer_dom	UniProtKB/TrEMBL
	Telomere_rpt-bd_fac_dimer_sf	UniProtKB/TrEMBL
	TERF1/2	UniProtKB/TrEMBL
NCBI Gene	Terf1	ENTREZGENE
PANTHER	TELOMERIC REPEAT-BINDING FACTOR 1	UniProtKB/TrEMBL
	TELOMERIC REPEAT-BINDING FACTOR 1 TERF1	UniProtKB/TrEMBL
Pfam	Myb_DNA-binding	UniProtKB/TrEMBL
	TRF	UniProtKB/TrEMBL
PIRSF	Telomere_bd-1_Pin2	UniProtKB/TrEMBL
PROSITE	HTH_MYB	UniProtKB/TrEMBL
	MYB_LIKE	UniProtKB/TrEMBL
SMART	SANT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
	SSF63600	UniProtKB/TrEMBL
UniProt	A0A8C2UPP8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Terf1	telomeric repeat binding factor 1		telomeric repeat binding factor (NIMA-interacting) 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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